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26

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8473	MLS000532223	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	MLS000532223 是一种具有高亲和力的 Rho 家族 GTPases 选择性抑制剂，其EC50=16~120 μM。它能阻止几种 GTPases 同 GTP 的结合。
T23372	SMIFH2	Others	Others
	SMIFH2 是formin 特异性抑制剂。它利用 Formins 阻碍肌动蛋白聚合，影响肌动蛋白细胞骨架。
T2029	Bohemine	ERK; CDK	Cell Cycle/Checkpoint; MAPK
	Bohemine 是一种合成的选择性CDK 抑制剂，是嘌呤类似物，具有抗癌活性。它对Cdk2/cyclin E、Cdk2/cyclin A 和Cdk9/cyclin T1的IC50分别为 4.6 μM、83 μM 和 2.7 μM。
T10460	Batabulin 巴他布林,T138067	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Batabulin (T138067) 是一种抗肿瘤剂，可与 β-微管蛋白同种型的子集共价且选择性地结合，从而破坏微管聚合。它影响细胞形态并导致细胞周期停滞，最终诱导细胞凋亡。
T21785	AG957	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Tyrphostin AG957 是一种酪氨酸激酶抑制剂，具有抗BCR/ABL 酪氨酸激酶活性。它能够抑制p210bcr/abl 酶活性 (IC50:2.9 μM)。
T4451	Estramustine phosphate sodium Ro 21-8837/001,Estramustine phosphate disodium,雌莫司汀磷酸钠	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Estramustine phosphate sodium (Ro 21-8837/001) 是雌二醇类似物，是一种具有口服活性抗微管化疗剂，通过与微管相关蛋白和微管蛋白结合而使微管解聚。它可诱导前列腺癌细胞凋亡，可研究前列腺癌。
T19512	Phalloidin	Others	Others
	Phalloidin is a mushroom-derived toxin which used to label F-actin of the cytoskeleton with fluorochrome .
T24494	MP265 S-(4-氯苄基)氯化异硫脲,MP-265,MP 265	Others	Others
	MP265 破坏 MreB 细胞骨架并具有抗增殖作用。
T28001	MDK-6983 MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983	Autophagy	Autophagy
	MDK-6983 (MDK-6983) 是一种自噬抑制剂，可破坏人黑色素瘤细胞中肌动蛋白细胞骨架的动力学。
T3580	FIPI 5-Fluoro-2-indolyl deschlorohalopemide	Phospholipase; Autophagy	Autophagy; Metabolism
	FIPI (5-Fluoro-2-indolyl deschlorohalopemide) 是 halopemide 的衍生物，抑制PLD1和PLD2，IC50值分别为 25 nM 和 20 nM。它防止 PLD 调节 F-肌动蛋白细胞骨架重组、细胞扩散和趋化性。
T16387	Ombrabulin AVE8062,AC7700	Microtubule Associated	Cytoskeletal Signaling
	Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.
T26075	Rhizopodin
	Rhizopodin is a potent natural macrolide antibiotic that effectively affects the actin cytoskeleton at nanomolar concentrations.
TP2249	Flutax 1	Others	Others
	A fluorescent taxol derivative used for direct imaging of the microtubule cytoskeleton
T29205	Zarilamide Zarilamid
	Zarilamide is inhibitor of the nuclear division in germinating zoospore cysts of Phytophthora capsici. Zarilamide destructs the microtubule cytoskeleton, resulting in a consequent inhibition of mitosis.
T28469	PT-262 PT 262
	PT-262 is a ROCK (Rho-associated coiled-coil forming protein kinase) inhibitor. It induces cytoskeleton remodeling and migration inhibition in lung carcinoma cells.
T41196	Phalloidin-FITC
	Phalloidin-FITC is a green fluorescent cytoskeleton stain. Binds and labels F-actin. For most fluorescent imaging applications, cells should be fixed and permeablilized. Excitation/emission maxima λ ~496/516 nm.
T24994	MreB Perturbing Compound A22 hydrochloride A22 hydrochloride,MreB Perturbing Compound A22
	A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been proved to be an antibiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport.
T78591	Zoxamide RH-7281
	Zoxamide (RH-7281) 是一种抑制辣椒疫霉幼苗中核分裂和破坏微管细胞骨架的卵菌杀菌剂。
T68708	Denibulin HCl
	Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy.
T36402	Kibdelone C
	Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a panel of human tumor cell lines, and kibdelone C has low nanomolar effectiveness in these assays. Kibdelone C disrupts the actin cytoskeleton without directly binding actin or affecting its polymerization in vitro.
T26821	BIPM
	BIPM is a potent inhibitor of Rho-associated protein kinase 2 (ROCK2). Exposure of SH-SY5Y cells to BIPM led to significant changes in cell migration, actin stress fibers and neurite length. BIPM significantly inhibits phosphorylation of cofilin, a regula
T69813	AZD-6126
	AZD6126, also known as ANG-453, a water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. AZD-6126 is an angiogenesis inhibitor and tubulin inhibitor potentially for the treatment of solid tumours. AZD6126 is converted in vivo into N-acetylcolchinol. N-acetylcolchinol binds to and destabilizes the tubulin cytoskeleton of endothelial cells in tumor blood vessels, which may result in tumor endothelial cel apoptosis, the selective occlusio...
T72552	Antitumor agent-88
	Antitumor agent-88 表现出有效的抗有丝分裂活性并使细胞停滞在 G2/M 期。Antitumor agent-88 扰乱表达 CYP1A1 的乳腺癌细胞中的微管和细胞骨架。Antitumor agent-88 也是 CYP1A1的竞争性抑制剂 (Ki: 1.4 μM)。
T16386	Ombrabulin hydrochloride AVE8062 (hydrochloride),AC7700 (hydrochloride)	Microtubule Associated	Cytoskeletal Signaling
	Ombrabulin hydrochloride 是一种合成的、具有选择性的 CA-4 磷酸酯或 Ombrabulin 的衍生物，能破坏内皮细胞的微管蛋白细胞骨架，具有抗血管作用。Ombrabulin 是是一种微管蛋白聚合抑制剂，是 combretastatin a -4化合物类的一员，是一种水溶性的微管蛋白解聚肿瘤血管破坏化合物。
T82877	Biotin-myelin basic protein (94-102)
	Biotin-myelin basic protein (94-102) 是一种多肽片段，承担着在神经系统中促进髓鞘形成的关键角色。作为细胞膜肌动蛋白结合蛋白，髓鞘碱性蛋白（Myelin basic protein）对于维持神经纤维多层髓鞘的紧密附着至关重要，并有可能参与传递细胞外信号，以促进少突胶质细胞的细胞骨架与髓鞘的联结。
T80253	S3 Fragment
	S3 Fragment 是具有生物活性的肽，含有 ADF/cofilin 的特异性 N-端磷酸化位点，即 LIM 激酶（LIMK）的靶点。LIMK1 通过在 ADF/cofilin 的丝氨酸 3 位磷酸化来失活该蛋白，是肌动蛋白细胞骨架重要调控因子。该肽段包含 ADF/cofilin 丝氨酸 3 位点，作为 LIMK1 的有效竞争性抑制剂而被广泛研究。

化合物

Cat.No: T8473

Target: Rho, Ras

Cat.No: T23372

Target: Others

Cat.No: T2029

Target: ERK, CDK

Cat.No: T10460

Synonym: 巴他布林,T138067

Target: Apoptosis, Microtubule Associated

Cat.No: T21785

Target: Bcr-Abl

Estramustine phosphate sodium

Cat.No: T4451

Synonym: Ro 21-8837/001,Estramustine phosphate disodium,雌莫司汀磷酸钠

Target: Apoptosis, Microtubule Associated

Cat.No: T19512

Target: Others

Cat.No: T24494

Synonym: S-(4-氯苄基)氯化异硫脲,MP-265,MP 265

Target: Others

Cat.No: T28001

Synonym: MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983

Target: Autophagy

Cat.No: T3580

Synonym: 5-Fluoro-2-indolyl deschlorohalopemide

Target: Phospholipase, Autophagy

Cat.No: T16387

Synonym: AVE8062,AC7700

Target: Microtubule Associated

Cat.No: T26075

Cat.No: TP2249

Target: Others

Cat.No: T29205

Synonym: Zarilamid

Cat.No: T28469

Synonym: PT 262

Phalloidin-FITC

Cat.No: T41196

MreB Perturbing Compound A22 hydrochloride

Cat.No: T24994

Synonym: A22 hydrochloride,MreB Perturbing Compound A22

Cat.No: T78591

Synonym: RH-7281

Cat.No: T68708

Cat.No: T36402

Cat.No: T26821

Cat.No: T69813

Antitumor agent-88

Cat.No: T72552

Ombrabulin hydrochloride

Cat.No: T16386

Synonym: AVE8062 (hydrochloride),AC7700 (hydrochloride)

Target: Microtubule Associated

Biotin-myelin basic protein (94-102)

Cat.No: T82877

Cat.No: T80253

Cat. No.	Product Name	Target	Signaling Pathways
TN1417	Azadirachtin	Apoptosis; Antifection	Apoptosis; Microbiology/Virology
	Azadirachtin 是一种有前途的植物源杀虫剂，能够诱导昆虫 Sf9、SL-1 和 BTI-Tn-5B1-4 细胞凋亡。它广泛用于害虫防治。
T20945	2,4-D Hedonal,Macondray,2,4-D acid,Chloroxone,2,4-二氯苯氧乙酸	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	2,4-Dichlorophenoxyacetic acid (Hedonal) 是一种合成生长素，用作植物生长调节剂，也用作植物细胞培养基中的补充剂。它是除草剂中的一种活性成分，用于破坏肌动蛋白细胞骨架，以控制根系伸长和细胞生成。
T3S1471	Cucurbitacin IIA 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis; Survivin	Apoptosis
	Cucurbitacin IIA (Dihydrocucurbitacin Q1) 是从园果雪胆中分离得到的一种三萜烯，可诱导细胞凋亡和增强自噬，有助于葫芦素IIA 对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达，降低磷酸化组蛋白 H3 的水平，增加裂解的 PARP 的水平。
T5S1981	alpha-Cyperone (+)-α-Cyperone,α-香附酮,α-Cyperone	Others; Endogenous Metabolite	Metabolism; Others
	alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。
TN4178	Gyrophoric acid	cAMP	GPCR/G Protein
	Vulpinic and gyrophoric acids are known as ultraviolet filters for natural lichen populations, they can effectively prevent cytotoxic, apoptotic and cytoskeleton alterative activities of 2.5 J/cm(2) UVB in a dose-dependent manner, suggest that vulpinic and gyrophoric acids can be promising cosmetic ingredients to photo-protect human skin cells. Gyrophoric acid also has anti-proliferative/cytotoxic effect.
T35782	Swinholide A MK-7684	Antifungal	Microbiology/Virology
	Swinholide A 是可从海绵中提取的聚酮化合物，可于肌动蛋白结合，使肌动蛋白二聚化，Kd 约为 50 nM。Swinholide A 是一种细胞毒素，可稳定肌动蛋白二聚体并切断肌动蛋白丝。Swinholide A 具有抗真菌 (antifungal)活性，可破坏细胞的肌动蛋白细胞骨架。

天然产物

Cat.No: TN1417

Target: Apoptosis, Antifection

Cat.No: T20945

Synonym: Hedonal,Macondray,2,4-D acid,Chloroxone,2,4-二氯苯氧乙酸

Target: DNA/RNA Synthesis

Cucurbitacin IIA

Cat.No: T3S1471

Synonym: 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA

Target: Apoptosis, Survivin

Cat.No: T5S1981

Synonym: (+)-α-Cyperone,α-香附酮,α-Cyperone

Target: Others, Endogenous Metabolite

Gyrophoric acid

Cat.No: TN4178

Target: cAMP

Cat.No: T35782

Synonym: MK-7684

Target: Antifungal

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