|
T37562
|
C16 Ceramide
N-acylsphingosine,C16 Ceramide (d18:1/16:0),Palmitoyl Ceramide,N-Palmitoylsphingosine
|
p53 |
Apoptosis |
|
C16 Ceramide (Palmitoyl Ceramide) 是一种天然小分子，通过直接选择性结合激活 p53。 |
|
T37436
|
C12-Ceramide
N-Laurylsphingosine,C12 Ceramide (d18:1/12:0),N-Lauroyl-D-erythro-sphingosine
|
|
|
|
C12-Ceramide (C12 Ceramide (d18:1/12:0)) 是一种存在于先兆子痫妇女所生婴儿围绕脐带血管的保护膜的神经酰胺，是 C12 鞘磷脂被酸性鞘磷脂酶（ASM）水解后形成的，可用于评估 A 型或 B 型尼曼-皮克病患者血浆中的 ASM 活性水平。 |
|
T37563
|
C22 Ceramide (d18:1/22:0)
Cer(d18:1/22:0),C22 Ceramide,Ceramide (d18:1/22:0)
|
|
|
|
C22 Ceramide (d18:1/22:0) (C22 Ceramide) 是一种从海绵Haliclona koremella 中分离出含有山嵛酸的长链神经酰胺，是一种内源性生物活性鞘脂。C22 Ceramide (d18:1/22:0) 可特异性抑制MCSR，降低离体大鼠肝线粒体和脂质体中 C16-神经酰胺通道的形成。 |
|
T61884
|
C6 Ceramide
N-hexanoylsphingosine,N-(hexanoyl)sphing-4-enine
|
Apoptosis |
Apoptosis |
|
C6 Ceramide (N-hexanoylsphingosine) 是神经酰胺途径的一种激活剂，通过激活ERK使细胞停滞在G0/G1期，可以在多种癌细胞系中发挥作用。 |
|
T35803
|
C14 Ceramide (d18:1/14:0)
Cer(d18:1/14:0),N-Myristoyl-D-sphingosine
|
|
|
|
C14 Ceramide (d18:1/14:0) 是由神经酰胺合成酶 6 生成的一种内源性神经酰胺,可用于研究帕金森。 |
|
T78461
|
C6 NBD Ceramide
Nbd-ceramide
|
|
|
|
C6 NBD Ceramide 是一种细胞膜渗透性高尔基体荧光探针（Ex=466 nm, Em=536 nm），是一种带有绿色荧光标记的神经酰胺，可识别活体及固定细胞的高尔基体，观测活细胞中高尔基体形态变化。C6 NBD Ceramide 在细胞内可代谢生成荧光鞘磷脂和葡糖基甘油酰胺，从而应用于鞘脂转运和代谢机制研究。 |
|
T36321
|
C6 Urea Ceramide
|
|
|
|
C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 μM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the ... |
|
T36230
|
C2 Ceramide (d14:1/2:0)
C2 Ceramide (d14:1/2:0)
|
|
|
|
C2 Ceramide (d14:1/2:0) is a bioactive sphingolipid. Dietary administration of C2 ceramide (d14:1/2:0) (100 μM) induces lipotoxic cardiomyopathy via increasing diastolic and systolic diameter as well as reducing fractional shortening and the number of normal cardiac contractile events in Drosophila. |
|
T36188
|
Ceramide Phosphoethanolamines (bovine)
|
|
|
|
Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group. It is the principal membrane phospholipid in invertebrates such as Drosophila, which lacks sphingomyelin. It is only produced in small amounts in mammalian cells, accounting for approximately 0.02 mol% of total phospholipids in mouse testis and brain. In Drosophila, CPE is biosynthesized by CPE synthase from ceramide and cytidine diphosphate-ethanolamine in the Golgi... |
|
T35873
|
C19 Ceramide (d18:1/19:0)
C19 Ceramide (d18:1/19:0)
|
|
|
|
C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3] |
|
T37457
|
C18 L-threo Ceramide (d18:1/18:0)
C18 L-threo Ceramide (d18:1/18:0)
|
|
|
|
C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 0.21 mol% (16.8 μM). |
|
T36324
|
C8 L-threo Ceramide (d18:1/8:0)
C8 L-threo Ceramide (d18:1/8:0)
|
|
|
|
C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 10 μM) and, like C8 D-threo ceramide , induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 L-erythro ceramide . C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~30 μg/ml. |
|
T37455
|
C18 D-threo Ceramide (d18:1/18:0)
C18 D-threo Ceramide (d18:1/18:0)
|
|
|
|
C18 D-threoCeramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50value of 16.6 μM.2[Matreya, LLC. Catalog No. 1855]
1.Koolath, S., Murai, Y., Suga, Y., et al.Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthaseChirality32(3)308-313(2019) 2.Usta, J., El Bawab, S., Roddy, P., et al.Structural requirements of ceramide and sphingosine bas... |
|
T36140
|
BODIPY-C12 Ceramide (d18:1/12:0)
BODIPY-C12 Ceramide (d18:1/12:0)
|
|
|
|
BODIPY-C12 Ceramide（B12Cer）是C12鞘氨醇的荧光标记形式，其激发/发射最大值分别为505/540 nm。BODIPY-C12 Ceramide 是一种带有荧光标记的神经酰胺。BODIPY-C12 Ceramide已被用于量化尼曼-匹克病患者血浆中酸性鞘磷脂酶的活性。 |
|
T35807
|
C18 dihydro Ceramide (d18:0/18:0)
C18 dihydro Ceramide (d18:0/18:0),Cer(d18:0/18:0)
|
|
|
|
C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond. [1] Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes. [2] It is also elevated in... |
|
T37564
|
C4 Ceramide (d18:1/4:0)
C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)
|
|
|
|
C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. [1] C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively). [2] C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing... |
|
T36322
|
C8 D-threo Ceramide (d18:1/8:0)
C8 D-threo Ceramide (d18:1/8:0)
|
|
|
|
C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein r... |
|
T37456
|
C18 L-erythro Ceramide (d18:1/18:0)
C18 L-erythro Ceramide (d18:1/18:0)
|
|
|
|
C18 L-erythro Ceramide is a naturally occurring ceramide and stereoisomer of C18 ceramide . It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 0.11 mol% (8.8 μM). |
|
T36320
|
C6 L-threo Ceramide (d18:1/6:0)
C6 L-threo Ceramide (d18:1/6:0)
|
|
|
|
C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 L-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 L-threo Ceramide enhances IL-4 production induced by phorbol 12-myristate 13-acetate in EL4 T cells when used at a concentration of 10 μM. |
|
T37565
|
C6 D-threo Ceramide (d18:1/6:0)
C6 D-threo Ceramide (d18:1/6:0)
|
|
|
|
C6 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 D-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 D-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 D-threo Ceramide promotes survival of isolated rat spinal neurons when used at concentrations up to 2.5 μM but induces cell death at concentrations greater... |
|
T35927
|
C2 L-threo Ceramide (d18:1/2:0)
C2 L-threo Ceramide (d18:1/2:0)
|
|
|
|
C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide . C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1... |
|
T37454
|
C16 dihydro Ceramide (d18:0/16:0)
Ceramide (d18:0/16:0),Cer(d18:0/16:0),N-hexadecanoyl-D-erythro-Dihydrosphingosine,N-Palmitoyl Sphinganine
|
|
|
|
C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) that lacks the 4,5-trans double bond.[1] C16 dihydro Ceramide (0-46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome C oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability ... |
|
T36319
|
C6 L-erythro Ceramide (d18:1/6:0)
C6 L-erythro Ceramide (d18:1/6:0)
|
|
|
|
C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide is cytotoxic to U937 cells (IC50 = 18 μM). |
|
T40849
|
C20 Ceramide
N-Arachidoyl-D-sphingosine
|
Endogenous Metabolite |
Metabolism |
|
C20 Ceramide (N-Arachidoyl-D-sphingosine) 是一种存在于大脑中的 20:0 神经酰胺，可穿越血脑屏障激活小胶质细胞，诱导抑郁样行为。 |
|
T20827
|
C8-Ceramide
N-辛酰基-D-神经鞘氨醇,N-Octanoyl-D-erythro-Sphingosine
|
|
|
|
C8 Ceramide, a cell-permeable analog, is analog to naturally occur ceramides. |
|
T30797
|
Ceramide 1 A
Linoleoyloxyheptacosanoyl-C18-phytosphingosine
|
|
|
|
Ceramide 1 A 是一种蜡状脂质化合物，是顶端皮肤层的脂质。它具有特殊的分子结构，因为它含有一种与长链ω-羟基酸相连的亚油酸。 |
|
T69361
|
C16-Urea-Ceramide
|
|
|
|
C16-Urea-Ceramide s a neutral ceramidase (nCDase) inhibitor. It is a bioactive ceramide. |
|
T37437
|
C17 Ceramide (d18:1/17:0)
|
|
|
|
C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine. It has been used as a marker of arylsulfatase A and sphingolipid activator B activity in patients undergoing enzyme replacement therapy for the genetic disease metachromatic leukodystrophy. |
|
T83880
|
C18 Ceramide-1-phosphate (d18:1/18:0) ammonium
Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate
|
|
|
|
C18 Ceramide-1-phosphate (d18:1/18:0) 是一种在鼠皮肤中发现的长链ceramide-1-phosphate。它能在0.5至5 µM的浓度范围内促进分离的小鼠骨髓来源的多能间充质细胞和人脐静脉内皮细胞（HUVECs）的迁移。与胰腺癌干细胞相比，CFPAC-1胰管腺癌细胞中C18 Ceramide-1-phosphate (d18:1/18:0)的水平有所增加。在Langendorff分离的灌流小鼠心脏的离体缺血模型中，心肌中C18 ceramide-1-phosphate (d18:1/18:0)的水平有所增加。 |
|
T35810
|
C24 dihydro Ceramide (d18:0/24:0)
Cer(d18:0/24:0)
|
|
|
|
C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell acute lymphoblastic leukemia (ALL) cell lines.[4] Levels of C24 dihydro ceramide are increased by 149.49-fold in dihydroceramide desaturase 1 (DEGS1) knockdown UM-SCC-22A human head and neck squam... |
|
T35808
|
C18:1 Ceramide (d18:1/18:1(9Z))
Cer(d18:1/18:1(9Z))
|
|
|
|
C18:1 Ceramide is a naturally occurring ceramide.[1][2][3] Levels of C18:1 ceramide are elevated in overweight and insulin-resistant mice and cattle.[1][2] C18:1 Ceramide is also increased in the plasma and ovarian tissue of patients with advanced ovarian cancer. [3] |
|
T82800
|
C12-NBD-ceramide
|
|
|
|
C12-NBD-ceramide，一种荧光标记的神经酰胺类似物，常用作神经酰胺酶实验的底物。 |
|
T35806
|
N-Stearoylsphingosine
C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide
|
Phosphatase |
Metabolism |
|
N-Stearoylsphingosine (Cer(d18:1/18:0)) 是一种广泛存在真核生物体内的酰胺类化合物，通过干扰PP2A与PP2A抑制剂2的结合来增强蛋白质磷酸酶2A(PP2A)活性，导致Akt去磷酸化。N-Stearoylsphingosine 可用于研究前列腺癌。 |
|
T74304
|
C16 PEG-Ceramide
|
|
|
|
C16 PEG-Ceramide为一种聚乙二醇化神经酰胺，具备脂质载体传递功能，并能诱导自噬(autophagy)，在癌症研究中有应用。 |
|
T74307
|
C8 PEG-Ceramide
|
|
|
|
C8 PEG-Ceramide 是一种脂质产品。C8 PEG-Ceramide 可合成脂质双层载体，用于药物递送。 |
|
T75396
|
Sphingolipid ceramide N-deacylase (SCDase)
|
|
|
|
Sphingolipid ceramide N-deacylase (SCDase) 催化糖鞘脂中的脂肪酸与鞘氨醇碱基间的N-酰基键断裂，进而生成溶血糖鞘脂。 |
|
T21658
|
ARN14974
|
Others |
Others |
|
ARN14974 是一种有效的全身活性的胞内酸性神经酰胺酶抑制剂 (IC50=79 nM)，是一种苯并恶唑酮甲酰胺化合物。 |
|
T82796
|
C-6 NBD-dihydro-Ceramide
|
|
|
|
C-6 NBD-dihydro-Ceramide是一种生物活性的短链荧光类似物，能够透过细胞膜。 |
|
T12148
|
N-Desmethyltamoxifen hydrochloride
|
Estrogen Receptor/ERR;
Endogenous Metabolite;
PKC |
Chromatin/Epigenetic;
Cytoskeletal Signaling;
Endocrinology/Hormones;
Metabolism |
|
N-Desmethyltamoxifen hydrochloride 是 Tamoxifen 在人体内主要的三苯氧胺代谢物。它是蛋白激酶 C 抑制剂，也是人体 AML 细胞神经酰胺代谢的有效调节因子，可限制神经酰胺糖基化、水解和鞘氨醇磷酸化。 |
|
TQ0155
|
Miglustat hydrochloride
NB-DNJ hydrochloride,盐酸美格鲁特,N-Butyldeoxynojirimycin hydrochloride,OGT918 hydrochloride
|
Transferase |
Metabolism |
|
Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) 是一种葡萄糖神经酰胺合酶抑制剂，可用于 I 型戈谢病的相关研究。 |
|
T10760
|
Ceramides Mixture
神经酰胺混合物,神经酰胺
|
Telomerase |
DNA Damage/DNA Repair |
|
Ceramides Mixture 是表皮渗透屏障的主要脂质成分，参与生长抑制，细胞周期停滞和端粒酶活性的调节。它是一种内源性神经酰胺，由含羟基和非羟基脂肪酸的神经酰胺组成。 |
|
T38946
|
C8 Dihydroceramide
C8 Dihydroceramide
|
|
|
|
C8 Dihydroceramide acts as a negative control for C8 Ceramide, a cell-permeable analog of natural ceramides. C8 Ceramide, also known as N-Octanoyl-D-erythro-sphingosine, exhibits potent chemotherapeutic properties and anti-proliferation effects. Additionally, it stimulates dendritic cells to enhance T cell responses during viral infections. In vitro studies have also shown that C8 Ceramide induces a slight activation of protein kinase (PKC) [4]. |
|
T37872
|
C16 Galactosylceramide (d18:1/16:0)
C16 Galactosylceramide (d18:1/16:0)
|
|
|
|
C16 Galactosylceramide is a glycosphingolipid that contains a galactose moiety attached to a ceramide acylated with palmitic acid . |
|
T38280
|
C22 dihydro 1-Deoxyceramide (m18:0/22:0)
C22 dihydro 1-Deoxyceramide (m18:0/22:0)
|
|
|
|
C22 dihydro 1-Deoxyceramide (m18:0/22:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C22 dihydro 1-Deoxyceramide (m18:0/22:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found as the most prevalent dihydro... |
|
T62664
|
Glucosylceramide synthase-IN-2
|
|
|
|
Glucosylceramide synthase-IN-2 (compound T-690) 是一种有效的、具有血脑屏障通透性的、口服具有活力的 glucosylceramide synthase (GCS) 抑制剂，作用于人 GCS (IC50: 15 nM) 和小鼠 GCS (IC50: 190 nM)。Glucosylceramide synthase-IN-2 能够非竞争性抑制 C8 神经酰胺和 UDP 葡萄糖。Glucosylceramide synthase-IN-2 能够用于研究戈谢病。 |
|
T38284
|
C24 dihydro 1-Deoxyceramide (m18:0/24:0)
C24 dihydro 1-Deoxyceramide (m18:0/24:0)
|
|
|
|
C24 dihydro 1-Deoxyceramide (m18:0/24:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C24 dihydro 1-Deoxyceramide (m18:0/24:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found in mouse brain, spinal cord, ... |
|
T36858
|
C12 Galactosylceramide (d18:1/12:0)
|
|
|
|
C12 Galactosylceramide is a bioactive sphingolipid. It inhibits IL-4 production by 53.84% in EL4 T cells when used at a concentration of 10 μM. C12 Galactosylceramide reduces the growth of human papillomavirus type 16-associated tumors in mice and reduces tumor recurrence following surgical removal or chemotherapy. It also reduces natural killer T cell activity, delays the onset of proteinuria, and improves survival in a mouse model of systemic lupus. |
|
T36323
|
C8 Galactosylceramide (d18:1/8:0)
C8 Galactosylceramide (d18:1/8:0)
|
|
|
|
C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo.... |
|
T38282
|
C22 Glucosylceramide (d18:1/22:0)
|
|
|
|
C22 Glucosylceramide (d18:1/22:0) is an endogenous glucosylceramide. Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precursors in the synthesis of lactosylceramide , as well as oligoglycolipids and gangliosides. Phospholipase A2 (PLA2) type XIIA knockdown increases C22 glucosylceramide (d18:1/22:0) expression in rat brain. It is also increased in the brain, but not the liver or spinal cord, of mice f... |
|
T36671
|
C2 Phytoceramide (t18:0/2:0)
|
|
|
|
C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 μM) in suspended polymorphonuclear cells. It increases COX-2 protein levels 15-fold through ERK signaling. It induces death of keratinocytes (20% viability) with an ED50 value of 30 μM, the same concentration at which 35% of cells in a TUNEL assay are apoptotic. C2 Phytoceramide also has antiproliferative effects in CHO cells, with greater than 80% cytotoxicity achieved at... |
沪公网安备 31010602006700号