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Targets Recommended: c-RET

27

抑制剂 & 化合物

11

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0277	Pralsetinib 普拉替尼,Blu667	c-RET	Apoptosis; Tyrosine Kinase/Adaptors
	Pralsetinib (Blu667) 是高效的、选择性的RET 抑制剂。它能够抑制 WT RET (IC50:0.4 nM)，RET 突变体 V804L (IC50:0.3 nM)，V804M (IC50:0.4 nM)，M918T (IC50:0.4 nM) 和 CCDC6-RET (IC50:0.4 nM) 的融合。
T8583	Tenilsetam 替尼西坦,3-(2-thienyl)- (9CI),Piperazinone	Others	Others
	Tenilsetam (Piperazinone) 是一种核酸内切酶调节剂；一种促智剂和晚期糖基化终产物 (AGE) 抑制剂，具有治疗阿尔茨海默病 (AD) 的潜力。
T16704L	Quilseconazole Formic acid(1340593-70-5 Free base) Quilseconazole Formic acid(1340593-70-5 Free base)	Antifungal	Microbiology/Virology
	Quilseconazole Formic acid 是真菌 Cyp51 的选择性抑制剂，对新型隐球菌和格特隐球菌具有有效活性。
TQ0225	Velsecorat AZD7594,AZ13189620	Glucocorticoid Receptor	Endocrinology/Hormones
	Velsecorat (AZD7594) 是非甾体类糖皮质激素受体的选择性调节剂(IC50:0.9 nM)。
T33355	Methylseleno carboxyethylglutamine Peptiselene
	Methylseleno carboxyethylglutamine is a bioactive chemical.
T77199	Methionylserine
	Methionylserine (H-MET-SER-OH) 是一种含有蛋氨酸和丝氨酸的二肽。Methionylserine 可与肠道二/三肽转运蛋白 1 (hPEPT1) 结合并易位，Km 值为 0.2 mM。Methionylserine 抑制ACE 酶的活性。Methionylserine 可用于高血压的研究。
T29654	Adenosylselenomethionine Adosemet
	Adenosylselenomethionine relates to metabolism of selenomethionine.
T70158	Quilseconazole besylate
	Quilseconazole besylate, also known as VT-1129 besylate, is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor.
T76252L	WLSEAGPVVTVRALRGTGSW TFA
	WLSEAGPVVTVTVRALGTGSW TFA 为心肌细胞特异性肽。该化合物通过表达外泌体，提高心肌细胞的特定摄取能力，降低心肌细胞凋亡率，并在体内心肌内注射后提升心脏潴留能力。
T78617	N-Acetylserine N-Acetyl-L-serine	Endogenous Metabolite	Metabolism
	N-Acetylserine（N-Acetyl-L-serine）可与CysB脱辅基蛋白结合，作为半胱氨酸生物合成中的生理诱导剂。此外，该化合物能够刺激cysJIH基因在体外（in vitro）的转录。
T33605	N-Benzyloxycarbonylserylleucinamide Cbz-ser-leu-NH2,N-Carbobenzoxy-seryl-leucinamide
	N-Benzyloxycarbonylserylleucinamide is a bioactive chemical.
T25311	Desmethylselegiline
	Desmethylselegiline is an Enzyme Inhibitor.
T29910	Alseroxylon Egalin
	Alseroxylon can be used to treat hypertension.
T80681	γ-Glutamylserine TFA γ-Glu-Ser TFA	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	γ-Glutamylserine TFA（γ-Glu-Ser TFA）为一种钙受体激活剂，常用于帕金森、糖尿病及肥胖相关研究。
T35578	Phosphatidylserines (sodium salt) Phosphatidylserines (sodium salt),L-α-Phosphatidylserine
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum (ER) and can be reversibly converted back by the same enzymes. It can also be irre...
TQ0277L	Pralsetinib HCl (2097132-94-8 free base) Pralsetinib HCl,Pralsetinib hydrochloride,BLU-667,BLU667,BLU 667
	Pralsetinib is a selective and next-generation RET inhibitor (IC50: 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T, and CCDC6-RET fusion). BLU-667 is an effective and selective inhibitor of RET mutations, fusions, and predicted resistant mutants.
T19176	Acetylseneciphylline N-oxide	Others	Others
	Acetylseneciphylline N-oxide is a pyrrolizine alkaloid.
T65056	L-N-Benzylserine
	L-N-Benzylserine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T65056，CAS号为 17136-45-7。
T16704	Quilseconazole VT-1129	Others	Others
	Quilseconazole is an effective, orally active fungal Cyp51 inhibitor. it also binds tightly to cryptococcal CYP51 but weakly inhibits humans CYP450 enzymes.
T78587	Se-Methylselenocysteine hydrochloride Methylselenocysteine hydrochloride,Se-Methylseleno-L-cysteine hydrochloride	Beta-Secretase	Neuroscience
	Se-Methylselenocysteine hydrochloride 是一种甲基硒的前体，展现出显著的癌症化学预防和抗氧化活性。该化合物拥有优良的口服生物活性，并能有效诱导细胞凋亡(apoptosis)。
T78287	Alsevalimab
	Alsevalimab为针对B7-H4的人源化单克隆抗体。
T34816	Tetraacetylsecologanin O,O,O,O-Tetraacetylsecologanin,Secologanin tetraacetate
	Tetraacetylsecologanin is a bioactive chemical.
T67157	1-Phenylsemicarbazide
	1-Phenylsemicarbazide 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67157，CAS号为 103-03-7。
T35208	Xylosylserine
	Xylosylserine is a biochemical.
T124471	2'-Prenylsemilicoisoflavone B
	2'-Prenylsemilicoisoflavone B 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124471。
T10823	trans-Pralsetinib cis-Pralsetinib,cis-BLU-667	c-RET	Apoptosis; Tyrosine Kinase/Adaptors
	trans-Pralsetinib (trans-BLU-667) is an inhibitor of rearranged during transfection (RET).
T76597	Prolylserine
	Prolylserine 是一种二肽，是 Mel-Ab 细胞中黑色素生成的抑制剂。Prolylserine 降低小眼相关转录因子 (MITF) 和酪氨酸酶的表达，诱导ERK 的磷酸化，但不诱导 cAMP 反应元件结合蛋白 (CREB)。

化合物

Cat.No: TQ0277

Synonym: 普拉替尼,Blu667

Target: c-RET

Cat.No: T8583

Synonym: 替尼西坦,3-(2-thienyl)- (9CI),Piperazinone

Target: Others

Quilseconazole Formic acid(1340593-70-5 Free base)

Cat.No: T16704L

Synonym: Quilseconazole Formic acid(1340593-70-5 Free base)

Target: Antifungal

Cat.No: TQ0225

Synonym: AZD7594,AZ13189620

Target: Glucocorticoid Receptor

Methylseleno carboxyethylglutamine

Cat.No: T33355

Synonym: Peptiselene

Methionylserine

Cat.No: T77199

Adenosylselenomethionine

Cat.No: T29654

Synonym: Adosemet

Quilseconazole besylate

Cat.No: T70158

WLSEAGPVVTVRALRGTGSW TFA

Cat.No: T76252L

Cat.No: T78617

Synonym: N-Acetyl-L-serine

Target: Endogenous Metabolite

N-Benzyloxycarbonylserylleucinamide

Cat.No: T33605

Synonym: Cbz-ser-leu-NH2,N-Carbobenzoxy-seryl-leucinamide

Desmethylselegiline

Cat.No: T25311

Cat.No: T29910

Synonym: Egalin

γ-Glutamylserine TFA

Cat.No: T80681

Synonym: γ-Glu-Ser TFA

Target: Calcium Channel

Phosphatidylserines (sodium salt)

Cat.No: T35578

Synonym: Phosphatidylserines (sodium salt),L-α-Phosphatidylserine

Pralsetinib HCl (2097132-94-8 free base)

Cat.No: TQ0277L

Synonym: Pralsetinib HCl,Pralsetinib hydrochloride,BLU-667,BLU667,BLU 667

Acetylseneciphylline N-oxide

Cat.No: T19176

Target: Others

L-N-Benzylserine

Cat.No: T65056

Cat.No: T16704

Synonym: VT-1129

Target: Others

Se-Methylselenocysteine hydrochloride

Cat.No: T78587

Synonym: Methylselenocysteine hydrochloride,Se-Methylseleno-L-cysteine hydrochloride

Target: Beta-Secretase

Cat.No: T78287

Tetraacetylsecologanin

Cat.No: T34816

Synonym: O,O,O,O-Tetraacetylsecologanin,Secologanin tetraacetate

1-Phenylsemicarbazide

Cat.No: T67157

Cat.No: T35208

2'-Prenylsemilicoisoflavone B

Cat.No: T124471

trans-Pralsetinib

Cat.No: T10823

Synonym: cis-Pralsetinib,cis-BLU-667

Target: c-RET

Cat.No: T76597

Cat. No.	Product Name	Target	Signaling Pathways
T5S0662	Gelsemine 钩吻碱,Gelsemin	Antioxidant	oxidation-reduction
	Gelsemine (Gelsemin) 是一种从中草药 Gelsemium elegans 中获得的生物碱，具有抗伤害和促进睡眠活性，可有效缓解慢性疼痛。
T7727	Se-Methylselenocysteine Se MSC,SeMCys,MSeC,L-硒甲基硒代半胱氨酸,Se-MSC,SeMSC	BCL; IAP; Caspase	Apoptosis; Proteases/Proteasome
	Se-Methylselenocysteine (Se-MSC) 是具有口服活性的甲基硒前体，具有强大的抗氧化活性和抗癌活性。Se-Methylselenocysteine 可诱导细胞凋亡。
TMA1122	N-Feruloylserotonin (E/Z)-Moschamine,Moschamine	Antioxidant	oxidation-reduction
	N-Feruloylserotonin ((E/Z)-Moschamine) 是可从 Carthamus tinctorius L. 中分离得到的一种血清素衍生物，具有抗氧化活性，有用于动脉粥样硬化和主动脉壁膨胀研究的潜能。
TN4615	(-)-N-Methylsedridine	Others	Others
	(-)-N-Methylsedridine是一种天然产物，属于景天科景天属，其产品编号为 TN4615，CAS号为 41447-15-8。(-)-N-Methylsedridine可用作对照参考。
TN4123	Gelsemiol	Others	Others
	Gelsemiol has neurotrophic factor-potentiating activity, markedly enhances an increase in the proportion of neurite-bearing cells and an extension of the neurite length in the presence of nerve growth factor.
TN1678	Gelsevirine 钩吻绿碱	Others	Others
	Gelsevirine has anxiolytic activity, may be via the agonist action of glycine receptor in the brain.
T35577	Phosphatidylserines (bovine)
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi...
TN3310	9,9'-Di-O-(E)-feruloylsecoisolariciresinol	mTOR	PI3K/Akt/mTOR signaling
	1,4-O-Diferuloylsecoisolariciresinol(9,9'-Di-O-(E)-feruloylsecoisolariciresinol),and pierreione B, two novel inhibitors of mTOR signaling, have strong anticancer activity. (+)-9,9'-O-Diferuloylsecoisolariciresinol has significant cytotoxic activity agains
TN4124	Gelsempervine A	Others	Others
	Gelsempervine A is a natural product from Gelsemium elegans.
T8095	O-Acetylserine O-乙酰-L-丝氨酸,O-Acetyl-L-serine,O-乙醯絲胺酸	Others; Endogenous Metabolite	Metabolism; Others
	O-Acetylserine (O-Acetyl-L-serine) 是细菌和植物中半胱氨酸合成过程中的中间体。
TN6031	11-Hydroxygelsenicine
	11-Hydroxygelsenicine是一种天然产物，属于马钱科断肠草属，其产品编号为 TN6031，CAS号为 1195760-68-9。11-Hydroxygelsenicine可用作对照参考。

天然产物

Cat.No: T5S0662

Synonym: 钩吻碱,Gelsemin

Target: Antioxidant

Se-Methylselenocysteine

Cat.No: T7727

Synonym: Se MSC,SeMCys,MSeC,L-硒甲基硒代半胱氨酸,Se-MSC,SeMSC

Target: BCL, IAP, Caspase

N-Feruloylserotonin

Cat.No: TMA1122

Synonym: (E/Z)-Moschamine,Moschamine

Target: Antioxidant

(-)-N-Methylsedridine

Cat.No: TN4615

Target: Others

Cat.No: TN4123

Target: Others

Cat.No: TN1678

Synonym: 钩吻绿碱

Target: Others

Phosphatidylserines (bovine)

Cat.No: T35577

9,9'-Di-O-(E)-feruloylsecoisolariciresinol

Cat.No: TN3310

Target: mTOR

Gelsempervine A

Cat.No: TN4124

Target: Others

Cat.No: T8095

Synonym: O-乙酰-L-丝氨酸,O-Acetyl-L-serine,O-乙醯絲胺酸

Target: Others, Endogenous Metabolite

11-Hydroxygelsenicine

Cat.No: TN6031

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02952	SIAE Protein, Human, Recombinant (His) CSE-C,AIS6,CSEC,LSE,YSG2,sialic acid acetylesterase	Human	Baculovirus Insect Cells
	Sialate O-acetylesterase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. It is widely expressed with high expression in the testis, prostate, and colon. The systematic name of this enzyme class is N-acyl-O-acetylneuraminate O-acetylhydrolase. Other names in common use include N-acetylneuraminate acetyltransferase, sialate 9(4)-O-acetylesterase, and sialidase. Sialate O-acetylesterase catalyzes the removal of O-acetyl ester groups from position 9 of the p...
TMPY-03438	Calsequestrin 1 Protein, Human, Recombinant CASQ,PDIB1,VMCQA,calsequestrin 1 (fast-twitch, skel...	Human	E. coli
	Calsequestrin-1 is an isoform of calsequestrin. Calsequestrin is a calcium-binding protein of the sarcoplasmic reticulum. It helps hold calcium in the cisterna of the sarcoplasmic reticulum after a muscle contraction, even though the concentration of calcium in the sarcoplasmic reticulum is much higher than in the cytosol. Two forms of calsequestrin have been identified: Calsequestrin-2 and Calsequestrin-1. Calsequestrin-1 is found in fast skeletal muscle. The release of calsequestrin-boun...

重组蛋白

SIAE Protein, Human, Recombinant (His)

Cat.No: TMPY-02952

Species: Human

Expression System: Baculovirus Insect Cells

Calsequestrin 1 Protein, Human, Recombinant

Cat.No: TMPY-03438

Species: Human

Expression System: E. coli

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