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Cat. No. | Product Name | Target | Signaling Pathways |
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T79137 |
Monlunabant
(S)-MRI-1891 |
Cannabinoid Receptor | GPCR/G Protein |
Monlunabant ((S)-MRI-1891)为一种固态分散体,并作为大麻素CB1受体的拮抗剂。 | |||
T39410 |
Zevaquenabant
(S)-MRI-1867 |
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Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD). | |||
T39074 |
(Rac)-Zevaquenabant
(Rac)-MRI-1867,(Rac)-Zevaquenabant |
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(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of the cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity (Ki) of 5.7 nM specifically for CB1R. Due to its characteristics, (Rac)-Zevaquenabant holds promise as an investigative tool in liver fibrosis research. | |||
T83533 |
(R)-Monlunabant
(R)-MRI-1891 |
Cannabinoid Receptor | GPCR/G Protein |
(R)-Monlunabant ((R)-MRI-1891)为CB1受体调节剂,应用于肥胖及代谢病研究领域。 | |||
T8406 |
Gadobutrol
ZK 135079,钆布醇 |
Others | Others |
Gadobutrol 是一种非离子的顺磁造影剂,可用于磁共振成象(MRI)。 | |||
T19333 |
Gadoteridol
ProHance,SQ-32692,钆特醇,Gd-HP-DO3A |
Others | Others |
Gadoteridol (Gd-HP-DO3A) 是含钆基的 MRI 造影剂,可用于中枢神经系统成像。 | |||
T1265 |
Amrinone
Inamrinone,Inocor,氨力农,Wincoram |
TNF; PDE | Apoptosis; Metabolism |
Amrinone (Inocor) 是一种正性肌力血管扩张剂,是一种具有口服活性的,非糖苷和非儿茶酚胺的强心剂,也是一种选择性磷酸二酯酶 III (phosphodiesterase III) 抑制剂,能够防止环磷酸腺苷分解,从而增加环磷酸腺苷水平。 | |||
T28078 |
MMRi64
|
Apoptosis; Mdm2; p53 | Apoptosis |
MMRi64 是 Mdm2-MdmX E3 连接酶活性的特异性抑制剂。MMRi64 能有效诱导 p53 积累,并诱导白血病/淋巴瘤细胞中 p53 途径的凋亡,破坏 Mdm2-MdmX 相互作用, 下调白血病细胞中的 Mdm2 和 MdmX。MMRi64 MMRi64 可用于癌症研究。 | |||
T60202 |
MMRi62
7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol |
Ferroptosis | Apoptosis |
MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol) 是一种铁死亡 (ferroptosis) 诱导剂,靶向 MDM2-MDM4 (抑癌基因 p53 负调控因子)。MMRi62 对胰腺导管腺癌 (PDAC) 细胞显示出 p53 独立的促凋亡 (apoptosis) 活性,并诱导其自噬 (autophagy)。MMRi62 诱导铁死亡,伴随着活性氧增加和铁蛋白重链 (FTH1) 溶酶体降解。MMRi62 还可导致突变型 p53 的蛋白酶体降解,并对具有 KRAS 和 TP53 高频突变特征的原位异种移植 PDAC 小鼠模型具有体内药效。 | |||
T6826 |
Emricasan
PF 03491390,恩利卡生,IDN-6556 |
Influenza Virus; Caspase | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Emricasan (IDN-6556) 是一种泛的 caspase 抑制剂,具有不可逆性。Emricasan 具有抗炎和抗凋亡活性,可以用于治疗感染和肝衰竭等。Emricasan 还可以抑制 Zika 病毒感染。 | |||
T26623 |
AMRI-59
AMRI 59 |
Others | Others |
AMRI-59 是一种有效的 PrxI 抑制剂,具有抗肿瘤活性。 | |||
T80471 |
α-Conotoxin MrIC
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α-Conotoxin MrIC为特异性α7nAChR偏向激动剂,仅针对II型正变构调节剂(例如PNU120596)调控的α7nAChR产生激活作用。该化合物适用于神经系统疾病研究,以及α7nAChR药理特性的探测。 | |||
T68742 |
Inamrinone lactate
|
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Inamrinone lactate is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. | |||
T81155 |
Simridarlimab
|
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Simridarlimab是一种针对CD274/CD47的人源化IG类抗体。 | |||
T36891 | MRIA9 | ||
MRIA9 是 ATP 竞争性的、pan-SIK 和PAK2/3抑制剂,其对 SIK1、SIK2 和SIK3的IC50值分别为 516 nM, 180 nM 和 127 nM。 | |||
T19332 |
Gadopentetic acid
gadolinium complex,钆喷酸,Gd-DTPA |
Others | Others |
Gadopentetic acid (gadolinium complex) 是一种顺磁性造影剂,通常通过静脉内注射 (i.v.) 的方式用于 DCE-MRI 研究。 | |||
T5161 |
Gadodiamide
|
Others | Others |
Gadodiamide 是一种含钆造影剂,可用于医学成像。 | |||
T67967 |
EOB-DTPA
N-((2s)-2-(bis(carboxymethyl)amino)-3-(4-ethoxyphenyl)propyl)-n-(2-(bis(carboxymethyl)amino)ethyl)glycine |
Others | Others |
EOB-DTPA 是一种生化试剂,可由其他化合物合成,常用于核磁共振成像。 | |||
T4506 |
Gadopentetate dimeglumine
Meglumine gadopentetate,SH-L-451A,Gd-DTPA,Gadopentetic acid dimeglumine,钆喷酸葡胺,Gadopentetic acid dimeglumine salt |
Others | Others |
Gadopentetate dimeglumine (Gd-DTPA) 可用于核磁共振成像 (MRI) 中,使血管、器官和其他非骨组织能够更清晰地被看到。 | |||
T15367 |
Gadoxetate Disodium
Gd-EOB-DTPA Disodium,钆塞酸二钠,ZK 139834 |
Others | Others |
Gadoxetate Disodium 是一种肝胆系统中磁共振成像 (MRI) 中的造影剂,能够在正常的功能性肝细胞中累积,可用于局灶性肝脏病变(如肝细胞癌或 T1 加权成像的肝转移)的研究。 | |||
T20110 |
Ethylene thiourea
ETU,Imidazolidinethione,NCI C03372,NCIC03372,NCI-C03372,亚乙基硫脲 |
Others | Others |
Ethylene thiourea (NCIC03372) 是一种用于水果和蔬菜生产的农药。它还用作基于质子化学交换依赖性饱和转移的 MRI 研究的新型造影剂。 | |||
T34699 |
Sprodiamide
S 043,S043,S-043 |
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Sprodiamide is a magnetic susceptibility-based MRI contrast agent. | |||
TNU0613 |
S-2-(4-aminobenzyl)-diethylenetriamine penta-t-butyl acetate
|
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Super-chelating agent& MRI contrast agent | |||
T33853 |
P 569
P569,P-569 |
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P 569 is an MRI contrast medium. | |||
T19413 |
Mangafodipir trisodium
|
Others | Others |
Mangafodipir trisodium can enhance contrast in magnetic resonance imaging (MRI) of the liver, is a contrast agent delivered intravenously. | |||
TNU0612 |
S-2-(4-Aminobenzyl)-diethylenetriamine pentaacetic acid TFA salt, p-NH2-Bn-DTPA-TFA
|
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Super-chelating agent & MRI contrast agent | |||
T6508 |
Gadodiamide Hydrate
Omniscan,钆双胺 |
Others | Others |
Gadodiamide Hydrate (Omniscan) 是一种造影剂,用于MR 中血管成像。它是非离子 Gd3+ 螯合物,经常静脉注射。 进入磁共振成像以增强对比度。 | |||
T8406L |
Gadobutrol Monohydrate
Gd-DO3A-butrol |
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Gadobutrol is a medicinal product used in diagnostic magnetic resonance imaging (MRI) in adults and children. It provides contrast enhancement during cranial, spinal, breast, or other investigations. In the central nervous system, Gadobutrol works by high | |||
T38783 |
DOTA-tri(t-butyl ester)
|
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DOTA-tri(t-butyl ester) is a versatile compound employed for the synthesis of third-generation (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents. These contrast agents find application in the fields of MR angiography and tumor angiogenesis imaging. | |||
T83663 |
Mn(III) Protoporphyrin IX Chloride
Manganese(III) Protoporphyrin IX Chloride |
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Mn(III) protoporphyrin IX chloride是一种金属卟啉,当浓度为10 µM时,能在鸡胚肝细胞中诱导δ-氨基酮戊二酸合成酶和血红素加氧酶(HO)基因的mRNA表达,这些酶分别催化血红素生物合成和降解的限速步骤。Mn(III) protoporphyrin IX chloride含纳米仿生物已被用于体外纤维蛋白凝块的磁共振成像(MRI)研究。此外,它还被用于Mn(III) protoporphyrin IX-6(7)-甘氨酰-甘氨酰-L-组氨酸甲酯(MnGGH)的合成,MnGGH是一种具有微过氧化物酶活性的金属卟啉衍生物。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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TJS1183 |
Cyclen
轮环藤宁,1,4,7,10-tetraazacyclododecane |
Others | Others |
Cyclen (1,4,7,10-tetraazacyclododecane) 是一种氮杂冠醚的类似物,是制备有效的大环螯合物的中间体,是制备磁共振造影剂的前体物质。 |