LDLR Protein, Human, Recombinant (His)

LDLR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is A0A024R7D5.

规格	价格/CNY		数量
50 μg	￥ 2,070	现货
100 μg	￥ 3,540	5日内发货
200 μg	￥ 6,030	5日内发货
500 μg	￥ 12,150	5日内发货

规格

价格/CNY

货期

数量

50 μg

￥ 2,070

现货

100 μg

￥ 3,540

5日内发货

200 μg

￥ 6,030

5日内发货

500 μg

￥ 12,150

5日内发货

生物活性	Immobilized Human LDLR/LDL Receptor His at 2 μg/mL (100 μL/well) can bind Mouse PCSK9 mFc , the EC50 of Mouse PCSK9 mFc is 100-800 ng/mL.
产品描述	LDLR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is A0A024R7D5.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	A0A024R7D5
别名	low density lipoprotein receptor, FHC, FH, LDLCQ2, LDL Receptor, LDL R
蛋白构建	extracellular domain of Human LDLR (NP_000518.1) precursor (Met 1-Arg 788)
蛋白纯度	> 85 % as determined by SDS-PAGE
分子量	86 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low-density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.