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Search Results for " m6 "

38

抑制剂 & 化合物

1

天然产物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T25225	Cephabacin M6 Cephabacin M(sub 6)
	Cephabacin M6 is a new cephem antibiotic isolated from bacterial.
T37645	Dasatinib metabolite M6 达沙替尼羧酸
	Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib, a potent and orally active inhibitor of both Bcr-Abl and Src family tyrosine kinases[1].
T31055	CP-457493 OSI-493,Erlotinib metabolite M6,CP457493,UNII-X0JH558S7E
	CP-457493 is a bio-active chemical.
T17105	TM6089	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	TM6089 是一种脯氨酰羟化酶抑制剂，可在没有铁螯合的情况下刺激 HIF 活性，诱导血管生成，并保护器官免受缺血。
T10896L	CSRM617 hydrochloride CSRM617 hydrochloride(787504-88-5 Free base)	Apoptosis; Others; Androgen Receptor	Apoptosis; Endocrinology/Hormones; Others
	CSRM617 hydrochloride 是转录因子ONECUT2(OC2，雄激素受体 AR 的主要调节剂) 的选择性小分子抑制剂，在 SPR 测定中Kd 为 7.43 uM，直接与 OC2-HOX 结构域结合。CSRM617 hydrochloride 通过裂解 Caspase-3 和 PARP 诱导细胞凋亡 (apoptosis)。CSRM617 hydrochloride 在小鼠的前列腺癌模型中具有良好的耐受性。
TP1993L	M617 acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	M617 acetate 是甘丙肽受体 1 (GAL1) 的选择性激动剂。 M617 acetate 通过中枢 GAL1 起作用，促进 GLUT4 表达，并提高 2 型糖尿病大鼠心肌中的 GLUT4 含量。 GAL1 和 GAL2 的 Ki 值分别为 0.23 和 5.71 nM。
T26629	Angstrom6 A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide	PAI-1	Metabolism
	Angstrom6 (A-6 peptide) 是一种从单链尿激酶纤溶酶原激活剂(scuPA)中提取的 8 肽，它能干扰 uPA/uPAR 级联反应并抑制下游效应。Angstrom6 具有抗肿瘤活性，能通过与 CD44 结合并调节 CD44 介导的细胞信号传导，抑制肿瘤细胞的迁移、侵袭和转移。
T29303	1M6 1M-6,1M 6,1-Methyl-6-nitroisatoic anhydride
	1M6 (1-Methyl-6-nitroisatoic anhydride) 是一种 SHAPE 试剂，可用于检测 RNA 化学结构。
T37292	M62812	TLR	Immunology/Inflammation
	M62812是一种 TLR4抑制剂，可在 HEK239细胞中抑制 LPS 诱导的NF-κB 活化。
T8649	TMBIM6 antagonist-1 BAX-inhibitor-1,1-（2-氨基苯基）-3-（3-硝基苯基）-2-丙烯-1-酮,BIA	mTOR	PI3K/Akt/mTOR signaling
	TMBIM6 antagonist-1 (BAX-inhibitor-1) 是有潜力的TMBIM6拮抗剂，能够抑制 TMBIM6 与 mTORC2 结合，抑制 mTORC2 活性，调节TMBIM6 释放 Ca2+。
T10896	CSRM617	Others	Others
	CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the
T80396	Im6
	Im6是一种具有针对金黄色葡萄球菌和枯草芽孢杆菌(革兰氏阳性细菌)的抗菌活性的抗菌肽。
T23826	BSBM6 BSBM 6,BSBM-6
	BSBM6 is an inhibitor of Aβ aggregation and neuronal toxicity that acts by reversing the aggregation and toxicity of amyloid-β peptides.
T71493	AM6580
	AM6580 is an irreversible monoacylglycerol lipase (MGL) inhibitor.
T28545	RM65
	RM65 is an arginine methyltransferase inhibitor.
T81891	M65
	M65为PAC1受体特异性拮抗剂，可抑制ANP释放。
T10563	BM635	Others	Others
	BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T74474	m7Gpppm6AmpG ammonium
	m7Gppm6AmpG ammonium 是一种三核苷酸 mRNA 5' 帽类似物，可用于体外 RNA 的合成。
T22563	AM6545	Others	Others
	CB1 selective neutral antagonist
T63613	JM6
	JM6 是弱犬尿氨酸 3-单加氧酶 (kynurenine 3-monooxygenase, KMO) 抑制剂，能够作用于小鼠 KMO (IC50: 19.85 μM)。JM6 能够用于研究阿尔茨海默病。
T14205	AM679	Others	Others
	AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively. IC50 value: 2.2 nM/0.6 nM/154 nM(FLAP binding/hLA/hWB) [1] AM679 showed an improved CYP inhibition profile (IC50 3A4 = 16.7 lM, 2C9 =
T28805	SLM6 NSC-107517,NSC 107517,Sangivamycin-Like Molecule 6,SLM 6,SLM-6
	SLM6, an inhibitor of cyclin-dependent kinase-9 (CDK9), exhibits potent anti-multiple myeloma activity.
T19405	LOM612	Others	Others
	LOM612 is a potent FOXO relocator, with an EC50 value of 1.5 μM in U2fox RELOC cells.
T34892	TM608 TM-608,TM 608
	TM608 is a potent selective c-Met inhibitor that targets mitochondria and kills erlotinib-resistant lung cancer cells, rapidly accumulates in mitochondria, and inhibits MET activation in high MET expression, erlotinib-resistant HCC827B cells (total cell l
T10563L2	BM635 mesylate (1493762-74-5 free base) BM635 mesylate	Others	Others
	BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T78561	M62812 free base
	M62812 (free base) 是一种TLR4信号转导抑制剂，能够抑制内皮细胞和白细胞的活化，有效预防小鼠致死性感染性休克，适用于脓毒症的研究。
T26281	TM6008 TM 6008,TM-6008
	TM6008 is an inhibitor of prolyl hydroxylase that protects against cell death after hypoxia.
T75817	M617 TFA
	M617 TFA 是一种选择性甘丙肽受体 1(GAL1)激动剂，对 GAL1 和 GAL2 的 Ki 分别为 0.23 和 5.71 nM。M617 TFA 通过其中枢 GAL1 作用，促进 2 型糖尿病大鼠心肌 GLUT4的表达，提高 GLUT4的含量。
T33138	M6407
	M6407 is a bioactive chemical.
T62358	BM635 hydrochloride
	BM635 hydrochloride 是一种 MmpL3 抑制剂，表现出显著的抗分歧杆菌效果，能够抑制结合分歧杆菌 H37Rv (MIC50: 0.08 μM)。与游离 BM635 相比，BM635 hydrochloride 在体内暴露量提高了一倍。
T63263	BM635 mesylate
	BM635 mesylate 是一种 MmpL3 的抑制剂，表现出明显的抗分歧杆菌作用，抑制和结合分歧杆菌 H37Rv 的 MIC50值为 0.6 μM。与游离态 BM635 相比，BM635 mesylate 能够明显提高生物利用度。
T10563L	BM635 hydrochloride (1493762-74-5 free base) BM635 hydrochloride	Others	Others
	BM635 hydrochloride is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T70071	SLM6031434 (free base)
	SLM6031434 (free base) is an inhibitor of sphingosine kinase type 2 (SphK2). It consists of pedant 1-guanidino-2-phenyloxadiazolylpyrrolidine group.
T74473	m7Gpppm6AmpG
	m7Gppm6AmpG 是一种三核苷酸 mRNA 5' 帽类似物，可用于体外 RNA 合成。
TP1993	M617
	Selective galanin GAL1 receptor agonist (Ki values are 0.23 and 5.71 nM for GAL1 and GAL2 receptors respectively). Enhances food consumption in rats following i.c.v. administration and reduces CAP-induced inflammatory pain.
T72020	AM6701
	AM6701 is a novel highly potent inhibitor of human alpha/beta hydrolase domain 6 (habhd6)
T28806	SLM6031434 HCl SLM 6031434,SLM6031434,SLM-6031434
	SLM6031434 is selective inhibitor of SphK2.
T73511	SZM679	RIP kinase	Apoptosis; NF-κB
	SZM679是一种口服有效的选择性RIPK1抑制剂，其对RIPK1的Kd值为8.6 nM，而对RIPK3的Kd值则大于5000 nM。该化合物能够逆转肿瘤坏死因子诱导的全身炎症反应，并在海马和皮质中降低Tau蛋白的过度磷酸化、神经炎症以及RIPK1磷酸化水平。SZM679可用于阿尔茨海默病（AD）的研究。

化合物

Cat.No: T25225

Synonym: Cephabacin M(sub 6)

Dasatinib metabolite M6

Cat.No: T37645

Synonym: 达沙替尼羧酸

Cat.No: T31055

Synonym: OSI-493,Erlotinib metabolite M6,CP457493,UNII-X0JH558S7E

Cat.No: T17105

Target: HIF/HIF Prolyl-Hydroxylase

CSRM617 hydrochloride

Cat.No: T10896L

Synonym: CSRM617 hydrochloride(787504-88-5 Free base)

Target: Apoptosis, Others, Androgen Receptor

Cat.No: TP1993L

Target: Neuropeptide Y Receptor

Cat.No: T26629

Synonym: A-6,A 6 peptide,A6,A 6,A6 peptide,A-6 peptide

Target: PAI-1

Cat.No: T29303

Synonym: 1M-6,1M 6,1-Methyl-6-nitroisatoic anhydride

Cat.No: T37292

Target: TLR

TMBIM6 antagonist-1

Cat.No: T8649

Synonym: BAX-inhibitor-1,1-（2-氨基苯基）-3-（3-硝基苯基）-2-丙烯-1-酮,BIA

Target: mTOR

Cat.No: T10896

Target: Others

Cat.No: T80396

Cat.No: T23826

Synonym: BSBM 6,BSBM-6

Cat.No: T71493

Cat.No: T28545

Cat.No: T81891

Cat.No: T10563

Target: Others

m7Gpppm6AmpG ammonium

Cat.No: T74474

Cat.No: T22563

Target: Others

Cat.No: T63613

Cat.No: T14205

Target: Others

Cat.No: T28805

Synonym: NSC-107517,NSC 107517,Sangivamycin-Like Molecule 6,SLM 6,SLM-6

Cat.No: T19405

Target: Others

Cat.No: T34892

Synonym: TM-608,TM 608

BM635 mesylate (1493762-74-5 free base)

Cat.No: T10563L2

Synonym: BM635 mesylate

Target: Others

M62812 free base

Cat.No: T78561

Cat.No: T26281

Synonym: TM 6008,TM-6008

Cat.No: T75817

Cat.No: T33138

BM635 hydrochloride

Cat.No: T62358

Cat.No: T63263

BM635 hydrochloride (1493762-74-5 free base)

Cat.No: T10563L

Synonym: BM635 hydrochloride

Target: Others

SLM6031434 (free base)

Cat.No: T70071

Cat.No: T74473

Cat.No: TP1993

Cat.No: T72020

Cat.No: T28806

Synonym: SLM 6031434,SLM6031434,SLM-6031434

Cat.No: T73511

Target: RIP kinase

Cat. No.	Product Name	Target	Signaling Pathways
T8878	urolithin M6 尿石素M6,3,8,9,10-tetrahydroxy urolithin	Others	Others
	urolithin M6 (3,8,9,10-tetrahydroxy urolithin) 是一种由肠道微生物群产生的鞣花单宁代谢物，被确定为推定的没食子黄素模拟物。

天然产物

Cat.No: T8878

Synonym: 尿石素M6,3,8,9,10-tetrahydroxy urolithin

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01334	EMMPRIN/CD147 Protein, Canine, Recombinant (His) Basigin,BSG,M6,OK,5F7,TCSF,CD147	Canine	HEK293 Cells
	CD147, also known as extracellular matrix metalloproteinase inducer (EMMPRIN) or basigin, is expressed in a variety of cell types. It is involved in the regulation of extracellular matrix (ECM) remodeling during physiological and pathological processes including wound healing, inflammatory diseases, and cancer. CD147 is a diagnostic and therapeutic target in cancer and inflammatory diseases, either directly or indirectly, by targeting CD147 partners.
TMPY-00685	EMMPRIN/CD147 Protein, Human, Recombinant CD147,TCSF,5F7,Basigin,OK,M6,basigin (Ok blood grou...	Human	HEK293 Cells
	EMMPRIN/CD147 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 20.7 kDa and the accession number is P35613-2.
TMPY-00684	EMMPRIN/CD147 Protein, Human, Recombinant (hFc) EMMPRIN,CD147,OK,M6,TCSF,Basigin,5F7,basigin (Ok bl...	Human	HEK293 Cells
	EMMPRIN/CD147 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is P35613-2.
TMPH-00797	HopQ Protein, Helicobacter pylori Hp M6, Recombinant (His & Myc)	Helicobacter pylori Hp M6	E. coli
	HopQ Protein, Helicobacter pylori Hp M6, Recombinant (His & Myc) is expressed in E. coli.
TMPH-00998	CD147 Protein, Human, Recombinant (aa 138-323, hFc) HAb18G,BSG,Basigin,CD147,EMMPRIN,Extracellular matrix metall...	Human	HEK293 Cells
	CD147 Protein, Human, Recombinant (aa 138-323, hFc) is expressed in HEK293.
TMPJ-00160	EMMPRIN/CD147 Protein, Human, Recombinant (His) 5F7,TCSF,OK Blood Group Antigen,Tumor Cell-Derived Collagena...	Human	HEK293 Cells
	Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) belongs to the immunoglobulin superfamily, which has the homology to both the immunoglobulin V domain and MHC class II antigen β-chain. EMMPRIN is a transmembrane glycoprotein with different forms, resulting from different modes of glycosylation and N-terminal sequence variants. EMMPRIN can be expressed in breast cancer, oral squamous cell carcinoma, glioma, lymphoma, lung, bladder, and melanoma carcinomas cells. EMMPRIN promotes invasion,...
TMPY-00971	CEACAM6 Protein, Human, Recombinant (His) NCA,CD66c,CEA,CEAL,carcinoembryonic antigen-related cell adh...	Human	HEK293 Cells
	CEACAM6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.6 kDa and the accession number is P40199.
TMPY-05850	CEACAM6 Protein, Cynomolgus, Recombinant (His) carcinoembryonic antigen-related cell adhesion molecule 6 (n...	Cynomolgus	HEK293 Cells
	CEACAM6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33.3 kDa and the accession number is XP_005589488.1.
TMPH-02634	TRIM63 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate...
TMPY-06760	CEACAM6 Protein, Human, Recombinant (hFc) carcinoembryonic antigen-related cell adhesion molecule 6 (n...	Human	HEK293 Cells
	CEACAM6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.94 kDa and the accession number is NP_002474.3.
TMPH-03282	TRIM63 Protein, Rat, Recombinant (His & Myc)	Rat	E. coli
	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate...
TMPK-00232	CEACAM6 Protein, Human, Recombinant (His & Avi) CEA,CD66c,CEAL,CEACAM6,NCA	Human	HEK293 Cells
	Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. CEACAM6 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 34.1 kDa and the accession number is P40199.
TMPK-01311	CEACAM6 Protein, Cynomolgus, Recombinant (aa 35-320, His) CEACAM6,CEAL,CEA,NCA,CD66c	Cynomolgus	HEK293 Cells
	Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. CEACAM6 Protein, Cynomolgus, Recombinant (aa 35-320, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 32.73 kDa and the accession number is XP_014979566.2.
TMPH-01271	TRIM63 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate...
TMPK-00233	CEACAM6 Protein, Human, Recombinant (aa 35-320, His & Avi), Biotinylated NCA,CEACAM6,CEA,CD66c,CEAL	Human	HEK293 Cells
	Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development. CEACAM6 Protein, Human, Recombinant (aa 35-320, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 34.1 kDa and the accession number is P40199.
TMPY-05460	CEACAM6 Protein, Human, Recombinant (His), Biotinylated CEAL,NCA,CEA,carcinoembryonic antigen-related cell adhesion ...	Human	HEK293 Cells
	CEACAM6 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.6 kDa and the accession number is P40199.
TMPY-06758	CEACAM6 Protein, Human, Recombinant (His & Avi), Biotinylated NCA,CEAL,CD66c,carcinoembryonic antigen-related cell adhesio...	Human	HEK293 Cells
	CEACAM6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 34.47 kDa and the accession number is NP_002474.3.
TMPY-00150	IGF2/IGF-II Protein, Human, Recombinant PP9974,胰岛素样生长因子,C11orf43,IGF-II,insulin-like growth factor 2	Human	P. pastoris (Yeast)
	Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in br...

重组蛋白

EMMPRIN/CD147 Protein, Canine, Recombinant (His)

Cat.No: TMPK-01334

Species: Canine

Expression System: HEK293 Cells

EMMPRIN/CD147 Protein, Human, Recombinant

Cat.No: TMPY-00685

Species: Human

Expression System: HEK293 Cells

EMMPRIN/CD147 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00684

Species: Human

Expression System: HEK293 Cells

HopQ Protein, Helicobacter pylori Hp M6, Recombinant (His & Myc)

Cat.No: TMPH-00797

Species: Helicobacter pylori Hp M6

Expression System: E. coli

CD147 Protein, Human, Recombinant (aa 138-323, hFc)

Cat.No: TMPH-00998

Species: Human

Expression System: HEK293 Cells

EMMPRIN/CD147 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00160

Species: Human

Expression System: HEK293 Cells

CEACAM6 Protein, Human, Recombinant (His)

Cat.No: TMPY-00971

Species: Human

Expression System: HEK293 Cells

CEACAM6 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-05850

Species: Cynomolgus

Expression System: HEK293 Cells

TRIM63 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02634

Species: Mouse

Expression System: E. coli

CEACAM6 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-06760

Species: Human

Expression System: HEK293 Cells

TRIM63 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03282

Species: Rat

Expression System: E. coli

CEACAM6 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00232

Species: Human

Expression System: HEK293 Cells

CEACAM6 Protein, Cynomolgus, Recombinant (aa 35-320, His)

Cat.No: TMPK-01311

Species: Cynomolgus

Expression System: HEK293 Cells

TRIM63 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01271

Species: Human

Expression System: E. coli

CEACAM6 Protein, Human, Recombinant (aa 35-320, His & Avi), Biotinylated

Cat.No: TMPK-00233

Species: Human

Expression System: HEK293 Cells

CEACAM6 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05460

Species: Human

Expression System: HEK293 Cells

CEACAM6 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06758

Species: Human

Expression System: HEK293 Cells

IGF2/IGF-II Protein, Human, Recombinant

Cat.No: TMPY-00150

Species: Human

Expression System: P. pastoris (Yeast)

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