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Cat. No. | Product Name | Target | Signaling Pathways |
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T20545 |
Benzarone
Benzarona,Vasoc,苯扎隆,Venagil,Benzaronum |
OAT | Membrane transporter/Ion channel |
Benzarone (Benzarona) 是人尿酸转运蛋白 1的有效抑制剂,IC50为 2.8 μM。它具有降低血清尿酸水平的作用。 | |||
T2397 |
Topiroxostat
托匹司他,FYX-051 |
P450; ROS; Xanthine Oxidase | Immunology/Inflammation; Metabolism |
Topiroxostat (FYX-051) 是一种有效的口服黄嘌呤氧化还原酶 (XOR) 抑制剂,IC50=5.3 nM,Ki=5.7 nM。它还表现出弱的CYP3A4抑制活性 (18.6%)。它有用于高尿酸血症的研究潜力。 | |||
T15251 |
Etebenecid
乙磺舒,Urelim |
Others | Others |
Etebenecid (Urelim) 是促尿酸排泄药,能够抑制青霉素自肾小管分泌。 | |||
T21302 |
UNC569
UNC 569 |
TAM Receptor | Tyrosine Kinase/Adaptors |
UNC569 (UNC 569) 是一种ATP 竞争性的、可逆、具有口服活性的Mer 激酶抑制剂,其IC50=2.9 nM,Ki=4.3 nM。它还抑制Axl 和Tyro3,IC50分别为 37 nM 和 48 nM。它可用于研究急性淋巴细胞白血病和非典型畸胎瘤/横纹肌瘤。 | |||
T79854 |
Lingdolinurad
|
OAT | Membrane transporter/Ion channel |
Lingdolinurad 是一种靶向 hURAT1的尿酸转运蛋白抑制剂,可用于研究高尿酸血症或痛风。 | |||
T5987 |
Potassium oxonate
Oxonic Acid (potassium salt),氧嗪酸钾,Potassium otastat,Potassium azaorotate |
Others | Others |
Potassium oxonate (Potassium azaorotate) 是用作尿酸酶抑制剂,都5-FU 磷酸化为5-fluorouridine-5'-monophosphate 具有抑制作用。 | |||
T21469 |
Cyclopenthiazide
Cyclomethiazide,Su-8341,SU 8341,环戊噻嗪 |
Others | Others |
Cyclopenthiazide (Cyclomethiazide) 是一种噻嗪类利尿剂,用于治疗高血压和心力衰竭。减少钙离子和尿酸的排泄,增加钠和钾离子的排泄。 | |||
T60625 |
Tigulixostat
|
||
Tigulixostat 是吲哚基杂芳羧酸的新型衍生物。Tigulixostat 是一种非嘌呤选择性的黄嘌呤氧化酶抑制剂,可降低尿酸的生成。 | |||
T15160 |
Dotinurad
(3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone |
OAT | Membrane transporter/Ion channel |
Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) 是有效的尿酸盐重吸收选择性抑制剂,抑制尿酸盐转运蛋白 1的IC50为 37.2 nM,具有促尿酸排泄的作用。 | |||
T26619 |
Amitivir
LY217896,LY 217896,阿米替韦,LY-217896 |
Others; Influenza Virus | Microbiology/Virology; Others |
Amitivir (LY 217896) 是一种噻二唑衍生物,对 A 和 B 型流感病毒均有效,对正粘病毒和副粘病毒具有广泛的抗病毒活性。 | |||
T61048 |
Puliginurad
YL-90148 |
OAT | Membrane transporter/Ion channel |
Puliginurad (YL-90148) 是一种具有有效性和选择性的尿酸盐转运蛋白 (URAT) 抑制剂,对尿酸的重吸收有抑制作用。Puliginurad 可用于预防和治疗高尿酸血症和痛风。 | |||
T6875 |
Lesinurad
RDEA594,雷西那德,来司诺雷 |
OAT | Membrane transporter/Ion channel |
Lesinurad (RDEA594) 是URAT1和OAT 抑制剂。Lesinurad 用作肾转运蛋白OAT1 和OAT3 的底物,Km 分别为 0.85 和 2 μM。 | |||
T77517 |
URAT1 inhibitor 7
|
OAT | Membrane transporter/Ion channel |
URAT1 inhibitor 7 是一种新型高效的人尿酸转运蛋白 URAT1 抑制剂 (IC50:12 nM)。URAT1 inhibitor 7 对 CYP2C9 具有抑制作用,IC50为4.2 μM。URAT1 inhibitor 7 可用于研究高尿酸血症和痛风。 | |||
T0782 |
Benzthiazide
Aquatag,苄噻嗪,Lemazide,Dihydrex |
Carbonic Anhydrase | Metabolism |
Benzthiazide (Lemazide) 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂,他对 CA9,CA2 和 CA1 的 Ki 分别为 8.0,8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。 | |||
T27697 |
JTT-552
|
||
JTT-552, a uric acid transporter 1 (URAT1) inhibitor, is used potentially for the treatment of hyperuricemia. | |||
T20548 |
Parabanic acid
NSC9789,NSC-9789,NSC 9789 |
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Parabanic acid is the oxidation product of uric acid by singlet oxygen. | |||
T26490 |
AA 193
AA-193,AA193 |
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AA 193 selectively inhibits the presecretory reabsorption of uric acid. | |||
T26710 |
Azapropazone
DuP-141,NSC-102824,AHR-3018,AHR 3018,MI-85 |
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Azapropazone is anti-inflammatory agent. Azapropazone has uricosuric properties used to treat rheumatoid arthritis and ankylosing spondylitis. Azapropazone lowered plasma uric acid but exerted only a modest and variable uricosuric effect without altering | |||
T13259 | URAT1 inhibitor 1 | OAT | Membrane transporter/Ion channel |
URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout. | |||
T71808 |
Tisopurine
|
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Tisopurine is a drug used in the treatment of gout in some countries. It reduces uric acid production through inhibiting an early stage in its production. | |||
T68437 | Febuxostat 67M-1 | ||
Febuxostat 67M-1 is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and reduces the risk of gout or kidney stone formation. | |||
T69282 |
Febuxostat 67M-2
|
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Febuxostat 67M-2 is a derivative compound of Febuxostat 67M-1 which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and also used to reduce the risk of gout or kidney stone formation. | |||
T73617 | Urate oxidase | ||
Urate oxidase (Uox) 尿酸氧化酶,即尿酸酶,常用于生化研究。Urate oxidase 是一种过氧化物酶,在大多数哺乳动物中催化尿酸氧化为尿囊素。 | |||
T76104 |
Xanthine oxidase
黄嘌呤氧化酶 |
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Xanthine oxidase 是一种黄嘌呤氧化还原酶,可产生活性氧 (ROS),催化次黄嘌呤氧化为黄嘌呤,进一步催化黄嘌呤氧化为尿酸。 | |||
T69281 |
Febuxostat 67M-4
|
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Febuxostat 67M-4 is a derivative compound of Febuxostat 67M-1 which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and reduces the risk of gout or kidney stone formation. | |||
T79177 | URAT1&XO inhibitor 2 | Xanthine Oxidase | Metabolism |
URAT1&XO inhibitor 2 (Compound BDEO)是一种针对xanthine oxidase (黄嘌呤氧化酶) 及URAT1的双重抑制剂,对xanthine oxidase展现出优异的抑制效果,IC50值为3.3 μM。该化合物在表达URAT1的HEK293细胞中显著抑制尿酸的摄取,其Ki值达到0.145 μM。在动物模型中,URAT1&XO inhibitor 2有效降低高尿酸血症小鼠的血清尿酸水平,并增加尿酸的排泄。该化合物主要用于高尿酸血症的研究。 | |||
T71326 |
1,3,7-Trimethyluric Acid-d9
|
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1,3,7-Trimethyluric acid-d9 is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine. It is formed from caffeine by the cytochrome P450 isoform CYP3A4. 1,3,7-Trimethyluric acid scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes. | |||
T60626 | Xanthine oxidase-IN-7 | ||
Xanthine oxidase-IN-7 (compound1h) 是一种口服的黄嘌呤氧化酶(XO)抑制剂 (IC50 = 0.36 μM)。Xanthine oxidase-IN-7 可有效降低血清尿酸水平,在高尿酸血症和痛风的研究中具有潜力。 | |||
T60935 |
H-Tyr-Phe-OH
|
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H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) 可用作区分良性甲状腺结节和甲状腺癌的生物标志物。H-Tyr-Phe-OH 是一种口服活性的血管紧张素转换酶抑制剂,在50 μM 时抑制率为 48%。H-Tyr-Phe-OH 具有黄嘌呤氧化酶抑制活性 (降低尿酸) ,可调节中性粒细胞样细胞中 IL-8 的产生。 | |||
T36660 |
Olsalazine-13C6
Olsalazine-13C6 |
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Olsalazine-13C6is intended for use as an internal standard for the quantification of olsalazine by GC- or LC-MS. Olsalazine is an orally bioavailable prodrug form of the anti-inflammatory agent 5-aminosalicylic acid that is cleaved by bacterial azo reductases in the gut to generate active 5-ASA.1In vitro, olsalazine increases ion transport in isolated rabbit distal ileum when applied to the luminal side (ED50= 0.3 mM) and stimulates fluid transport in rat jejunum when used at a concentration of ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0626 |
Uric Acid
尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate |
Reactive Oxygen Species; Endogenous Metabolite; Phosphorylase | Immunology/Inflammation; Metabolism; NF-κB |
Uric Acid (Lithic acid) 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ,如单线态氧和过氧亚硝酸盐,抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。 | |||
T41242 |
Uric acid sodium
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Uric acid sodium 是氧自由基 (oxygen radical) 的清除剂,是一种有效的、常见的抗氧化剂,有助于维持机体血压稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS),如单线态氧和过氧亚硝酸盐,对脂质过氧化有抑制作用,与痛风性关节病的发病机理和草酸钙结石的形成有关。 | |||
T4746 |
Purine
7H-Imidazo(4,5-d)pyrimidine,嘌呤 |
Others; Endogenous Metabolite | Metabolism; Others |
Purine (7H-Imidazo(4,5-d)pyrimidine) 是内源性代谢产物的一种。 | |||
T1362 |
Hypoxanthine
次黄嘌呤,6-羟基嘌呤,6-Hydroxypurine,Purin-6-ol,Sarcine,Sarkin |
Others; Endogenous Metabolite | Metabolism; Others |
Hypoxanthine (Purin-6-ol),也被称为 purine-6-ol 或 Hyp,是一种天然存在的嘌呤衍生物,是腺苷代谢和核苷酸补救途径形成核酸的反应中间体。在正常情况下,Hypoxanthine 很容易转化为尿酸。Hypoxanthine 首先被氧化为黄嘌呤,黄嘌呤再被黄嘌呤氧化酶氧化为尿酸。 | |||
T0256 |
Citric acid trilithium salt tetrahydrate
Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate |
Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells |
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。 | |||
T35954 |
Allantoic acid
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Allantoic acid, a byproduct of uric acid degradation, is implicated in purine metabolism [1][2][3]. | |||
T7814L |
Alloxan
NSC 7169,NSC7169,NSC-7169 |
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Alloxan is an acidic compound formed by the oxidation of URIC ACID. | |||
T0665 |
Xanthine
2,6-Dihydroxypurine,海生丁(黄嘌呤),黄嘌呤,Isoxanthine |
Endogenous Metabolite; Adenosine Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Xanthine (Isoxanthine) 是一种植物生物碱,存在于茶、咖啡和可可中。Xanthine 是温和的中枢神经系统激活剂,也是嘌呤降解途径的中间产物。 |