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Search Results for " lc3 "

Targets Recommended: Others Autophagy ATTECs

17

抑制剂 & 化合物

3

天然产物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8081	LC3-mHTT-IN-AN1	Others; Autophagy; ATTECs	Autophagy; Others; PROTAC
	LC3-mHTT-IN-AN1 是一种 mHTT-LC3 接头化合物，可与突变亨廷顿蛋白 (mHTT) 和 LC3B 相互作用。它将 mHTT 靶向自噬体以等位基因选择性方式降低培养的亨廷顿病小鼠神经元中的 mHTT 水平。
T8903	Retro-2 Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino}	Others; Virus Protease; Parasite; Autophagy	Autophagy; Microbiology/Virology; Others
	Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) 是一种植物毒素蓖麻毒素抑制剂，它保护 HeLa 细胞免受蓖麻毒素、Stx1 和 Stx2 的侵害，选择性地阻断早期内体蛋白质-高尔基体界面处的逆行毒素运输。
T116970	TLC3407-3786
	MMV665916 是一种喹唑啉二酮衍生物，是一种抗疟药。MMV665916 对恶性疟原虫 FcB1 菌株具有显著的抗疟原虫生长抑制活性，EC50值为 0.4 μM，并呈现出高选择性指数 (SI>250)。
T36279	VH 032 amide-alkylC3-amine VH 032 amide-alkylC3-amine
	Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl C3 linker and terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
T36278	VH 032 amide-alkylC3-acid VH 032 amide-alkylC3-acid
	Functionalized von-Hippel-Lindau protein ligand (VHL) for research and development; incorporates an E3 ligase ligand plus alkylC3 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules.
T61871	DC-LC3in-D5
	DC-LC3in-D5 is a chemical compound that functions as an autophagy inhibitor by diminishing the process of LC3B lipidation. It forms a binding association with LC3B, disrupting the LC3B-LBP2 interaction with an IC50 of 200 nM. This compound, DC-LC3in-D5, exhibits potential for application in anti-HCV or combination cancer treatments by effectively inhibiting autophagy [1].
T36250	Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
	Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC1-PEG3-alkylC3 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
T23716	AMDE-1 AMDE 1	Autophagy	Autophagy
	AMDE-1 是一种自噬调节剂，以 Atg5 依赖性方式触发自噬。 AMDE-1 将 Atg16 募集到自噬体前位点并导致 LC3 脂化。
T19188	ALLO-1	Autophagy	Autophagy
	ALLO-1 is a crucial autophagy receptor responsible for facilitating the formation of autophagosomes around paternal organelles. It directly interacts with the worm LC3 homologue, LGG-1, through its LC3-interacting region (LIR) motif.
T83945	XIE62-1004
	XIE62-1004 是一种促进p62与LC3相互作用的诱导剂。通过与p62的ZZ域结合，导致p62自我聚集并与自噬体膜上的LC3相互作用；促进货物蛋白被送往自噬体以便降解。在体外及体内以浓度依赖和时间依赖的方式活性，并特异性针对野生型p62。在体外诱导突变型huntingtin的降解。也可以用于AUTAC蛋白质降解系统，通过p62自我聚集及与LC3的相互作用来诱导自噬。
T71151	Z36
	Z36 is a novel Bcl-xL inhibitor, upregulating the expression levels of FAM134B, LC3, and Atg9, inducing autophagy along with autophagic cell death, resulting in ER stress and the unfolded protein response (UPR).
T27187	DK-1-49
	DK-1-49 is an autophagonizer. It causes accumulation of autophagy-associated LC3-II and enhanced levels of autophagosomes and acidic vacuoles.
T76599	Ac-Leu-Val-Lys-Aldehyde
	Ac-Leu-Val-Lys-Aldehyde 是有效的组织蛋白酶 B (cathepsin B) 抑制剂，其 IC50 值为 4 nM。该化合物能显着降低喹啉酸引起的纹状体细胞死亡，并促使 LC3-II 积累。
T60453	TrxR-IN-3
	TrxR-IN-3 (Compound 2c) 是TrxR 的有效抑制剂。TrxR-IN-3 对五种人类癌细胞系表现出强大的抗增殖活性，特别是对乳腺肿瘤细胞。TrxR-IN-3 增加 ROS 水平并通过调节乳腺癌细胞中细胞凋亡相关蛋白的表达导致明显的细胞凋亡。TrxR-IN-3 还通过促进 LC3-II 和 Beclin-1 的表达并减少 LC3-I 和 p62 蛋白的表达，来触发自噬体和自溶酶体的形成。
T35747	Quinacrine analog 34
	Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels ...
T83765	Dendrogenin A DDA
	Dendrogenin A (DDA) 作为一种选择性肝X受体(LXR)调节剂(SLiM)、胆固醇环氧水解酶(ChEH; Ki = 120 nM)的抑制剂及胆固醇的活性代谢产物，通过DDA合成酶将5,6α-环氧胆固醇与组胺结合形成。DDA在非癌性人乳腺上皮细胞和上皮黑色素细胞中存在，但在多种乳腺癌细胞或黑色素瘤细胞中未发现，且在分离的人乳腺肿瘤组织中仅以低水平存在。它抑制22(R)-羟基胆固醇诱导的LXRβ和LXRα激活(分别以IC50 = 76和362 nM)，但也是LXR的部分激动剂，在B16/F10小鼠黑色素瘤细胞中增加Nur77、NOR-1、LC3-I和LC3-II的蛋白水平。DDA选择性调节LXRα和LXRβ，而非孕烯X受体(PXR)、芳香烃受体(AhR)、维生素D受体(VDR)、维甲酸X受体γ(RXRγ)、维甲酸受体α(RARα)、过氧化物酶体增殖物激活受体α(PPARα)、PPARγ、糖皮质激素受体、雄激素受体、雌激素受体α(ERα)及ERβ在2.5 µM下。此外，DDA在2.5和5 µM的浓度下增加B16/F10和SK-MEL-28癌细胞中LC3-II的蛋白水平，并在2...
T61580	Autophagy inducer 3
	Autophagy Inducer 3 is a chemical compound that exhibits autophagy-induced activity, specifically inducing robust autophagic cell death in various cancer cells while sparing normal cells. This compound induces lethal autophagy through the formation of distinct autophagic vacuoles, LC3 puncta formation, and upregulation of signature autophagy markers such as Beclin and Atg family proteins [1].

化合物

LC3-mHTT-IN-AN1

Cat.No: T8081

Target: Others, Autophagy, ATTECs

Cat.No: T8903

Synonym: Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino}

Target: Others, Virus Protease, Parasite, Autophagy

Cat.No: T116970

VH 032 amide-alkylC3-amine

Cat.No: T36279

Synonym: VH 032 amide-alkylC3-amine

VH 032 amide-alkylC3-acid

Cat.No: T36278

Synonym: VH 032 amide-alkylC3-acid

Cat.No: T61871

Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine

Cat.No: T36250

Synonym: Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine

Cat.No: T23716

Synonym: AMDE 1

Target: Autophagy

Cat.No: T19188

Target: Autophagy

Cat.No: T83945

Cat.No: T71151

Cat.No: T27187

Ac-Leu-Val-Lys-Aldehyde

Cat.No: T76599

Cat.No: T60453

Quinacrine analog 34

Cat.No: T35747

Cat.No: T83765

Synonym: DDA

Autophagy inducer 3

Cat.No: T61580

Cat. No.	Product Name	Target	Signaling Pathways
T5070	LC3-mHTT-IN-AN2 5,7-二羟基-4-苯基香豆素,5,7-Dihydroxy-4-phenylcoumarin	Antibacterial; Autophagy; ATTECs	Autophagy; Microbiology/Virology; PROTAC
	LC3-mHTT-IN-AN2 (5,7-Dihydroxy-4-phenylcoumarin) 是一种 mHTT-LC3 接头化合物，可与突变亨廷顿蛋白(mHTT) 和 LC3B 相互作用。它将 mHTT 靶向自噬体以等位基因选择性方式降低培养的亨廷顿病小鼠神经元中的 mHTT 水平。它存在于西番莲植物中，具有抗菌活性。
T1152	Albendazole SKF-62979,阿苯达唑	HIF/HIF Prolyl-Hydroxylase; Microtubule Associated; Antibiotic; Parasite	Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Microbiology/Virology
	Albendazole (SKF-62979) 是一种广谱抗寄生虫剂，具有高效，低宿主毒性的特点。它用于研究人类和动物的胃肠道寄生虫。
T8166	Pennogenin 3-O-beta-chacotrioside 偏诺皂苷元-3-O-Α-L-吡喃鼠李糖-(1→4)[Α-L-吡喃鼠李糖基](1→2)-Β-D-葡萄糖苷	Autophagy	Autophagy
	Pennogenin 3-O-beta-chacotrioside 是从七叶一枝花中分离得到的一种天然产物，具有抗结肠癌活性。它可以调节自噬，增加自噬相关蛋白 LC3 和 Beclin-1 的表达。

天然产物

LC3-mHTT-IN-AN2

Cat.No: T5070

Synonym: 5,7-二羟基-4-苯基香豆素,5,7-Dihydroxy-4-phenylcoumarin

Target: Antibacterial, Autophagy, ATTECs

Cat.No: T1152

Synonym: SKF-62979,阿苯达唑

Target: HIF/HIF Prolyl-Hydroxylase, Microtubule Associated, Antibiotic, Parasite

Pennogenin 3-O-beta-chacotrioside

Cat.No: T8166

Synonym: 偏诺皂苷元-3-O-Α-L-吡喃鼠李糖-(1→4)[Α-L-吡喃鼠李糖基](1→2)-Β-D-葡萄糖苷

Target: Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01321	MAP1LC3B Protein, Human, Recombinant Autophagy-related ubiquitin-like modifier LC3	Human	E. coli
	Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. MAP1LC3B is one of the four genes in the MAP1LC3 subfamily (others include MAP1LC3A, MAP1LC3C, and MAP1LC3B2). It is moat abundantly expressed in heart, brain, skeletal muscle and testis. LMAP1LC3B is a subunit of neuronal microtubule and functions in formation of autophagosomal vacuoles (autophagosomes). It associat...
TMPY-03340	MAP1LC3A Protein, Human, Recombinant (His) LC3,ATG8E,microtubule-associated protein 1...	Human	E. coli
	LC3A, also known as MAP1LC3A, is one of the light chain subunits that function together with both MAP1A and/or MAP1B. MAP1A and MAP1B are microtubule-associated proteins that mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. As a light chain subunit, MAP1LC3A has an important part in neuronal development and in maintaining the balance between neuronal plasticity and r...
TMPY-03749	LC3B Protein, Human, Recombinant (His) microtubule-associated protein 1 light chain 3 beta...	Human	E. coli
	MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 beta, also known as LC3B) is a Protein Coding gene. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. LC3B is a member of the MAP1 LC3 family. It is most abundantly expressed in the heart, brain, skeletal muscle, and testis. LC3B is a subunit of the neuronal microtubule and functions in the formation of autophagosomal...
TMPH-02979	SLC30A8 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. SLC30A8 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 43.0 kDa and the accession number is Q8BGG0.
TMPH-01684	MAP1LC3C Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins. MAP1LC3C Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 20.7 kDa and the accession number is Q9BXW...
TMPH-02323	SLC30A8 Protein, Human, Recombinant (His)	Human	E. coli
	Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. SLC30A8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 43.6 kDa and the accession number is Q8IWU4.
TMPH-02324	SLC39A6 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	May act as a zinc-influx transporter. SLC39A6 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 35.0 kDa and the accession number is Q13433.
TMPH-01468	SLC31A1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	SLC31A1 Protein, Human, Recombinant (His & SUMO) is expressed in in vitro E. coli expression system.
TMPY-06226	SLC39A6/LIV-1 Protein, Cynomolgus, Recombinant (His) solute carrier family 39 member 6	Cynomolgus	HEK293 Cells
	Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. SLC39A6, also known as LIV-1, belongs to a new subfamily of Zrt, Irt-like protein zinc transporters (LZTs). It is involved in maintaining the intracellular homeostasis of zinc, an ion that is essential in the control of cellular growth and differentiation. SLC39A6 plays a critical role in maintaining zinc homeostasis, and was originally identified as a...
TMPH-02322	SLC30A10 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	SLC30A10 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.9 kDa and the accession number is Q6XR72.
TMPY-03461	GABARAPL2 Protein, Human, Recombinant (His) GATE16,ATG8,ATG8C,GEF-2,GATE-16,GEF2,GABA(A) receptor-associ...	Human	E. coli
	GATE-16, also known as ATG8, belongs to the MAP1 LC3 family. It is expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. GATE-16 is expressed at very low levels in lung, thymus and small intestine. GATE-16 is involved in intra-Golgi traffic. It modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.
TMPH-02282	Ubiquilin-1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its in...
TMPY-00587	GABARAP Protein, Human, Recombinant (His & MBP) GABARAP-a,GABA(A) receptor-associated protein,ATG8A,MM46	Human	E. coli
	The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in vivo by delaying cell death and its associated immune-related response. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases. GABARAPs as the first known direct interaction partners of Nef that are essential...

重组蛋白

MAP1LC3B Protein, Human, Recombinant

Cat.No: TMPJ-01321

Species: Human

Expression System: E. coli

MAP1LC3A Protein, Human, Recombinant (His)

Cat.No: TMPY-03340

Species: Human

Expression System: E. coli

LC3B Protein, Human, Recombinant (His)

Cat.No: TMPY-03749

Species: Human

Expression System: E. coli

SLC30A8 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02979

Species: Mouse

Expression System: E. coli

MAP1LC3C Protein, Human, Recombinant (His)

Cat.No: TMPH-01684

Species: Human

Expression System: E. coli

SLC30A8 Protein, Human, Recombinant (His)

Cat.No: TMPH-02323

Species: Human

Expression System: E. coli

SLC39A6 Protein, Human, Recombinant (His)

Cat.No: TMPH-02324

Species: Human

Expression System: Baculovirus Insect Cells

SLC31A1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01468

Species: Human

Expression System: E. coli

SLC39A6/LIV-1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-06226

Species: Cynomolgus

Expression System: HEK293 Cells

SLC30A10 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02322

Species: Human

Expression System: E. coli

GABARAPL2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03461

Species: Human

Expression System: E. coli

Ubiquilin-1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02282

Species: Human

Expression System: E. coli

GABARAP Protein, Human, Recombinant (His & MBP)

Cat.No: TMPY-00587

Species: Human

Expression System: E. coli

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