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Search Results for " pif "

Targets Recommended: PDK

20

抑制剂 & 化合物

4

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T16670	PS210	PDK	PI3K/Akt/mTOR signaling
	PS210 是针对 PDK1的 PIF 结合口袋的、选择性的、有效的 PDK1激活剂，对其他蛋白激酶无活性。在细胞中，它的前药 PS423 可作为 PDK1的底物选择性抑制剂，抑制 S6K 的磷酸化和活化。
T6271	Tipifarnib 替吡法尼,R115777,Zarnestra,IND 58359	Transferase	Metabolism
	Tipifarnib (IND 58359) 能够抑制法尼基转移酶 (FTase)，IC50=0.86 nM，具有潜在抗肿瘤特性。
T12472	Pifithrin-α, p-Nitro, Cyclic PFN-α	p53	Apoptosis
	Pifithrin-α, p-Nitro, Cyclic (PFN-α) 是 p53 的细胞渗透性和活性形式抑制剂。它对暴露于 Etoposide 的皮层神经元的保护作用比 Pifithrin-α 强一个数量级，ED50为30 nM。它也作为 p53 转录后的活性抑制剂。
T3637	Pifithrin-β hydrobromide Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis; p53	Apoptosis
	Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂，可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。
T17102	Tipifarnib (S enantiomer) Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer	Transferase	Metabolism
	Tipifarnib S enantiomer ((S)-(-)-R-115777) 是Tipifarnib 的 S 型对映体，它比 Tipifarnib 特性低。其中 Tipifarnib 是farnesyltransferase 高效特异性抑制剂，IC50=0.6 nM。
T31224	Piflufolastat DCFPYL	Epigenetic Reader Domain	Chromatin/Epigenetic
	Piflufolastat (DCFPYL) 是一种针对前列腺癌 PSMA 的 PET 显像剂。是一种含氟前列腺特异性膜抗原（PSMA）制剂。Piflufolastat 可用于制备 piflufolastat F 18 (DCFPyL F-18)。
T77749	Upifitamab	Others	Others
	Upifitamab 是 upifitamab rilsodotin 的裸抗，可用于合成抗体偶联活性分子 UPRI,可用用于研究癌症。
T6210	Pifithrin-μ PFTμ,NSC 303580,2-Phenylethynesulfonamide	HSP; p53; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Metabolism
	Pifithrin-μ (NSC-303580) 是 p53和 HSP70的抑制剂，具有抗肿瘤和神经保护作用。
T2707	Pifithrin-α hydrobromide Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide	Ferroptosis; Aryl Hydrocarbon Receptor; p53	Apoptosis; Immunology/Inflammation
	Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) 是一种 p53 抑制剂，可抑制 p53 反应基因的 p53 依赖性反式激活。它也是芳烃受体的激动剂。
T4379	Tropifexor LJN452	FXR; Autophagy	Autophagy; Metabolism
	Tropifexor (LJN452) 是一种新型的高效 FXR 激动剂，EC50 为 0.2 nM。
T71882	Pifexole
	Pifexole is the 1,2,4-oxadiazole derivative. It has a similar profile of muscle-relaxant activity in animals to that of chlorzoxazone. In rats, pifexole is reported to be seven times more potent than chlorzoxazone in inhibition of strychnine-induced convulsions.
T69473	Pifoxime
	Pifoxime是一种COX-1/2抑制剂，属于非甾体类抗炎剂(NSAID)。它展示出抗炎活性，可用于神经精神病学研究。
T23156	Pifithrin-β	Others	Others
	potent p53 inhibitor
T38897	RapiFluor-MS
	RapiFluor-MS labeling used for LC-MS/MS analysis of N-glycans.
T21978	p-nitro-Pifithrin-α
	p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].
T3163	PS 48	PDK	PI3K/Akt/mTOR signaling
	PS 48 已被证明是一种 PKB 激酶 (PDK1) 激活剂 (Kd: 10.3 μM)。该化合物选择性地与 PKB 激酶 (PDK1) 的 PIF 结合口袋结合。
T24676	PS423 PS210AM,PS 210 AM,PS 423,PS210-AM,PS-423
	PS423 is a substrate-selective protein kinase PDK1 inhibitor that acts by binding to the PIF-pocket allosteric docking site.
T71939	PS77
	PS77 is a Pkh inhibitor directed to the PIF-pocket with increased selectivity for C. albicans Pkh2.
T28458	PS432 PS-432,PS 432
	PS432 is an allosteric inhibitor of atypical PKCs. PS432 targets the PIF-pocket resulting in significantly reduce tumor growth without side effects in mouse xenograft model.
T16671	PS315	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. PS315 is a derivative of PS48 and is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing d

化合物

Cat.No: T16670

Target: PDK

Cat.No: T6271

Synonym: 替吡法尼,R115777,Zarnestra,IND 58359

Target: Transferase

Pifithrin-α, p-Nitro, Cyclic

Cat.No: T12472

Synonym: PFN-α

Target: p53

Pifithrin-β hydrobromide

Cat.No: T3637

Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Target: Ferroptosis, p53

Tipifarnib (S enantiomer)

Cat.No: T17102

Synonym: Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer

Target: Transferase

Piflufolastat

Cat.No: T31224

Synonym: DCFPYL

Target: Epigenetic Reader Domain

Cat.No: T77749

Target: Others

Cat.No: T6210

Synonym: PFTμ,NSC 303580,2-Phenylethynesulfonamide

Target: HSP, p53, Autophagy

Pifithrin-α hydrobromide

Cat.No: T2707

Synonym: Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide

Target: Ferroptosis, Aryl Hydrocarbon Receptor, p53

Cat.No: T4379

Synonym: LJN452

Target: FXR, Autophagy

Cat.No: T71882

Cat.No: T69473

Cat.No: T23156

Target: Others

Cat.No: T38897

p-nitro-Pifithrin-α

Cat.No: T21978

Cat.No: T3163

Target: PDK

Cat.No: T24676

Synonym: PS210AM,PS 210 AM,PS 423,PS210-AM,PS-423

Cat.No: T71939

Cat.No: T28458

Synonym: PS-432,PS 432

Cat.No: T16671

Target: PKC

Cat. No.	Product Name	Target	Signaling Pathways
T3768	Epifriedelanol 表木栓醇,Epifriedelinol	Others	Others
	Epifriedelanol (Epifriedelinol) 是一种分离自 Ulmus davidiana 根皮中的三萜类化合物，具有抗肿瘤作用，可以减缓人原始细胞的衰老。
TN4443	Lipiferolide	Telomerase; Antifection	DNA Damage/DNA Repair; Microbiology/Virology
	Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, it possesses cytotoxic activity against KB cells. Liriodenine also has antiplasmodial activity.
TN2572	10-O-Caffeoyl-6-epiferetoside	Others	Others
	10-O-Caffeoyl-6-epiferetoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2572，CAS号为 83348-22-5。
TN3968	Epifriedelanol acetate	Others	Others
	Epifriedelanol exhibits antibacterial activities. It also can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases. Epifriedelanol and friedel

天然产物

Cat.No: T3768

Synonym: 表木栓醇,Epifriedelinol

Target: Others

Cat.No: TN4443

Target: Telomerase, Antifection

10-O-Caffeoyl-6-epiferetoside

Cat.No: TN2572

Target: Others

Epifriedelanol acetate

Cat.No: TN3968

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00545	Dermcidin Protein, Human, Recombinant (hFc) AIDD,PIF,HCAP,dermcidin,DCD-1,DSEP	Human	HEK293 Cells
	Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely diagnoses. Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis ...
TMPY-00168	MPIF-1/CCL23 Protein, Human, Recombinant (His) MIP3,MIP-3,Ckb-8-1,CK-BETA-8,Ckb-8,MPIF-1,MPIF<...	Human	P. pastoris (Yeast)
	MPIF-1/CCL23 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.9 kDa and the accession number is P55773.3.
TMPY-03851	BPIFB1 Protein, Human, Recombinant (His) LPLUNC1,BPI fold containing family B, member 1,C20orf114	Human	HEK293 Cells
	BPIFB1, also known as LPLUNC1, belongs to the BPI/LBP/Plunc superfamily, plunc family. BPIFB1 may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. BPIFB1 is expressed in the upper respiratory tract and oral cavity, which may function in host defence. The expression of BPIF proteins is associated with CF lung disease in humans and mice. It is unclear if this elevation of protein production, which results from phenotypic alteration of the cel...
TMPY-02966	BPIFA2 Protein, Human, Recombinant (hFc) bA49G10.1,BPI fold containing family A, member 2,PSP,C20orf7...	Human	HEK293 Cells
	BPIFA2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.8 kDa and the accession number is Q96DR5.
TMPY-03121	BPIFA2 Protein, Human, Recombinant (His) SPLUNC2,bA49G10.1,BPI fold containing family A, member 2,PSP...	Human	HEK293 Cells
	BPIFA2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is Q96DR5.
TMPY-03886	MPIF-1/CCL23 Protein, Human, Recombinant SCYA23,CKb8,Ckb-8,MPIF-1,MPIF1,chemokine (...	Human	E. coli
	MPIF-1/CCL23 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 11.4 kDa and the accession number is P55773-1.
TMPK-01201	BPIFA1/LUNX Protein, Human, Recombinant Lung-specific protein X,BPI fold-containing family A member ...	Human	E. coli
	Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submucosal tissue in the human soft palate, lung, uvula, and nasal cavity. BPIFA1 is a critical component of the innate immune response that prevents upper airway diseases.

重组蛋白

Dermcidin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00545

Species: Human

Expression System: HEK293 Cells

MPIF-1/CCL23 Protein, Human, Recombinant (His)

Cat.No: TMPY-00168

Species: Human

Expression System: P. pastoris (Yeast)

BPIFB1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03851

Species: Human

Expression System: HEK293 Cells

BPIFA2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02966

Species: Human

Expression System: HEK293 Cells

BPIFA2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03121

Species: Human

Expression System: HEK293 Cells

MPIF-1/CCL23 Protein, Human, Recombinant

Cat.No: TMPY-03886

Species: Human

Expression System: E. coli

BPIFA1/LUNX Protein, Human, Recombinant

Cat.No: TMPK-01201

Species: Human

Expression System: E. coli

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