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18

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T78181	MMP-7-IN-2	MMP; Others	Others; Proteases/Proteasome
	MMP-7-IN-2 可作为一种具有选择性和有效性的 MMP7 抑制剂，可用于研究炎症反应和与血管相关的疾病。
T72069	MMP-9-IN-7
	MMP-9-IN-7抑制前基质金属蛋白酶活化,可用于预防、治疗或改善 MMP9和/或 MMP13介导的综合征。
T21806	HNHA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HNHA 是组蛋白去乙酰化酶抑制剂。它通过 p21诱导将细胞周期阻滞在 G1/S 期，抑制肿瘤生长及肿瘤新生血管形成。HNHA 可能是一种有效的抗乳腺癌药物。
T81778	MMP-7-IN-3	MMP	Proteases/Proteasome
	MMP-7-IN-3为一种高效MMP-7选择性抑制剂，能够在单侧输尿管梗阻的小鼠模型中阻止肾纤维化的发展。
T6885	Marimastat BB2516,马立马司他,KB-R8898,TA2516	MMP	Proteases/Proteasome
	Marimastat (BB2516) 是一种血管生成和转移抑制剂，限制血管的生长和生成。它是一种广谱的，具有口服活性的MMPs 抑制剂，有效抑制 MMP-9 , MMP-1, MMP-2, MMP-14, MMP-7，用于癌症的研究。
T14322	ARP-100 MMP-2 Inhibitor III	MMP	Proteases/Proteasome
	ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM)，MMP-3 (4.5 μM)，MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1＇口袋相互作用，并在体外对基质胶的侵袭模型中显示抗侵袭特性。
T36712	BPHA MMP-2/MMP-9 Inhibitor II	MMP	Proteases/Proteasome
	BPHA (MMP-2/MMP-9 Inhibitor II) 是一种有效的、具有选择性和口服活性的抑制剂，对MMP-2、MMP-9 和 MMP-14 具有抑制作用，IC50 分别为 12 nM、16 nM 和 17 nM。BPHA 不抑制 MMP-1、-3 和 -7 (IC50 分别为 974、>1000 和 795 nM)。BPHA 具有抗血管生成和抗肿瘤活性。
T6011	Batimastat 巴马司他,BB94	MMP	Proteases/Proteasome
	Batimastat (BB94) 是广谱MMP 抑制剂，能够抑制MMP-1 (IC50:3 nM)，MMP-2 (IC50:4 nM)，MMP-9 (IC50:4 nM)，MMP-7 (IC50:6 nM) 和 MMP-3 (IC50:20 nM)。
TP1501L	CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)	MMP	Proteases/Proteasome
	CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base) 是基质金属蛋白酶 (MMP)-2 和 MMP-9 的抑制剂。它也被称为IV 型胶原酶或明胶酶。明胶酶是癌症治疗干预的潜在靶点，这些酶的抑制剂可以防止肿瘤进展。
T10461	Batimastat sodium salt BB-94 sodium salt	MMP	Proteases/Proteasome
	Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3).
T36363	Dnp-RPLALWRS (trifluoroacetate salt)
	Dnp-RPLALWRS is a fluorogenic substrate for matrix metalloproteinase-7 (MMP-7). The activity of MMP-7 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group.
T37025	Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2
	Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Upon cleavage by MMP-14, 7-methoxycoumarin-4-acetyl (Mca) is released and its fluorescence can be used to quantify MMP activity. Mca displays excitation/emission maxima of 328/420 nm, respectively.
T37983	GM 1489
	GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phor...
T83759	MMP-3 Fluorogenic Substrate TFA Mca-RPKPVE-Nval-WR-K(Dnp)-NH2,Matrix Metalloproteinase-3 Fluorogenic Substrate,Stromelysin-1 Fluorogenic Substrate
	MMP-3 fluorogenic substrate 是一种针对基质金属蛋白酶-3（MMP-3）的荧光底物。当被MMP-3切割后，7-甲氧基香豆素-4-乙酰基（Mca）会释放并且其荧光可用于量化MMP-3活性。Mca的激发/发射峰值分别为328/420 nm。
T81777	MMP-9-IN-8
	MMP-9-IN-8（Compound 3）是MMP-9抑制剂，10 μM浓度下抑制活性为42.16%，50 μM时达58.28%。该化合物展现抗癌活性，能诱导MCF-7细胞凋亡，IC50为23.42 μM。
T41079	MMP13-IN-2 MMP13-IN-2
	MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases.
T83708	Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 (Dpa = N-3-(2,4-dinitrophenyl)l-α,β-diaminopropionyl),FS-6
	Mca-KPLGL-Dap(Dnp)-AR-NH2是一种用于矩阵金属蛋白酶(MMPs)的荧光底物。当被MMPs切割时，7-甲氧基香豆素-4-乙酰基(Mca)会释放，其荧光可用来定量MMP活性。Mca的激发/发射峰值分别为328/420 nm。
T36844	Inostamycin A
	Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes) and is selective for CDP-diacylglycerol:inositol 3-phosphatidyltransferase over phospholipase C (PLC) and phosphatidylinositol kinase at 10 μg/ml.2Inostamycin A decreases viability of YCU-T892, KCC-TC873, KB, HSC-4, and YCU-T891 oral squamous cell carcinoma (OSCC) cells in a con...

化合物

Cat.No: T78181

Target: MMP, Others

Cat.No: T72069

Cat.No: T21806

Target: HDAC

Cat.No: T81778

Target: MMP

Cat.No: T6885

Synonym: BB2516,马立马司他,KB-R8898,TA2516

Target: MMP

Cat.No: T14322

Synonym: MMP-2 Inhibitor III

Target: MMP

Cat.No: T36712

Synonym: MMP-2/MMP-9 Inhibitor II

Target: MMP

Cat.No: T6011

Synonym: 巴马司他,BB94

Target: MMP

CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)

Cat.No: TP1501L

Target: MMP

Batimastat sodium salt

Cat.No: T10461

Synonym: BB-94 sodium salt

Target: MMP

Dnp-RPLALWRS (trifluoroacetate salt)

Cat.No: T36363

Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2

Cat.No: T37025

Synonym: Mca-PLAC(p-OMeBz)-WAR(Dpa)-NH2

Cat.No: T37983

MMP-3 Fluorogenic Substrate TFA

Cat.No: T83759

Synonym: Mca-RPKPVE-Nval-WR-K(Dnp)-NH2,Matrix Metalloproteinase-3 Fluorogenic Substrate,Stromelysin-1 Fluorogenic Substrate

Cat.No: T81777

Cat.No: T41079

Synonym: MMP13-IN-2

Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA

Cat.No: T83708

Synonym: Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 (Dpa = N-3-(2,4-dinitrophenyl)l-α,β-diaminopropionyl),FS-6

Cat.No: T36844

Cat. No.	Product Name	Target	Signaling Pathways
T4115	Auraptene 橙皮油内酯,7-geranyloxycoumarin,橙皮油素	MMP; BACE	Neuroscience; Proteases/Proteasome
	Auraptene 是一种丰富的天然香叶氧基香豆素。它能够抑制基质金属蛋白酶 2 以及关键炎症因子，包括 IL-6，IL-8 和趋化因子 (C-C 基序) 配体-5 (CCL5）的分泌。
T5S1026	Apigenin-7-glucuronide Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸	MMP	Proteases/Proteasome
	Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) 能够抑制基质金属蛋白酶的活性，其对 MMP-3 (IC50:12.87 μM)，MMP-8 (IC50:22.39 μM)，MMP-9 (IC50:17.52 μM)，MMP-13 (IC50:0.27 μM)。
T3850	Luteolin 7-O-glucuronide Luteolin-7-glucuronide,木犀草素-7-O-葡萄糖醛酸苷	MMP	Proteases/Proteasome
	Luteolin 7-O-glucuronide (Luteolin-7-glucuronide) 是一种自由基清除剂，能够抑制基质金属蛋白酶的活性，其对 MMP-1，MMP-3，MMP-8，MMP-9，MMP-13的IC50值分别为 17.63，7.99，11.42，12.85，0.03 μM。
T5S0045	Isofraxidin 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶	MMP; ERK; p38 MAPK; TLR; COX	Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome
	Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分，抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞，抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达，还抑制TLR4/髓样分化蛋白 2 复合物的形成。
T3729	Ethyl gallate Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯	MMP; NF-κB; Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。
TN4978	Scutellarein-7-O-glucoside	MMP	Proteases/Proteasome
	Scutellarein-7-O-glucoside inhibites MMP-2 activity.

天然产物

Cat.No: T4115

Synonym: 橙皮油内酯,7-geranyloxycoumarin,橙皮油素

Target: MMP, BACE

Apigenin-7-glucuronide

Cat.No: T5S1026

Synonym: Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸

Target: MMP

Luteolin 7-O-glucuronide

Cat.No: T3850

Synonym: Luteolin-7-glucuronide,木犀草素-7-O-葡萄糖醛酸苷

Target: MMP

Cat.No: T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶

Target: MMP, ERK, p38 MAPK, TLR, COX

Cat.No: T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯

Target: MMP, NF-κB, Akt, Antibacterial

Scutellarein-7-O-glucoside

Cat.No: TN4978

Target: MMP

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