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Search Results for " ogd "

Targets Recommended: MAO Monoamine Oxidase

11

抑制剂 & 化合物

3

天然产物

11

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6651	Safinamide mesylate PNU-151774E,FCE28073,PNU-151774E,NW-1015,EMD 1195686 mesylate,沙芬酰胺甲磺酸盐	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Safinamide mesylate (EMD 1195686 mesylate) 是选择性的、有效的、可逆的单胺氧化酶 B 的抑制剂，对 MAO-A 选择性较低。它能够阻断钠通道和调节谷氨酸释放。它具有神经保护作用，可用于研究帕金森病、缺血脑卒中等疾病。
T25450	GGTI 2147 GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147	NF-κB; Rho	Cell Cycle/Checkpoint; NF-κB
	GGTI 2147 降低 Rac1 活性，下调 p65 的表达，改善 OGD/R 诱导的神经元凋亡。
T14912	CD3254	Retinoid Receptor	Metabolism
	CD3254 是一种具有选择性和强效性的类视黄醇 X 受体 (RXR) 激动剂，可抑制伴有OGD/再氧合的神经元细胞死亡。
T13920L	Terlipressin Acetate Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous,醋酸特利加压素	Vasopressin Receptor	GPCR/G Protein
	Terlipressin Acetate 是一种高度选择性的加压素 V1 受体激动剂，对氧和葡萄糖剥夺/再氧合 (OGD/R) 诱导的肠上皮细胞损伤 (IEC-6) 具有抗炎和抗氧化作用，可用于肝肾综合征和耐去甲肾上腺素的败血性休克的研究。
T3560	Desmethylanethol trithione ADT-OH	VEGFR; Akt	Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Desmethylanethol trithione (ADT-OH) 是合成硫化氢的供体。它利用上调 FADD 诱导细胞凋亡，并对体内黑色素瘤的形成具有一定的抑制作用，可用于研究癌症疾病。
T83043	Anti-MI/R injury agent 1
	Anti-MI/R injury agent 1 (compound 18) 是一种口服有效的人参三醇衍生物，专用于抗心肌缺血/再灌注 (MI/R) 损伤。该化合物能增强经氧-葡萄糖剥夺和再灌注 (OGD/R) 诱导心肌细胞损伤模型中的细胞活力，显着缩小大鼠心肌梗死面积，减少循环心肌肌钙蛋白 I (cTnI) 的释放，并减轻心脏组织损害。
T80418	TAT-NEP1-40	Apoptosis	Apoptosis
	TAT-NEP1-40是一种能够穿透血脑屏障的多肽。它能够保护PC12细胞不受缺氧和葡萄糖剥夺(OGD)所致的损伤，同时促进神经突的生长。此外，TAT-NEP1-40通过阻断缺血性脑损伤中的细胞凋亡，对缺血后的神经功能恢复具有积极作用。该化合物适用于中枢神经系统损伤，特别是中风后的轴突再生与功能恢复方面的研究。
T60528	PDPOB
	PDPOB 是一种苯基羧酸衍生物，具有用于脑缺血研究的潜力。PDPOB 被证明可以防止 SH-SY5Y 细胞中 OGD/R 诱发的多方面神经元退化，减轻的线粒体功能障碍、氧化应激和细胞凋亡证明了这一点。
T80420	TAT-NEP1-40 acetate	Apoptosis	Apoptosis
	TAT-NEP1-40 acetate 是促进脑卒中后轴突再生和功能恢复的候选分子。该化合物能够抵御PC12细胞的氧和葡萄糖剥夺(OGD)损伤，并促进神经突生长。它通过抑制神经元凋亡(apoptosis)作用，保护大脑免受缺血再灌注伤害，并能有效传递至大鼠的脑内。
T80419	TAT-NEP1-40 TFA	Apoptosis	Apoptosis
	TAT-NEP1-40 TFA 是一种能够穿透血脑屏障的多肽。它能够保护 PC12 细胞抵御缺氧和葡萄糖剥夺 (OGD) 的损害，并促进神经突的生长。此外，TAT-NEP1-40 TFA 可通过减少缺血性脑损伤中的细胞凋亡，以改善神经系统功能。该化合物在中枢神经系统损伤，包括中风后轴突再生及功能恢复的研究中具有潜在应用价值。
T36570	KUS121
	KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, an inducer of ER stress, in HeLa cells when used at concentrations of 20, 50, and 50 μM, respectively. KUS121 (100 μM) inhibits ATP depletion and cell death induced by oxygen-glucose deprivation (OGD) in rat primary cortical neurons in anin vitromodel of cerebral ischemia.2It red...

化合物

Safinamide mesylate

Cat.No: T6651

Synonym: PNU-151774E,FCE28073,PNU-151774E,NW-1015,EMD 1195686 mesylate,沙芬酰胺甲磺酸盐

Target: MAO, Monoamine Oxidase

Cat.No: T25450

Synonym: GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147

Target: NF-κB, Rho

Cat.No: T14912

Target: Retinoid Receptor

Terlipressin Acetate

Cat.No: T13920L

Synonym: Terlipressin diacetate anhydrous,Terlipressin acetate anhydrous,醋酸特利加压素

Target: Vasopressin Receptor

Desmethylanethol trithione

Cat.No: T3560

Synonym: ADT-OH

Target: VEGFR, Akt

Anti-MI/R injury agent 1

Cat.No: T83043

Cat.No: T80418

Target: Apoptosis

Cat.No: T60528

TAT-NEP1-40 acetate

Cat.No: T80420

Target: Apoptosis

TAT-NEP1-40 TFA

Cat.No: T80419

Target: Apoptosis

Cat.No: T36570

Cat. No.	Product Name	Target	Signaling Pathways
TN1957	Mulberrofuran Q MulberrofuranQ
	Mulberrofuran Q是一种有活性的化合物，可抑制12-羟基-5,8,10-十七碳三烯酸(HHT)和血栓烷B2(环加氧酶产物)的形成，可保护神经细胞免受缺氧-缺糖（OGD）诱导的氧化应激的影响。
T6S1740	Nardosinone 苷松新酮,甘松新酮	Others	Others
	Nardosinone 是一个 dbcAMP 和 staurosporine 的神经生成作用增强剂，分离自Nardostachys chinensis 中。Nardosinone 可能成为一种有用的药理学工具，不仅可用于研究神经生长因子 (NGF) 的作用机理，而且可用于研究神经毒性物质的作用机理。
TN4168	Grifolin	Others	Others
	Grifolin has anti-cancer effects, it induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways; it enhances the differentiation and proliferation of oligodendrocyte precurs

天然产物

Mulberrofuran Q

Cat.No: TN1957

Synonym: MulberrofuranQ

Cat.No: T6S1740

Synonym: 苷松新酮,甘松新酮

Target: Others

Cat.No: TN4168

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01011	FGFR1 Protein, Human, Recombinant (His) KAL2,FLT2,FGFBR,HRTFDS,OGD,FLG,HBGFR,bFGF-R-1,CD331...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is H9FRD4.
TMPY-06034	FGFR1 Protein, Human, Recombinant (beta (IIIb), His) FLG,CD331,N-SAM,HBGFR,HRTFDS,BFGFR,OGD,KAL2,fibrobl...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (beta (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.8 kDa and the accession number is H9FRD4.
TMPY-06036	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) FGFR-1,FLG,CD331,HH2,FLT2,KAL2,FGFBR,HBGFR,CEK,HRTFDS,fibrob...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (alpha (IIIb), His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40.5 kDa and the accession number is P11362-7.
TMPY-06033	FGFR1 Protein, Human, Recombinant (beta (IIIb), hFc) HBGFR,BFGFR,bFGF-R-1,FLG,FGFR-1,fibroblast growth factor rec...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (beta (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56 kDa and the accession number is H9FRD4.
TMPY-05761	FGFR1 Protein, Human, Recombinant (His), Biotinylated FLT-2,KAL2,FGFBR,HRTFDS,BFGFR,fibroblast growth factor recep...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is H9FRD4.
TMPY-04371	FGFR1 Protein, Human, Recombinant (His & GST) HRTFDS,CEK,OGD,FLG,FLT2,FGFBR,bFGF-R-1,N-SAM,fibrob...	Human	Baculovirus Insect Cells
	FGFR1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75 kDa and the accession number is H9FRD4.
TMPY-05777	FGFR1 Protein, Human, Recombinant (hFc) N-SAM,OGD,HH2,HBGFR,FLT2,CEK,FLG,FGFR-1,FGFBR,HRTFD...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.15 kDa and the accession number is NP_001341297.1.
TMPY-06035	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) KAL2,OGD,N-SAM,CEK,FLT2,HH2,FLG,CD331,BFGFR,HBGFR,F...	Human	HEK293 Cells
	FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 65.7 kDa and the accession number is P11362-7.
TMPH-00850	OGDC-E1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	OGDC-E1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 59.1 kDa and the accession number is Q02218.
TMPH-02475	OGDC-E Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	OGDC-E Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.8 kDa and the accession number is Q60597.
TMPH-00667	OGDC-E2 Protein, E. coli O157:H7, Recombinant (His)	E. coli	E. coli
	E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). OGDC-E2 Protein, E. coli O157:H7, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 49.9 kDa and the accession number is P0AFG7.

重组蛋白

FGFR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01011

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (beta (IIIb), His)

Cat.No: TMPY-06034

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (alpha (IIIb), His)

Cat.No: TMPY-06036

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (beta (IIIb), hFc)

Cat.No: TMPY-06033

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05761

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04371

Species: Human

Expression System: Baculovirus Insect Cells

FGFR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05777

Species: Human

Expression System: HEK293 Cells

FGFR1 Protein, Human, Recombinant (alpha (IIIb), hFc)

Cat.No: TMPY-06035

Species: Human

Expression System: HEK293 Cells

OGDC-E1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-00850

Species: Human

Expression System: E. coli

OGDC-E Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02475

Species: Mouse

Expression System: E. coli

OGDC-E2 Protein, E. coli O157:H7, Recombinant (His)

Cat.No: TMPH-00667

Species: E. coli

Expression System: E. coli

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