Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7500 |
Isoxazole
1,2-oxazole,异恶唑 |
AChR | Neuroscience |
Isoxazole (1,2-oxazole) 是乙酰胆碱酯酶 (AChE) 的抑制剂。异恶唑的配体结合并抑制 Sxc-反转运蛋白。 | |||
T2003 |
ISX-9
Isoxazole 9,Isoxazole 9 (ISX-9) |
Calcium Channel; Wnt/beta-catenin | Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells |
ISX-9 (Isoxazole 9) 是一种神经干细胞分化的有效诱导剂,可诱导 Notch 激活的心外膜衍生细胞(NEC) 的心肌分化。它可通过电压门控的 Ca2+通道和 NMDA 受体来激活 Ca2+流入,并增加 NeuroD 表达。 | |||
T8911 |
methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
|
MAPK | MAPK |
methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate 靶向 MAPK。 | |||
T19588 |
TP748
2-苄氧基恶唑 |
Others | Others |
TP748 是一种异恶唑,也是合成四环素的关键中间体。 | |||
T66589 | 5-Chloro-3-phenylbenzo[c]isoxazole | ||
5-Chloro-3-phenylbenzo[c]isoxazole 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66589,CAS号为 719-64-2。 | |||
T50032 |
5-(2-furyl)-N-propylisoxazole-3-carboxamide
|
Others | Others |
5-(2-furyl)-N-propylisoxazole-3-carboxamide 是一种用作分子结构单元的化合物,被认为是 NMDA 受体的调节剂,已被证明对神经元细胞中谷氨酸诱导的兴奋性毒性和氧化应激具有保护作用。它也被发现具有抗炎活性,使其成为阿尔茨海默病和帕金森病等疾病的潜在治疗剂。 | |||
T0644 |
3-Amino-5-methylisoxazole
|
Others | Others |
3-Amino-5-methylisoxazole 是医药中间体,用于生产磺胺类药物。 | |||
T0750 |
Sulfisoxazole
NU-445,磺胺二甲异唑,Sulfafurazole,磺胺异恶唑 |
Endothelin Receptor; Antibacterial; Antibiotic; Autophagy | Autophagy; GPCR/G Protein; Microbiology/Virology |
Sulfisoxazole (Sulfafurazole) 是一种内皮素受体拮抗剂,是磺胺类抗生素。它靶向内皮素受体 A,抑制乳腺癌外显子释放。 | |||
T20766 |
Sulfisoxazole acetyl
Gantrisin,Acetylsulfisoxazole,Gantrisin Pediatric,Lipo Gantrisin,乙酰磺胺异噁唑 |
Antibacterial | Microbiology/Virology |
Sulfisoxazole acetyl (Gantrisin) 是 Sulfisoxazole 的一种衍生物,是口服有效的二氢蝶酸合酶抑制剂。Sulfisoxazole acetyl 显示出抗菌作用。 | |||
T61498 | Sulfisoxazole diethanolamine | ||
Sulfisoxazole diethanolamine, also known as Sulfafurazole diethanolamine, is a sulfonamide antibacterial compound with an oxazole substituent. It acts as an endothelin receptor antagonist, specifically targeting endothelin receptor A with an IC50 value of 0.60 μM and endothelin receptor B with an IC50 value of 22 μM. Additionally, Sulfisoxazole diethanolamine has been found to inhibit the release of breast cancer exosomes by specifically targeting endothelin receptor A [1] [2]. | |||
T68575 | Pyrisoxazole | ||
Pyrisoxazole is a novel fungicide inhibitor of Sterol 14α-demethylase. | |||
T64868 |
5-Methyl-3-phenylisoxazole-4-carbonyl chloride
|
||
5-Methyl-3-phenylisoxazole-4-carbonyl chloride 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64868,CAS号为 16883-16-2。 | |||
T65275 |
5-Methyl-3-(2'-chlorophenyl)-4-isoxazolecarboxylic acid
|
||
5-Methyl-3-(2'-chlorophenyl)-4-isoxazolecarboxylic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65275,CAS号为 23598-72-3。 | |||
T66198 | 5-Methyl-3,4-diphenylisoxazole | ||
5-Methyl-3,4-diphenylisoxazole 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66198,CAS号为 37928-17-9。 | |||
T65267 | 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid | ||
3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65267,CAS号为 3919-74-2。 | |||
T66496 |
5-Methylisoxazole-4-carboxylic acid
|
||
5-Methylisoxazole-4-carboxylic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66496,CAS号为 42831-50-5。 | |||
T1813 |
VGX-1027
VGX1027,VGX 1027,GIT 27 |
IL Receptor; TNF; Interleukin | Apoptosis; Immunology/Inflammation |
VGX-1027 (GIT 27) 是一种口服有效的异恶唑化合物,靶向巨噬细胞,减少促炎性介质 TNF-α、IL-1β和 IL-10 的产生,具有免疫调节特性。它通过限制细胞因子介导的免疫炎症而具有抗糖尿病作用。 | |||
T19781 |
Clomazone
Gamit,FMC 57020,Command,异恶草松,Dimethazone,Magister |
Others | Others |
Clomazone (Magister) 是一种能够用于控制棉花,豌豆,南瓜,大豆,地瓜,烟草的一年生草和阔叶杂草的广谱抗菌剂。 | |||
T12513 |
PNZ5
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
PNZ5 是一个有效的、异恶唑类的、BET 的广泛抑制剂,有着类似(+)-JQ1 的高选择性和强效作用,其对 BRD4(1) 的 KD 值为 5.43 nM。 | |||
T11308 |
FM26
|
ROR | Metabolism |
FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. | |||
T79561 |
Mtb-IN-5
|
||
Mtb-IN-5(化合物(-)17j)是一种异恶唑类化合物,对结核分枝杆菌(Mtb)具有活性。它能够抑制宿主巨噬细胞内Mtb的呼吸及生物膜生长,且能够增强异烟肼(INH)对耐INH Mtb突变株的抑制效果。 | |||
T69017 | Ibotenic acid hydrate | ||
Ibotenic acid hydrate is a neurotoxic isoxazole (similar to Kainic acid and Muscimol) found in Amanita mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist. | |||
T79559 | Mtb-IN-4 | ||
Mtb-IN-4(化合物17h)是一种异恶唑类化合物,显示出针对结核分枝杆菌(Mtb)的抗活性,其IC50值为0.70 μM。它能阻断巨噬细胞内Mtb的呼吸和生物膜形成,并可以增强抗生素异烟肼(INH)对耐INH Mtb突变体的抑制效果。 | |||
T62622 |
MRL-871
|
||
MRL-871 (compound 3) 是一种有效的异生维甲酸受体相关孤儿受体 γt (RORγt) 反向激动剂 (IC50: 264 nM)。MRL-871 表现出独特的异恶唑化学型,可有效减少 EL4 细胞中 IL-17a mRNA 的产生。 | |||
T73608 |
Muscimol hydrochloride
|
||
Muscimol (Agarin; Agarine) hydrochloride 是一种具有精神活性的异恶唑。Muscimol hydrochloride 也是抑制性神经递质 GABA 离子型受体的选择性激动剂。Muscimol hydrochloride 可以从毒蝇伞和相关蘑菇中分离出来。总之,Muscimol 是一种有效的 GABAA 受体激动剂 (EC50=0.2 μM),部分 GABAC 受体激动剂和无活性的 GABAB 受体激动剂。Muscimol hydrochloride 具有镇静、抗焦虑和致幻作用。 | |||
T38844 |
MK-8245 Trifluoroacetate
|
||
MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. IC50 value: 1 nM (hSCD1) Target: SCD1 in vitro: MK-8245, a phenoxy piperidine isoxazole derivative, has been identified as a potent and liver-specific SCD inhibitor. It contains a tetrazole acetic acid moiety, which is the key molecule for OATPs recognition and liver-targeting. MK... |