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Targets Recommended: JNK

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T7008	Vacquinol-1 Vacquinol 1	JNK	MAPK
	Vacquinol-1 能够激活 MAPK 通路，是MKK4特异性激活剂。它可以诱导肝细胞癌细胞凋亡，在多形性胶质母细胞瘤小鼠模型中特异性诱导人胶质母细胞瘤细胞死亡、减缓肿瘤进展并延长生存期。
T73182	BSJ-04-122	JNK	MAPK
	BSJ-04-122 是一种共价 MKK4/7 双重抑制剂，对 MKK4 和 MKK7 有抑制作用，IC50 值分别为 4 nM 和 181 nM。BSJ-04-122 可用于研究癌症。
T72956	Darizmetinib HRX215	MAPK	MAPK
	Darizmetinib (HRX215) 是一种 MKK4 抑制剂，MKK4 的抑制导致 MKK7 和 JNK1 信号通路的增强，进而激活转录因子 ATF2 和 ELK1，促进细胞增殖和肝再生。
T61755	E6201
	E6201 (ER-806201) is a potent dual kinase inhibitor targeting MEK1 and FLT3, inhibiting their activities in an ATP-competitive manner. It effectively suppresses MEK1-induced ERK2 phosphorylation (IC50 = 5.2 nM), MKK4-induced JNK phosphorylation (IC50 = 91 nM), and MKK6-induced p38 MAPK phosphorylation (IC50 = 19 nM). E6201 exhibits anti-tumor and anti-psoriasis effects [1] [2].
T6643L	Ro 31-8220
	Ro 31-8220 是一种有效的PKC 抑制剂，对 PKCα，PKCβI，PKCβII，PKCγ，PKCε 和大鼠大脑 PKC 的IC50值为 5，24，14，27，24 和 23 nM。Ro 31-8220还显著抑制 MAPKAP-K1b，MSK1，S6K1 和 GSK3β，IC50值分别为3，8，15，38 nM，对 MKK3，MKK4，MKK6 和 MKK7 无作用。

化合物

Vacquinol-1

Cat.No: T7008

Synonym: Vacquinol 1

Cat. No.	Product Name	Target	Signaling Pathways
TN1236	3',4',7-Trihydroxyisoflavone	MAPK; JNK	MAPK
	3',4',7-Trihydroxyisoflavone 是大豆异黄酮大豆苷元衍生物，是 Cot (Tpl2/MAP3K8) 和 MKK4 抑制剂，具有抗癌、抗血管生成和自由基清除特性。3',4',7-Trihydroxyisoflavone 通过调节小鼠胆碱能功能和BDNF信号通路增强记忆作用，可改善因内源性或外源性糖皮质激素而受损的皮肤屏障功能，可用于研究特应性皮炎。
TN4263	Isoangustone A	MMP; GSK-3; NF-κB; ROS; Akt; PI3K; CDK; JNK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-ÎºB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.

天然产物

3',4',7-Trihydroxyisoflavone

Cat.No: TN1236

Synonym:

Target: MAPK, JNK

Isoangustone A

Cat.No: TN4263

Synonym:

Target: MMP, GSK-3, NF-κB, ROS, Akt, PI3K, CDK, JNK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04572	MKK4 Protein, Mouse, Recombinant (His & GST) MKK4,MEK4,PRKMK4,Sek1,JN...	Mouse	Baculovirus Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / ...

重组蛋白

MKK4 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04572

Species: Mouse

Expression System: Baculovirus Insect Cells

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