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79

抑制剂 & 化合物

21

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4017	Relebactam 瑞来巴坦,MK-7655	Antibacterial	Microbiology/Virology
	Relebactam (MK-7655) 是一种有广谱抗β内酰胺酶活性的二氮杂双环辛烷抑制剂。
T19794	Temafloxacin 替马沙星,Omniflox	Antibiotic	Microbiology/Virology
	Temafloxacin (Omniflox) 是一种喹诺酮类广谱抗菌剂，对革兰氏阳性菌、革兰氏阴性菌和厌氧菌均有效。
T83680	Azurin (50-77) (P. aeruginosa) TFA Azurin p28,p28
	Azurin (50-77)是一种含铜细菌蛋白azurin的肽段，存在于P. aeruginosa中，具有细胞周期停滞、抑制癌细胞增殖和调节血管生成活性。作为VEGFR2的抑制剂（IC20约为10.7 µM），Azurin (50-77)（20 µM）能在MCF-7乳腺癌细胞中诱导G2/M期的细胞周期停滞。在50 µM的浓度下，减少MCF-7和ZR-75-1乳腺癌细胞的增殖。Azurin (50-77)以25 µM的浓度减少VEGF-A诱导的毛细管管腔形成（IC50 = 12 µM），降低人脐静脉内皮细胞（HUVECs）中与细胞膜相关的F-actin、焦点粘附激酶（FAK）和paxillin的水平，并增加胞外的血小板内皮细胞粘附分子-1（PECAM-1）的水平。在体内，Azurin (50-77)（每日10 mg/kg）在MCF-7小鼠异种移植模型中减少肿瘤体积。
T6179	Moxalactam sodium salt Latamoxef sodium,6059 S,拉氧头孢钠,Moxalactam Disodium,LY-127935,Antibiotic 6059S,Shiomarin,FestamoxinLy	Antibacterial; Antibiotic	Microbiology/Virology
	Moxalactam sodium salt (LY-127935) 是一种抗生素, 对大肠杆菌和绿脓杆菌有作用。
T8533	ML318	Others; Antibiotic	Microbiology/Virology; Others
	ML318 是 PvdQ 酰基转移酶的联芳基腈抑制剂，可以结合在酰基结合位点上，IC50为 20 nM。它抑制铜绿假单胞菌的 IC50为 19 μM。它可防止嘧啶的产生并限制了铜绿假单胞菌在铁限制条件下的生长。
TP1663L	CysHHC10 acetate CysHHC10 acetate(1408311-03-4 free base)	Antibacterial	Microbiology/Virology
	CysHHC10 acetate 对革兰氏阳性菌和革兰氏阴性菌均具有抗菌活性，对大肠杆菌、铜绿假单胞菌、金黄色葡萄球菌和表皮葡萄球菌的 MIC 分别为 10.1、20.2、2.5 和 1.3 mM。
T41275	PF-04753299	Others	Others
	PF-04753299 是一种有效的、选择性的LpxC 抑制剂。PF-04753299 对淋球菌分离株具有杀菌作用，对大肠杆菌、铜绿假单胞菌和肺炎菌株的抑制的MIC90值分别为 2 μg/ml、4 μg/ml 和 16 μg/ml。PF-04753299 用于革兰氏阴性菌感染的研究。
T13395L	Zidebactam 齐德巴坦,WCK-5107	Antibacterial	Microbiology/Virology
	Zidebactam (WCK-5107) 是一种β-内酰胺酶抑制剂。它也是一种青霉素结合蛋白 2 抑制剂，IC50值为 0.26 μg/ml。
T14043	4-(tert-Butyl)-benzhydroxamic Acid	Others	Others
	4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively, and it reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1].
T14492	BAL-30072	Others	Others
	BAL30072 shows MIC90 values of 4 μg/mL for MDR Acinetobacter spp. and 8 μg/mL for MDR P. aeruginosa, respectively[1][2]. BAL-30072, a siderophore sulfactam, is a monocyclic beta-lactam antibiotic, with activity against multiresistant gram-negative bacilli
T62773	OX11
	OX11 是一种 S. pneumoniae、P. aeruginosa 和 E. coli 细菌的选择性抑制剂。
T38334	Corynecin III
	Corynecin III is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It inhibits the growth of Gram-positive and Gram-negative bacteria, including S. faecalis, S. aureus, B. subtilis, E. coli, P. aeruginosa, P. vulgaris, S. sonnei, S. typhosa, and K. pneumoniae (MICs = 2.6-83 μg/ml).
T80285	KAMP-19
	KAMP-19，一款角蛋白衍生的抗菌肽，展示出对铜绿假单胞菌 (P. aeruginosa) 的有效抗菌作用。
T60249	RhlR antagonist 1
	RhlR antagonist 1 is a highly effective antagonist of the RhlR protein, showing an IC50 value of 26 μM. It exhibits selective antagonistic activity against RhlR, with minimal effect on LasR and PqsR. RhlR antagonist 1 strongly inhibits biofilm formation in both static and dynamic environments and reduces the production of virulence factors, such as rhamnolipid and pyocyanin, in P. aeruginosa. These characteristics make RhlR antagonist 1 a valuable tool for the development of molecules that modul...
T38824	GT-1 LCB10-0200,GT-1
	GT-1 (LCB10-0200) is a siderophore-linked cephalosporin compound that effectively combats clinical isolates of various bacterial species, including P. aeruginosa, Klebsiella oxytoca, Proteus spp., Serratia marcescens, and Enterobacter aerogenes.
T61484	LasR-IN-1
	LasR-IN-1 (compound 9g) is a highly effective inhibitor of LasR, exhibiting strong potency against E. coli. It also demonstrates significant anti-bacterial properties, displaying a minimum inhibitory concentration (MIC) of 28.13 μM against P. aeruginosa [1].
T37464	CAY10711
	CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria. It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 μM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively. CAY10711 reduces biofilm formation and promotes biofilm dispersal in P. aeruginosa. It is synergistic with kanamycin and has limited adverse ef...
T64012	DNA gyrase B-IN-1
	DNA gyrase B-IN-1 是 DNA gyrase B 的有效抑制剂，表现出良好的结合亲和力和稳定性。DNA gyrase B-IN-1 能够抑制 P. aeruginosa/i> DNA gyrase B (IC50: 2.2 μM)。
T80284	LMW peptide
	LMW peptide是具有广泛抗菌活性的化合物，能有效针对多种细菌，包括革兰氏阳性菌如B. subtilis和L. monocytogenes，以及革兰氏阴性菌如E. coli、P. aeruginosa和V. cholera。
T83847	SP-A (196-215) (human) TFA Surfactant Protein A,SPA4
	表面活性蛋白A（SP-A）（196-215）是一种合成肽，与人类SP-A的C末端碳水化合物识别域的196至215氨基酸序列相对应。当浓度为1和10 µM时，它能抑制JAWSII鼠树突细胞中由LPS诱导的TNF-α释放。SP-A（196-215）（75 µM）促使JAWSII细胞吞噬P. aeruginosa。通过气管内给药，SP-A（196-215）（50 µg/动物）降低了小鼠P. aeruginosa感染模型的疾病严重程度和肺部形成菌落数。
T80281	Melimine	Parasite	Microbiology/Virology
	Melimine是一种合成的抗菌肽，由蜂毒肽和鱼精蛋白融合而成。该化合物对P. aeruginosa和S. aureus表现出抗菌活性，且具有针对细菌、真菌和原生动物的广谱抗菌性能。
T80526	L-K6L9
	L-K6L9 对于囊性纤维化患者的铜绿假单胞菌 (P. aeruginosa) 表现出显著的抗菌 (antimicrobial) 活性和抗生物膜 (anti-biofilm) 能力。该化合物的抗酶解性质保证了其在体内的稳定性，且不引发细菌的耐药性。
T82281	Gly-Gly-AMC
	Gly-Gly-AMC，作为一种荧光蛋白底物，用于评估绿脓杆菌和金黄色葡萄球菌蛋白酶活性。
T80371	Distinctin
	Distinctin是一种源自青蛙皮肤的抗菌肽，具有针对E. faecalis, P. aeruginosa, S. aureus和E. coli的抗菌活性，其最小抑菌浓度(MIC)分别为14.5 μM，28.0 μM，28.0 μM和14.5 μM。
T62740	Antibacterial agent 110
	Antibacterial agent 110 (Compound 4e) 是一种有效的抗细菌 (antibacterial) 剂，作用于 P. aeruginosa (MIC: 1 μg/ml)。Antibacterial agent 110 可以使代谢停滞和细胞内氧化应激，并阻碍 DNA 复制。Antibacterial agent 110 可以破坏细胞膜，具有良好的抗菌膜作用。
T76755	Panobacumab
	Panobacumab (KBPA101) 是一种完全人 IgM/κ 单克隆抗体，由人类 B 淋巴细胞产生，对血清型 O11P. aeruginosa 的 LPS O 多糖具有抗性。
T37731	TPU-0037A
	TPU-0037A is an antibiotic and a congener of lydicamycin . It inhibits the growth of Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA), B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml), but not Gram-negative E. coli, P. mirabilis, P. vulgaris, or P. aeruginosa strains (MICs = >50 μg/ml).
T39790	LpxC-IN-5
	LpxC-IN-5 is a potent, non-hydroxamate inhibitor of LpxC, which is an enzyme known as UDP-3-O-acyl-N-acetylglucosamine deacetylase. It exhibits an IC50 value of 20 nM. Furthermore, LpxC-IN-5 displays antibacterial activity against various strains including E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883, and P. aeruginosa 5567. The minimum inhibitory concentration (MIC) values for these strains are 16 μg/mL, 4 μg/mL, 64 μg/mL, and 4 μg/mL, respectively.
T80139	CRAMP-18 (mouse)	Antibiotic	Microbiology/Virology
	CRAMP-18 (mouse)为一种抗生素肽，具备抗革兰氏阴性菌能力而不具溶血活性，能有效抑制包括S. typhimurium和P. aeruginosa在内的菌株。此外，CRAMP-18 (mouse)展现了抗真菌、抗细菌及抗肿瘤的研究潜力。
T80275	Lynronne-2
	Lynronne-2是抗菌肽，对革兰氏阳性细菌，包含MDR菌株具有活性（耐甲氧西林MRSA菌株MIC: 32-256 μg/mL）。该化合物亦对P. aeruginosa感染展现效用。
T61126	Antibacterial synergist 1
	Antibacterial synergist 1 (compound 20P) is a potent inhibitor of bacterial biofilm formation. It effectively suppresses the production of pyocyanin, with an IC 50 of 8.6 μM, and inhibits biofilm formation with an IC 50 of 4.5 μM. Antibacterial synergist 1 shows promise in the research of P. aeruginosa infections [1].
T37039	Betulinic Aldehyde oxime
	Betulinic aldehyde oxime is a pentacyclic triterpenoid and derivative of the cholesterol biosynthesis inhibitor betulin .1It is active againstE. aerogenes,E. coli,E. faecalis,P. aeruginosa,S. aureus, andC. albicans, as well asL. donovaniamastigotes, when used at a concentration of 50 μM.1,2Betulinic aldehyde oxime (50 μM) is cytotoxic to Huh7 hepatocellular carcinoma cells.2
T37730	Saccharocarcin A
	Saccharocarcin A is an antibiotic originally isolated from S. aerocolonigenes subsp. antibiotica. It is active against M. luteus, S. aureus, E. coli, P. aeruginosa, and C. albicans in a disc assay. Saccharocarcin A inhibits C. trachomatis infection by 88% without inducing cytotoxicity in McCoy cells when used at a concentration of 0.5 μg/ml.
T37282	1-Palmitoyl Lysophosphatidic Acid	Antibacterial	Microbiology/Virology
	1-Palmitoyl Lysophosphatidic Acid 是 LPA 的类似物，通过结合 Ca2+ 和 Mg2+ 提高氨苄西林、哌拉西林和头孢他啶对各种铜绿假单胞菌菌株的作用。
T70386	QZN34
	QZN34 is a PqsR inhibitor which prevents S. aureus biofilm formation, severely damaged established S. aureus biofilms, and perturbed P. aeruginosa biofilm development. The mechanism of action of QZN 34 toward Gram-positive bacteria is shown to involve membrane perturbation and dissipation of transmembrane potential.
T75172	Antibacterial agent 143
	Antibacterial agent 143 (Compound 5a) 是一种抗菌 (antibacterial) 剂，对 B. subtilisATCC6633、. aureusATCC6538、P. aeruginosaATCC13525 和E. coliATCC35218 的 MIC 值分别为 25、25、50 和 50 μg/mL。
T61067	MurB-IN-1
	MurB-IN-1 (compound 44) is a potent inhibitor of MurB, an essential enzyme involved in the synthesis of bacterial cell wall. With a binding affinity of K d 3.57 μM, MurB-IN-1 effectively hinders the activity of MurB, presenting a promising therapeutic option against P. aeruginosa, a highly virulent and opportunistic pathogen associated with severe infections and mortality [1].
T75996	Murepavadin TFA
	Murepavadin (POL7080) (TFA)，一种 14 个氨基酸的环肽，是一种高效的特异性抗生素。Murepavadin 对P. aeruginosa 表现出有效的抗菌活性。MIC50和MIC90值均为 0.12 mg/L。Murepavadin 还可以靶向脂多糖转运蛋白 D。Murepavadin 可用于细菌耐药性的研究。
T62015	PqsR/LasR-IN-1
	PqsR/LasR-IN-1 (Compound 2a) 是铜绿假单胞菌中LasR 和PqsR 系统的有效抑制剂。PqsR/LasR-IN-1 也是 hERG 的抑制剂，IC50为 6.77 μM。
T60770	PqsR/LasR-IN-3
	PqsR/LasR-IN-3 (Compound 7a) 抑制 hERG，IC50值为 109.01 μM。它也是铜绿假单胞菌中PqsR 和LasR 系统的有效抑制剂。
T80307	Dermaseptin-B3
	Dermaseptin-B3，在对抗革兰氏阳性菌与革兰氏阴性菌方面显示出抑制作用，其最小抑菌浓度（MIC）分别针对S. aureus、P. aeruginosa、E. (ATCC 25922)、E. (54127)为1.3、2.3、5.0、2.6、2.3 μM。此外，该化合物亦能有效抑制肿瘤细胞的增殖。
T76225	c[Arg-Arg-Arg-Arg-Dip-Dip-Dip]
	Compound 8C [c(Arg-Arg-Arg-Arg-Dip-Dip-Dip)] 对 MRSA (ATCC BAA-1556)、S. aureus (ATCC 29213)、P. aeruginosa (ATCC 27883) 及 E. coli (ATCC 25922) 的最小抑菌浓度（MIC）分别为3.1μg/mL、3.1μg/mL、12.5μg/mL 和 12.5μg/mL，展现了对耐药革兰氏阳性菌与革兰氏阴性菌的广谱活性。
T80274	Lynronne-1
	Lynronne-1 是一种具备抗革兰氏阳性细菌能力的抗菌肽，尤其对包括多重耐药(MDR)菌株有效（MRSA菌株的MIC为8-32 μg/mL）。在MRSA感染的伤口小鼠模型中，Lynronne-1能显著降低细菌负荷。此外，Lynronne-1对P. aeruginosa感染也显示出活性。
T76226	c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]
	Compound 9C [c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]] 对耐药革兰氏阳性菌及革兰氏阴性菌显示出广谱活性，其最小抑菌浓度（MIC）针对 MRSA (ATCC BAA-1556)、S. aureus(ATCC 29213)、P. aeruginosa(ATCC 27883) 以及 E. coli(ATCC 25922) 分别是 3.1、3.1、12.5 与 25 μg/mL。
T80091	Ranalexin
	Ranalexin为一抗菌肽，对金黄色葡萄球菌、大肠杆菌及铜绿假单胞菌的最小抑菌浓度(MIC)分别为4、32、128 μg/mL。
T71011	Perfluorinated SAHA
	Perfluorinated SAHA is an HDAC inhibitor for use in cancer treatment regimens, with demonstrated greater antiproliferative properties than SAHA . PFSAHA has also been shown to have higher selectivity for PA3774, an HDAC-like enzyme from P. aeruginosa, as well as other HDACs, which may prove beneficial for developing novel chemotherapeutic treatments for cancer.
T63252	Antibacterial agent 113
	Antibacterial agent 113 是有效的抗菌剂 (antibacterial)，对P.aeruginosa、S.mutans、B.subtilis、E.coli、E.faecalis、S.typhimuriumand 和S.aureus microorganisms 表现出抗菌作用，MIC 值均为 15625 μM。
T78673	Antibacterial agent 135
	Antibacterialagent 135（示例7）是一种针对多种细菌具有抑制作用的有效抗菌剂，包括铜绿假单胞菌、鲍曼不动杆菌、大肠杆菌和肺炎克雷伯菌，其最小抑菌浓度（MIC）大于64 μg/mL。
T83738	SMAP 29 (ovine) TFA Sheep Myeloid Antimicrobial Peptide 29
	SMAP 29是一种抗微生物肽，同时也是绵羊防御素前体肽的C末端切割产物。在低盐和高盐条件下，对P. aeruginosa菌株PAO1具有杀菌作用，该作用在能量依赖的发光测定中表现出来（EC50s分别为0.05和0.06 µM）。它还能够以浓度依赖的方式引起绵羊红细胞的溶血。
T83717	Cys-Pexiganan TFA
	Cys-pexiganan是一种抗微生物肽，是pexiganan的衍生物，具有N-末端的半胱氨酸。它对P. aeruginosa和S. aureus具有活性（MICs分别为64和16 µg/ml）。Cys-pexiganan与含醋酸纤维素的聚乙烯醇电纺垫结合，可以加速隔离的重钙化人类血浆的凝血。

化合物

Cat.No: T4017

Synonym: 瑞来巴坦,MK-7655

Target: Antibacterial

Cat.No: T19794

Synonym: 替马沙星,Omniflox

Target: Antibiotic

Azurin (50-77) (P. aeruginosa) TFA

Cat.No: T83680

Synonym: Azurin p28,p28

Moxalactam sodium salt

Cat.No: T6179

Synonym: Latamoxef sodium,6059 S,拉氧头孢钠,Moxalactam Disodium,LY-127935,Antibiotic 6059S,Shiomarin,FestamoxinLy

Target: Antibacterial, Antibiotic

Cat.No: T8533

Target: Others, Antibiotic

CysHHC10 acetate

Cat.No: TP1663L

Synonym: CysHHC10 acetate(1408311-03-4 free base)

Target: Antibacterial

Cat.No: T41275

Target: Others

Cat.No: T13395L

Synonym: 齐德巴坦,WCK-5107

Target: Antibacterial

4-(tert-Butyl)-benzhydroxamic Acid

Cat.No: T14043

Target: Others

Cat.No: T14492

Target: Others

Cat.No: T62773

Cat.No: T38334

Cat.No: T80285

RhlR antagonist 1

Cat.No: T60249

Cat.No: T38824

Synonym: LCB10-0200,GT-1

Cat.No: T61484

Cat.No: T37464

DNA gyrase B-IN-1

Cat.No: T64012

Cat.No: T80284

SP-A (196-215) (human) TFA

Cat.No: T83847

Synonym: Surfactant Protein A,SPA4

Cat.No: T80281

Target: Parasite

Cat.No: T80526

Cat.No: T82281

Cat.No: T80371

Antibacterial agent 110

Cat.No: T62740

Cat.No: T76755

Cat.No: T37731

Cat.No: T39790

CRAMP-18 (mouse)

Cat.No: T80139

Target: Antibiotic

Cat.No: T80275

Antibacterial synergist 1

Cat.No: T61126

Betulinic Aldehyde oxime

Cat.No: T37039

Saccharocarcin A

Cat.No: T37730

1-Palmitoyl Lysophosphatidic Acid

Cat.No: T37282

Target: Antibacterial

Cat.No: T70386

Antibacterial agent 143

Cat.No: T75172

Cat.No: T61067

Murepavadin TFA

Cat.No: T75996

Cat.No: T62015

Cat.No: T60770

Cat.No: T80307

c[Arg-Arg-Arg-Arg-Dip-Dip-Dip]

Cat.No: T76225

Cat.No: T80274

c[Arg-Arg-Arg-Arg-Nal-Nal-Nal]

Cat.No: T76226

Cat.No: T80091

Perfluorinated SAHA

Cat.No: T71011

Antibacterial agent 113

Cat.No: T63252

Antibacterial agent 135

Cat.No: T78673

SMAP 29 (ovine) TFA

Cat.No: T83738

Synonym: Sheep Myeloid Antimicrobial Peptide 29

Cys-Pexiganan TFA

Cat.No: T83717

Cat. No.	Product Name	Target	Signaling Pathways
T5779	MOSLOFLAVONE	IL Receptor; Virus Protease; TNF; Antibacterial	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Mosloflavone 从Scutellaria baicalensis Georgi 中分离出的类黄酮，具有抗EV71活性。它可抑制铜绿假单胞菌的毒力和生物膜形成，有作为杀菌剂的潜力。它在病毒感染的初始阶段抑制 VP2 病毒复制和蛋白质表达，并抑制病毒 VP2 衣壳蛋白合成。
TN1877	Lonicerin 忍冬苦苷,金银花	Apoptosis; Antibacterial	Apoptosis; Microbiology/Virology
	Lonicerin 是一种抗藻酸盐分泌蛋白的黄酮类化合物，对铜绿假单胞菌有抑制作用。它可预防脂多糖诱导的急性肺损伤的炎症和细胞凋亡。
T1505	Imipenem monohydrate N-Formimidoyl thienamycin monohydrate,亚胺培南,Imipenem,亚胺培南一水物	Antibacterial; Antibiotic	Microbiology/Virology
	Imipenem monohydrate (Imipenem) 是从微生物 Streptomyces cattleya 分离得到的碳青霉烯类抗生素，是一种用于静脉注射的β 内酰胺类抗生素，作用于细菌细胞壁，能广泛有效抑制多种革兰氏阳性和阴性菌。
T8433	HQNO	Mitochondrial Metabolism	Metabolism
	HQNO 是一种电子传递链抑制剂，对 complex III 的Kd 值为 64 nM，由P. aeruginosa 产生的。它是许多物种的线粒体NDH-2的有效抑制剂。
T38373	2-heptyl-3-hydroxy-4(1H)-Quinolone 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal	Others	Others
	2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) 是一种铜绿假单胞菌为应对细胞密度增加而产生的一种法定人数感应信号分子。它增加了铜绿假单胞菌中lasB 基因的表达，增加代谢物焦蓝蛋白和凝集素PA-IL 的分泌，以及增加铜绿假单胞菌种群的生物膜生产。当使用浓度为40 μM 时，它还会降低铜绿假单胞菌生长介质中的铁含量，并在硫酸铁溶液中充当一种铁螯合剂。
T4816	6-Hydroxynicotinic acid 6-Hydroxypyridine-3-carboxylic acid,6-羟基烟酸,2-Hydroxy-5-pyridinecarboxylic acid	Others; Endogenous Metabolite	Metabolism; Others
	6-Hydroxynicotinic acid (6-Hydroxypyridine-3-carboxylic acid) 用于核磁共振波谱或气相色谱-质谱法诊断尿路感染中的铜绿假单胞菌。在引起尿液感染的常见细菌中，只有铜绿假单胞菌从烟酸中产生6-羟基烟酸。
T11219	Equisetin	Others	Others
	Equisetin, an N-methylserine-derived acyl tetramic acid isolated from the terrestrial fungus Fusarium equiseti NRRL 5537, functions as a Quorum-sensing inhibitor (QSI) that specifically attenuates QS-regulated virulence phenotypes in P. aeruginosa, presenting a potent lead for treating P. aeruginosa infections without hindering bacterial growth. This tetramate-containing natural product possesses antibiotic and cytotoxic properties, effectively inhibiting the growth of Gram-positive bacteria and...
TN3978	Epitaraxerol	Antifection	Microbiology/Virology
	Epitaraxerol shows moderate antifungal activity against C. albicans and low antimicrobial activity against T. mentagrophytes, A. niger, S. aureus, E. coli, P. aeruginosa, and B. subtilis.
TN5930	Ocotillone
	Ocotillone has potent antibacterial activity against Gram-negative bacteria, P. aeruginosa and S. typhimurium, that are without hemolytic activity, whereas it has weak antimicrobial activity against Gram-positive bacteria and fungi. Ocotillone shows only
T83902	Polymyxin E1 sulfate Colistin A sulfate
	Polymyxin E1，是一种肽类抗生素，也是原初从B. polymyxa分离得到的阳离子脂肽抗生素colistin的主要成分。对P. aeruginosa和E. coli具有活性（MICs分别为2和0.8 µg/ml）。
T83903	Polymyxin B2 sulfate
	Polymyxin B2是一种抗生素，并且是从B. polymyxa分离出的阳离子脂肽抗生素polymyxin B的主要成分。该化合物对P. aeruginosa、A. baumannii、K. pneumoniae和E. cloacae菌株具有活性（MICs分别为1-2、0.5-1、0.25-0.5和0.25-1 µg/ml）。在体内实验中，以4 mg/kg剂量的Polymyxin B2能显著降低P. aeruginosa血液感染小鼠模型中的血液集落形成单位(CFUs)数量。
T83918	Clazamycin A hydrochloride NSC 332188
	Clazamycin A是一种最初从链霉菌中分离出的抗生素和微生物代谢产物。它对多种细菌具有活性，包括S. aureus、B. anthracis、B. subtilis、E. coli和P. aeruginosa（MICs分别为100、6.25、100、50和25 µg/ml）。
T38086	Neohydroxyaspergillic Acid
	Neohydroxyaspergillic acid is a fungal metabolite produced by A. sclerotiorum that has antibiotic and antifungal activities. It inhibits the growth of P. aeruginosa, M. smegmatis, S. aureus, E. coli, K. pneumoniae, B. mycoides, and B. subtilis bacteria (MICs = 125-500 μg/ml). Neohydroxyaspergillic acid also inhibits the growth of G. convolute, S. consortiale, P. blakesleeanus, C. globosum, and T. mentagrophytes (MICs = 175-700 μg/ml) but not A. niger, P. notatum, M. verrucaria, or S. cerevisiae ...
T75439	Angustifoline hydrochloride
	Angustifoline hydrochloride是从狭叶狼疮(Lupinus angustifolius L.)的生物碱提取物中分离出的一种生物碱，展现出对金黄色葡萄球菌、枯草芽孢杆菌、大肠杆菌、铜绿假单胞菌和苏云金芽孢杆菌的抑制作用，证明了其抗菌活性。
T38016	Hirsutide
	Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella. It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm3, respectively). Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm3, respectively).
T72235	Antibacterial synergist 2
	Antibacterial synergist 2 是菌膜抑制剂。Antibacterial synergist 2 对肠球菌、金色葡萄球菌、铜绿假单胞菌和白色假单胞菌具有抑制效应。Antibacterial synergist 2 可用于与形成菌膜的病原体的相关研究。
T36403	Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate
	Preterramide C is a fungal metabolite that has been found inA. terreus.1It is active againstS. aureus(MIC = 52.4 μM) but notE. aerogenes,P. aeruginosa, orC. albicans(MICs = >100 μM for all).2Preterramide C inhibits the growth of L5178Y mouse lymphoma cells with an IC50value of 0.1 μg/ml.3It also inhibits nitric oxide (NO) production induced by LPS in RAW 264.7 cells (IC50= 5.48 μM).
TN5014	Shoreic acid	Antifection; HSV	Microbiology/Virology
	Shoreic acid exhibits antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively, it also shows antifungal activity against C. albicans and T. mentagrophytes with AI
TN4264	Isoapetalic acid 胡桐，海棠木	HIV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	Isoapetalic acid and apetalic acid exhibit cytotoxic activities towards both cancer cell lines(human breast cancer (MCF-7) and human lung carcinoma (A-549) cell lines) and both Gram-positive bacteria(two Gram-positive bacteria, S. aureus and B. subtilis a
T36329	Terpendole I
	Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 \|1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter...
TN1991	Norchelerythrine	Antifection	Microbiology/Virology
	Norchelerythrine shows significant inhibitory activity against Staphylococcus aureus ATCC 6538 with MIC values ranging from 12.5 to 50 ug/mL. It exhibits strong antifeeding activity in a concentration-dependant manner with the EC50 of 62.67 ppm.

天然产物

Cat.No: T5779

Target: IL Receptor, Virus Protease, TNF, Antibacterial

Cat.No: TN1877

Synonym: 忍冬苦苷,金银花

Target: Apoptosis, Antibacterial

Imipenem monohydrate

Cat.No: T1505

Synonym: N-Formimidoyl thienamycin monohydrate,亚胺培南,Imipenem,亚胺培南一水物

Target: Antibacterial, Antibiotic

Cat.No: T8433

Target: Mitochondrial Metabolism

2-heptyl-3-hydroxy-4(1H)-Quinolone

Cat.No: T38373

Synonym: 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal

Target: Others

6-Hydroxynicotinic acid

Cat.No: T4816

Synonym: 6-Hydroxypyridine-3-carboxylic acid,6-羟基烟酸,2-Hydroxy-5-pyridinecarboxylic acid

Target: Others, Endogenous Metabolite

Cat.No: T11219

Target: Others

Cat.No: TN3978

Target: Antifection

Cat.No: TN5930

Polymyxin E1 sulfate

Cat.No: T83902

Synonym: Colistin A sulfate

Polymyxin B2 sulfate

Cat.No: T83903

Clazamycin A hydrochloride

Cat.No: T83918

Synonym: NSC 332188

Neohydroxyaspergillic Acid

Cat.No: T38086

Angustifoline hydrochloride

Cat.No: T75439

Cat.No: T38016

Antibacterial synergist 2

Cat.No: T72235

Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate

Cat.No: T36403

Cat.No: TN5014

Target: Antifection, HSV

Isoapetalic acid

Cat.No: TN4264

Synonym: 胡桐，海棠木

Target: HIV Protease, Antifection

Cat.No: T36329

Norchelerythrine

Cat.No: TN1991

Target: Antifection

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