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26

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4546	Dinoprost tromethamine salt Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,地诺前列素氨丁三醇,Prostaglandin F2α THAM	Apoptosis; Endogenous Metabolite; Prostaglandin Receptor; Autophagy; PROTAC Linker	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; PROTAC
	Dinoprost tromethamine salt (PGF2α THAM) 是一种口服有效的前列腺素 F 受体激动剂。它是在子宫内膜腔上皮和黄体中局部产生的溶酶激素，在分娩过程中起关键作用。
T4977	Sofalcone 索法酮,SU-88	Antibacterial; Autophagy	Autophagy; Microbiology/Virology
	Sofalcone (SU-88) 可诱导血红素加氧酶-1在胃肠上皮中的表达，是一种抗胃溃疡剂。
T4182	lavendustin B 薰草菌素B	Tyrosinase; transporter; HIV Protease	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Lavendustin B 是一种酪氨酸激酶抑制剂，是 HIV-1 整合酶 (IN) 与其同源细胞辅助因子、晶状体上皮衍生生长因子 (LEDGF/p75) 相互作用的抑制剂。
T25466	GS-9191 GS 9191	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	GS-9191是一种DNA 聚合酶α和ß 的强效抑制剂，是一种新型核苷类似物9-(2-膦酰甲氧基乙基)鸟嘌呤(PMEG)的原药，可渗透皮肤并在上皮层代谢为活性核苷三磷酸类似物。GS-9191具有抗增殖活性，以剂量相关的方式减少乳头瘤的大小。GS-9191可能对治疗HPV 引起的病变有作用。
T34710	STA 2 ONO 11113,STA-2,STA2
	STA 2 is an analogue of TXA2, a thromboxane receptor in the colonic epithelium.
TP2253	GLP-2(rat) GLP-2 (rat)	Others	Others
	intestinal epithelium-specific growth factor
T34566	Sch 12223 Sch12223,Sch-12223
	SCH 12223 is a unique drug that protects the stomach and intestinal epithelium from harmful irritation.
T34551	SC 32855 SC-32855,SC32855
	SC 32855 is a 1,4-benzodiazepine that has been shown to arrest of spermatogenesis and degeneration of the germinal epithelium.
T68682	Piriprost
	Piriprost is a leukotriene inhibitor attenuates the smoke-induced increase in alveolar-capillary barrier permeability and decrease in plasminogen activator activity and causes a swelling of type I alveolar epithelium.
T81341	Pyr-Gly
	Pyr-Gly为抑制肽类化合物，能够抑制视网膜色素上皮(RPE)细胞及成纤维细胞的增殖作用。
TP1157	GLP-2(1-33)(human) GLP-2 (human),Glucagon-like peptide 2 (human)
	GLP-2(1-33) (human) is an enteroendocrine hormone which stimulates the growth of the intestinal epithelium.
TP1487	Glucagon-Like Peptide (GLP) II, human
	Glucagon-like peptide 2 (GLP-2) is a recently identified intestinal epithelium-specific growth factor that has been shown to reduce the severity of inflammatory disorders of the intestine in rodent models. Currently Glucagon-Like Peptide 2 is used as a po
T69429	Y27632 HCl hydrate
	Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats, increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium, affects initial heart myofibrillogenesis in cultured chick blastoderm, promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord...
T76806	Bezlotoxumab
	Bezlotoxumab 是一种针对 C. difficile 毒素 B 的人单克隆抗体。Bezlotoxumab 与 C. difficile 毒素 B 结合，可预防肠上皮损伤和结肠炎。
T74699	Avacincaptad pegol
	Avacincaptad pegol 是核酸适配体，作为 C5 补体抑制剂，用以减轻炎症导致的视网膜色素上皮 (RPE) 损伤。该化合物可用于研究 stargardt 黄斑营养不良 (STGD1) 与地理萎缩 (GA)。
T81720	N,N'-Dinitrosopiperazine 1,4-Dinitrosopiperazine,DNP
	N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) 为已知致癌物，与鼻咽癌发展及其转移关联。该化合物通过影响包括LYRIC在内的多条信号通路，特别是通过蛋白磷酸化作用于丝氨酸568位，发挥作用。
T78404	Pyridinium bisretinoid A2E TFA A2E TFA	Apoptosis	Apoptosis
	Pyridinium bisretinoid A2E TFA作为一种荧光团，能从视网膜色素上皮(RPE)的脂褐素中分离得到，是蓝光诱导的细胞凋亡(apoptosis)诱导剂。该化合物具有光活化特性，可介导自噬(autophagy)和活性氧(reactive oxygen species)的产生，常用于视网膜退行性疾病的研究。
T36714	Sucrose octasulfate (potassium salt)
	Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum-sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury. It can bind to exosite II of thrombin (KD = ~1.4 μM) and inhibit its catalytic activity (IC50 = 4.5 μM) and, as such, has been used as a surrogate for heparin. Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by pr...
TP1749	IRBP (1-20), human
	IRBP (1-20), human is the 1-20 fragment of interphotoreceptor retinoid binding protein (IRBP).This peptide is a 1 to 20 amino acid fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP is a 140-kDa glycolipoprotein residing in the inter
T38220	11-cis Retinol
	11-cisRetinol is an isomer of vitamin A . It is formed from vitamin A,viaatrans-retinyl ester intermediate, by the enzyme RPE65 in the retinal pigment epithelium and then converted to 11-cis retinal as part of the visual cycle.1,211-cisRetinol is an agonist of salamander and human red rod opsins expressed in COS cells and an inverse agonist of salamander red cone opsin, as well as human red and green cone opsins expressed in COS cells.3It promotes pigment formation in cone, but not rod, photorec...
T81900	LVGRQLEEFL (mouse) (TFA)
	LVGRQLEEFL (mouse) TFA，即G*肽，对应[113,122]apoJ中的第113至122位氨基酸序列，表现出抗炎与抗动脉粥样硬化的特性。该肽能够整合至apoJ模拟物，生成HM-10/10肽，一种新型嵌合高密度脂蛋白模拟肽。HM-10/10肽能够保护视网膜色素上皮(RPE)及光感受器，防止氧化剂引起的细胞死亡。
T81901	LVGRQLEEFL (mouse)
	LVGRQLEEFL（mouse）即G*肽，为[113,122]apoJ中113至122位氨基酸序列。该化合物展现抗炎与抗动脉粥样硬化功能。将LVGRQLEEFL（mouse）整合至apoJ模拟物，可生成HM-10/10肽，此为一种模拟肽及新型嵌合高密度脂蛋白。HM-10/10肽能守护视网膜色素上皮（RPE）及光感受器，防止氧化剂诱导下的细胞死亡。
T38309	LL-37 amide (trifluoroacetate salt)
	LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ...
T83700	IRBP (651-670) (human) TFA IRBP651-670,Interphotoreceptor Retinoid-Binding Protein (651-670)
	IRBP651-670（Interphotoreceptor retinoid-binding protein (651-670)）是IRBP（亦称为retinoid-binding protein 3）的肽段，参与色素再生，通过将视黄醇和视黄醛从光感受细胞传输到视网膜色素上皮。在C57BL/6小鼠中，利用IRBP651-670诱导自身免疫性葡萄膜炎，这些小鼠携带H-2b单体型。用IRBP651-670（300 µg/动物）免疫增加了小鼠眼部IL-1β、IL-6、IL-17、TNF-α和IFN-γ水平，免疫细胞浸润及光感受器损伤。
T83681	IRBP (1-20) (human, rat) TFA IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)
	IRBP1-20（1-20）是IRBP的一个十二肽片段，亦称视黄醇结合蛋白3，负责运输视锥细胞中的视黄醇和视黄醛至视网膜色素上皮，参与色素再生。在携带H-2b等位基因型的C57BL/6小鼠中，IRBP1-20用于诱导自身免疫性葡萄膜视网膜炎。IRBP1-20（3 µM）能增加初级小鼠脾淋巴细胞分泌IL-4、IL-5和IL-6的水平。用IRBP1-20免疫并再次挑战，可增加IFN-γ缺乏小鼠的耳部肿胀、眼部血管炎症、免疫细胞浸润和视锥细胞层损伤，以及视网膜脱落。
T8761	[Leu15]-Gastrin I human Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2	Others	Others
	[Leu15]-Gastrin I human (Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2) 基因编码人体内的蛋白质 [Leu15]-胃泌素 I。在人类染色体中，GAST 基因定位于 17q21.2。胃窦中的 G 细胞产生 [Leu15]-胃泌素 I 的前体前胃泌素。前胃泌素经过裂解和加工产生胃泌素，它对整个胃肠道上皮细胞具有营养作用。胃泌素对消化系统的生长至关重要，并刺激壁细胞产生胃酸。胃泌素通过称为胆囊收缩素(CCK) 或 CCK-B 受体 (CCK-BR) 的 G 蛋白偶联受体发挥其功能。胃泌素的释放受到食物的刺激，尤其是蛋白质饮食，并受到非常低的 pH 值的抑制。萎缩性胃炎、幽门螺杆菌感染和长期服用质子泵抑制剂感染可能导致胃泌素过度表达。胃腺癌显示高水平的胃泌素。

化合物

Dinoprost tromethamine salt

Cat.No: T4546

Synonym: Dinoprost Tromethamine,Zinoprost,Prostin F2 alpha,PGF2α THAM,Dinolytic,地诺前列素氨丁三醇,Prostaglandin F2α THAM

Target: Apoptosis, Endogenous Metabolite, Prostaglandin Receptor, Autophagy, PROTAC Linker

Cat.No: T4977

Synonym: 索法酮,SU-88

Target: Antibacterial, Autophagy

Cat.No: T4182

Synonym: 薰草菌素B

Target: Tyrosinase, transporter, HIV Protease

Cat.No: T25466

Synonym: GS 9191

Target: DNA/RNA Synthesis

Cat.No: T34710

Synonym: ONO 11113,STA-2,STA2

Cat.No: TP2253

Synonym: GLP-2 (rat)

Target: Others

Cat.No: T34566

Synonym: Sch12223,Sch-12223

Cat.No: T34551

Synonym: SC-32855,SC32855

Cat.No: T68682

Cat.No: T81341

GLP-2(1-33)(human)

Cat.No: TP1157

Synonym: GLP-2 (human),Glucagon-like peptide 2 (human)

Glucagon-Like Peptide (GLP) II, human

Cat.No: TP1487

Y27632 HCl hydrate

Cat.No: T69429

Cat.No: T76806

Avacincaptad pegol

Cat.No: T74699

N,N'-Dinitrosopiperazine

Cat.No: T81720

Synonym: 1,4-Dinitrosopiperazine,DNP

Pyridinium bisretinoid A2E TFA

Cat.No: T78404

Synonym: A2E TFA

Target: Apoptosis

Sucrose octasulfate (potassium salt)

Cat.No: T36714

IRBP (1-20), human

Cat.No: TP1749

Cat.No: T38220

LVGRQLEEFL (mouse) (TFA)

Cat.No: T81900

LVGRQLEEFL (mouse)

Cat.No: T81901

LL-37 amide (trifluoroacetate salt)

Cat.No: T38309

IRBP (651-670) (human) TFA

Cat.No: T83700

Synonym: IRBP651-670,Interphotoreceptor Retinoid-Binding Protein (651-670)

IRBP (1-20) (human, rat) TFA

Cat.No: T83681

Synonym: IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20)

[Leu15]-Gastrin I human

Cat.No: T8761

Synonym: Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T15133	Dinoprost Prostaglandin F2a,PGF2α,地诺前列素	Endogenous Metabolite	Metabolism
	Dinoprost (Prostaglandin F2a) 是口服有效的、内源性的前列腺素 F 受体激动剂。它是在子宫内膜腔上皮和黄体中局部产生的溶酶激素。它在分娩过程中起关键作用。
T10938	D-Kynurenine D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103	GPR; AhR; Endogenous Metabolite	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism
	D-Kynurenine (ZINC901103) 是 D-色氨酸的代谢物和 GPR109B 的激动剂。 D-Kynurenine 激活 AhR 并促进上皮细胞向间充质的转化。 D-Kynurenine 在 D-氨基酸氧化酶的荧光分析中用作底物。
T3S0509	Gaultherin	COX	Immunology/Inflammation; Neuroscience
	Gaultherin 是一种分离自 Gaultheria yunnanensis 中的天然水杨酸酯衍生物。它是一种非甾体类抗炎药，具有止痛和抗炎作用，与 Aspirin 相比没有胃溃疡作用。
T11124	Duramycin Lancovutide,Moli1901	Others	Others
	Duramycin is a cyclic peptide lantibiotic derived from Streptomyces cinnamoneuma. Duramycin interacts with phosphatidylethanolamine (PE) and has antibacterial, antiviral effects. Duramycin stimulates chloride secretion in airway epithelium and has the potential for cystic fibrosis treatment.
T75608	Myricetin 3-O-α-L-arabinopyranoside
	Myricetin 3-O-α-L-arabinopyranoside 抑制 A2E 光氧化诱导的RPE 细胞死亡。Myricetin 3-O-α-L-arabinopyranoside 对视网膜变性具有保护作用，可保护蓝光 (BL) 诱导对 RPE 细胞和小鼠模型的损伤。

天然产物

Cat.No: T15133

Synonym: Prostaglandin F2a,PGF2α,地诺前列素

Target: Endogenous Metabolite

Cat.No: T10938

Synonym: D-尿嘧啶,(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103

Target: GPR, AhR, Endogenous Metabolite

Cat.No: T3S0509

Target: COX

Cat.No: T11124

Synonym: Lancovutide,Moli1901

Target: Others

Myricetin 3-O-α-L-arabinopyranoside

Cat.No: T75608

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