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Cat. No.	Product Name	Target	Signaling Pathways
T28141	Nek2-IN-5 NCL00017509	MAPK	MAPK
	Nek2-IN-5 (NCL00017509) 是一种具有有效性和选择性的 NIMA 相关激酶 2（Nek2）抑制剂。
T73287	Nek2-IN-6
	Nek2-IN-6 是一种有效的 NIMA 相关激酶 2 (Nek2) 抑制剂。
T11960	MBM-55	GSK-3; MAPK; DYRK; Akt; Chk; Bcr-Abl; CDK; S6 Kinase; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	MBM-55 是一种有效的中心体相关激酶 2 (NEK2) 抑制剂，IC50 为 1 nM。 MBM-55 通过诱导细胞周期停滞和凋亡有效抑制癌细胞的增殖。
T8216	T-1101 tosylate TAI-95 tosylate	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	T-1101 tosylate (TAI-95 tosylate) 是一种具有抗肿瘤活性的 Hec1/Nek2抑制剂。
T11961	MBM-55S	GSK-3; MAPK; Akt; Bcr-Abl; CDK; S6 Kinase; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	MBM-55S 是一种有效的 Nek2 抑制剂，IC50 为 1 nM。 MBM-55S 抑制细胞周期停滞和凋亡，从而抑制癌细胞的增殖。 MBM-55S 表现出抗肿瘤作用。
T11657	INH154	Others	Others
	INH154 是一种高效的 Nek2 和 Hec1 结合抑制剂，能够抑制 Hela 细胞(IC50:200 nM)、 MB468 细胞(IC50:120 nM)。
T6180	INH6	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	INH6 是一种有效的 Hec1 抑制剂，可选择性地破坏 Hec1/Nek2 相互作用并诱导染色体错位。它抑制HeLa 细胞生长的IC50值为2.4 μM。
T6691	TAI-1	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	TAI1 是一种具有口服活性的特异性 Hec1 抑制剂，有抗肿瘤活性，在 K562 细胞中的 GI50值为 13.48 nM。
T2502	INH1 IBT13131	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	INH1 (IBT13131) 通过直接结合Hec1，特异性干扰 Hec1/Nek2 的相互作用。它在体内外均表现出良好的抗肿瘤活性。
T9880	ZINC05007751	MAPK	MAPK
	ZINC05007751 是 NIMA 相关激酶 NEK6 的有效抑制剂（IC50 = 3.4 μM）。 ZINC05007751 对 NEK1 和 NEK6 具有很强的特异性，对 NEK2、NEK7 和 NEK9 没有显着的活性。
T11958	MBM-17	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	MBM-17 is a potent inhibitor of NIMA-related kinase 2 (Nek2,IC50 of 3 nM). It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
T11959	MBM-17S	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	MBM-17S, a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM, effectively inhibits cancer cell proliferation by inducing cell cycle arrest and apoptosis. It demonstrates antitumor activities without evident toxicity to mice.
T28498	rac-CCT-250863
	Rac-CCT-250863, a potent Nek2 inhibitor, exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.
T27052	CMP3a CMP-3a,CMP 3a
	CMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase E
T38710	JH295
	JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alkylation of Cys22. Importantly, JH295 does not exhibit any inhibitory effects toward Cdk1, Aurora B, or Plk1, which are kinases involved in mitotic processes. Furthermore, JH295 has no impact on bipolar spindle assembly or the spindle assembly checkpoint mechanism.
T24130	HCI-2184 HCI2184,HCI 2184
	HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.
T61061	JH295 hydrate
	JH295 hydrate 通过 Cys22 烷基化从而抑制细胞Nek2，它是有效的，不可逆和选择性的NIMA 相关激酶 2 (Nek2)抑制剂 (IC50 = 770 nM)。JH295 hydrate 对有丝分裂激酶 Cdk1，Aurora B 或 Plk1 不具有活性，不干扰双极纺锤体组件或纺锤体组件检查点。
T81696	NBI-961
	NBI-961为高效NEK2抑制剂，能阻断蛋白酶体降解作用。该化合物在弥漫性大B细胞淋巴瘤(DLBCL)细胞中诱导G2/有丝分裂停滞及细胞凋亡(apoptosis)。
T28498L	rac-CCT-250863 HCl rac-CCT-250863 HCl(1364269-06-6 Free base)	Apoptosis	Apoptosis
	rac-CCT-250863 HCl 是一种具有选择性和可逆性的 NEK 2 抑制剂。rac-CCT-250863 HCl 能诱导细胞周期停滞，对癌细胞有较好的抗增殖活性，与 Pomalidomide 联用能诱导细胞凋亡，可用于联合抗癌的研究。

化合物

Cat.No: T28141

Synonym: NCL00017509

Target: MAPK

Cat.No: T73287

Cat.No: T11960

Target: GSK-3, MAPK, DYRK, Akt, Chk, Bcr-Abl, CDK, S6 Kinase, Aurora Kinase

T-1101 tosylate

Cat.No: T8216

Synonym: TAI-95 tosylate

Target: Apoptosis, Microtubule Associated

Cat.No: T11961

Target: GSK-3, MAPK, Akt, Bcr-Abl, CDK, S6 Kinase, Aurora Kinase

Cat.No: T11657

Target: Others

Cat.No: T6180

Target: Apoptosis, Microtubule Associated

Cat.No: T6691

Target: Apoptosis, Microtubule Associated

Cat.No: T2502

Synonym: IBT13131

Target: Apoptosis, Microtubule Associated

Cat.No: T9880

Target: MAPK

Cat.No: T11958

Target: Aurora Kinase

Cat.No: T11959

Target: Aurora Kinase

Cat.No: T28498

Cat.No: T27052

Synonym: CMP-3a,CMP 3a

Cat.No: T38710

Cat.No: T24130

Synonym: HCI2184,HCI 2184

Cat.No: T61061

Cat.No: T81696

rac-CCT-250863 HCl

Cat.No: T28498L

Synonym: rac-CCT-250863 HCl(1364269-06-6 Free base)

Target: Apoptosis

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