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Cat. No.	Product Name	Target	Signaling Pathways
T2556	Nandrolone decanoate 癸酸诺龙,19-Nortestosterone decanoate	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Nandrolone decanoate (19-Nortestosterone decanoate) 是一种合成代谢雄激素，通过涉及谷氨酸诱导的 N-甲基-D-天冬氨酸受体过度兴奋的机制诱导攻击性行为表征。
T23483	U 99194 maleate U-99194A maleate,U-99194 maleate salt,U-99194 maleate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	U 99194 maleate (U-99194A maleate) 是一种 D3 拮抗剂，可增加隔离诱导的攻击性雄性小鼠的社会行为。
T11421	Glutaminase-IN-1 CB839 derivative	transporter	Metabolism
	Glutaminase-IN-1 (CB839 derivative)，是一种新型 1,3,4-硒二氮基肾型谷氨酰胺酶(KGA) 的变构抑制剂，在侵袭性 H22 肝癌异种移植模型中显示出抗肿瘤活性。
T3275	Nefazodone hydrochloride Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754,萘法唑酮盐酸盐	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Nefazodone hydrochloride (Serzone) 是一种强效和选择性的5HT2A 拮抗剂，Ki 为5.8 nM，对 5-HT 和去甲肾上腺素摄取具有中度抑制作用，IC50分别为 290 和 300 nM。它是一种苯哌嗪类抗抑郁药，具有微弱的 α-肾上腺素阻断活性，用于治疗抑郁症、攻击性行为和恐慌症。
T17206	UPGL00004	Others; Glutaminase	Others; Proteases/Proteasome
	UPGL00004 是一种有效的谷氨酰胺酶 C (GAC) 抑制剂，其 IC50为29 nM。UPGL00004 对 GAC 的 Kd 为27 nM。UPGL00004 对高度侵袭性三阴性乳腺癌细胞系的增殖具有很强的抑制作用。
T24519	Naprodoxime HCl Naprodoxime hydrochloride,L 7660,L7660,L-7660
	Naprodoxime HCl is an antidepressant. It also is an anti-aggressive agent.
T28850	SR57227A SR 57227A,SR-57227A
	SR 57227A is a highly selective of peripheral and central 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive beh
T70960	Maprotiline-d3 hydrochloride
	Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in r...
T68189	Anpirtoline free base
	Anpirtoline free base is a highly potent 5-HT1B receptor agonist. Anpirtoline has been shown to decreases central serotonin synthesis and attenuate aggressive behavior in vivo. Anpirtoline also acts as an antagonist at 5-HT3 receptors and can bypass the blood-brain barrier.
T78526	4A3-SC8	Others	Others
	4A3-SC8为一种模块化降解型树突状分子，其功能是在侵袭性肝癌模型中使小RNA延长生存期。
T78145	HDAC10-IN-2 hydrochloride	Autophagy	Autophagy
	HDAC10-IN-2 hydrochloride（化合物10c）是一种对HDAC10具有高效性和高选择性的抑制剂，IC50值为20 nM。该化合物能够调控FLT3-ITD阳性急性髓系白血病细胞的自噬过程。
T60760	HDAC10-IN-2
	HDAC10-IN-2 (化合物 10c) 调节侵袭性 FLT3-ITD 阳性急性髓系白血病细胞的自噬。HDAC10-IN-2是HDAC10的高选择性抑制剂 (IC50 = 20 nM)。
T60794	HDAC10-IN-1
	HDAC10-IN-1 (化合物 13b) 是一种有效且高选择性的HDAC10抑制剂 (IC 50 = 58 nM)，可用于调节侵袭性 FLT3-ITD 阳性急性髓系白血病细胞的自噬。
T63368	CDK7-IN-2
	CDK7-IN-2 是 CDK7 的有效抑制剂。其中 CDK7 利用 RNA 聚合酶 II (RNAPII) 的 Rbpl 亚基的磷酸化参与转录起始过程，其与细胞周期和转录活性的时间控制有关。CDK7 对癌症疾病，尤其是侵袭性和难以治疗的癌症具有研究潜力。
T80981	Tisagenlecleucel CTL019
	Tisagenlecleucel (CTL019) 是一种自体抗CD19嵌合抗原受体 (CAR) T 细胞治疗，专门针对并消除表达CD19的 B 细胞。该疗法主要用于研究治疗难治性侵袭性弥漫性大 B 细胞淋巴瘤。
T68400	STA-9584
	STA-9584 is a potent vascular disrupting agent, which exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors. In vitro, 2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-4-yl)aniline (STA-9122) (active metabolite of STA-9584 ) displayed increased potency relative to other tubulin-binding agents and was highly cytotoxic to tumor cells. STA-9584 induced significant tumor regressions in prostate and breast xenograft models in vivo and, ...
T63902	XP-524
	XP-524 是 BET 和 EP300 的有效抑制剂。 XP-524 在体内具有显著的杀肿瘤作用，能够阻止 KRAS 诱导的体内肿瘤转化，并延长两种侵袭性 PDAC 转基因小鼠模型的存活时间。XP-524 也提高了自身肽的表达及将肿瘤细胞向细胞毒性 T 淋巴细胞的募集。XP-524 对胰腺导管腺癌（PDAC）表现出研究潜力。
T38145	Eltoprazine
	Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no...

化合物

Nandrolone decanoate

Cat.No: T2556

Synonym: 癸酸诺龙,19-Nortestosterone decanoate

Target: Others, HIV Protease

U 99194 maleate

Cat.No: T23483

Synonym: U-99194A maleate,U-99194 maleate salt,U-99194 maleate

Target: Dopamine Receptor

Glutaminase-IN-1

Cat.No: T11421

Synonym: CB839 derivative

Target: transporter

Nefazodone hydrochloride

Cat.No: T3275

Synonym: Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754,萘法唑酮盐酸盐

Target: 5-HT Receptor, Adrenergic Receptor

Cat.No: T17206

Target: Others, Glutaminase

Naprodoxime HCl

Cat.No: T24519

Synonym: Naprodoxime hydrochloride,L 7660,L7660,L-7660

Cat.No: T28850

Synonym: SR 57227A,SR-57227A

Maprotiline-d3 hydrochloride

Cat.No: T70960

Anpirtoline free base

Cat.No: T68189

Cat.No: T78526

Target: Others

HDAC10-IN-2 hydrochloride

Cat.No: T78145

Target: Autophagy

Cat.No: T60760

Cat.No: T60794

Cat.No: T63368

Tisagenlecleucel

Cat.No: T80981

Synonym: CTL019

Cat.No: T68400

Cat.No: T63902

Cat.No: T38145

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