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Cat. No.	Product Name	Target	Signaling Pathways
T11561	HIF-2α-IN-2	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	HIF-2α-IN-2 是低氧诱导因子抑制剂，IC50=16 nM。
T15482	HIF-2α-IN-1	HIF	Angiogenesis; Chromatin/Epigenetic
	HIF-2α-IN-1是一种有效的 HIF-2α 抑制剂, IC50值小于500 nM。
T67831	HIF-2α agonist 2	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	HIF-2α agonist 2 是一种 HIF-2α 激动剂，对HIF-2α的EC50 值为 1.68 μM。HIF-2α agonist 2可以促进HIF-2a-ARNT 复合物3z 结构中ARNT A/B 环的稳定性，对 786-O-HRE-Luc 细胞无细胞毒性。HIF-2α agonist 2可用于氧代谢研究，与癌症的发生密切相关。
T11562	HIF-2α-IN-3	HIF	Angiogenesis; Chromatin/Epigenetic
	HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.
T50099	HIF-2α-IN-4	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	HIF-2a translation inhibitor 是一种有效的HIF-2α翻译抑制剂，IC50=5 μM，能够抑制组成型和缺氧诱导的 HIF-2α 蛋白表达。其中 HIF-2α-IN-4 将 5'UTR 铁响应元件与氧传感联系起来。
T36711	FM19G11 FM19G11,HIF-1alpha/2alpha Inhibitor	HIF	Angiogenesis; Chromatin/Epigenetic
	FM19G11 是一种低氧诱导因子 (HIF) α-亚基抑制剂（在低氧诱导的荧光素酶试验中 IC50 为 80 nM）。
T29797	AKB-6899 AKB6899	VEGFR; HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism; Tyrosine Kinase/Adaptors
	AKB-6899 是脯氨酰羟化酶结构域 3 (PHD3) 的抑制剂，可增加 GM-CSF 处理的巨噬细胞产生的 VEGF 受体的可溶形式 (sVEGFR-1)。 AKB-6899 能稳定 HIF-2α，从而诱导肿瘤相关巨噬细胞产生 sVEGFR-1 并减少肿瘤生长。
T0692	Allopurinol Zyloric,别嘌醇,Zyloprim,Lopurin,别嘌呤醇	ROS; Xanthine Oxidase	Immunology/Inflammation; Metabolism
	Allopurinol (Zyloric) 是一种黄嘌呤氧化酶(XO)抑制剂，IC50=7.82±0.12 μM。
T6376	Allopurinol Sodium 1H-吡唑并[3,4-D]嘧啶-4-醇单钠盐,Allopurinol sodium salt,Sodium allopurinol	ROS	Immunology/Inflammation
	Allopurinol Sodium 是黄嘌呤氧化酶抑制剂，其IC50= 0.2~50 μM。它能够抗利什曼原虫，也可用于研究痛风以及高尿酸血症。
T72997	HIF-2α-IN-7
	HIF-2α-IN-7 是一种缺氧诱导因子 2α(HIF-2α)抑制剂。HIF-2α-IN-7 抑制 HIF-2α，EC50值为 6 nM。HIF-2α-IN-7 可用于多种疾病的研究，包括癌症、肝病、炎性疾病、肺病和铁负荷紊乱。
T61367	HIF-2α-IN-6
	HIF-2α-IN-6 (117) 是HIF-2α的抑制剂。
T61614	HIF-2α-IN-5
	HIF-2α-IN-5 是一种有效的 HIF-2α的抑制剂，IC50小于 50 nM。
T78937	HIF-2α-IN-9	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	HIF-2α-IN-9（compound 35r）为HIF-2α抑制剂，能够抑制VEGF-A（IC50=305 nM），影响肿瘤细胞生长基因表达并促进巨噬细胞介导的肿瘤免疫反应。
T61442	HIF-1/2α-IN-1
	HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α. Its inhibitory effect on HIF-2α activity is significant, with an IC 50 value of 0.92 μM. Furthermore, HIF-1/2α-IN-1 has the ability to decrease HIF-1α levels. This compound is particularly valuable for research on clear cell renal cell carcinoma (ccRCC) [1].
T61102	HIF-1/2α-IN-2
	HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α. This compound elicits an iron starvation response by specifically targeting ISCA2, a key protein involved in Iron Sulfur Cluster Assembly 2. [1]
T12675L	PT2399	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	PT2399 是高选择性的HIF-2α拮抗剂，能直接结合 HIF-2α PAS B 结构域，IC50=6 nM，具有显著的体内抗肿瘤特性。
T17009	TC-S 7009	HIF	Angiogenesis; Chromatin/Epigenetic
	TC-S 7009是一种有效的和具有选择性的HIF-2α抑制剂(Kd: 81 nM)。TC-S 7009对HIF-2α的亲和力大于HIF-1α (Kd >> 5 μM)。 TC-S 7009破坏HIF-2α异源二聚化，降低HIF-2α靶基因表达，降低dna 结合活性。
T7848	PT-2385	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	PT-2385 是一种选择性HIF-2α抑制剂，Ki< 50 nM。
T7802	M1001	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	M1001 是较弱的HIF-2α激动剂，直接与 HIF-2α PAS-B 结构域结合，Kd=667 nM，能够提高 HIF-2α-ARNT 复合体之间的稳定性。
T16679	Belzutifan PT2977,MK-6482	HIF	Angiogenesis; Chromatin/Epigenetic
	Belzutifan (MK-6482) 是具有口服活性的 HIF-2α选择性抑制剂，IC50为 9 nM。Belzutifan 具有提高的效力和改善的药代动力学特征。Belzutifan (MK-6482) 可以抑制透明细胞肾细胞癌。
T12675	(Rac)-PT2399	HIF	Angiogenesis; Chromatin/Epigenetic
	(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
T69080	T1001
	T1001 is an antagonist of hypoxia-inducible factor-2α subunit (HIF-2α) which displaces residue M252 from inside the HIF-2α PAS-B pocket toward the ARNT subunit to weaken heterodimerization.
T6804	Chetomin Chaetomin,NSC289491,BRN0077366	Apoptosis; HSP; HIF	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
	Chetomin (BRN0077366) 是球毛壳菌的活性成分，是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。
TP2046	TAT-cyclo-CLLFVY
	Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cance
T36492	CMC2.24
	CMC2.24 (TRB-N0224) is an orally active tricarbonylmethane agent that demonstrates effectiveness in inhibiting Ras activation and the downstream effector ERK1/2 pathway, thus effectively combating pancreatic tumor formation in mice. Additionally, CMC2.24 exerts potent inhibitory effects on zinc-dependent MMPs, with IC50s ranging from 2.0-69 μM. Furthermore, CMC2.24 aids in alleviating the progression of osteoarthritis by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis throug...
T69966	Roxadustat-d5
	Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ...

化合物

Cat.No: T11561

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T15482

Target: HIF

HIF-2α agonist 2

Cat.No: T67831

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T11562

Target: HIF

Cat.No: T50099

Target: Others, HIF/HIF Prolyl-Hydroxylase

Cat.No: T36711

Synonym: FM19G11,HIF-1alpha/2alpha Inhibitor

Target: HIF

Cat.No: T29797

Synonym: AKB6899

Target: VEGFR, HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T0692

Synonym: Zyloric,别嘌醇,Zyloprim,Lopurin,别嘌呤醇

Target: ROS, Xanthine Oxidase

Allopurinol Sodium

Cat.No: T6376

Synonym: 1H-吡唑并[3,4-D]嘧啶-4-醇单钠盐,Allopurinol sodium salt,Sodium allopurinol

Target: ROS

Cat.No: T72997

Cat.No: T61367

Cat.No: T61614

Cat.No: T78937

Target: HIF/HIF Prolyl-Hydroxylase

HIF-1/2α-IN-1

Cat.No: T61442

HIF-1/2α-IN-2

Cat.No: T61102

Cat.No: T12675L

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T17009

Target: HIF

Cat.No: T7848

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T7802

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T16679

Synonym: PT2977,MK-6482

Target: HIF

Cat.No: T12675

Target: HIF

Cat.No: T69080

Cat.No: T6804

Synonym: Chaetomin,NSC289491,BRN0077366

Target: Apoptosis, HSP, HIF

TAT-cyclo-CLLFVY

Cat.No: TP2046

Cat.No: T36492

Cat.No: T69966

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