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Cat. No. | Product Name | Target | Signaling Pathways |
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T8357 |
SB-200646
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
SB-200646 是 5-HT2B/5-HT2C 受体的选择性强效拮抗剂,对5-HT2B、5-HT2C 和 5-HT2A 的pKi 值分别为 7.5、6.9 和 5.2。它有口服活性,在体内具有电生理和抗焦虑特性。 | |||
T2067 |
NS11394
NS 11394 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
NS11394 是可口服GABAA 的阳性变构调节剂 (PAM),Ki 值为 0.5 nM。它对GABAA 的选择性依次为 α5、α3、α2 和α1 受体,具有抗炎和抗焦虑活性。 | |||
T24885L |
Tiaspirone hydrochloride
BMY-13859 hydrochloride,Tiaspirone hydrochloride(87691-91-6 Free base) |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Tiaspirone hydrochloride (BMY-13859 hydrochloride) 具有抗精神病活性。 Tiaspirone hydrochloride 影响大鼠大脑黑质致密带(A9 DA 细胞)和腹侧被盖区(A10 DA 细胞)多巴胺能神经元的电生理活性。 | |||
T70540 |
Pinokalant
LOE-908 |
SARS-CoV; TRP/TRPV Channel | Membrane transporter/Ion channel; Microbiology/Virology |
Pinokalant (LOE-908) 是一种新型非选性阳离子通道抑制剂。Pinokalant 在体内实验中可显著减少皮质梗死体积,可改善缺血半影区的代谢和电生理状态,可减少大鼠大脑中动脉闭塞后急性期磁共振图像上的病变大小。Pinokalant是一种潜在的SARS-CoV-2蛋白酶抑制剂,可用于研究脑卒中。 | |||
T61025 |
GSK-1482160
|
P2X Receptor | Membrane transporter/Ion channel; Neuroscience |
GSK-1482160是一种CNS-渗透的P2X7受体负变构调节剂,具有口服活性。P2X7受体参与中枢和外周免疫细胞产生促炎细胞因子,因此GSK-1482160具有研究炎症性疾病的潜力。GSK-1482160具有出色的体外效价(在包括人类在内的多种物种的重组和初始P2X7受体的功能和电生理测试中)和交叉靶标选择性。 | |||
T0866 |
Propafenone
Rythmol,普罗帕酮,Propafenonum |
Potassium Channel; MRP; Sodium Channel | Immunology/Inflammation; Membrane transporter/Ion channel |
Propafenone (Propafenonum) 是钠通道阻滞剂,它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ,具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡,从而抑制食管癌增殖。 | |||
T68185 | U 66985 | ||
U 66985 is a Platelet-activating factor (PAF) receptor antagonist that inhibit the electrophysiological effects of PAF. | |||
T68399 |
Pitrazepin
|
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Pitrazepin is a new GABAA receptor antagonist reported to antagonize electrophysiological effects of GABA | |||
T26751 |
BBR 2160
BBR-2160,BBR2160 |
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BBR 2160 is a dihydropyridine derivative belonging to the group of the so-called tiampidine. BBR 2160 has calcium-antagonistic properties in cardiac tissue. Intracellular microelectrodes have been used to characterize the electrophysiological properties o | |||
T32030 |
GYKI-16638 HCl
GYKI 16,638,GYKI16,638,GYKI-16638,GYKI-16,638,GYKI16638,GYKI 16638 |
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GYKI-16638 is a novel antiarrhythmic agent that demonstrates combined class IB and class III antiarrhythmic properties in human ventricular muscles, similar to the electrophysiological findings after chronic amiodarone treatment. In addition, GYKI 16638 h | |||
T35082 |
VU6010608
VU-6010608,VU 6010608 |
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VU6010608 is an effective mGlu7 NAM with excellent CNS permeability and is powerful in electrophysiological studies in blocking long-term enhancement of high-frequency stimuli. | |||
T22423 |
SB-200646A
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
SB-200646A 是一个对 5-HT2B/2C 的选择性超过 5-HT2A 的拮抗剂,5-HT2B,5-HT2C 和 5-HT2A 的 pKi 值分别为 7.5、6.9 和 5.2。SB-200646A 具有口服活性,在体内具有电生理和抗焦虑特性。 | |||
TP2078 |
AC 253
|
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Amylin (AMY3) receptor antagonist. Inhibits andrenomedulin-stimulated cAMP production in vitro. Protects against oligomeric Aβ-induced increase in intracellular Ca2+, activation of PKA, MAPK, Akt and cFOS and cell death in neuronal cell culture. Blocks el | |||
T71000 |
RO-5328673
|
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RO-5328673 is a dual NK2/NK3 antagonist. O5328673. [(3)H]RO5328673 bound to a single saturable site on hNK2, hNK3 and gpNK3 with high-affinity. RO5328673 acted as an insurmountable antagonist at both human and guinea-pig NK3 receptors in the [(3)H]IP accumulation assay. In binding kinetic analyses, [(3)H]RO5328673 had fast association and dissociation rates at hNK2 while it had a fast association rate and a remarkably slow dissociation rate at gp and hNK3. In electrophysiological recordings of g... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T20636 |
Latrunculin B
LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644 |
Antifungal | Microbiology/Virology |
Latrunculin B 是一种 来自红海海绵的生物碱,是一种肌动蛋白聚合 (actin polymerization) 抑制剂,具有抗真菌和抗原生动物活性。Latrunculin B 调节肺静脉电生理特征并减轻牵张性心律失常的发生,可用于研究青少年青光眼。 |