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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T15461	Halopemide	Others; Phospholipase; Dopamine Receptor	GPCR/G Protein; Metabolism; Neuroscience; Others
	Halopemide 是一种有效的 PLD 抑制剂（对人 PLD1 和 PLD2 的 IC50 = 220 和 310 nM）。 Halopemid 是多巴胺受体的拮抗剂。Halopemid 可用于精神药物研究。
T0308	Etidronic acid HEDPA,Etidronate,HEDP,羟乙磷酸	Apoptosis; Phosphatase; Others; HBV	Apoptosis; Metabolism; Microbiology/Virology; Others
	Etidronic acid (HEDP) 是一种影响钙代谢的二膦酸盐，抑制异位钙化并减缓骨吸收和骨转换，可应用于洗涤，水处理，化妆品和制药业。
T1210	Sodium etidronate 依替膦酸钠,Didronel	Phosphatase	Metabolism
	Sodium etidronate (Didronel) 是一种内源性 pyrophosphate 的合成治疗性 diphosphonate 类似物。作为称为 bisphosphonates 盐类药物家族的一员，etidronate disodium 与内源性 pyrophosphate 的不同之处在于其对酶水解的耐受性。该药剂吸附 hydroxyapatite 细胞并减少破骨细胞的数量，从而抑制异常骨吸收。 Etidronate 还可以直接刺激成骨细胞的骨形成。
T3280	Clodronate disodium tetrahydrate clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Clodronate disodium tetrahydrate (Clastoban) 是一种选择性、高效的，可逆、Cl-竞争性的囊泡核苷酸转运体阻滞剂(IC50:15.6 nM)。是一种双膦酸盐，具有抗骨质疏松、抗炎作用，可用于缓解疼痛的研究。它可抑制神经元释放囊泡 ATP，缓解慢性神经病理性疼痛和炎症性疼痛。
T29067	Upacicalcet PLS-240,SK-1403,AJT-240	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Upacicalcet (AJT-240) 是一种静脉内拟钙剂，是一种可用于人血液透析的 SHPT，通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌，从而降低血液中的 PTH 水平。 3 Upacicalcet 是钙敏感受体的正变构调节剂，可预防大鼠腺嘌呤诱导的继发性甲状旁腺功能亢进模型中的血管钙化和骨骼疾病。
T33856	PA 21 PA21
	PA 21 is an iron-based noncalcium phosphate binder that prevents vascular calcification in chronic renal failure rats.
T83406	2,3-Diphospho-D-glyceric acid pentasodium salt 2,3-DPG pentasodium salt
	2,3-Diphospho-D-glyceric acid pentasodium salt 是一种聚磷化合物，具有明显的阴离子性质。它在红细胞的凹中心起作用，通过结合血红蛋白降低氧亲和力。作为血管钙化 (VC) 的内源性选择性抑制剂，2,3-Diphospho-D-glyceric acid 能显著推迟结晶钙蛋白颗粒 (CPP) 的生成，并在小鼠血管平滑肌细胞系 (MOVAS) 中抑制钙化作用，同时不引起细胞毒性。
T35604	Osteocalcin (1-49) (human) (trifluoroacetate salt)
	Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget's disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in w...

化合物

Halopemide

Cat.No: T15461

Synonym:

Target: Others, Phospholipase, Dopamine Receptor

Etidronic acid

Cat.No: T0308

Synonym: HEDPA,Etidronate,HEDP,羟乙磷酸

Target: Apoptosis, Phosphatase, Others, HBV

Sodium etidronate

Cat.No: T1210

Synonym: 依替膦酸钠,Didronel

Target: Phosphatase

Clodronate disodium tetrahydrate

Cat.No: T3280

Synonym: clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium

Target: IL Receptor, TNF

Upacicalcet

Cat.No: T29067

Synonym: PLS-240,SK-1403,AJT-240

Target: Calcium Channel

2,3-Diphospho-D-glyceric acid pentasodium salt

Cat.No: T83406

Synonym: 2,3-DPG pentasodium salt

Target:

Osteocalcin (1-49) (human) (trifluoroacetate salt)

Cat.No: T35604

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T27538	Hexasodium phytate SNF 472,SNF472,SNF-472
	Hexasodium phytate is used potentially to treat vascular calcification and calciphylaxis.
TN2553	1-Methyl-2-undecyl-4(1H)-quinolone 1-Methyl-2-undecylquinolin-4(1H)-one	MAO	Metabolism; Neuroscience
	1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodia rutaecarpa (Juss.) Benth. 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of type B MAO (MAO-B) activity with the IC(50) value of 15.3 microM using a substrate kynuramine, but does not inhibit type A MAO (MAO-A) activity.It can mitigate high phosphate-induced human aortic valve interstitial cells (HAVICs) calcification ...

天然产物

Hexasodium phytate

Cat.No: T27538

Synonym: SNF 472,SNF472,SNF-472

Target:

1-Methyl-2-undecyl-4(1H)-quinolone

Cat.No: TN2553

Synonym: 1-Methyl-2-undecylquinolin-4(1H)-one

Target: MAO

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