62
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3693 |
DHFR-IN-3
7-bromoquinazoline-2,4-diamine,7-溴-2,4-二氨基喹唑啉 |
Others | Others |
DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) 是一种活性生化剂。 | |||
T6120 |
Pralatrexate
Folotyn,10-炔丙基-10-去氮杂氨基蝶呤,10-Propargyl-10-deazaaminopterin,普拉曲沙 |
Apoptosis; DHFR; Antifolate; TAM Receptor | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Tyrosine Kinase/Adaptors |
Pralatrexate (10-Propargyl-10-deazaaminopterin) 是一种抗叶酸剂,也是二氢叶酸还原酶抑制剂,Ki 值为 13.4 pM。它具有抗肿瘤活性,可研究复发/难治性 T 细胞淋巴瘤。它是叶酰聚谷氨酸合成酶的底物,具有改善的细胞摄取和保留能力。 | |||
T29460 |
5-Methyldihydrofolate
|
||
5-Methyldihydrofolate is the primary biologically active form of folate used for DNA reproduction, the cysteine cycle, and the regulation of homocysteine. | |||
T20340 |
10-Formyldihydrofolate
|
||
10-Formyldihydrofolate is a Methotrexate metabolite. It inhibits thymidylate synthetase and glycinamide ribotide transformylase. | |||
T24962 | 10-Formylfolic acid | DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
10-Formylfolic acid 是一种新型有效的二氢叶酸还原酶 (dihydrofolate reductase) 抑制剂,可用于研究白血病。 | |||
T17257L |
WR99210 hydrochloride(47326-86-3 free base)
WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine |
Others | Others |
WR99210 hydrochloride 是恶性疟原虫二氢叶酸还原酶 (pfDHFR) 的有效抑制剂,pfDHFR 是主要的疟疾药物靶点。它对野生型、双突变体和四突变体二氢叶酸还原酶具有亚纳摩尔效力。 | |||
T19858 |
Brodimoprim
|
DHFR; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Brodimoprim 是甲氧苄啶的一种类似物,是口服有效的二氢叶酸还原酶抑制剂,对广谱革兰氏阴性和革兰氏阳性细菌具有高度的抑制作用。 | |||
T0849 |
Pyrimethamine
Pirimecidan,RP 4753,Pirimetamin,乙胺嘧啶 |
DHFR; Antifolate; Parasite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Pyrimethamine (Pirimecidan) 是一种二氢叶酸还原酶的竞争性抑制剂,用作抗疟药。 | |||
TQ0113 |
Iclaprim
艾拉普林,AR-100 |
Antibacterial; Antibiotic | Microbiology/Virology |
Iclaprim (AR-100) 是一种细菌二氢叶酸的选择性新型抑制剂, 可抑制金黄色葡萄球菌的生长, 其 MIC90值为 0.06 μg/mL。 | |||
T61486 | DHFR-IN-4 | DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
DHFR-IN-4 是一种高效的二氢叶酸还原酶 (DHFR) 抑制剂,具有抗肿瘤活性,抑制 EGFR 和 HER2 ,可用于研究胰腺癌。 | |||
T25886 |
Methotrexate Diglutamate
NSC-269401,NSC 269401,NSC269401 |
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Methotrexate Diglutamate 存在于肝脏中的小分子化合物,可作为部分纯化的人二氢叶酸还原酶抑制剂。 | |||
T24644 |
Piritrexim
BW 301U |
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Piritrexim (BW 301U) 是一种可口服的脂溶性二氢叶酸还原酶抑制剂,具有肺毒性,用于研究尿路上皮癌和转移性乳腺癌。 | |||
T1485 |
Methotrexate
NCI-C04671,WR19039,Amethopterin,甲氨蝶呤,CL14377 |
Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Methotrexate (WR19039) 是一种叶酸类似物,一种二氢叶酸还原酶 DHFR 的抑制剂。Methotrexate 具有抗代谢、抗肿瘤和免疫抑制等活性,常用于类风湿关节炎和多种肿瘤的研究。 | |||
T20339 |
7-Hydroxymethotrexate
NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962 |
Drug Metabolite | Metabolism |
7-Hydroxymethotrexate 是 Methotrexate 主要的代谢产物。Methotrexate 对叶酸具有抑制作用,抑制二氢叶酸还原酶,从而防止叶酸转化为四氢叶酸,并抑制 DNA 合成。Methotrexate 对代谢也具有抑制作用。 | |||
T36692 |
Fanotaprim
|
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Fanotaprim 是二氢叶酸还原酶的有效抑制剂,抑制 tgDHFR (Toxoplasma gondiiDHFR) 和 hDHFR (human DHFR)的 IC50分别为 1.57 和 308 nM。Fanotaprim 在研究弓形虫病方面具有价值。 | |||
T64295 |
Talotrexin ammonium
|
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Talotrexin ammonium 是一种不可多聚谷氨酸抗叶酸类药物。Talotrexin ammonium 通过针对二氢叶酸还原酶(DHFR)来抑制肿瘤生长,从而提高了在广泛癌症模型中的抗肿瘤活性,有助于抑制肿瘤的增长。 | |||
T5420 |
Cycloguanil hydrochloride
Chloroguanide Triazine,环氯胍盐酸盐 |
Parasite; Drug Metabolite | Metabolism; Microbiology/Virology |
Cycloguanil hydrochloride (Chloroguanide Triazine) 是抗疟化合物氯胍的活性代谢物。 它作为二氢叶酸还原酶的抑制剂,对于疟原虫和人类形式的 Kis 值分别为 0.3 和 1.5 nM。 | |||
T4382 |
Proguanil hydrochloride
Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil |
Others; Dehydrogenase; DNA/RNA Synthesis; Antifolate; Parasite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Others |
Proguanil hydrochloride (Chloroquanil) 是一种双胍类抗疟疾剂,在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。 | |||
T30761 |
CB 3703
CB3703,NSC 289522,CB-3703 |
||
CB 3703 is an inhibitor of dihydrofolate reductase and thymidylate synthase. | |||
T17164 |
Trimetrexate
三甲曲沙,CI-898 |
Others | Others |
Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase. | |||
T29003 |
TRC-19
|
||
TRC-19 is a potent and selective inhibitor of Toxoplasma gondii dihydrofolate reductase. TRC-19 shows an IC50 of 9 nM and 89-fold selectivity in favor of Toxoplasma gondii dihydrofolate reductase. | |||
T24459 |
Metioprim
Ro126995,Ro 126995,He 909,He909,Ro 12-6995 |
||
Metioprim is a competitive bacterial dihydrofolate reductases inhibitor. | |||
T24571 |
Ornithine-methotrexate
ADMPO |
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Ornithine-methotrexate is a ornithine analog of methotrexate. It is an inhibitors of dihydrofolate reductase. | |||
T23883 |
Chlorasquin
Ccnsc-529,861,Ccnsc 529,861,SK 29861,Ccnsc529,861,SK-29861 |
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Chlorasquin is a dihydrofolate reductase inhibitor. | |||
T25079 |
Aminopterin N-hydroxysuccinimide ester
Nhs-aminopterin,N-Hydroxysuccinimide aminopterin |
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Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrof | |||
T24427 |
Lysine-methotrexate
ADMPL |
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Lysine-methotrexate is an anticancer drug. It is an inhibitor of dihydrofolate reductase. | |||
T7730L |
Aminopterin sodium
NSC739,NSC 739 [as the base],NSC-739 |
||
Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effe | |||
T25381 |
Epiroprim
Epiroprime,Ro11-8958,Ro 11-8958,Ro-11-8958 |
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Epiroprim is an analog of trimethoprim and a dihydrofolate reductase inhibitor. | |||
T10916 |
Cycloguanil D6
Chlorguanide triazine D6 |
Others | Others |
Cycloguanil D6 is a dihydrofolate reductase inhibitor, deuterium-labeled Cycloguanil. | |||
T25332 |
Dihydrohomofolic acid
|
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Dihydrohomofolic acid is a substrate for dihydrofolate reductase that produces tetrahydro-homo folate which in turn suppresses thymidylate synthetase and then DNA synthesis. | |||
T70080 |
Methasquin
|
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Methasquin is a folic acid antagonist that has been used in the treatment of experimental leukemia; acts by inhibiting the dihydrofolate reductase in the cell. | |||
T27002 |
CH-1504
CH 1504,MobileTrex |
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CH-1504, dihydrofolate reductase (DHFR) inhibitor, is used potentially for the treatment of rheumatoid arthritis. | |||
T25324 |
Dichloromethotrexate
NSC 29630,3988-B-129-4,NSC29630,Dichloroamethopterin,NSC-29630 |
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Dichloromethotrexate is an enzyme dihydrofolate reductase inhibitor, thus preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis. This agent is metabolized and excreted by the liver. | |||
T69591 | Cycloguanil nitrate | ||
Cycloguanil nitrate is a dihydrofolate reductase inhibitor and is a metabolite of the antimalarial drug proguanil. | |||
T10915 |
Cycloguanil D6 Nitrate
Chlorguanide triazine D6 Nitrate |
Others | Others |
Cycloguanil D6 Nitrate is a dihydrofolate reductase inhibitor, deuterium-labeled Cycloguanil. | |||
T25980 |
Pralatrexate, (R)-
|
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Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr | |||
T68684 |
Piritrexim isethionate
|
||
Piritrexim isethionate is a lipid-soluble inhibitor of dihydrofolate reductase (DHFR) that appears to be an active agent in patients with metastatic urothelial cancer when administered as a 5-day, low-dose oral schedule. | |||
T22409 |
Proguanil
氯胍,chloroguanide,chlorguanide |
Others | Others |
Proguanil, a prophylactic antimalarial drug, inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of pyrimidines and purines, which are essential for DNA synthesis and cell multiplication. | |||
T25981 | Pralatrexate, (S)- | ||
Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr | |||
T39862 | Trimethoprim lactate | ||
Trimethoprim lactic is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactic is active against a wide range of Gram-positive and Gram-negative aerobic bacteria . Trimethoprim lactic has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment. | |||
T12742 |
Ro 20-0657/000
|
Others | Others |
Ro 20-0657/000 is a Trimethoprim metabolite. Trimethoprim is an inhibitor of dihydrofolate reductase, used as an antibacterial agent in human and veterinary medicine. | |||
T25374 |
Emofolin sodium
NSC139490,MeTHHF disodium,NSC-139490,NSC 139490 |
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Emofolin sodium is the sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity,which competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition of tetrahydrofolate synthesis, deple | |||
T81639 |
NSC309401 dihydrochloride
|
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NSC309401为大肠杆菌DHFR抑制剂,具有IC50值为189 nM和KD值为14.57 nM。 | |||
T63985 |
Trimetrexate glucuronate
|
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Trimetrexate glucuronate (NSC 352122) 是一种叶酸拮抗剂,能够抑制二氢叶酸还原酶 (dihydrofolate reductase),进而阻断嘌呤核苷酸和胸苷酸的合成,影响 DNA 和 RNA 合成,表现出潜在的抗肿瘤效果。 | |||
T69089 |
Trimethoprim sulfate
|
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Trimethoprim sulfate is a pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. | |||
T79912 |
NSC309401
|
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NSC309401 是一种针对大肠杆菌DHFR的抑制剂,具有IC50值为189 nM和KD值为14.57 nM。 | |||
T82571 |
DHFR-IN-10
|
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DHFR-IN-10(化合物4c)是针对结核分枝杆菌DHFR的高效抑制剂,其IC50为4.21 μM,显示出卓越的抗结核活性。 | |||
T41148 |
Phototrexate
|
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Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate. Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark.cis-Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared withtrans-Phototrexate (IC50 = 34 μM). | |||
T73328 |
DHFR-IN-5
|
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DHFR-IN-5 是一种有效且具有口服活性的二氢叶酸还原酶 (DHFR) 抑制剂,对Plasmodiumfalciparum 突变体的Ki 值为 0.54 nM。DHFR-IN-5显示抗疟疾活性[1]。 | |||
T75259 | Baquiloprim | ||
Baquiloprim为一种抗生素,作为细菌二氢叶酸还原酶的选择性抑制剂,对革兰氏阴性及革兰氏阳性细菌展现体外抑菌活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15128 |
Dihydrofolic acid
7,8-Dihydrofolic acid,Dihydrofolate |
Others | Others |
Dihydrofolic acid (7,8-Dihydrofolic acid) 是一种叶酸衍生物,在二氢叶酸还原酶的作用下生成四氢叶酸。 | |||
T1153 |
Trimethoprim
NIH 204,BW 56-72,甲氧苄啶,NSC-106568 |
DHFR; DNA/RNA Synthesis; Antifolate; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Trimethoprim (NSC-106568) 是抑菌抗生素,也是具有口服活性的二氢叶酸还原酶抑制剂。它对多种革兰氏阳性和革兰氏阴性需氧细菌具有活性,可用于尿路感染,肺孢子菌肺炎和志贺氏菌病的研究。 | |||
T7730 |
Aminopterin
APGA,氨基蝶呤,4-Aminofolic acid |
Antifolate | Cell Cycle/Checkpoint |
Aminopterin (4-Aminofolic acid) 是叶酸的 4-氨基衍生物,是叶酸拮抗剂,具有抗癌和免疫抑制活性,用于研究儿童白血病。它催化叶酸还原为四氢叶酸,竞争性抑制二氢叶酸还原酶,Ki 值为 3.7 pM。 |