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Cat. No. | Product Name | Target | Signaling Pathways |
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T11663 | Integrin-IN-2 | Others | Others |
Integrin-IN-2 is an orally bioavailable pan αv integrin inhibitor.Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively. | |||
T5488 |
ILK-IN-2
OSU-T315 |
Integrin | Cytoskeletal Signaling |
ILK-IN-2 (OSU-T315) 是一种新型强效口服活性的整合素连接激酶(ILK)抑制剂,IC50 为 0.6 μM。 | |||
T13473L |
αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA |
Integrin | Cytoskeletal Signaling |
αvβ1 integrin-IN-1 TFA 是一种有效的αvβ1整合素抑制剂(IC50: 0.63 nM)。 | |||
T5485 |
OSU-T315
OSU-T315 (1,5-regioisomer),ILK-IN-2 |
Apoptosis; Integrin; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling |
OSU-T315 (OSU-T315 (1,5-regioisomer)) 是一种整联蛋白连接激酶抑制剂,通过去磷酸化 AKT-Ser473 和其他 ILK 靶标抑制 PI3K/AKT 信号传导。它阻止 AKT 转位到脂筏消除 AKT 的活化,并以 ILK 非依赖性方式触发 Caspase 依赖性细胞凋亡。它通过自噬和凋亡导致细胞死亡。 | |||
TP1484L |
α2β1 Integrin Ligand Peptide acetate
α2β1 Integrin Ligand Peptide acetate (134580-64-6) |
Integrin | Cytoskeletal Signaling |
α2β1 Integrin Ligand Peptide acetate (α2β1 Integrin Ligand Peptide acetate (134580-64-6)) 是 α2β1 整合素受体的潜在拮抗剂。它与细胞膜上的 α2β1 整合素受体相互作用,介导细胞外信号进入细胞。 | |||
T79792 |
αvβ1 integrin-IN-2
|
Integrin | Cytoskeletal Signaling |
αvβ1integrin-IN-2(compound 32)作为整合素ανβ1与α5β1的抑制剂,展现出高效性,其IC50值分别为0.9 nM和33 nM。此外,该化合物对其他整合素亦有抑制作用,其IC50分别为380 nM(ανβ3)、280 nM(ανβ5)、230 nM(ανβ6)、87 nM(ανβ8)。 | |||
T79140 |
αvβ6 integrin inhibitor 2
|
Integrin | Cytoskeletal Signaling |
αvβ6integrin inhibitor 2 是一种高效的αvβ6整联蛋白抑制剂,具有96.5 nM的半抑制浓度(IC50)。 | |||
T6806 |
Cilengitide TFA
|
Integrin; Autophagy | Autophagy; Cytoskeletal Signaling |
Cilengitide TFA 是一种选择性的 αvβ3和 αvβ5受体整合素抑制剂,IC50分别为 4 nM 和 79 nM。对 GP IIb/IIIa 的选择性约为 10 倍。 | |||
T36291 | Integrin modulator 1 | ||
Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM[1]. Integrin modulator 1 (2-10 μg/mL; 30 min) significantly increases Jurkat E6.1 cell adhesion[1].Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1/2 phosphorylation in Jurkat E6.1 cells[1].Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the... | |||
T76378 |
RGD-4C
|
||
RGD-4C(ACDCRGDCFC)是一种携带Arg-Gly-Asp(RGD)序列的肽,具备与αv整合素结合的能力,用于模拟细胞外基质蛋白的整合素识别特性。作为αv整合素的配体,它能够与生物活性分子进行偶联,进而在动物模型中展现出抗肿瘤活性。 | |||
T76979 | Tadocizumab | ||
Tadocizumab(C4G1; YM-337)是针对整合素αIIbβ3的人源化单克隆抗体。它展现出抗血小板与抗血栓功能,适用于心血管疾病的研究。 | |||
T36296 | BIO5192 hydrate | ||
BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels[1][2]. The combination of BIO5192 hydrate (1 mg/kg; i.v.) and Plerixafor (5 mg/kg; s.c.) exert an additive effect on progenitor mobilization[1].BIO5192 hydrate (30 mg/kg; s.c; bid; during days... | |||
T77154 | Etrolizumab | ||
Etrolizumab (rhuMAb Beta7) 是一种肠道选择性抗-β7整合素单克隆抗体。Etrolizuma b 是针对α4β7和 αEβ7 整合素的 β7 亚基的特异性靶向活性分子。Etrolizumab 可用于炎症性肠病 (IBD) 的研究。 | |||
T75765 |
GRGDSPK TFA
|
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GRGDSPK TFA (EMD 56574 TFA) 是一种含有精氨酸-甘氨酸-天冬氨酸 (RGD) 序列的多肽。作为竞争性且可逆的抑制剂,它能够抑制整联蛋白与纤连蛋白的结合,用于探究整联蛋白在骨形成及吸收过程中的功能。 | |||
T76007 |
RGD peptide (GRGDNP) (TFA)
|
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RGD peptide (GRGDNP) TFA 作为整合素-配体之间相互作用的竞争性抑制剂,阻碍α5β1与细胞外基质(ECM)的结合,并通过激活增强pro-caspase-3的自我加工和构象变化来促进细胞凋亡。该化合物在细胞粘附、迁移、生长和分化等过程中扮演着关键角色。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S0055 |
Chelidonine
Helidonine,Khelidonin,白屈菜碱,Stylophorin |
Apoptosis; Others; Influenza Virus | Apoptosis; Microbiology/Virology; Others |
Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱,有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞,诱导 caspase 依赖和非依赖性的细胞凋亡。 | |||
T4S0498 |
Glaucocalyxin A
蓝萼甲素,Wangzaozin B,Leukamenin F |
Apoptosis; Akt; Caspase; PI3K | Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜,具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位,诱导骨肉瘤凋亡。 | |||
T36295 | Echistatin TFA | ||
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ... |