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18

抑制剂 & 化合物

30

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19512	Phalloidin	Others	Others
	Phalloidin is a mushroom-derived toxin which used to label F-actin of the cytoskeleton with fluorochrome .
T3754	Hydrocinnamic alcohol 3-Phenyl-1-Propanol,3-苯丙醇,3-Phenylpropanol	Others	Others
	Hydrocinnamic alcohol (3-Phenyl-1-Propanol) 存在于 storax 和蕨香脂中，也存在于越橘属水果、番石榴果和果皮、黑莓、其他水果、朗姆酒、白葡萄酒、香菇、松茸和泥煤麦芽中。它是一种调味成分。
T29709	Agaridoxin
	Agaridoxin is a mushroom metabolite.
T32318	Judeol
	Judeol is found in mushrooms. Judeol is a metabolite of Armillaria mellea (honey mushroom).
T34452	Russuphelin A Russuphelin-A
	Russuphelin A is a cytotoxic compound from the mushroom Russula subnigricans Hongo.
T28035	MHY908
	MHY908, a novel inhibitor of melanogenesis, potently inhibits mushroom tyrosinase activity in a dose-dependent manner.
T33623	Necatorin Necatorine
	Necatorin is a mutagenic compound from edible mushroom Lactarius necator.
T25406	Fasciculic acid C
	Fasciculic acid C is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.
T25404	Fasciculic acid A
	Fasciculic acid A is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.
T29898	alpha-Methylcinnamaldehyde Z-alpha-Methylcinnamaldehyde
	alpha-Methylcinnamaldehyde 是 Cinnamaldehyde 的α-取代衍生物，可被用作蘑菇酪氨酸酶的抑制剂。
T25405	Fasciculic acid B
	Fasciculic acid B is the ester of fasciculol B and 3-hydroxy-3-methylglutaric acid. Fasciculic acid B is calmodulin antagonist from mushroom Naematoloma fasciculare.
T13474	β-Amanitin	Others	Others
	β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom, and inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis.
T35759	Cardol triene
	Cardol triene is a phenol found in cashew nut shell liquid that competitively and irreversibly inhibits mushroom tyrosinase (IC50 = 22.5 μM). It is schistosomicidal, killing 25, 75, and 100% of S. mansoni worms after 24 hours when used at concentrations of 50, 100, or 200 μM, respectively. It has been used as a starting material for the synthesis of bis-benzoxazines.
T75714	Decapeptide-12
	Decapeptide-12，一个小型寡肽，作为tyrosinase的抑制剂，通过与tyrosinase的C末端残基相互作用(Kd: 61.1 μM)发挥作用。作为mushroom tyrosinase的竞争性抑制剂(IC50: 40 µM)，Decapeptide-12有效上调SIRT的转录水平，并能减少黑色素细胞中的黑色素含量，适用于黑色素生成、衰老和炎症的研究。
T36471	Ternatin
	Ternatin is a cyclic heptapeptide first isolated from the mushroom C. versicolor that has been shown to have cytotoxic and anti-adipogenic effects in vitro. It inhibits adipogenesis with an IC50 value of 27 nM and becomes cytotoxic to 3T3-L1 mouse adipocytes at 10-fold higher concentrations. Ternatin is reported to inhibit HCT116 cell proliferation with an IC50 value of 71 nM. Note that this metabolite should not be confused with the plant flavonoid of the same name.
T36328	Termitomycamide B
	Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified termitomycamides, extracts from the fruiting bodies of T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites Termitomycamide B is a fatty acid i...
T37832	CAY10761 CAY10761
	CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4 \|1. Khan, K.M., Fatima, N., Rasheed, M., et al. 1,3,4-Oxadiazole-2(3H)-thione and its analogues: A new class of non-competitive nucleotide pyrophosphatases/p...
T73608	Muscimol hydrochloride
	Muscimol (Agarin; Agarine) hydrochloride 是一种具有精神活性的异恶唑。Muscimol hydrochloride 也是抑制性神经递质 GABA 离子型受体的选择性激动剂。Muscimol hydrochloride 可以从毒蝇伞和相关蘑菇中分离出来。总之，Muscimol 是一种有效的 GABAA 受体激动剂 (EC50=0.2 μM)，部分 GABAC 受体激动剂和无活性的 GABAB 受体激动剂。Muscimol hydrochloride 具有镇静、抗焦虑和致幻作用。

化合物

Cat.No: T19512

Target: Others

Hydrocinnamic alcohol

Cat.No: T3754

Synonym: 3-Phenyl-1-Propanol,3-苯丙醇,3-Phenylpropanol

Target: Others

Cat.No: T29709

Cat.No: T32318

Cat.No: T34452

Synonym: Russuphelin-A

Cat.No: T28035

Cat.No: T33623

Synonym: Necatorine

Fasciculic acid C

Cat.No: T25406

Fasciculic acid A

Cat.No: T25404

alpha-Methylcinnamaldehyde

Cat.No: T29898

Synonym: Z-alpha-Methylcinnamaldehyde

Fasciculic acid B

Cat.No: T25405

Cat.No: T13474

Target: Others

Cat.No: T35759

Cat.No: T75714

Cat.No: T36471

Termitomycamide B

Cat.No: T36328

Cat.No: T37832

Synonym: CAY10761

Muscimol hydrochloride

Cat.No: T73608

Cat. No.	Product Name	Target	Signaling Pathways
T8087	Tropolone	Tyrosinase	Proteases/Proteasome
	Tropolone 是一种 mushroom tyrosinase 抑制剂，IC50=0.4 μM，它的抑制作用可以通过透析或过量的 CU2+逆转。它是 2 位上带有羟基的 tropone 衍生物，是许多 Azulene 衍生物的前体，如 2-methylazulene-1-carboxylate。
T33817	Orellanine 2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one	Others	Others
	Orellanine 是一种从蘑菇 Cortinarius orellanus 中提取的肾毒性化合物。 Orellanine 强烈抑制 Madin-Darby 犬肾细胞和大鼠肝线粒体中大分子（蛋白质、RNA 和 DNA）的合成。
TCS1709	BENZYLACETONE 苄基丙酮,4-Phenylbutan-2-one,Methyl 2-phenylethyl ketone,4-Phenyl-2-butanone	Tyrosinase	Proteases/Proteasome
	Benzylacetone (4-Phenyl-2-butanone) 是一种从沉香木中提取的芳香族化合物。它具有增强食欲和减少运动的作用。它具有较强且可逆的抗蘑菇酪氨酸酶作用，对单酚酶和双酚酶作用的IC50值分别为 2.8 mM 和 0.6 mM。
T5889	Kojic acid	Tyrosinase; Parasite	Microbiology/Virology; Proteases/Proteasome
	Kojic acid 是 Aspergillus oryzae 产生的一种真菌代谢物，用作抗氧化剂和防辐射剂，可抑制酪氨酸酶。
T20488	4-Isopropylbenzoic acid NSC1907,NSC-1907,NSC 1907,Cumic acid	Antifungal	Microbiology/Virology
	4-Isopropylbenzoic acid (Cumic acid) 是一种芳香单萜,从 Bridelia retusa 的茎皮中分离得到。4-Isopropylbenzoic acid 显示出抗真菌活性。4-Isopropylbenzoic acid 也是一种可逆的、非竞争性的蘑菇酪氨酸酶 (mushroom tyrosinase) 抑制剂。
T4S1658	Benzoyloxypaeoniflorin 苯甲酰氧化芍药苷,Benzoyloxypeoniflorin,苯甲酰氧芍药苷	NF-κB; Tyrosinase	NF-κB; Proteases/Proteasome
	Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) 是一种酪氨酸酶抑制剂，分离于Paeonia suffruticosa 的根，对mushroom tyrosinase 的 IC50为 0.453 mM。它是一种NF-κB 抑制剂，它通过对血小板聚集和凝血的抑制作用，有助于改善血液循环。
TN7099	antcin A	NOD	Immunology/Inflammation; NF-κB
	antcin A 是一种类固醇类植物化学物质，从珍贵的食用菌牛樟芝子实体中分离出来，具有很强的抗炎和抗肿瘤作用。
TN1928	Methyl rosmarinate	MMP; Anti-infection; Tyrosinase	Microbiology/Virology; Proteases/Proteasome
	Methyl rosmarinate 是一种非竞争性 tyrosinase 抑制剂，从 Rabdosia serra 中分离得到的，对蘑菇酪氨酸酶作用的 IC50值为 0.28 mM，也能抑制a-glucosidase。
T40298	Phallacidin
	Phallacidin, a phallotoxin family member, targets and binds to F-actin in mushroom toxins.
TN3423	Anthracophyllone	Others	Others
	Anthracophyllone is a natural product from the mushroom Anthracophyllum sp. BCC18695.
TN3644	Chlorophorin	Tyrosinase; Antifection	Microbiology/Virology; Proteases/Proteasome
	Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of 2.5 ± 0.408 uM; it inhibits α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells.
TN5376	Axinysone B (-)-Axinysone B
	Axinysone B is a natiral product from the metabolites of the mushroom Anthracophyllum sp. BCC18695.
TN3372	Alboctalol	Others	Others
	Alboctalol inhibits mushroom tyrosinase activity.
TN3545	Buddlenoid A	Tyrosinase	Proteases/Proteasome
	Buddlenoid A shows high inhibition of mushroom tyrosinase.
T37961	P-Tolualdehyde	Tyrosinase; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	p-Tolualdehyde 是一种 RIFM 香料，对蘑菇酪氨酸酶显示出抑制作用。
T39649	ε-Amanitin
	ε-Amanitin is a cyclic peptide obtained from various mushroom species. It exhibits a strong affinity for RNA polymerase II and effectively inhibits its activity.
T75471	Chetoseminudin B
	Chetoseminudin B 具有对蘑菇酪氨酸酶 (mushroomtyrosinase) 的抑制活性，IC50为 31.7 μM。
TN2672	2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran	Tyrosinase	Proteases/Proteasome
	2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran shows radical scavenging activities. It also shows mushroom tyrosinase inhibitory activity with an IC50 value of 5.2 micronM and acts as a competitive inhibitor.
TN2288	Uralenol 乌拉尔醇	Others; Estrogen/progestogen Receptor; Tyrosinase	Endocrinology/Hormones; Others; Proteases/Proteasome
	Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate( IC50 =49.5 μM). Uralenol shows potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro.
TN5448	Steppogenin Norartocarpanone
	Steppogenin exhibits significant tyrosinase inhibition activity, ;it also shows strong mushroom tyrosinase inhibitory activity with IC(50) values lower than 50 microM, more potent than kojic acid (IC(50) = 71.6 microM), a well-known tyrosinase inhibitor.
T82031	Isoguaiacin
	Isoguaiacin为一种天然产物，具有复杂的多环化合物结构，广泛应用于生物医药研究领域。
TN3444	Aristolactam BII	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Aristolactam BII exhibits antimicrobial and antiinflammatory activity, it shows significant activity towards DPPH radical scavenging and potent inhibitory effects against tyrosinase mushroom. Aristolactam BII also exerts its significant neuroprotective ef
TMA0593	Broussoflavonol F	Tyrosinase	Proteases/Proteasome
	Broussoflavonol F has antiplatelet effect, is partially due to an inhibitory effect on cyclooxygenase, can inhibit arachidonic acid (AA)-induced platelet aggregation. Broussoflavonol F shows inhibitory activities on mushroom tyrosinase. Broussoflavonol F
TN3744	Cyclomorusin	NOS; AChR	Immunology/Inflammation; Neuroscience
	Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion generation in fMLP-stimulated rat neutrophils. Cyclomorusin , neocyclomorusin
T75470	Phaeosphaone D
	Phaeosphaone D 是一种硫代二酮哌嗪生物碱化合物，从内生真菌Phaeosphaeria fuckelii 中分离出来。Phaeosphaone D 具有蘑菇酪氨酸酶抑制活性，IC50值为 33.2 μM。
T72579	Dihydroaltenuene B
	Dihydroaltenuene B 是一种有效的 mushroomtyrosinase 抑制剂，IC50为 38.33 µM。Dihydroaltenuene B 显示了 3-OH 和 4'-OH 与酪氨酸酶的 His244、Met280 和 Gly281 残基之间的氢键相互作用。
TN7240	Erinacine A	ROS	Immunology/Inflammation
	Erinacine A 是一种可从猴头菇中提取出的抗癌化合物，能够通过活性氧类 (ROS) 的产生促使癌细胞死亡。Erinacine A 可能通过参与信号通路的调节从而发挥其抗癌活性。Erinacine A 具有抗癌、抗肿瘤和神经保护活性。
TN4179	Haginin A	ERK; Tyrosinase; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activation, MITF, and also by the subsequent downregulation of tyrosinase and TRP-1 production. Hag
T39562	γ-Amanitin
	γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin.
TN1840	Kurarinol	Tyrosinase; HBV; STAT	JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, is a candidate as skin-whitening agents.

天然产物

Cat.No: T8087

Target: Tyrosinase

Cat.No: T33817

Synonym: 2-(1,3-dihydroxy-4-oxopyridin-2-yl)-1,3-dihydroxypyridin-4-one

Target: Others

Cat.No: TCS1709

Synonym: 苄基丙酮,4-Phenylbutan-2-one,Methyl 2-phenylethyl ketone,4-Phenyl-2-butanone

Target: Tyrosinase

Cat.No: T5889

Target: Tyrosinase, Parasite

4-Isopropylbenzoic acid

Cat.No: T20488

Synonym: NSC1907,NSC-1907,NSC 1907,Cumic acid

Target: Antifungal

Benzoyloxypaeoniflorin

Cat.No: T4S1658

Synonym: 苯甲酰氧化芍药苷,Benzoyloxypeoniflorin,苯甲酰氧芍药苷

Target: NF-κB, Tyrosinase

Cat.No: TN7099

Target: NOD

Methyl rosmarinate

Cat.No: TN1928

Target: MMP, Anti-infection, Tyrosinase

Cat.No: T40298

Anthracophyllone

Cat.No: TN3423

Target: Others

Cat.No: TN3644

Target: Tyrosinase, Antifection

Cat.No: TN5376

Synonym: (-)-Axinysone B

Cat.No: TN3372

Target: Others

Cat.No: TN3545

Target: Tyrosinase

Cat.No: T37961

Target: Tyrosinase, Endogenous Metabolite

Cat.No: T39649

Chetoseminudin B

Cat.No: T75471

2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran

Cat.No: TN2672

Target: Tyrosinase

Cat.No: TN2288

Synonym: 乌拉尔醇

Target: Others, Estrogen/progestogen Receptor, Tyrosinase

Cat.No: TN5448

Synonym: Norartocarpanone

Cat.No: T82031

Aristolactam BII

Cat.No: TN3444

Target: HIV Protease

Broussoflavonol F

Cat.No: TMA0593

Target: Tyrosinase

Cat.No: TN3744

Target: NOS, AChR

Cat.No: T75470

Dihydroaltenuene B

Cat.No: T72579

Cat.No: TN7240

Target: ROS

Cat.No: TN4179

Target: ERK, Tyrosinase, Akt

Cat.No: T39562

Cat.No: TN1840

Target: Tyrosinase, HBV, STAT

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