Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4330 |
CaCCinh-A01
|
Chloride channel | Membrane transporter/Ion channel |
CaCCinh-A01 是钙激活氯离子通道和TMEM16A 抑制剂,IC50值分别为 10 和 2.1 μM。 | |||
TQ0046 |
Bavisant
JNJ-31001074 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Bavisant (JNJ-31001074) 是一种特异性和口服活性的人 H3 受体拮抗剂。 Bavisant 可用于作用机制的研究,包括觉醒和认知以及 ADHD 的治疗。 | |||
T1180 |
Blonanserin
布南色林,AD-5423 |
Dopamine Receptor; Sigma receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Blonanserin (AD-5423) 是一种有效的5-HT2A 和多巴胺 D2 受体拮抗剂,Ki 为 0.812 和 0.142 nM,是一种非典型的抗精神病试剂。 | |||
T2150 |
Guanfacine hydrochloride
盐酸胍法辛,Tenex,Intuniv,Guanfacine |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Guanfacine hydrochloride (Intuniv) 是一种 α2A 肾上腺素受体激动剂,Kd=31 nM,具有抗高血压作用。 | |||
T12352L |
Oxidopamine hydrobromide
6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide |
Mitophagy; Dopamine Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Oxidopamine hydrobromide (6-OHDA hydrobromide) 是一种神经递质多巴胺拮抗剂,可选择性地破坏多巴胺能神经元,是一种广泛使用的神经毒素。 | |||
T12352 |
Oxidopamine hydrochloride
6-Hydroxydopamine hydrochloride,6-OHDA hydrochloride,6-羟基多巴胺盐酸盐 |
Mitophagy; Dopamine Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) 是一种神经递质多巴胺拮抗剂,可选择性地破坏多巴胺能神经元,是一种广泛使用的神经毒素。 | |||
T10052 |
AR-08
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
AR-08 是一种有效的 α2 肾上腺素能受体 (α2-adrenergic receptor) 激动剂,可用于研究多动症与注意力缺陷。 | |||
T7070 |
Nomifensine maleate
Nomifensine (maleate),诺米芬新马来酸盐,(±)-Nomifensine maleat |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Nomifensine maleate (Nomifensine (maleate)) 是一种多巴胺摄取的选择性抑制剂,可用于成人注意力缺陷障碍的研究。 | |||
T60201 |
CX717
|
GluR | Neuroscience |
CX 717 是 AMPA 受体的正变构调节剂,具有抗抑郁样作用。CX 717 可用于成人注意力缺陷多动障碍(ADHD)的研究。 | |||
T12054L |
MK-0249 FA
MK-0249 FA(862309-06-6 Free base) |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
MK-0249 FA 是一种具有口服活性、选择性和高效性的组胺 H3 反向激动剂,可用于研究成人注意力缺陷、多动症神经分裂和认知障碍。 | |||
T31604 |
Edivoxetine
LY-2216684,LY 2216684,LY2216684 |
||
Edivoxetine( LY2216684) is a selective norepinephrine reuptake inhibitor being developed as a treatment for attention deficit hyperactivity disorder (ADHD) and antidepressants. | |||
T24857 |
TBTC
|
||
TBTC is a selective agonist of retinoid X receptor α that acts by improving behavioral deficit in Alzheimer's disease model mice. | |||
T27976 |
Manifaxine
BW1555U88,BW-1555U-88,1555U88,1555U-88,GW-320659,GW320659 |
||
Manifaxine, a norepinephrine-dopamine reuptake inhibitor, is used potentially for the treatment of attention deficit. | |||
T10226 |
Sofiniclin
ABT 894 |
Others | Others |
Sofiniclin (ABT 894) is an agonist of nicotinic acetylcholine receptor (nAChR). It is used for the research for attention-deficit/hyperactivity disorder (ADHD). | |||
T14970 |
Cipralisant
GT-2331 |
Others | Others |
Cipralisant is a selective histamine H3 receptor antagonist in vivo, and an agonist in vitro (pKi: 9.9 for histamine H3 receptor; Ki: 0.47 nM for rat histamine H3 receptor). It has the potential for the treatment of attention-deficit hyperactivity disorde | |||
T26529 |
ABT-418
ABT 418,ABT418,A 81418,A81418,A-81418 |
||
ABT-418, a nicotinic acetylcholine receptor (nAchR) agonist, is used potentially for the treatment of attention deficit disorder. | |||
T34752 |
Samelisant dihydrochloride
SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl |
||
Samelisant dihydrochloride (SUVN-G3031) is a antagonist of histamine H3 receptor with potential for the treatment of cognitive impairment, dementia, attention deficit hyperactivity disorder, epilepsy, sleep disorders, obesity, schizophrenia, eating disorders, and pain. | |||
T61544 |
Edivoxetine hydrochloride
|
||
Edivoxetine hydrochloride is a highly effective and specialized compound used primarily as a norepinephrine reuptake inhibitor (NERI), indicated for the treatment of depressive disorder and attention-deficit/hyperactivity disorder. | |||
T69595 | Ispronicline hemigalactarate | ||
Ispronicline, also known as AZD3480; TC 1734; TC-0173, and RJR 1734, is a alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. Ispronicline is potentially useful for the treatment of attention-deficit/hyperactivity disorder in adults. | |||
T8443L |
MCI-225 hydrochloride hydrate
AA-10021,AA10021,MCI225,DDP-225,AA-10025,AA-10026 |
||
MCI-225 is a norepinephrine reuptake/5-HT3/5-HT reuptake inhibitor. MCI-225 could be effective in the treatment of senile dementia of the Alzheimer type, which is accompanied with both deficit in the BF-cortex cholinergic neuron and cerebral glucose hypom | |||
T60739 | Y13g | ||
Y13g 是白细胞介素 6 (IL-6) 和乙酰胆碱酯酶 (AChE)的有效抑制剂, 这两个靶点阿尔茨海默症 (AD) 进展的有关。Y13g 逆转 STZ 诱导的记忆缺陷,并表现出与正常动物相似的组织病理学。 | |||
T60369 |
Droxidopa hydrochloride
|
||
Droxidopa (L-DOPS) hydrochloride 是一种有效的、具有口服活性的去甲肾上腺素前体。Droxidopa hydrochloride 可增加站立血压,改善直立性低血压症状并提高站立能力。Droxidopa hydrochloride 具有研究神经源性直立性低血压(nOH)和替代性多动症 (注意缺陷多动障碍) 的潜力[3]。 | |||
T28653 |
S-8510 free base
SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510 |
||
S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ameliorated memory impairment induced | |||
T35591 |
Guanfacine-13C,15N3
Guanfacine-13C,15N3 |
||
Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin... | |||
T35560 |
SAR502250
|
||
SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2]. SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ25-35-induced cell death in rat embryonic hippocampal neurons[2]. SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mic... |