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Search Results for " ldlr "

Targets Recommended: Others

11

抑制剂 & 化合物

1

天然产物

16

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9920	Evolocumab	Others	Others
	Evolocumab 是人源化单克隆抗体PCSK9的抑制剂。它与循环的 PCSK9 蛋白结合，使得PCSK9与 LDLR 结合受到抑制。它可用研究于高胆固醇血症以及动脉粥样硬化性心血管疾病的研究。
T9276	SBC-115337	Others; Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism; Others
	SBC-115337 是苯并呋喃化合物，也是 PCSK9抑制剂 (IC50:0.5 μM) 。
T15561	Imanixil HOE-402(free base)	Others	Others
	Imanixil is an inducer of the LDL receptor (LDLR) and it is also a potent cholesterol-lowering compound. It also inhibits very low density-lipoprotein (VLDL) production and consequently decreases atherosclerosis development.
T67776	PCSK9-IN-11	Others	Others
	PCSK9-IN-11 (compound 5r) 是口服有效的 PCSK9 抑制剂。 PCSK9-IN-11 在 HepG2 细胞中抑制 PCSK9 转录活性 (IC50= 5.7 μM)。 PCSK9-IN-11 可以增加 LDL 受体 (LDLR) 蛋白水平，可用于动脉粥样硬化研究。
T72025	PCSK9-IN-10	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	PCSK9-IN-10 是一种有效的，具有口服活性的PCSK9抑制剂，IC50值为 6.4 µM。PCSK9-IN-10 增加LDLR 蛋白的表达并降低 PCSK9 的表达。PCSK9-IN-10 可减缓动脉粥样硬化进展。PCSK9-IN-10 具有研究高脂血症的潜力。
T78806	PPARδ agonist 9	PPAR	DNA Damage/DNA Repair; Metabolism
	PPARδ agonist9 (compound 21) 作为PPARδ激动剂，展现出EC50为3.6 nM的活性。在体内实验中，PPARδ agonist9能有效降低小鼠血清中MCP-1水平，并在LDLr-KO模型中显著抑制动脉粥样硬化的发展，其抑制率达50-60%。
T81535	PCSK9-IN-20
	PCSK9-IN-20（Compound 3i）作为一种PCSK9抑制剂，具有IC50为 3.96 µM，能有效降低体外PCSK9水平并提升LDLR蛋白表达。
T39528	PCSK9-IN-2 PCSK9-IN-2
	PCSK9-IN-2 is a newly developed small molecule that effectively inhibits the protein-protein interaction (PPI) between PCSK9 and LDLR. It has been found to have a potent inhibitory activity with an IC50 value of 7.57 μM.
T77014	Frovocimab
	Frovocimab (LY 3015014)为一种人源化IgG4单克隆抗体(mAb)，其功能为中和PCSK9，通过抑制PCSK9与LDL受体(LDLR)的结合，促使已结合的PCSK9正常进行蛋白水解切割。
T74577	Milpocitide
	Milpocitide为针对低密度脂蛋白受体（human LDL receptor, LDLR）（293-333）的肽片段（EGF-like domain 1）的化合物。
T78718	Dim16
	Dim16是一种同时抑制PCSK9和HMG-CoAR的化合物，其对PCSK9的IC50为19 nM，并且能够阻断PCSK9与LDLR的结合，此作用的IC50为0.8 nM。Dim16还能提升HepG2细胞对LDL的吸收。

化合物

Cat.No: T9920

Target: Others

Cat.No: T9276

Target: Others, Serine/threonin kinase

Cat.No: T15561

Synonym: HOE-402(free base)

Target: Others

Cat.No: T67776

Target: Others

Cat.No: T72025

Target: Serine/threonin kinase

PPARδ agonist 9

Cat.No: T78806

Target: PPAR

Cat.No: T81535

Cat.No: T39528

Synonym: PCSK9-IN-2

Cat.No: T77014

Cat.No: T74577

Cat.No: T78718

Cat. No.	Product Name	Target	Signaling Pathways
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。

天然产物

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00989	LDLR Protein, Human, Recombinant (His) low density lipoprotein receptor,FHC,FH,LDLCQ2,LDL Receptor,...	Human	HEK293 Cells
	LDLR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is A0A024R7D5.
TMPJ-00394	LDLR Protein, Human, Recombinant (Avi & His), Biotinylated Low-Density Lipoprotein Receptor,LDL Receptor,LDLR	Human	HEK293 Cells
	Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repeats. This protein binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, it functions as a r...
TMPK-01297	LDLR Protein, Cynomolgus, Recombinant (His) LDLR,LDL R,LDL receptor,FH,LDLCQ2,FHC	Cynomolgus	HEK293 Cells
	The low density lipoprotein receptor (LDLR) is the founding member of the LDL R family of widely expressed cell surface scavenger receptors. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. LDLR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 86 kDa and the accession number is XP_005588053.1.
TMPK-00402	LDLR Protein, Human, Recombinant (His & Avi) FH,LDLCQ2,LDL R,LDLR,FHC,LDL receptor	Human	HEK293 Cells
	The low density lipoprotein receptor (LDLR) is the founding member of the LDL R family of widely expressed cell surface scavenger receptors. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. LDLR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 87.6 kDa and the accession number is P01130-1.
TMPY-01014	LDLR Protein, Mouse, Recombinant (His) low density lipoprotein receptor,Hlb301	Mouse	HEK293 Cells
	LDLR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85.7 kDa and the accession number is P35951.
TMPY-05323	LDLR Protein, Human, Recombinant (mFc) LDL R,FH,LDLCQ2,LDL Receptor,low density lipoprotein recepto...	Human	HEK293 Cells
	LDLR Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 111.2 kDa and the accession number is A0A024R7D5.
TMPY-05499	LDLR Protein, Human, Recombinant (His), Biotinylated LDL Receptor,LDL R,low density lipoprotein receptor,FHC,FH,L...	Human	HEK293 Cells
	LDLR Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is A0A024R7D5.
TMPY-05348	LDLR Protein, Mouse, Recombinant (His), Biotinylated Hlb301,low density lipoprotein receptor	Mouse	HEK293 Cells
	LDLR Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 85.7 kDa and the accession number is P35951.
TMPY-05809	LDLR Protein, Human, Recombinant (193D/A, His) low density lipoprotein receptor,LDL R,LDL Receptor,FHC,FH,L...	Human	HEK293 Cells
	LDLR Protein, Human, Recombinant (193D/A, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.19 kDa and the accession number is A0A024R7D5.
TMPY-01085	VLDLR Protein, Human, Recombinant (His) VLDLRCH,CAMRQ1,CHRMQ1,very low density lipoprotein ...	Human	HEK293 Cells
	The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar sdomain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is ...
TMPY-00383	LDLRAD3 Protein, Human, Recombinant (hFc) LRAD3,low density lipoprotein receptor class A domain contai...	Human	HEK293 Cells
	LDLRAD3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.8 kDa and the accession number is Q86YD5-1.
TMPK-00928	VLDLR Protein, Mouse, Recombinant (His) CHRMQ1,VLDLR,FLJ35024,VLDLRCH,RP11-320E16....	Mouse	HEK293 Cells
	VLDLR cerebellar hypoplasia (VLDLR-CH) is characterized by non-progressive congenital ataxia that is predominantly truncal and results in delayed ambulation, moderate-to-profound intellectual disability, dysarthria, strabismus, and seizures.VLDLR-CH is inherited in an autosomal recessive manner. Carrier testing for at-risk relatives, prenatal testing for a pregnancy at increased risk and preimplantation genetic testing are possible when the pathogenic variants in a family are known.
TMPY-01451	MESDC2 Protein, Human, Recombinant (His) MESD,mesoderm development candidate 2,BOCA	Human	HEK293 Cells
	MESD (Mesoderm Development LRP Chaperone) is a Protein Coding gene. LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61, and MESDC2, is a member of the MESD family. It is widely expressed in the thyroid, placenta, and other tissues. MESDC2 is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). The LDLR maturation activity reside...
TMPJ-00443	PCSK9 Protein, Macaca nemestrina, Recombinant (His) Proprotein Convertase Subtilisin/Kexin Type 9,PCSK9,PC9,Prop...	Macaca nemestrina	HEK293 Cells
	Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.
TMPJ-01412	LRP-12 Protein, Human, Recombinant (His) LRP-12,ST7,Suppressor of Tumorigenicity 7 Protein,LRP12,Low-...	Human	HEK293 Cells
	Low-Density Lipoprotein Receptor-Related Protein 12 (LRP12) belongs to the LDLR family. LRP12 is a type I transmembrane protein annd widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. LRP12 contains 2 CUB domain and 5 LDL-receptor class A domain. LRP12 has been shown to interact with GNB2L1, ZFYVE9 and ITGB1BP3. LRP12 is a receptor probably, which may be involved in the internalization of lipophilic molecules and/or signal transduction. In addition, LRP12 may act as ...
TMPY-02604	UBE2D4 Protein, Human, Recombinant (His) HBUCE1,ubiquitin-conjugating enzyme E2D 4 (putative)	Human	E. coli
	UBE2D4 is a member of the ubiquitin-conjugating E2 family whose members perform the second step in the ubiquitination reaction. Initially identified as the main process for protein degradation, ubiquitination is believed nowadays to be crucial for a wider range of cellular processes. The outcome of the ubiquitin-conjugation reaction, and thereby the fate of the substrate, is heavily dependent on the number of ubiquitin molecules attached and how these ubiquitin molecules are inter-connected. To ...

重组蛋白

LDLR Protein, Human, Recombinant (His)

Cat.No: TMPY-00989

Species: Human

Expression System: HEK293 Cells

LDLR Protein, Human, Recombinant (Avi & His), Biotinylated

Cat.No: TMPJ-00394

Species: Human

Expression System: HEK293 Cells

LDLR Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01297

Species: Cynomolgus

Expression System: HEK293 Cells

LDLR Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00402

Species: Human

Expression System: HEK293 Cells

LDLR Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01014

Species: Mouse

Expression System: HEK293 Cells

LDLR Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05323

Species: Human

Expression System: HEK293 Cells

LDLR Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-05499

Species: Human

Expression System: HEK293 Cells

LDLR Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-05348

Species: Mouse

Expression System: HEK293 Cells

LDLR Protein, Human, Recombinant (193D/A, His)

Cat.No: TMPY-05809

Species: Human

Expression System: HEK293 Cells

VLDLR Protein, Human, Recombinant (His)

Cat.No: TMPY-01085

Species: Human

Expression System: HEK293 Cells

LDLRAD3 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00383

Species: Human

Expression System: HEK293 Cells

VLDLR Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00928

Species: Mouse

Expression System: HEK293 Cells

MESDC2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01451

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Macaca nemestrina, Recombinant (His)

Cat.No: TMPJ-00443

Species: Macaca nemestrina

Expression System: HEK293 Cells

LRP-12 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01412

Species: Human

Expression System: HEK293 Cells

UBE2D4 Protein, Human, Recombinant (His)

Cat.No: TMPY-02604

Species: Human

Expression System: E. coli

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