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Cat. No.	Product Name	Target	Signaling Pathways
T2569	Chlorotrianisene tris(p-methoxyphenyl)chloroethylene,氯丁烯二烯,CTA,tri-p-anisylchloroethylene,氯烯雌醚,TACE	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Chlorotrianisene (tri-p-anisylchloroethylene) 是长效、可口服、亲脂性高的合成三苯乙烯 (TPE) 衍生物和选择性雌激素受体调节剂，有雌激素活性，也有抗雌激素活性。它还有效抑制COX-1并抑制全血中的血小板聚集。
T8961	GW280264X Carbamic acid	MMP	Proteases/Proteasome
	GW280264X (Carbamic acid) 是一种 ADAM10/TACE (ADAM17)金属蛋白酶抑制剂。它有效阻断 TACE (ADAM17)和 ADAM10的 IC50分别为 8.0 nM 和 11.5 nM。其中ADAM10/17 能够调节胶质母细胞瘤起始细胞的免疫原性。
T0914	Metacetamol 酰胺苯酚,3-Acetamidophenol	Others	Others
	Metacetamol (3-Acetamidophenol) 是对乙酰氨基酚的衍生物，为其无毒区域异构体，是一种非处方镇痛剂和解热剂，也可用作有机合成中间体。
T1888	Tacedinaline Acetyldinaline,N-acetyldinaline,PD-123654,CI994,Goe-5549	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Tacedinaline (CI994) 是一种组蛋白脱乙酰酶抑制剂，抑制重组 HDAC 1, 2 和 3 的IC50值分别为 0.9，0.9，1.2 μM。
TP1413L	Crustacean Cardioactive Peptide Acetate CCAP acetate
	Crustacean Cardioactive Peptide Acetate (CCAP acetate) 是是节肢动物中最保守和普遍存在的神经肽，在昆虫中由腹侧神经索中的保守神经元网络产生。Crustacean Cardioactive Peptide Acetate 是一种环酰胺化九肽激素，常见于昆虫，甲壳类动物和其他节肢动物中。
T10218	Abatacept CTLA4lg	Others	Others
	Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extracellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains). It is a selective T-cell co-stimulation modulator and a protein drug for au
TP1413	Crustacean Cardioactive Peptide (CCAP) Crustacean Cardioactive Peptide CCAP,甲壳类心脏活性肽
	Crustacean cardioactive peptide (CCAP) is a highly conserved, amidated cyclic nonapeptide with the primary structure PFCNAFTGC-NH2 (ProPheCysAsnAlaPheTyrGlyCys-NH2) and a disulfide bridge between Cys3 and Cys9. It is found in crustaceans and insects where
T64239	Belatacept
	Belatacept (BMS 224818) 是一种选择性的 T 细胞共刺激 (T-cell costimulation) 阻滞剂。Belatacept 能够结合 CD 80/86 配体，从而对 CD-28 介导的 T 细胞共刺激表现出抑制作用。Belatacept 能够用于研究器官移植免疫抑制。
T24705	Ramentaceone NSC-208733,NSC 624625,NSC 208733,NSC208733,NSC-624625
	Ramentaceone is an antineoplastic.
T82666	Crustacean cardioactive peptide CCAP
	CCAP（Crustacean cardioactive peptide）为一种具有调节昆虫心脏功能的非极性肽，由9个氨基酸组成，最初自tobacco hawkmoth（Manduca sexta）中分离。其结构特征包括第3位与第9位氨基酸的半胱氨酸残基形成的二硫键，以及羧基末端的氨化。
T4368	Miriplatin 米铂,SM-11355	DNA Alkylator/Crosslinker	DNA Damage/DNA Repair
	Miriplatin (SM-11355) 是一种烷化剂，是一种用于 TACE 的铂络合物，有望用于治疗肝细胞癌。
T30531L	BMS-561392 Formic acid BMS-561392 Formic acid(611227-74-8 Free base)	MMP	Proteases/Proteasome
	BMS-561392 Formic acid 是 TACE 的选择性抑制剂，可降低 TNFalpha 水平。
T21297	Miriplatin hydrate SM-11355 (hydrate),Miripla,Miriplatin,SM 11355,SM11355,SM-11355,Miriplatin hydrate	DNA Alkylation	DNA Damage/DNA Repair
	Miriplatin hydrate (SM-11355 (hydrate)) (MPT)是一种用于TACE 的新型铂类化合物，在肝细胞癌(HCC)的治疗中显示出良好的前景。米铂是一种亲脂性铂复合物，容易悬浮在碘油中，并在肿瘤组织中逐渐释放活性铂化合物。
T7522	GI254023X GI 254023X	MMP; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	GI254023X 是MMP9和ADAM10抑制剂，它们的IC50s 分别为 2.5 和 5.3 nM。
T27592	IK-862 IK 862
	IK-862 is a selective inhibitor of TACE (ADAM17).
T70664	TAPI-0
	TAPI-0 is a matrix metalloprotease (MMP) and TACE inhibitor.
T27507	GW-3333 GW 3333,GW3333
	GW-3333 is an matrix metalloproteinase inhibitor. It is also a tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) inhibitor. The efficacy of GW3333 suggests that dual inhibitors of matrix metalloproteinases and TACE may prove therapeutic as antiar
T69181	BMS-566394
	BMS-566394 is a potent, exceptionally selective inhibitor of TNF-α converting enzyme (TACE).
T6009	TAPI1 TAPI 1,TAPI,TAPI-1	MMP	Proteases/Proteasome
	TAPI1 (TAPI) 是一种 ADAM17/TACE 抑制剂，可抑制细胞因子受体的脱落。
T4122	TAPI-1 trifluoroacetate (163847-77-6(free base))	MMP	Proteases/Proteasome
	TAPI-1 trifluoroacetate 是一种 ADAM17/TACE 抑制剂，可阻断细胞因子受体的脱落。
TQ0129	TNF Protease Inhibitor 2 TAPI-2	MMP	Proteases/Proteasome
	TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM).
TP2107	TAPI 0
	ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.
T41179	CL 82198 hydrochloride
	CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibitsin vitroinvasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.
T14312	Apratastat	MMP; TNF	Apoptosis; Proteases/Proteasome
	Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1].
T63390	(S,S)-TAPI-1
	(S,S)-TAPI-1 是一种 TAPI-1 的异构体。其中 TAPI-1是金属蛋白酶 (MMP) 抑制剂，也是 TACE(ADAM17) 抑制剂，对多种细胞表面蛋白脱落表现出有效的抑制作用。
TP2108	TAPI 2
	ADAM-17 (TACE) and MMP inhibitor (Ki = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-α from cell membranes.
T28985	TMI-1 WAY-171318	Apoptosis; MMP	Apoptosis; Proteases/Proteasome
	TMI-1 (WAY-171318) 是一种有效的抑制剂，用于抑制去整合素金属酶17 (ADAM17) 和其他基质金属蛋白酶MMPs。TMI-1 能够有效地抑制LPS 诱导的人原代单核细胞和人全血中TNF-α的分泌。TMI-1 在三阴性 (TN) 和过度表达ERBB2的乳腺肿瘤细胞系中选择性地诱导Caspase 依赖的细胞凋亡。
T37726	MMP-9 Inhibitor I
	MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.
T41079	MMP13-IN-2 MMP13-IN-2
	MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.

化合物

Chlorotrianisene

Cat.No: T2569

Synonym: tris(p-methoxyphenyl)chloroethylene,氯丁烯二烯,CTA,tri-p-anisylchloroethylene,氯烯雌醚,TACE

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, COX

Cat.No: T8961

Synonym: Carbamic acid

Target: MMP

Cat.No: T0914

Synonym: 酰胺苯酚,3-Acetamidophenol

Target: Others

Cat.No: T1888

Synonym: Acetyldinaline,N-acetyldinaline,PD-123654,CI994,Goe-5549

Target: Apoptosis, HDAC

Crustacean Cardioactive Peptide Acetate

Cat.No: TP1413L

Synonym: CCAP acetate

Cat.No: T10218

Synonym: CTLA4lg

Target: Others

Crustacean Cardioactive Peptide (CCAP)

Cat.No: TP1413

Synonym: Crustacean Cardioactive Peptide CCAP,甲壳类心脏活性肽

Cat.No: T64239

Cat.No: T24705

Synonym: NSC-208733,NSC 624625,NSC 208733,NSC208733,NSC-624625

Crustacean cardioactive peptide

Cat.No: T82666

Synonym: CCAP

Cat.No: T4368

Synonym: 米铂,SM-11355

Target: DNA Alkylator/Crosslinker

BMS-561392 Formic acid

Cat.No: T30531L

Synonym: BMS-561392 Formic acid(611227-74-8 Free base)

Target: MMP

Miriplatin hydrate

Cat.No: T21297

Synonym: SM-11355 (hydrate),Miripla,Miriplatin,SM 11355,SM11355,SM-11355,Miriplatin hydrate

Target: DNA Alkylation

Cat.No: T7522

Synonym: GI 254023X

Target: MMP, Immunology/Inflammation related

Cat.No: T27592

Synonym: IK 862

Cat.No: T70664

Cat.No: T27507

Synonym: GW 3333,GW3333

Cat.No: T69181

Cat.No: T6009

Synonym: TAPI 1,TAPI,TAPI-1

Target: MMP

TAPI-1 trifluoroacetate (163847-77-6(free base))

Cat.No: T4122

Target: MMP

TNF Protease Inhibitor 2

Cat.No: TQ0129

Synonym: TAPI-2

Target: MMP

Cat.No: TP2107

CL 82198 hydrochloride

Cat.No: T41179

Cat.No: T14312

Target: MMP, TNF

Cat.No: T63390

Cat.No: TP2108

Cat.No: T28985

Synonym: WAY-171318

Target: Apoptosis, MMP

MMP-9 Inhibitor I

Cat.No: T37726

Cat.No: T41079

Synonym: MMP13-IN-2

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