30
2
4
4
15
Cat. No. | Product Name | ||
---|---|---|---|
L7300 | 钾通道分子库 | 152 compounds | |
152 种钾通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L7400 | 钠通道分子库 | 118 compounds | |
118 种钠通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L7200 | 钙通道分子库 | 140 compounds | |
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2300 | 离子通道库 | 931 compounds | |
931 种与离子通道相关的生物活性小分子化合物的特有集合,用于离子通道相关的疾病和药物研究,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
CL0067 |
Sodium Channel inhibitor kit
Sodium Channel inhibitor kit |
||
CL0055 |
Potassium Channel inhibitor kit
Potassium Channel inhibitor kit |
||
CL0082 |
TRP Channel inhibitor kit
TRP Channel inhibitor kit |
||
CL0054 |
Calcium Channel antagonist/agonist kit
Calcium Channel antagonist/agonist kit |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T77711 |
Calcium Channel antagonist 4
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Calcium Channel antagonist 4 是一种电压门控钙通道抑制剂(IC50 : 5-20μM)。 | |||
T10674 |
Potassium Channel Activator 1
钾离子通道激活剂1,ZINC34634569 |
Potassium Channel | Membrane transporter/Ion channel |
Potassium Channel Activator 1 可用于治疗多巴胺能系统被破坏的疾病或病症的研究,例如情绪障碍 ADHD、精神分裂症和其他精神病状态。 | |||
T72170 |
NaV1.2/1.6 channel blocker-1
|
Sodium Channel | Membrane transporter/Ion channel |
NaV1.2/1.6 channel blocker-1 是一种有效的 NaV1.2/1.6 channel 阻滞剂,对 rNaV1.6 和 hNaV1.2 有抑制作用。NaV1.2/1.6 channel blocker-1 可用于研究全身性癫痫和运动障碍。 | |||
T12042 |
Minnelide
|
Others | Others |
Minnelide is a prodrug of triptolide,and shows potent antitumor activity in a number of tumor types. | |||
T10101 |
Calcium channel-modulator-1
|
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Calcium channel-modulator-1是钙离子通道调节剂(IC50:0.8 μM),具有阻塞主动脉收缩的专业化。 | |||
T77712 |
Calcium Channel antagonist 3
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Calcium Channel antagonist 3 是一种电压门控钙通道抑制剂(IC50 : 5-20μM)。 | |||
T77710 |
Calcium Channel antagonist 2
WAY-327363 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Calcium Channel antagonist 2是一种 calcium channel 拮抗剂 (IC50=5-20 μM),可用于研究像疼痛和糖尿病等由于 Ca2+ 通道造成的疾病。 | |||
T10659 |
Ca2+ channel agonist 1
|
Calcium Channel; CDK | Cell Cycle/Checkpoint; Membrane transporter/Ion channel; Metabolism |
Ca2+channel agonist 1 是 N-型钙离子通道激动剂和Cdk2的抑制剂,EC50分别为 14.23 μM 和 3.34 μM,可用作运动神经末梢功能障碍的潜在治疗方法。 | |||
T80274 |
Lynronne-1
|
||
Lynronne-1 是一种具备抗革兰氏阳性细菌能力的抗菌肽,尤其对包括多重耐药(MDR)菌株有效(MRSA菌株的MIC为8-32 μg/mL)。在MRSA感染的伤口小鼠模型中,Lynronne-1能显著降低细菌负荷。此外,Lynronne-1对P. aeruginosa感染也显示出活性。 | |||
T79280 |
Nav1.3 channel inhibitor 1
|
Sodium Channel | Membrane transporter/Ion channel |
Nav1.3 channel inhibitor 1 (化合物 15b) 为状态依赖性电压门控钠通道Nav1.3的抑制剂,具有IC50值为20 nM。该化合物能穿透血脑屏障,适用于神经系统疾病研究。 | |||
T71113 | Minnelide free acid | ||
Minnelide is an effective therapy against pancreatic cancer. Minnelide Inhibits Androgen Dependent, Castration Resistant Prostate Cancer Growth by Decreasing Expression of Androgen Receptor Full Length and Splice Variants. Minnelide reduced tumor volume in multiple models of pancreatic cancer. Minnelide was a more effective drug against pancreatic cancer models. It effectively reduced tumor burden and tumor related morbidity in different unique but complementary mouse models. It reduced metastat... | |||
T39816 |
Ceftaroline fosamil inner salt
TAK-599 free acid,PPI0903freeacid |
||
Ceftaroline fosamil (TAK-599) inner salt, a cephalosporin derivative, is an N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) T-91825. Ceftaroline fosamil inner salt can be used for the research of MRSA infection. | |||
T80275 |
Lynronne-2
|
||
Lynronne-2是抗菌肽,对革兰氏阳性细菌,包含MDR菌株具有活性(耐甲氧西林MRSA菌株MIC: 32-256 μg/mL)。该化合物亦对P. aeruginosa感染展现效用。 | |||
TP1491 |
Kv3, Channel Containing Protein 567-585
|
||
Kv3 channel protein is expressed by parvalbumin (PV)-containing pallidal neurons.Kv3, Channel Containing Protein (567-585) corresponds to amino acids 567 to 585 fragment of the Kv3.1b channel containing protein. | |||
T12951 |
Sodium Channel inhibitor 2
|
Sodium Channel | Membrane transporter/Ion channel |
Sodium Channel inhibitor 2 is a blocker of sodium channel. | |||
T60986 | KCa2 channel modulator 2 | ||
KCa2 channel modulator 2 (compound 2q) 是有效的亚型选择性KCa2通道的正调节剂,对人KCa2.3 通道和大鼠 KCa2.2 通道亚型显示出相似的效力,EC50值分别为 0.6 μM 和 0.64 μM。 | |||
T65053 | (Methoxycarbonylsulfamoyl)triethylammonium hydroxide, inner salt | ||
(Methoxycarbonylsulfamoyl)triethylammonium hydroxide, inner salt 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65053,CAS号为 29684-56-8。 | |||
T82403 |
Fibronectin Type III Connecting Segment Fragment 1-25
|
||
Fibronectin Type III Connecting Segment Fragment 1-25,一种多肽,主要作用于黑色素瘤细胞的粘附,并在鸡的周围神经系统发育中扮演关键角色。 | |||
T82684 |
Connexin mimetic peptide 40,37GAP26
|
||
Connexin mimetic peptide 40,37GAP26是一种生物活性肽,对应Cx37和Cx40主要血管连接蛋白的胞外环GAP26结构域,命名基于Cx同源性为37,40Gap26。本化合物主要用于研究间隙连接对环吡嗪酸(CPA)通过啮齿动物髂动脉壁导致的内皮超极化扩散的影响。Cx37和Cx40形成的间隙连接斑块在内皮细胞中高度丰富,而Connexin mimetic peptide 40,37GAP26能抑制内膜下超极化。 | |||
T80276 |
Lynronne-3
|
||
Lynronne-3 是一种具有抗革兰氏阳性细菌活性的抗菌肽,涵盖 MDR 菌株(对MRSA菌株的 MIC 为 32-128 μg/mL)。此外,Lynronne-3 亦对 P. aeruginosa 感染显示出效力。 | |||
T81134 |
Sodium Channel inhibitor 4
|
Sodium Channel | Membrane transporter/Ion channel |
Sodium Channel Inhibitor4 是一种抑制钠通道的化合物。 | |||
T12948 |
Sodium Channel inhibitor 1
|
Others | Others |
Sodium Channel inhibitor1 is a novel and selective voltage-gated sodium channel for pain treatment. (IC50 Value of 0.16 uM and 0.41 uM for Na v1.7, V hold-90mV and Na v1.7, V hold-90mV) | |||
T64203 | T-Type calcium channel inhibitor 2 | ||
T-Type calcium channel inhibitor 2 (compound 6g) 是一种 T 型钙通道的有效抑制剂,能够作用于 Cav3.1 (α1G) (IC50: 31.0 μM)、Cav3.2 (α1H) (IC50: 83.1 μM)、Cav3.3 (α1I) (α1H) (IC50: 69.3 μM)。T-Type calcium channel inhibitor 2 对 A549、HCT-116 细胞表现出细胞毒性,IC50s 分别为5.0、6.4 μM。 | |||
T82683 |
Connexin mimetic peptide 40GAP27
|
||
Connexin mimetic peptide 40GAP27 是一种生物活性肽,对应于主要的血管连接蛋白Cx40第二个细胞外环的GAP27结构域(40Gap27)。该化合物在研究氧化应激所致的损伤以及间隙连接通讯机制中有应用。40Gap27能够在给药后减少内皮依赖性的内膜下平滑肌的超极化现象。 | |||
T12153 |
N-type calcium channel blocker-1
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels. | |||
T72195 |
KCa1.1 channel activator-2
|
||
KCa1.1 channel activator-2 (化合物 3F) 是一种槲皮素衍生物,是选择性的血管 KCa1.1 channel 刺激剂。KCa1.1 channel activator-2 具有强效的肌肉松弛活性。 | |||
T11927 |
M2 ion channel blocker
|
Others | Others |
M2 ion channel blocker ,Antiviral agent, is capable of inhibiting and blocking the activity of M2 ion channel. | |||
T72194 |
KCa1.1 channel activator-1
|
||
KCa1.1 channel activator-1 (化合物 1E) 是一种槲皮素衍生物,是选择性的血管 KCa1.1 channel 刺激剂。KCa1.1 channel activator-1 也显示 CaV1.2 channel 通道阻断活性。KCa1.1 channel activator-1 表现出较弱的肌肉松弛活性。 | |||
T60985 |
KCa2 channel modulator 1
|
||
KCa2 channel modulator 1 (compound 2o) 是有效的亚型选择性的K/Ca 通道的正调节剂,其增强大鼠 KCa2.2 通道亚型的EC50值为 0.99 μM 和人KCa2.3 通道亚型的EC50值为 0.19 μM。 | |||
T61605 |
SK3 Channel-IN-1
|
||
SK3 Channel-IN-1 (compound 7a) is a powerful and selective modulator of the SK3 channel. It demonstrates significant efficacy in inhibiting breast cancer MDA-MB-435 cell migration while maintaining low cytotoxicity in other cell lines. Furthermore, SK3 Channel-IN-1 exhibits the ability to modulate ion channel activity in cancer cells [1]. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2275 |
Tinnevellin glucoside
|
Others | Others |
Tinnevellin glucoside 是一种从 Cassia senna 的叶和豆荚中分离得到的萘糖苷。 | |||
TN5426 |
Sonnerphenolic B
(+)-Sonnerphenolic B |
||
Sonnerphenolic B 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5426,CAS号为 1627516-10-2。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02412 |
ENO1 Protein, Human, Recombinant (His)
PPH,NNE,enolase 1, (alpha),ENO1L1,HEL-S-17,MPB1,eno... |
Human | E. coli |
ENO1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 49.3 kDa and the accession number is P06733-1. | |||
TMPH-02505 |
ENO1 Protein, Mouse, Recombinant (His)
Alpha-enolase,2-phospho-D-glycerate hydro-lyase,Eno1,Eno-1,N... |
Mouse | E. coli |
Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. ENO1 Protein, Mouse, Reco... | |||
TMPY-02540 |
Annexin V/ANXA5 Protein, Human, Recombinant
RPRGL3,HEL-S-7,PP4,annexin A5,ENX2,ANX5 |
Human | E. coli |
Annexin V/ANXA5 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 35.9 kDa and the accession number is P08758. | |||
TMPH-02411 |
Lol p 1 Protein, Lolium perenne, Recombinant (His & Myc)
|
Lolium perenne | E. coli |
Lol p 1 Protein, Lolium perenne, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.2 kDa and the accession number is P14946. | |||
TMPY-06471 |
Influenza A H3N2 (A/Minnesota/41/2019) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H3N2 | HEK293 Cells |
Influenza A H3N2 (A/Minnesota/41/2019) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.50 kDa. | |||
TMPY-04837 |
Influenza A H3N2 (A/Johannesburg/33/1994) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H3N2 | Baculovirus Insect Cells |
Influenza A H3N2 (A/Johannesburg/33/1994) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.4 kDa and the accession number is I6TFC9. | |||
TMPY-04744 |
Influenza A H3N2 (A/Johannesburg/33/1994) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H3N2 | HEK293 Cells |
Influenza A H3N2 (A/Johannesburg/33/1994) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.1 kDa and the accession number is I6TFC9. | |||
TMPY-04186 |
Influenza A H10N3 (A/mallard/Minnesota/Sg-00194/2007) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N3 | HEK293 Cells |
Influenza A H10N3 (A/mallard/Minnesota/Sg-00194/2007) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.7 kDa and the accession number is C6Y4Y2. | |||
TMPY-05883 |
Influenza A H1N2 (A/Minnesota/14/2012) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H1N2 | HEK293 Cells |
Influenza A H1N2 (A/Minnesota/14/2012) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.5 kDa and the accession number is X5FSZ1. | |||
TMPY-02592 |
Annexin VI/ANXA6 Protein, Human, Recombinant (His)
ANX6,annexin A6,CBP68 |
Human | E. coli |
Annexin A6, also known as ANXA6 or ANXAⅥ, belongs to a family of Ca2+-dependent membrane and phospholipid binding proteins. Members of this family have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 6 is phosphorylated in vivo associated with cell growth. Annexin 6 was not phosphorylated in quiescent cells, but was phosphorylated on serine and to a lesser extent threonine, several hours following cell stimulation. Experiment has revealed the presenc... | |||
TMPY-00585 |
Annexin A8 Protein, Human, Recombinant (His)
ANX8,annexin A8 |
Human | E. coli |
We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA8 mRNA is expressed in low-proliferative isolated pubertal mouse mammary ductal epithelium and after enforced involution, but not in isolated highly proliferative terminal end buds (TEB) or during pregnancy. ANXA8 as a potential mediator of quiescence in the normal mouse mammary ... | |||
TMPY-05759 |
Annexin V/ANXA5 Protein, Human, Recombinant, Biotinylated
RPRGL3,ANX5,HEL-S-7,annexin A5,PP4,ENX2 |
Human | E. coli |
Annexin V/ANXA5 Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 35.9 kDa and the accession number is P08758. | |||
TMPH-02410 |
Lol p 5a Protein, Lolium perenne, Recombinant (His & Myc & SUMO)
|
Lolium perenne | E. coli |
Lol p 5a Protein, Lolium perenne, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 48.4 kDa and the accession number is Q40240. | |||
TMPY-05869 |
Influenza A H1N1 (A/Swine/Minnesota/55551/2000) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H1N1 | HEK293 Cells |
Influenza A H1N1 (A/Swine/Minnesota/55551/2000) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.4 kDa and the accession number is Q8QT91. | |||
TMPY-02416 |
Influenza A H10N3 (A/mallard/Minnesota/Sg-00194/2007) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N3 | Baculovirus Insect Cells |
Influenza A H10N3 (A/mallard/Minnesota/Sg-00194/2007) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 57.9 kDa and the accession number is C6Y4Y2. |