Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T72408 |
PI3K/mTOR Inhibitor-5
|
||
PI3K/mTOR Inhibitor-5 是一种有效的 PI3K 和mTOR 双抑制剂,其IC50值分别为 86.9 nM 和 14.6 nM。 | |||
T2265 |
Bimiralisib
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,PQR309,PI3K-IN-2 |
Others; PI3K; S6 Kinase; mTOR | MAPK; Others; PI3K/Akt/mTOR signaling |
Bimiralisib (PI3K-IN-2) 是一种有效的,可渗透脑的 mTOR/PI3K 抑制剂,是一种 mTORC1和 mTORC2抑制剂。它能够抑制 PI3Kα,PI3Kδ,PI3Kβ,PI3Kγ和 mTOR,IC50分别为 33 nM,451 nM,661 nM,708 nM 和 89 nM。 | |||
T0365 |
Thioridazine hydrochloride
盐酸硫利达嗪,Mellaril,Aldazine |
Apoptosis; Potassium Channel; Dopamine Receptor; 5-HT Receptor; Antibacterial; Adrenergic Receptor; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience |
Thioridazine hydrochloride (Mellaril) 是一种多巴胺受体D2家族蛋白的拮抗剂,有抗精神病和抗焦虑活性。它也是一种PI3K-Akt-mTOR 信号通路的抑制剂,具有抗血管生成作用。它在多种类型的癌细胞中显示出抗增殖和凋亡诱导作用,对靶向癌症干细胞具有特异性。 | |||
T2235 |
Dactolisib
2-甲基-2-[4-[3-甲基-2-氧代-8-(喹啉-3-基)-2,3-二氢咪唑并[4,5-c]喹啉-1-基]苯基]丙腈,BEZ235,NVP-BEZ235 |
ATM/ATR; PI3K; mTOR; Autophagy | Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Dactolisib (BEZ235) 是一种可口服的 pan-class IPI3K 和 mTOR 抑制剂,抑制 mTORC1和 mTORC2,作用于 p110α/γ/δ/β和 mTOR,IC50分别为 4 nM/5 nM/7 nM/75 nM 和 20.7 nM。 | |||
T14552 |
Dactolisib Tosylate
BEZ235 Tosylate,NVP-BEZ 235 Tosylate |
PI3K; mTOR | PI3K/Akt/mTOR signaling |
Dactolisib Tosylate (BEZ235 Tosylate) 是一种双重激酶抑制剂,针对 PI3K 和mTOR。Dactolisib Tosylate 表现出对于PI3Kα, β, γ, δ的IC50值分别为4, 75, 7, 5 nM。Dactolisib Tosylate 抑制 mTORC1 和 mTORC2。 | |||
T1916 |
Apitolisib
RG 7422,GNE 390,GDC-0980 |
Apoptosis; PI3K; mTOR | Apoptosis; PI3K/Akt/mTOR signaling |
Apitolisib (RG 7422) 是一种口服有效的 PI3K 和 mTOR(TORC1/2) 激酶抑制剂,抑制 PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ的活性,IC50值为 5 nM/27 nM/7 nM/14 nM,抑制 mTOR,Ki 为 17 nM。它用于乳腺癌、前列腺癌、肾细胞癌和子宫内膜癌等实体癌的试验研究 。 | |||
T36084 |
PKI-179
|
||
PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo[1][2]. PKI-179 inhibits the cell proliferation, with IC50s of 22 nM and 29 nM for MDA361 and PC3 cells, respectively[1].PKI-179 shows inhibitory activity against a panel of 361 other ... |