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Cat. No. | Product Name | Target | Signaling Pathways |
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T37547 |
trans-Urocanic Acid
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trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine. It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis. Upon UVB exposure, trans-urocanic ... | |||
T41037 |
Ecamsule disodium
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Ecamsule disodium is a versatile UVA filter compound commonly employed in the formulation of sunscreen products. Its primary role is to mitigate the potential harm posed by solar radiation through the prevention of various biological repercussions induced by UV exposure. These include the inhibition of pyrimidine dimer formation, the reduction of p53 protein accumulation, and the downregulation of collagenase 2 expression. | |||
T83892 |
33-BCRP Inhibitor
33-Breast Cancer Resistance Protein Inhibitor |
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33-BCRP抑制剂是一种乳腺癌耐药蛋白(BCRP)的抑制剂。它使得对米托蒽醌耐药的H460/MX20肺癌细胞对米托蒽醌诱导的细胞死亡更加敏感,无论是单独使用还是与UV辐射联合使用。33-BCRP抑制剂还能够增强表达P-糖蛋白(P-gp,亦称为多药耐药蛋白MDR)的KB-C2表皮癌细胞对秋水仙碱诱导的细胞死亡的敏感性。当使用5 µM浓度时,它能增加米托蒽醌在H460/MX20细胞中的细胞内积累。 | |||
T36894 |
5-Bromouridine
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5-Bromouridine is a brominated analog of the nucleoside uridine .1It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine .25-Bromouridine decreases the viability of HL-60 and MOLT-4 cells (LC50s = 10 and 20 μM, respectively). It induces apoptosis and halts the cell cycle at the S phase in HL-60 cells. It is photoreactive, and UV irradiation has been used to cross-link RNA containing 5-bromouridine to proteins in the study of of RNA-protein interactions.... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T5826 |
Eupalinolide A
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HSP | Cytoskeletal Signaling; Metabolism |
Eupalinolide A 是分离于林泽兰中的一种天然产物,通过抑制 HSF1 与 HSP90 的相互作用,激活 HSF1,诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。 | |||
TN1362 |
Afzelin
阿福豆苷,Kaempferol-3-O-rhamnoside |
PTEN; p38 MAPK; TNF; Mitochondrial Metabolism; Antibacterial; Prostaglandin Receptor; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Afzelin (Kaempferol-3-O-rhamnoside) 具有多种细胞活性,例如 DNA 保护、抗菌、抗氧化和抗炎以及 UV 吸收活性,并且可以通过 UV 吸收和细胞活性的组合保护人体皮肤免受 UVB 引起的损伤。 Afzelin 减轻线粒体损伤,增强线粒体生物合成并降低线粒体自噬相关蛋白、parkin 和 putative kinase 1 的水平。 | |||
TN1299 |
Desmethylglycitein
4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone |
PI3K; CDK; PKC | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) 是大豆中苷元的代谢产物,具有抗氧化性和抗癌活性。它是蛋白激酶 C(PKC)α 的直接抑制剂,抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2,抑制 CDK1 和 CDK2 活性。 | |||
TN2286 |
Tsugaric acid A
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NO Synthase | Immunology/Inflammation |
Tsugaric acid A 能够显著抑制超氧阴离子的形成,还可以保护人类角质形成细胞,使其免受紫外线 B 诱导的损害。 | |||
TN2006 |
Odoriflavene
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Others | Others |
Odoriflavene has antioxidant activity, and it also shows inhibition effects on the decrease of glutathione level of rat lens induced by UV irradiation. Odoriflavene shows cytotoxic activity against a SH-SY5Y cell line in vitro. |