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Search Results for " rac1 "

Targets Recommended: Rho

26

抑制剂 & 化合物

1

天然产物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP2131L	Rac1 Inhibitor W56 acetate(1095179-01-3 free base)	Rho	Cell Cycle/Checkpoint
	Rac1 Inhibitor W56 acetate(1095179-01-3 free base) 包含 Rac1 的鸟嘌呤核苷酸交换因子 (GEF) 识别/激活位点的残基 45-60 的肽；选择性抑制 Rac1 与 Rac1 特异性 GEF TrioN、GEF-H1 和 Tiam1 的相互作用。
T61448	AZA1 Rac1/Cdc42-IN-1	Apoptosis; Rho; CDK	Apoptosis; Cell Cycle/Checkpoint
	AZA1 (Rac1/Cdc42-IN-1) 是一种有效的Rac1和Cdc42双重抑制剂。AZA1 诱导前列腺癌细胞凋亡，抑制癌细胞增殖，迁移和侵袭。
T6342	NSC 23766 trihydrochloride Rac1 Inhibitor,NSC 23766	Apoptosis; Rho; Ras	Apoptosis; Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	NSC 23766 trihydrochloride (Rac1 Inhibitor) 是一种 Rac GTPase 抑制剂，靶向 GEF 对 Rac 的激活，IC50值约为 50 μM。
TP2131	Rac1 Inhibitor W56
	Rac1 Inhibitor W56 is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. Rac1 Inhibitor W56 selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1 and Tiam1.
TP2130L	Rac1 Inhibitor F56, control peptide acetate Rac1 Inhibitor F56, control peptide acetate(1315378-77-8 free base)	Rho	Cell Cycle/Checkpoint
	Rac1 Inhibitor F56, control peptide acetate(1315378-77-8 free base) 是 Rac1 Inhibitor 的对照肽版本；包含Rac1的残基45-60，其中Trp56被Phe 取代。不影响 GEF-Rac1 相互作用。
TP2130	Rac1 Inhibitor F56, control peptide
	Control peptide version of Rac1 Inhibitor; comprises residues 45-60 of Rac1 with Trp56 replaced by Phe. Does not affect GEF-Rac1 interaction.
T8527	CPYPP	Others	Others
	CPYPP 是DOCK2-Rac1相互作用的抑制剂。它能够结合DOCK2DHR-2结构域，并以剂量依赖性方式抑制 DOCK2DHR-2 (IC50:22.8 µM) 对 Rac1 的鸟嘌呤核苷酸交换因子活性。它还抑制DOCK180和DOCK5，对 DOCK9 的抑制作用较小。
T79869	Rac1-IN-3	Ras	GPCR/G Protein; MAPK
	Rac1-IN-3（Compound 2）作为一种Rac1抑制剂，展现出46.1 μM的IC50值。
T75932	Rac1 Inhibitor W56 TFA
	Rac1 Inhibitor W56 TFA，为Rac1中残基45-60的抑制剂，能够阻止Rac1与鸟嘌呤核苷酸交换因子TrioN、GEF-H1及Tiam的相互作用。
T22991	ML-099	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	ML-099 是广谱的 Ras 相关GTPases 激活剂，对Rac1、cell division cycle 42、Ras、Rab7和Rab-2A 均有激活作用。
T2427	EHop-016 EHop 016	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	EHop-016 是一种特异性 Rac GTPase 抑制剂，对 MDA-MB-231 和 MDA-MB-435 细胞中的 Rac1 的 IC50 为 1.1 μM，也可抑制Rac3 。它还抑制 Vav2 与 Rac，Rac 激活的 PAK1 相互作用，片状脂蛋白形成和细胞迁移。
T21970	ML-097	GTPase	GPCR/G Protein
	ML-097 是 Ras 相关 GTP 酶的泛激活剂。
T6483	EHT 1864 EHT 1864 2HCl	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	EHT 1864 是 Rac 家族 GTPase 抑制剂，对 Rac1、Rac1b、Rac2 和 Rac3的Kd 为 40、50、60 和 250 nM。
T37113	Z62954982 ZINC08010136	Rho	Cell Cycle/Checkpoint
	Z62954982 (ZINC08010136) 是一种具有选择性的 Rac1 抑制剂，神经突的生长和分支变得迟钝。Z62954982 抑制 Rac1 激活，减少肺动脉中的增殖、p38 磷酸化和 IL-6 水平。
T14004	1A-116	Rho	Cell Cycle/Checkpoint
	1A-116 是 Rac1的抑制剂，对几种类型的癌症具有抗肿瘤和抗转移作用，如乳腺癌。
T24833	ZINC69391 ZINC-69391,ZINC 69391,N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine,CysHHC10 acetate(1408311-03-4 free base)	Apoptosis; Rho	Apoptosis; Cell Cycle/Checkpoint
	ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) 是 Rac1 的选择性抑制剂，具有抗增殖和抗转移作用。 ZINC69391 干扰 Rac1 与 Dock180 的相互作用，降低 Rac1-GTP 水平并诱导细胞凋亡。
T25450	GGTI 2147 GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147	NF-κB; Rho	Cell Cycle/Checkpoint; NF-κB
	GGTI 2147 降低 Rac1 活性，下调 p65 的表达，改善 OGD/R 诱导的神经元凋亡。
T22106	MLS-573151	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	MLS-573151 是 GTPase Cdc42 的选择性抑制剂，EC50 为 2 μM。它通过阻止 GTP 与 Cdc42 的结合来发挥作用。
T1237	Azathioprine 硫唑嘌呤,BW 57-322	Apoptosis; GPR; Rho	Apoptosis; Cell Cycle/Checkpoint; Endocrinology/Hormones; GPCR/G Protein
	Azathioprine (BW 57-322) 是一种免疫抑制剂。
T16745	Rhosin hydrochloride	Apoptosis; Rho; Ras	Apoptosis; Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	Rhosin hydrochloride 是一种特异性 RhoA 亚家族Rho GTPases 抑制剂，抑制 RhoA-GEF 相互作用。它通过增强 D1 中棘神经元的可塑性和降低过度兴奋性来促进应激恢复，可诱导细胞凋亡。
T12452	Digeranyl bisphosphonate DGBP	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	Digeranyl bisphosphonate (DGBP) 是一种有效的香叶基焦磷酸香叶酯 (GGPP) 合酶抑制剂，对 Rac1 的香叶基焦磷酸化有抑制作用。Digeranyl bisphosphonate 诱导细胞发生自噬却不诱导细胞凋亡。
T15602	ITX3	Others; Rho	Cell Cycle/Checkpoint; Others
	ITX3 是特异的、无毒的、有活性的、具有选择性的TrioN RhoGEF 抑制剂，IC50 值为 76 μM。 ITX3具有抗癌作用，能抑制trion 介导的GTP 在RhoG 和Rac1上的交换，抑制ngf 介导的PC12细胞神经突的生长和trion 诱导的REF52成纤维细胞结构的形成。
T81754	mP6 Myr-FEEERA-OH	Integrin	Cytoskeletal Signaling
	mP6（Myr-FEEERA-OH）为肉豆蔻酰化肽，能特异性抑制Gα13与整合素β3间相互作用，且不影响talin依赖的整合素功能。它还能阻碍Rac1、Rap1、Rab7的GTP利用，有效抑止CHO-A24细胞感染。
T71627	CX-5011	Casein Kinase	Metabolism; Stem Cells
	CX-5011是CK2抑制剂，能够诱导Rac1激活，同时促使细胞凋亡(apoptosis)并导致癌细胞死亡。
T16746	Rhosin	Rho	Cell Cycle/Checkpoint
	Rhosin is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0.4 uM). Rhosin does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin causes cell apoptosis.
T4047L	Bisantrene HCl CL216942,CL-216942,NSC-337766,CL 216942
	Bisantrene (CL-216942; NSC 337766) is a topoisomerase II poison and DNA intercalator. It can be used as a Rac1 inhibitor or model compound to study P-glycoprotein-mediated multi-drug resistance (MDR1). Bisantrene inserts and disrupts the configuration of

化合物

Rac1 Inhibitor W56 acetate(1095179-01-3 free base)

Cat.No: TP2131L

Target: Rho

Cat.No: T61448

Synonym: Rac1/Cdc42-IN-1

Target: Apoptosis, Rho, CDK

NSC 23766 trihydrochloride

Cat.No: T6342

Synonym: Rac1 Inhibitor,NSC 23766

Target: Apoptosis, Rho, Ras

Rac1 Inhibitor W56

Cat.No: TP2131

Rac1 Inhibitor F56, control peptide acetate

Cat.No: TP2130L

Synonym: Rac1 Inhibitor F56, control peptide acetate(1315378-77-8 free base)

Target: Rho

Rac1 Inhibitor F56, control peptide

Cat.No: TP2130

Cat.No: T8527

Target: Others

Cat.No: T79869

Target: Ras

Rac1 Inhibitor W56 TFA

Cat.No: T75932

Cat.No: T22991

Target: Rho, Ras

Cat.No: T2427

Synonym: EHop 016

Target: Rho, Ras

Cat.No: T21970

Target: GTPase

Cat.No: T6483

Synonym: EHT 1864 2HCl

Target: Rho, Ras

Cat.No: T37113

Synonym: ZINC08010136

Target: Rho

Cat.No: T14004

Target: Rho

Cat.No: T24833

Synonym: ZINC-69391,ZINC 69391,N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine,CysHHC10 acetate(1408311-03-4 free base)

Target: Apoptosis, Rho

Cat.No: T25450

Synonym: GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147

Target: NF-κB, Rho

Cat.No: T22106

Target: CDK, Ras

Cat.No: T1237

Synonym: 硫唑嘌呤,BW 57-322

Target: Apoptosis, GPR, Rho

Rhosin hydrochloride

Cat.No: T16745

Target: Apoptosis, Rho, Ras

Digeranyl bisphosphonate

Cat.No: T12452

Synonym: DGBP

Target: Rho, Ras

Cat.No: T15602

Target: Others, Rho

Cat.No: T81754

Synonym: Myr-FEEERA-OH

Target: Integrin

Cat.No: T71627

Target: Casein Kinase

Cat.No: T16746

Target: Rho

Cat.No: T4047L

Synonym: CL216942,CL-216942,NSC-337766,CL 216942

Cat. No.	Product Name	Target	Signaling Pathways
T5S1981	alpha-Cyperone (+)-α-Cyperone,α-香附酮,α-Cyperone	Others; Endogenous Metabolite	Metabolism; Others
	alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。

天然产物

Cat.No: T5S1981

Synonym: (+)-α-Cyperone,α-香附酮,α-Cyperone

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00004	RAC1 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	RAC1 Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 24.6 kDa; 30 kDa, reducing conditions and the accession number is P63000.
TMPY-01187	Rac1 Protein, Human, Recombinant (GST) Rac-1,p21-Rac1,...	Human	Baculovirus Insect Cells
	RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for RAC1 gene. RAC1 is a plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, bind...
TMPY-03180	Ribonuclease A Protein, Human, Recombinant (His) RNS1,ribonuclease, RNase A family, 1 (panc...	Human	HEK293 Cells
	RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily. It is a pancreatic-type of secretory ribonuclease. RNase A is a basic protein and its many positive charges are consistent with its binding to RNA (a poly-anion). More generally, RNase A is unusually polar or, rather, unusually lacking in hydrophobic groups, especially aliphatic ones. As an endonuclease, RNase A cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) ...
TMPH-02580	CHRAC1 Protein, Mouse, Recombinant (His & Myc) CHRAC-1,NF-YC-like protein,Chrac<...	Mouse	E. coli
	Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1. Does not enhance nucleosome sliding activity of the ACF-5 ISWI chromatin remodeling complex. CHRAC1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 21.4 kDa and the accession number is Q9JKP8.
TMPH-02473	14-3-3 zeta/delta Protein, Mouse, Recombinant (His & SUMO) Ywhaz,14-3-3 protein zeta/delta,SEZ-2,KCIP-1	Mouse	E. coli
	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation. In neurons, regulates spine maturation through the modulation of ARHGEF7 activity. 14-3-3 zeta/delta Prot...
TMPY-04397	PAK-3 Protein, Human, Recombinant (His) PAK3β,hPAK3,bPAK,PAK3beta,MRX30,MRX47,CDKN1A,p2...	Human	Baculovirus Insect Cells
	PAK3 is a member of PAK proteins, a family of serine/threonine p21-activating kinases, serve as effectors of small Rho GTPases Cdc42 and RAC and have been implicated in a wide range of biological activities. There are six mammalian PAKs which can be divided into two groups: group I PAKs (PAK1-3) and group II PAKs (PAK4-6). Although the two PAK groups are architecturally similar there are differences in their mode of regulation suggesting their cellular functions are likely to be different. Group...
TMPY-04443	NEK3 Protein, Mouse, Recombinant (His & GST) NIMA-related kinase 3	Mouse	Baculovirus Insect Cells
	NEK3 (NIMA (never in mitosis gene a)-related expressed kinase 3), contains 1 protein kinase domain and is a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. Members of the NEK family of protein kinases share high amino acid homology with NIMA (never in mitosis gene a). NEK3 differs from other NimA family members in that it is not the cell cycle-regulated and is found primarily in the cytoplasm. It is activated by prolactin stimulation, leading to phosphorylatio...
TMPY-02439	Rac2 Protein, Human, Recombinant (His) p21-Rac2,HSPC022,Gx,EN-7,ras-related C3 bo...	Human	E. coli
	Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is attached to the small G-protein, the enzyme is inactivated. Release of the GDP and replace of the GTP cativate the GTPasee. Rac2 remains active until the GTP is hydrolyzed to GDP. Rac2 is a hematopoietic-specific Rho family GTPase implicated as an important constituent of the NADP...
TMPH-01257	Dystonin Protein, Human, Recombinant (His) DT,BP230,Dystonin,BP240,DST,DMH,BPAG1,KIAA0728	Human	P. pastoris (Yeast)
	Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transpo...
TMPH-01256	Dystonin Protein, Human, Recombinant (His & SUMO) DT,DST,BPAG1,BP240,BP230,KIAA0728,Dystonin,DMH	Human	E. coli
	Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transpo...
TMPY-01000	BVES Protein, Human, Recombinant (GST) CARICK,LGMD2X,POP1,blood vessel epicardial substanc...	Human	E. coli
	Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protective role both in ulcerative and infectious colitis and identify BVES as a critical protector of colonic mucosal integrity. The Popeye domain containing1, also called Bves (Popdc1/Bves), is a transmembrane protein that functions in muscle regeneration, heart rate regulation, hypoxi...
TMPY-04455	PKC iota Protein, Human, Recombinant (GST) PKCI,nPKC-iota,protein kinase C, ι,DXS1179...	Human	Baculovirus Insect Cells
	Protein kinase C iota type, also known as Atypical protein kinase C-lambda/iota, aPKC-lambda/iota and PRKCI, is a cytoplasm, membrane and nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and PKC subfamily. PRKCI contains one AGC-kinase C-terminal domain, one OPR domain, one phorbol-ester/DAG-type zinc finger and one protein kinase domain. PRKCI is predominantly expressed in lung and brain, but also expressed at lower levels in many tissues includ...
TMPY-02191	BLNK Protein, Human, Recombinant (His) BLNK-S,bca,SLP-65,B-cell linker,LY57,SLP65,AGM4,BASH	Human	HEK293 Cells
	B-cell linker protein, also known as B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65 and BLNK, is a cytoplasm and cell membrane protein which contains oneSH2 domain. BLNK is expressed in B-cell lineage and fibroblast cell lines. Highest levels of expression is in the spleen, with lower levels in the liver, kidney, pancreas, small inte...

重组蛋白

RAC1 Protein, Human, Recombinant (His)

Cat.No: TMPH-00004

Species: Human

Expression System: P. pastoris (Yeast)

Rac1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01187

Species: Human

Expression System: Baculovirus Insect Cells

Ribonuclease A Protein, Human, Recombinant (His)

Cat.No: TMPY-03180

Species: Human

Expression System: HEK293 Cells

CHRAC1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02580

Species: Mouse

Expression System: E. coli

14-3-3 zeta/delta Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02473

Species: Mouse

Expression System: E. coli

PAK-3 Protein, Human, Recombinant (His)

Cat.No: TMPY-04397

Species: Human

Expression System: Baculovirus Insect Cells

NEK3 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04443

Species: Mouse

Expression System: Baculovirus Insect Cells

Rac2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02439

Species: Human

Expression System: E. coli

Dystonin Protein, Human, Recombinant (His)

Cat.No: TMPH-01257

Species: Human

Expression System: P. pastoris (Yeast)

Dystonin Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01256

Species: Human

Expression System: E. coli

BVES Protein, Human, Recombinant (GST)

Cat.No: TMPY-01000

Species: Human

Expression System: E. coli

PKC iota Protein, Human, Recombinant (GST)

Cat.No: TMPY-04455

Species: Human

Expression System: Baculovirus Insect Cells

BLNK Protein, Human, Recombinant (His)

Cat.No: TMPY-02191

Species: Human

Expression System: HEK293 Cells

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