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15

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1158	Copper tripeptide [N2-(N-甘氨酰-L-组氨酰)-L-赖氨酸]铜,GHK-Cu	Others; Endogenous Metabolite	Metabolism; Others
	Copper tripeptide (GHK-Cu) 是天然存在的三肽，首先从人血浆中分离，但也能够在唾液和尿液中发现。它能够提高成纤维细胞中胶原蛋白，弹性蛋白，蛋白多糖和糖胺聚糖中信使 RNA 的产生。在伤口愈合期间，它能够通过蛋白水解从现有的细胞外蛋白质中除去，并且用作炎性和内皮细胞的化学引诱物。它是皮肤再生中多种细胞途径的天然调节剂。
T0211L	Azelastine hydrochloride Optivar,Azelastine HCl,Allergodil,盐酸氮卓斯汀,Astelin	SARS-CoV; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Azelastine hydrochloride (Astelin) 是一种选择性组胺 1拮抗剂，可研究过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 。
T0211	Azelastine Azelastina,Astelin,Azelastinum,氮卓斯汀	SARS-CoV; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Azelastine (Azelastinum) 是一种选择性组胺 1 拮抗剂，可研究过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 。
T70674	(S)-Azelastine
	(S)-Azelastine is an antihistamine which has been shown to down-regulate H1R, M1R and M3R levels. This compound has also been shown to inhibit HNEpC proliferation.
T70481	(R)-Azelastine hydrochloride
	(R)-Azelastine hydrochloride is an antihistamine which has been shown to down-regulate H1R, M1R and M3R levels. This compound has also been shown to inhibit HNEpC proliferation.
T68527	Temelastine
	Temelastine is a selective, competitive histamine H1-receptor antagonist which does not penetrate the central nervous system.
T21109	(S)-Azelastine hydrochloride Azelastine hydrochloride (S)-
	(S)-Azelastine hydrochloride, an antihistamine, has been shown to down-regulate H1R, M1R and M3R levels. It has also been shown to inhibit proliferation of HNEpC.
T74583	Desmethylazelastine
	Desmethylazelastine是Azelastine经由细胞色素P450酶系统的氧化代谢形成的主要活性代谢物，具有97%的蛋白结合率和54小时的消除半衰期。Azelastine作为一种口服活性的组胺H1受体拮抗剂，特点是选择性高和亲和力强。它主要用于治疗过敏性鼻炎、哮喘、糖尿病高脂血症以及用于SARS-CoV-2的研究。
T70675	(R)-Azelastine
	(R)-Azelastine is an antihistamine which has been shown to down-regulate H1R, M1R and M3R levels. This compound has also been shown to inhibit HNEpC proliferation.
T0907	Sulfasalazine 柳氮磺吡啶,NSC 667219,Azulfidine	Apoptosis; Ferroptosis; NF-κB; COX; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	Sulfasalazine (Azulfidine) 是一种合成的水杨酸衍生物，对含有弹性蛋白的结缔组织具有亲和力，并配制成前药。
TP2490	Palmitoyl Hexapeptide-12 Acetate Palmitoyl Hexapeptide-12 Acetate(171263-26-6 Free base)	Others	Others
	Palmitoyl Hexapeptide-12 Acetate (Palmitoyl Hexapeptide-12 Acetate (171263-26-6 Free base)) 可以促进胶原蛋白、弹性蛋白和透明质酸的增殖。可用于改善皮肤含水量，增加真皮层厚度，减少细纹。
T38294	4-Deoxypyridoxine hydrochloride	S1P Receptor	GPCR/G Protein
	4-Deoxypyridoxine hydrochloride 通过抑制 S1P 裂解酶 (SPL) 活性来抑制细胞内 S1P 的降解，与 S1P 一样，减少化学诱导的胰岛素瘤细胞系的细胞凋亡。
T81005	Tetrapeptide-4
	Tetrapeptide-4，一种护肤产品中常用的肽，具备减少皱纹与增强胶原蛋白、弹性蛋白及纤连蛋白的功能，展现出显著的抗衰老特性。
TP2362	Acetyl decapeptide-3 Rejuline,Ac-tyr-arg-ser-arg-lys-tyr-thr-ser-trp-tyr-NH2
	Acetyl decapeptide-3 is a peptide that can stimulate collagen and elastin to increase skin elasticity and increase cell growth and improve healing and repair.
T74782	CXJ-2	PI3K	PI3K/Akt/mTOR signaling
	CXJ-2，一种环状肽，对EDP（弹性蛋白衍生肽）具中等亲和力。该化合物有效抑制PI3K/ERK通路，减少肝星状细胞的增殖与迁移，展现出显著的抗纤维化能力。

化合物

Copper tripeptide

Cat.No: TP1158

Synonym: [N2-(N-甘氨酰-L-组氨酰)-L-赖氨酸]铜,GHK-Cu

Target: Others, Endogenous Metabolite

Azelastine hydrochloride

Cat.No: T0211L

Synonym: Optivar,Azelastine HCl,Allergodil,盐酸氮卓斯汀,Astelin

Target: SARS-CoV, Histamine Receptor

Cat.No: T0211

Synonym: Azelastina,Astelin,Azelastinum,氮卓斯汀

Target: SARS-CoV, Histamine Receptor

Cat.No: T70674

(R)-Azelastine hydrochloride

Cat.No: T70481

Cat.No: T68527

(S)-Azelastine hydrochloride

Cat.No: T21109

Synonym: Azelastine hydrochloride (S)-

Desmethylazelastine

Cat.No: T74583

Cat.No: T70675

Cat.No: T0907

Synonym: 柳氮磺吡啶,NSC 667219,Azulfidine

Target: Apoptosis, Ferroptosis, NF-κB, COX, Antibacterial, Antibiotic, Autophagy

Palmitoyl Hexapeptide-12 Acetate

Cat.No: TP2490

Synonym: Palmitoyl Hexapeptide-12 Acetate(171263-26-6 Free base)

Target: Others

4-Deoxypyridoxine hydrochloride

Cat.No: T38294

Target: S1P Receptor

Cat.No: T81005

Acetyl decapeptide-3

Cat.No: TP2362

Synonym: Rejuline,Ac-tyr-arg-ser-arg-lys-tyr-thr-ser-trp-tyr-NH2

Cat.No: T74782

Target: PI3K

Cat. No.	Product Name	Target	Signaling Pathways
T5565	Undecanedioic acid	Others; Endogenous Metabolite	Metabolism; Others
	Undecanedioic acid 是存在于人体主动脉的部分区域中，其中晚期动脉粥样硬化病变与细胞间基质大分子相关，特别是与弹性蛋白相关。

天然产物

Undecanedioic acid

Cat.No: T5565

Target: Others, Endogenous Metabolite

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