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24

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8760	NNMTi 5-Amino-1-methylquinolinium	Others	Others
	NNMTi (5-Amino-1-methylquinolinium) 是烟酰胺 N -甲基转移酶的抑制剂 (IC50=1.2 μM)，可选择性地结合 NNMT 底物结合位点残基。它能诱导体外成肌细胞分化，提高老年小鼠肌肉干细胞融合和再生能力。
T20657	Muscimol HBr Agarin hydrobromide,Muscimol Hydrobromide,Agarin HBr	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Muscimol HBr (Agarin HBr) 是GABAA 受体的激动剂
T13491	Neuromuscular-targeting compound 1	Others	Others
	Neuromuscular-targeting compound 1 可用于研究肌肉萎缩和神经肌肉相关疾病。
T23034	Muscarine iodide (+)-Muscarine iodide	Others	Others
	Muscarinic acetylcholine receptor agonist
TP2299	tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]	Others	Others
	Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent tra
T24507	Muscarine (+)-Muscarine,Muskarin
	Muscarine is a toxic alkaloid found in Amanita muscaria and other fungi of the Inocybe species.
T81893	M1/M4 muscarinic agonist 2
	M1/M4 muscarinic antagonist 2（compound 40）为选择性抑制M1与M4受体的化合物，其IC50值分别为19 nM和42 nM。
T82467	Endotrophin (Mus musculus)
	Endotrophin (Mus musculus) 为Col6的裂解产物，其上调可能导致纤维化和炎症基因表达增强。
T24508	Muscarine chloride HSDB-3515,(+)-Muscarine chloride,HSDB 3515,L-(+)-Muscarine chloride,EINECS 218-963-2
	Muscarine chloride is a toxic alkaloid found in Amanita muscaria and other fungi of the Inocybe species.
T80183	Muscarinic toxin 7
	Muscarinic toxin 7，一种肽类毒素，特异性地针对毒蕈碱M1受体表现出选择性和非竞争性的拮抗活性。
TP2259	immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus]	Others	Others
	Immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus] is a fragment on the variable region of the human and mouse immunoglobulin light chain. Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule
T22856	IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]	Others	Others
	IgG has four forms, provides the majority of antibody-based immunity against invading pathogens. The only antibody capable of crossing the placenta to give passive immunity to the fetus. Eliminates pathogens in the early stages of B cell-mediated (humoral
T28965	Thiomuscimol hydrobromide
	Thiomuscimol hydrobromide is an agonist of GABAA receptor.
T39138	Muscotoxin A
	Muscotoxin A is an ADC cytotoxin with lipopeptide properties that effectively permeabilizes mammalian cell membranes, ultimately inducing necrotic cell death.
T80477	Muscarinic toxin 3 MT3	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Muscarinic toxin 3 (MT3) 是高效的非竞争性mAChR及adrenoceptors拮抗剂，对M1、M4、α1A、α1B、α1D、α2A、α2B、α2C受体展示出不同程度的选择性，其pIC50值分别为6.71、8.79、8.86、7.57、8.13、8.49、6.5、7.29。该化合物具有显著的肾上腺素受体抑制活性。
T73608	Muscimol hydrochloride
	Muscimol (Agarin; Agarine) hydrochloride 是一种具有精神活性的异恶唑。Muscimol hydrochloride 也是抑制性神经递质 GABA 离子型受体的选择性激动剂。Muscimol hydrochloride 可以从毒蝇伞和相关蘑菇中分离出来。总之，Muscimol 是一种有效的 GABAA 受体激动剂 (EC50=0.2 μM)，部分 GABAC 受体激动剂和无活性的 GABAB 受体激动剂。Muscimol hydrochloride 具有镇静、抗焦虑和致幻作用。
T60253	(±)-Muscarine chloride
	(±)-Muscarine chloride 是 Muscarine chloride 的外消旋体。Muscarine 是一种原型毒蕈碱乙酰胆碱受体 (mAChR) 激动剂。
T22676	Prothrombin (474-477) [Mus musculus]	Others	Others
	Prothrombin (coagulation factor II) is produced in the liver and is post-translationally modified in a vitamin K-dependent reaction that converts ten glutamic acids on prothrombin into gamma-carboxyglutamic acid. Prothrombin is proteolytically cleaved to
T75381	Bodipy TMR-X muscimol
	Bodipy TMR-X muscimol为标记有Bodipy的Muscimol（Ex=543 nm, Em=572 nm），是GABAA受体的激动剂。该化合物适用于可视化可逆脑失活的扩散研究。
T10059	Neuromuscular Disorder-Targeting Compound 1	Others	Others
	Neuromuscular Disorder-Targeting Compound 1 is a compound used in the research of neuromuscular disorders, for example, symptoms of chronic fatigue syndrome and fibromyalgia syndrome.
T61338	MS023 dihydrochloride MS023 2HCl	Histone Methyltransferase	Chromatin/Epigenetic
	MS023 dihydrochloride (MS023 2HCl) 是一种具有选择性、细胞活性和高效性的人I 型蛋白精氨酸甲基转移酶 (PRMTs)抑制剂，具有抗肿瘤活性，抑制 PRMT1，PRMT3，PRMT4，PRMT6和PRMT8，增加离体培养的 MuSC 的增殖能力，可用于研究乳腺癌。
T28685	SB236057 SB-236057,SB 236057
	SB236057 is a potent and selective inverse agonist for the 5-HT receptor, acting especially at 5-HT autoreceptors on nerve terminals. It produces a rapid increase in 5-HT levels in the brain. SB236057 also acts as a potent teratogen, producing severe musc
T3074L	CHIR98014 HCl (252935-94-7 free base) CT-98014,CHIR-98014 hydrochloride,CHIR-98014,CHIR98014 HCl,CHIR98014,CHIR 98014
	CHIR98014 is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50s: 0.65 and 0.58 nM). Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50: 106 nM), potentiates insulin-dependent glucose transport in isolated musc
TP1747	Bradykinin (1-6)
	Bradykinin (1-6) is an amino-truncated Bradykinin peptide. Bradykinin (1-6) is a stable metabolite of Bradykinin, cleaved by carboxypeptidase Y (CPY).Bradykinin (1-6) is a fragment of bradykinin. Bradykinin activates pain receptors. It induces smooth musc

化合物

Cat.No: T8760

Synonym: 5-Amino-1-methylquinolinium

Target: Others

Cat.No: T20657

Synonym: Agarin hydrobromide,Muscimol Hydrobromide,Agarin HBr

Target: GABA Receptor

Neuromuscular-targeting compound 1

Cat.No: T13491

Target: Others

Muscarine iodide

Cat.No: T23034

Synonym: (+)-Muscarine iodide

Target: Others

tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]

Cat.No: TP2299

Target: Others

Cat.No: T24507

Synonym: (+)-Muscarine,Muskarin

M1/M4 muscarinic agonist 2

Cat.No: T81893

Endotrophin (Mus musculus)

Cat.No: T82467

Muscarine chloride

Cat.No: T24508

Synonym: HSDB-3515,(+)-Muscarine chloride,HSDB 3515,L-(+)-Muscarine chloride,EINECS 218-963-2

Muscarinic toxin 7

Cat.No: T80183

immunoglobulin light chain variable region fragment [Homo sapiens]/[Mus musculus]

Cat.No: TP2259

Target: Others

IgG light chain variable region [Homo sapiens]/IgM/kappa antibody [Mus musculus]

Cat.No: T22856

Target: Others

Thiomuscimol hydrobromide

Cat.No: T28965

Cat.No: T39138

Muscarinic toxin 3

Cat.No: T80477

Synonym: MT3

Target: Adrenergic Receptor

Muscimol hydrochloride

Cat.No: T73608

(±)-Muscarine chloride

Cat.No: T60253

Prothrombin (474-477) [Mus musculus]

Cat.No: T22676

Target: Others

Bodipy TMR-X muscimol

Cat.No: T75381

Neuromuscular Disorder-Targeting Compound 1

Cat.No: T10059

Target: Others

MS023 dihydrochloride

Cat.No: T61338

Synonym: MS023 2HCl

Target: Histone Methyltransferase

Cat.No: T28685

Synonym: SB-236057,SB 236057

CHIR98014 HCl (252935-94-7 free base)

Cat.No: T3074L

Synonym: CT-98014,CHIR-98014 hydrochloride,CHIR-98014,CHIR98014 HCl,CHIR98014,CHIR 98014

Bradykinin (1-6)

Cat.No: TP1747

Cat. No.	Product Name	Target	Signaling Pathways
T2893	Muscone 3-Methylcyclopentadecanone,Methylexaltone,麝香酮	MMP; TNF; NF-κB; NOD-like Receptor (NLR); P-gp; Interleukin	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB; Proteases/Proteasome
	Muscone (3-Methylcyclopentadecanone) 是中药麝香的一种主要活性单体。它抑制NF-κB 和NLRP3炎性小体的活化，显著降低炎性细胞因子水平，并最终改善心脏功能和存活率。
T5794	Saponin C from Liriope muscari Liriope muscari baily Saponins C
	Saponin C from Liriope muscari 可从百合科植物 Liriope muscari中提取。
T3809	Liriope muscari baily saponins C	Others	Others
	Liriope muscari baily saponins C 是一种L. muscari (Decne.) Baily 的主要活性成分。它已被作为肿瘤转移候选药物进行研究。它具有很强的抗炎、免疫药理和心脏保护作用。

天然产物

Cat.No: T2893

Synonym: 3-Methylcyclopentadecanone,Methylexaltone,麝香酮

Target: MMP, TNF, NF-κB, NOD-like Receptor (NLR), P-gp, Interleukin

Saponin C from Liriope muscari

Cat.No: T5794

Synonym: Liriope muscari baily Saponins C

Liriope muscari baily saponins C

Cat.No: T3809

Target: Others

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