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Search Results for " valine "

52

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9298	D-Valine Valine, D-,(R)-Valine,D-缬氨酸,H-D-Val-OH	Endogenous Metabolite	Metabolism
	D-Valine (H-D-Val-OH) 是一直 L-Valine 的对映体。其中 L-Valine 是二十种蛋白氨基酸中的其中一种，是一种必需氨基酸。
TP1017L	Angiotensin II 5-valine TFA Angiotensin II 5-valine TFA(58-49-1 free base)	RAAS	Endocrinology/Hormones
	Angiotensin II 5-valine TFA 是血管紧张素受体的激动剂。
T8104	Glycyl-L-valine	Others; Endogenous Metabolite	Metabolism; Others
	Glycyl-L-valine 是含有甘氨酸和缬氨酸的二肽。
T25441	Fructosylvaline Fru-val,N-Fructosyl Valine	Others	Others
	Fructosylvaline（Fru-val）存在于味噌、白葡萄酒和清酒中，与白葡萄酒和清酒的氧化褐变有关。
TP1017	Angiotensin II 5-valine Valine angiotensin II,5-L-Valine angiotensin II,血管紧张素 Ⅱ 5-缬氨酸
	ngiotensin II 5-valine is an angiotensin II analog which is an agonist at angiotensin receptors.
T80665	Leu-Val L-leucyl-L-valine	Parasite; Antifungal	Microbiology/Virology
	Leu-Val (L-leucyl-L-valine) 是一种新型有效的二肽，具有抗菌和抗疟活性。
T35921	N-Oleoyl Valine
	N-Oleoyl valine is an endogenous N-acyl amine that acts as an antagonist at the transient receptor potential vanilloid type 3 (TRPV3) receptor, which is involved in thermoregulation. N-Oleoyl valine is increased in mice following cold exposure for up to at least 16 days. Acute lung injury in mice increases the concentration of N-Oleoyl valine in lung tissue. N-acyl amines also promote mitochondrial uncoupling.
T35029	Valine-valine-ganciclovir Valganciclovir N-valyl impurity
	Valine-valine-ganciclovir is a peptide.
T37915	Monodes(N-carboxymethyl)valine Daclatasvir
	Monodes(N-carboxymethyl)valine Daclatasvir, also known as Daclatasvir Impurity A, is the principal degradation product of Daclatasvir.Daclatasvir is a potent inhibitor of the HCV NS5A protein[1].
T34209	Pyroglutamylvaline Pyroglutamyl-valine,Pyro-glu-val,Pyroglutamyl valine
	Pyroglutamylvaline is a dipeptide.
T31927	G-Glu-Val gamma-Glutamyl-L-valine,H gGlu Val OH,gamma Glutamyl L valine
	G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".
T80931	Tri-valine NSC 35938
	Tri-valine (NSC 35938) 为多肽类化合物，可从肌酸激酶 (Creatine kinase)、β-烯醇化酶、三磷酸异构酶 (Triosephosphate isomerase) 及甘油醛 3-磷酸脱氢酶中分离得到。
T77939	WBC100 14-D-Valine-TPL	c-Myc	Cell Cycle/Checkpoint
	WBC100（14-D-Valine-TPL），一款高效、选择性和具口服活性的c-Myc小分子降解剂，通过针对泛素E3连结酶CHIP介导的26S蛋白酶体途径实现其作用。主要应用于c-Myc过表达肿瘤的研究领域。
T66894	N-Acetyl-D-valine
	N-Acetyl-D-valine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66894，CAS号为 17916-88-0。
T3503	MC-Val-Cit-PABC-PNP Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate,马来酰亚胺基己酰-L-缬氨酸-L-瓜氨酸对氨基苄醇对硝基苯基碳酸脂	Others; AChR	Neuroscience; Others
	MC-Val-Cit-PABC-PNP 是一种组织蛋白酶可裂解的 ADC 肽接头，可用于合成抗体偶联药物。
T67538	Cbz-D-Valine
	Cbz-D-Valine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67538，CAS号为 1685-33-2。
T40839	H-Val-βNA L-Valine β-naphthylamide,H-Val-βNA
	H-Val-βNA, also known as L-Valine β-naphthylamide, serves as a substrate for aminopeptidase and Valine arylamidase activities.
T65884	N-Methyl-L-valine
	N-Methyl-L-valine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65884，CAS号为 2480-23-1。
T66844	N-Fmoc-glycyl-L-valine
	N-Fmoc-glycyl-L-valine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66844，CAS号为 86895-14-9。
T66012	(tert-Butoxycarbonyl)-L-valyl-L-valine
	(tert-Butoxycarbonyl)-L-valyl-L-valine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66012，CAS号为 69209-73-0。
T83502	[Deamino-4-valine, 8-D-arginine]-Vasopressin dVDAVP
	[Deamino-4-valine, 8-D-arginine]-Vasopressin (dVDAVP)为一种抗利尿药，具有高效性、特异性以及延长的药效特点。
T35088	VYN00459 Glutamic acid-Valine-Citruline,VYN 00459,NH2-Glu(OBu)-Val-Cit,NH2-Glu(OBu-t)-Val-Cit,VYN-00459
	VYN00459, also known as NH2-Glu(OBu-t)-Val-Cit, is a tripeptide linker, which is enzymatic cleavable. VYN00459 has sequence of Glutamic acid-Valine-Citruline with glutamic acid side chain protected with t-butyl ester. VYN00459 has no formal name, its name
T65258	N-(tert-Butoxycarbonyl)-N-methyl-L-valine
	N-(tert-Butoxycarbonyl)-N-methyl-L-valine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65258，CAS号为 45170-31-8。
T20566L	Valylvaline acetate	Others	Others
	Valylvaline acetate 是一种二肽和 PEPT1 激动剂，EC50 为 0.07mM。
T64916	D(-)-Norvaline
	D(-)-Norvaline 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64916，CAS号为 2013-12-9。
T25990	Prolylvaline Val-pro,L-Valyl-L-proline,Pro-val,Valylproline
	Prolylvaline is used as a peptide with antibacterial properties.
T32214	Isoleucylvaline Ile-val
	Isoleucylvaline is a dipeptide.
T20562	Ureidovaline
	Ureidovaline is an intermediate in the Ritonavir synthesis.
T20566	Valylvaline Val-val
	Valylvaline is a chemical with bioactive activity.
T31199	Dansylhydrazide trivaline H-Val-val-val-N2H2-dns,DGTV
	Dansylhydrazide trivaline can exhibit florescence.
T37584	Tryptoquivaline D
	Tryptoquivaline D is a fungal metabolite that has been found inNeosartorya siamensisand has anticancer activity.1,2It induces nuclear chromatin condensation, a marker of apoptosis, in HCT116 colon and HepG2 liver cancer cells when used at a concentration of 150 μM.1Tryptoquivaline D (1-100 μM), alone or in combination with doxorubicin , reduces the viability of A549 lung cancer cells.2
T19350	H-Val-Ala-OH 缬氨酰-丙氨酸,Valyl-alanine	Endogenous Metabolite	Metabolism
	H-Val-Ala-OH (Valyl-alanine) 是由 L-缬氨酸和 L-丙氨酸残基形成的二肽，具有代谢作用。
T14199	ALZ-801 Valiltramiprosate	Beta Amyloid	Neuroscience
	ALZ-801 是一种可口服的小分子 β-淀粉样蛋白抗寡聚体和聚集抑制剂，是曲米酸的缬氨酸偶联前药，与母体化合物相比，具有显著改善的 PK 特性和胃肠道耐受性。它是治疗阿尔茨海默病的先进且显著改善的候选药物。
T13278	Valecobulin hydrochloride CKD-516 hydrochloride	Microtubule Associated	Cytoskeletal Signaling
	Valecobulin hydrochloride (CKD-516 hydrochloride) 是 S516 的缬氨酸前体药和血管阻断剂。Valecobulin hydrochloride 对β-微管蛋白聚合有强效的抑制作用，对小鼠和人类的实体肿瘤具有显著的抗肿瘤活性。
T18870	Vc-MMAD	Others	Others
	Vc-MMAD 由 linker (Val-Cit) 和微管抑制剂 MMAD 组成。Vc-MMAD 可用于偶联抗体。
T22043	BCATc Inhibitor 2	Others	Others
	BCATc Inhibitor 2 是选择性分支链氨基转移酶抑制剂，可用于神经退行性疾病的研究。能够抑制 rBCATc (IC50:0.2 μM)，hBCATc (IC50:0.8 μM)、 rBCATm (IC50:3.0 μM)。其中BCATc 也称为 BCAT1，存在于细胞质基质中的亚型。
T33263	Mdl 27013 Mdl27,013,Mdl27013,Mdl-27013,Mdl-27,013,Mdl 27,013
	Mdl 27013 is a derivative of methoxysuccinyl-alanyl-alanyl-prolyl-valine.
T26314	Valyl-ochratoxin A
	Valyl-ochratoxin A is a phenylalanyl moiety of ochratoxin A replaced by valine. It is a yeast valyl-tRNA synthetase inhibitor.
T35032	Valyllysine Val-lys,Valyl-lysine
	Valyllysine is a dipeptide composed of valine and lysine. It is an incomplete breakdown product of protein digestion or protein catabolism.
T13278L	Valecobulin CKD-516	Others	Others
	Valecobulin is a potent β-tubulin polymerization inhibitor. Valecobulin is a valine prodrug of (S516) and an avascular disrupting compound.
T13222	TTT-28	Others	Others
	TTT-28 is a thiazole-valine peptidomimetic, and is a selective ABCB1 (P-gp/MDR1) inhibitor with high efficacy and low toxicity, which reverses the ATP-binding cassette sub-family B member 1 (ABCB1)-mediated Multidrug resistance (MDR) by selectively blocki
T25702L	Levovirin valinate HCl Levovirin valinate hydrochloride,R 1518,R-1518,R1518
	Levovirin valinate HCl is a valine ester prodrug of levovirin as a new investigational drug for the therapy of the hepatitis C virus.
T39458	DGN549-C DGN549-C
	DGN549-C is a novel compound featuring a cleavable ADC (antibody-drug conjugate) linker composed of valine-alanine (va) and a PBD (pyrrolobenzodiazepine) dimer. This compound possesses a unique DNA-alkylating cytotoxic payload, DGN549, which is utilized in the development of ADCs.
T36834	Abacavir Carboxylate
	Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir . It is formed from abacavir via reactive aldehyde intermediates that can form adducts with proteins on valine residues.
T36842	Isobutyryl Coenzyme A (sodium salt)
	Isobutyryl coenzyme A (isobutyryl-CoA) is a short-chain branched acyl CoA. Isobutyryl-CoA is a substrate for isobutyryl-CoA dehydrogenase (IBDH) in the catabolism of valine and an intermediate in the synthesis of isobutyryl-L-carnitine , which accumulates in IBDH deficiency.
T77827	DBCO-PEG4-acetic-Val-Cit-PAB
	DBCO-PEG4-acetic-Val-Cit-PAB为含四单元聚乙二醇（PEG）的ADC可分解连接体，适用于合成抗体药物偶联物（ADC）。
T81073	Suc-Val-Pro-Phe-SBzl
	Suc-Val-Pro-Phe-SBzl 是一种CatG酶抑制剂，其半抑制浓度（IC50）为 111-225 mM。
T76108	Leucine dehydrogenase
	Leucine dehydrogenase 能够从球形芽孢杆菌中纯化得到。Leucine dehydrogenase 催化L-亮氨酸、L-缬氨酸、L-异亮氨酸、L-去甲缬氨酸、左旋α-氨基丁酸酯和L-去甲亮氨酸的氧化脱氨，以及它们的酮类似物的还原胺化。
T77864	SC239
	SC239为一种2-氨基苯基半紫杉烷类活性分子连接剂，具有可裂解特性。该化合物适用于抗体药物偶联物（ADC）的活性分子连接。
T75292	Biotin sodium
	Biotin (Vitamin B7) sodium 是一种水溶性维生素 B，是人体五种羧化酶的辅酶，参与脂肪酸、异亮氨酸和缬氨酸的合成，并参与糖异生。Biotin sodium 是细胞生长、脂肪酸产生以及脂肪和氨基酸代谢的必需物质。

化合物

Cat.No: T9298

Synonym: Valine, D-,(R)-Valine,D-缬氨酸,H-D-Val-OH

Target: Endogenous Metabolite

Angiotensin II 5-valine TFA

Cat.No: TP1017L

Synonym: Angiotensin II 5-valine TFA(58-49-1 free base)

Target: RAAS

Glycyl-L-valine

Cat.No: T8104

Target: Others, Endogenous Metabolite

Fructosylvaline

Cat.No: T25441

Synonym: Fru-val,N-Fructosyl Valine

Target: Others

Angiotensin II 5-valine

Cat.No: TP1017

Synonym: Valine angiotensin II,5-L-Valine angiotensin II,血管紧张素 Ⅱ 5-缬氨酸

Cat.No: T80665

Synonym: L-leucyl-L-valine

Target: Parasite, Antifungal

N-Oleoyl Valine

Cat.No: T35921

Valine-valine-ganciclovir

Cat.No: T35029

Synonym: Valganciclovir N-valyl impurity

Monodes(N-carboxymethyl)valine Daclatasvir

Cat.No: T37915

Pyroglutamylvaline

Cat.No: T34209

Synonym: Pyroglutamyl-valine,Pyro-glu-val,Pyroglutamyl valine

Cat.No: T31927

Synonym: gamma-Glutamyl-L-valine,H gGlu Val OH,gamma Glutamyl L valine

Cat.No: T80931

Synonym: NSC 35938

Cat.No: T77939

Synonym: 14-D-Valine-TPL

Target: c-Myc

N-Acetyl-D-valine

Cat.No: T66894

MC-Val-Cit-PABC-PNP

Cat.No: T3503

Synonym: Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate,马来酰亚胺基己酰-L-缬氨酸-L-瓜氨酸对氨基苄醇对硝基苯基碳酸脂

Target: Others, AChR

Cat.No: T67538

Cat.No: T40839

Synonym: L-Valine β-naphthylamide,H-Val-βNA

N-Methyl-L-valine

Cat.No: T65884

N-Fmoc-glycyl-L-valine

Cat.No: T66844

(tert-Butoxycarbonyl)-L-valyl-L-valine

Cat.No: T66012

[Deamino-4-valine, 8-D-arginine]-Vasopressin

Cat.No: T83502

Synonym: dVDAVP

Cat.No: T35088

Synonym: Glutamic acid-Valine-Citruline,VYN 00459,NH2-Glu(OBu)-Val-Cit,NH2-Glu(OBu-t)-Val-Cit,VYN-00459

N-(tert-Butoxycarbonyl)-N-methyl-L-valine

Cat.No: T65258

Valylvaline acetate

Cat.No: T20566L

Target: Others

Cat.No: T64916

Cat.No: T25990

Synonym: Val-pro,L-Valyl-L-proline,Pro-val,Valylproline

Isoleucylvaline

Cat.No: T32214

Synonym: Ile-val

Cat.No: T20562

Cat.No: T20566

Synonym: Val-val

Dansylhydrazide trivaline

Cat.No: T31199

Synonym: H-Val-val-val-N2H2-dns,DGTV

Tryptoquivaline D

Cat.No: T37584

Cat.No: T19350

Synonym: 缬氨酰-丙氨酸,Valyl-alanine

Target: Endogenous Metabolite

Cat.No: T14199

Synonym: Valiltramiprosate

Target: Beta Amyloid

Valecobulin hydrochloride

Cat.No: T13278

Synonym: CKD-516 hydrochloride

Target: Microtubule Associated

Cat.No: T18870

Target: Others

BCATc Inhibitor 2

Cat.No: T22043

Target: Others

Cat.No: T33263

Synonym: Mdl27,013,Mdl27013,Mdl-27013,Mdl-27,013,Mdl 27,013

Valyl-ochratoxin A

Cat.No: T26314

Cat.No: T35032

Synonym: Val-lys,Valyl-lysine

Cat.No: T13278L

Synonym: CKD-516

Target: Others

Cat.No: T13222

Target: Others

Levovirin valinate HCl

Cat.No: T25702L

Synonym: Levovirin valinate hydrochloride,R 1518,R-1518,R1518

Cat.No: T39458

Synonym: DGN549-C

Abacavir Carboxylate

Cat.No: T36834

Isobutyryl Coenzyme A (sodium salt)

Cat.No: T36842

DBCO-PEG4-acetic-Val-Cit-PAB

Cat.No: T77827

Suc-Val-Pro-Phe-SBzl

Cat.No: T81073

Leucine dehydrogenase

Cat.No: T76108

Cat.No: T77864

Cat.No: T75292

Cat. No.	Product Name	Target	Signaling Pathways
T9294	DL-Valine DL-缬氨酸,Valine, DL-,H-DL-Val-OH,2-Amino-3-methylbutanoic acid	Others	Others
	DL-Valine (H-DL-Val-OH) 是 2-氨基-3-甲基丁酸。它是在植物中从丙酮酸开始通过几个步骤合成的。
T2O2776	L-Valine	Others; Endogenous Metabolite	Metabolism; Others
	L-Valine 是蛋白二十种氨基酸中的其中一种。它是必需氨基酸。
T4788	L-Norvaline	Others; Endogenous Metabolite	Metabolism; Others
	L-Norvaline 是一种精氨酸酶抑制剂，也是一种非蛋白支链氨基酸。 L-Norvaline 先前已被报道为枯草芽孢杆菌抗真菌肽的天然成分。 L-Norvaline 和其他修饰的支链氨基酸在研究中受到了关注，因为它们似乎被掺入到大肠杆菌中发现的一些重组蛋白中。
T11054	DL-Norvaline 2-Aminopentanoic acid,DL-正缬氨酸	Arginase; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	DL-Norvaline (2-Aminopentanoic acid) 是精氨酸酶的非竞争性抑制剂，是L-norvaline 的代谢物。
T38095	Acetylvaline
	Acetylvaline 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 T38095，CAS号为 96-81-1。
T7357	(S)-b-aminoisobutyric acid	Endogenous Metabolite	Metabolism
	(S)-b-aminoisobutyric acid 是由胸腺嘧啶和缬氨酸分解代谢得到的非蛋白质氨基酸。
T5248	(R)-3-Hydroxybutanoic acid	Others; Endogenous Metabolite	Metabolism; Others
	(R)-3-Hydroxybutanoic acid 是一种代谢物，在 3-羟基丁酸脱氢酶催化下由乙酸乙酯转化而成。它可以作为营养来源和抗生素、维生素和信息素的前体。
T37753	Aureusimine B	Cysteine Protease; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Aureusimine B 是一种钙蛋白酶抑制剂，由金黄色葡萄球菌生物膜产生，可能是金黄色葡萄球菌生物膜感染的潜在生物标志物。

天然产物

Cat.No: T9294

Synonym: DL-缬氨酸,Valine, DL-,H-DL-Val-OH,2-Amino-3-methylbutanoic acid

Target: Others

Cat.No: T2O2776

Target: Others, Endogenous Metabolite

Cat.No: T4788

Target: Others, Endogenous Metabolite

Cat.No: T11054

Synonym: 2-Aminopentanoic acid,DL-正缬氨酸

Target: Arginase, Endogenous Metabolite

Cat.No: T38095

(S)-b-aminoisobutyric acid

Cat.No: T7357

Target: Endogenous Metabolite

(R)-3-Hydroxybutanoic acid

Cat.No: T5248

Target: Others, Endogenous Metabolite

Cat.No: T37753

Target: Cysteine Protease, Antibacterial

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