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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3971 |
CASIN
Pirl1-related Compound 2 |
CDK; STAT; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; JAK/STAT signaling; MAPK; Stem Cells |
CASIN (Pirl1-related Compound 2) 是选择性GTPase Cdc42抑制剂,IC50值是 2 uM。 | |||
T7558 |
CID-1067700
2-[[(苯甲酰基氨基)硫代甲酰]氨基]-4,7-二氢-5,5-二甲基-5H-噻吩并[2,3-C]吡喃-3-羧酸 |
Ras | GPCR/G Protein; MAPK |
CID-1067700 是泛 GTPase 抑制剂,可竞争性抑制大脑 7 (Rab7) 中的 Ras 相关蛋白,Ki 为 13 nM。 | |||
T7764 |
CCG-222740
|
ROCK; Rho; Ras | Cell Cycle/Checkpoint; Cytoskeletal Signaling; GPCR/G Protein; MAPK; Stem Cells |
CCG-222740 是一种口服有效的选择性Rho/MRTF 途径抑制剂。它也是 α-平滑肌的肌动蛋白表达抑制剂,可减少皮肤纤维化并阻止黑色素瘤转移。 | |||
T22991 |
ML-099
|
Rho; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
ML-099 是广谱的 Ras 相关GTPases 激活剂,对Rac1、cell division cycle 42、Ras、Rab7和Rab-2A 均有激活作用。 | |||
T21970 |
ML-097
|
GTPase | GPCR/G Protein |
ML-097 是 Ras 相关 GTP 酶的泛激活剂。 | |||
T2700 |
FTI-277 hydrochloride
FTI 277 HCl |
Apoptosis; Transferase; Ras | Apoptosis; GPCR/G Protein; MAPK; Metabolism |
FTI-277 hydrochloride (FTI 277 HCl) 是一种法尼基转移酶FTase 抑制剂,高效 Ras CAAX 肽模拟物,可抑制H-Ras 和K-Ras 信号转导,还可抑制hepatitis delta virus 感染。 | |||
T74698 |
RMC-6236
RAS-IN-2 |
||
RMC-6236是一种相关的 RAS(ON) 多选择性抑制剂,对CypA蛋白(KD1)的亲和力为55.3 nmol/L,RMC-6236对KRAS突变癌细胞系HPAC (KRASG12D/WT, PDAC)和Capan-2 (KRASG12V/WT, PDAC), EC50分别为1.2和1.4 nmol/L,可用于癌症治疗。[1,2] | |||
T9533 |
BC-LI-0186
4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide |
Others | Others |
BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) 是选择性抑制亮氨酸 tRNA 合成酶与 Ras 相关的 GTP 结合蛋白 D 相互作用(IC50=46.11 nM)。BC-LI-0186能有效抑制肿瘤相关 MTOR 突变体的特性和雷帕霉素耐药癌细胞的生长,能够用于肺癌的相关研究。 | |||
T69618 |
XR3054
|
||
XR3054 is a novel inhibitor of farnesyl protein transferase (FPTase). XR3054 inhibited the proliferation of the prostatic cancer cell lines LnCAP and PC3 and the colon carcinoma SW480 and HT1080 (IC50 values of 12.4, 12.2, 21.4 and 8.8 microM, respectively) but was relatively inactive when tested against a panel of breast carcinoma cell lines. The activity did not relate to the presence of mutant or wild-type ras in the cell lines tested. In conclusion XR3054 inhibits ras farnesylation, MAP kina... | |||
T72344 | KRAS G12C inhibitor 41 | ||
KRAS G12C inhibitor 40 是一种有效的 KRAS G12C 抑制剂。Ras 蛋白家族是一种重要的细胞内信号分子,在生长发育中起重要作用。KRAS G12C inhibitor 40 具有研究 KRAS G12C 介导的癌症的潜力。 | |||
T72340 |
KRAS G12C inhibitor 37
|
||
KRAS G12C inhibitor 37 是一种有效的 KRAS G12C 抑制剂。Ras 蛋白家族是一种重要的细胞内信号分子,在生长发育中起重要作用。KRAS G12C inhibitor 37 具有研究 KRAS G12C 介导的癌症的潜力。 | |||
T37496 |
Alamandine
|
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Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effe... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3314 |
Perillyl alcohol
Isocarveol,Perilla alcohol,紫苏醇 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Perillyl alcohol (Isocarveol) 是一种单萜,可在不影响正常细胞的情况下诱导肿瘤细胞凋亡。 | |||
T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 |