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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T20365	Monopotassium glutamate L-谷氨酸钾盐,Potassium glutamate,Potassium L-glutamate	Others	Others
	Monopotassium glutamate (Potassium glutamate) 可在食品中用作增味剂。
T6504	Flupirtine maleate Katadolon maleate,氟吡啶马来酸,马来酸氟吡汀	Potassium Channel; NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Flupirtine maleate (Katadolon maleate) 是可透过血脑屏障的、具有口服活性的非阿片类化合物。它是间接 NMDAR 拮抗剂，可用于缓解疼痛的研究，具有神经保护特性。
T0030	Bupivacaine hydrochloride Vivacaine,Bupivacaine HCl,盐酸布比卡因	Sodium Channel	Membrane transporter/Ion channel
	Bupivacaine hydrochloride (Vivacaine) 是NMDA 受体抑制剂，可用于慢性疼痛的研究。它可阻断钠、L-钙和钾通道，还阻断SCN5A 通道，IC50为 69.5 μM。
T0675	Topiramate RWJ 17021,McN 4853,托吡酯	Potassium Channel; Calcium Channel; GABA Receptor; Sodium Channel; GluR; Carbonic Anhydrase; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Topiramate (RWJ 17021) 是一种GluR5受体拮抗剂，可通过增强GABAergic 活性，抑制kainate/AMPA 受体，抑制钠和钙通道的电压敏感，增加钾电导并抑制碳酸酐酶来产生抗癫痫作用，用于治疗部分性和全身性癫痫发作。
T36482	Lamotrigine isethionate
	Water-soluble salt of lamotrigine . Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents. Leach et al (1991) Neurochemical and behavioral aspects of lamotr. Epilepsia 32 S4 PMID:1685439 \|Smith and Meldrum (1995) Cardioprotective effect of lamotr. after focal ischemia in rats. Stroke 26 117 PMID:7839380 \|Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522 PMI...
T75793	ω-Agatoxin IVA TFA
	ω-Agatoxin IVA TFA 是一种高效的针对P/Q型Ca2+(Cav2.1)通道的选择性阻滞剂，IC50对P型为2 nM，对Q型为90 nM。此化合物能够抑制高钾条件下的谷氨酸释放和钙流入，IC50在30-225 nM范围。同时，ω-Agatoxin IVA TFA阻断高钾诱发的5-羟色胺及去甲肾上腺素释放，但不影响L型或N型Ca2+通道。

化合物

Monopotassium glutamate

Cat.No: T20365

Synonym: L-谷氨酸钾盐,Potassium glutamate,Potassium L-glutamate

Target: Others

Flupirtine maleate

Cat.No: T6504

Synonym: Katadolon maleate,氟吡啶马来酸,马来酸氟吡汀

Target: Potassium Channel, NMDAR, iGluR

Bupivacaine hydrochloride

Cat.No: T0030

Synonym: Vivacaine,Bupivacaine HCl,盐酸布比卡因

Target: Sodium Channel

Topiramate

Cat.No: T0675

Synonym: RWJ 17021,McN 4853,托吡酯

Target: Potassium Channel, Calcium Channel, GABA Receptor, Sodium Channel, GluR, Carbonic Anhydrase, iGluR

Lamotrigine isethionate

Cat. No.	Product Name	Target	Signaling Pathways
T1186	Ifenprodil Tartrate	Potassium Channel; NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Ifenprodil tartrate 是典型的非竞争性 NMDA 受体拮抗剂，抑制 GIRK (Kir3)，通过基底 GIRK 活性减少内向电流，有用做脑血管舒张试剂的潜力。它对 NR1A/NR2B 受体亲和力是 NR1A/NR2A 受体的 400 倍。