Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SBC-115337 是苯并呋喃化合物,也是 PCSK9抑制剂 (IC50:0.5 μM) 。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 995 | 现货 | ||
5 mg | ¥ 2,490 | 现货 | ||
10 mg | ¥ 3,990 | 现货 | ||
25 mg | ¥ 6,390 | 现货 | ||
50 mg | ¥ 8,730 | 现货 | ||
100 mg | ¥ 11,700 | 现货 | ||
500 mg | ¥ 23,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,590 | 现货 |
产品描述 | SBC-115337 is a PCSK9 inhibitor. |
靶点活性 | PSCK9:0.5μM |
体外活性 | The potent compound (SBC-115,337) showed an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. All the investigated compounds exhibited no effect on the synthesis, processing and secretion of PCSK9. Compound SBC-115,337 at 1.2 μM induced more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increased uptake of fluorescently labeled DiI-LDL and lowered LDL-c levels in mice fed a high-fat diet.[1] |
分子量 | 473.48 |
分子式 | C29H19N3O4 |
CAS No. | 423148-46-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6mg/mL (12.67mM), ultrasonic and warming and heat to 60℃
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.112 mL | 10.5601 mL | 21.1202 mL | 52.8005 mL |
5 mM | 0.4224 mL | 2.112 mL | 4.224 mL | 10.5601 mL | |
10 mM | 0.2112 mL | 1.056 mL | 2.112 mL | 5.2801 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SBC-115337 423148-46-3 Cell Cycle/Checkpoint Metabolism Others Serine/threonin kinase SBC115337 Serine endopeptidases benzofuran LDLR Threonine proteases SBC 115337 Ser/Thr Protease inhibit Inhibitor recombinant potent DiI-LDL Serine proteases HepG2 inhibitor