Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1765 |
Erastin
|
Ferroptosis; VDAC | Apoptosis; Membrane transporter/Ion channel |
Erastin 是一种作用于线粒体 VDAC 的铁死亡激活剂,具有 ROS 和铁依赖性。Erastin 具有抗肿瘤活性,选择性作用于 RAS 致癌突变的肿瘤细胞。该产品在溶液中不稳定,建议现配现用。 | |||
T16540 |
Piperazine Erastin
|
Ferroptosis | Apoptosis |
Piperazine Erastin 是erastin 的类似物。它会导致一种铁依赖形式的非凋亡性细胞死亡,称为铁死亡。 | |||
T5523 |
Imidazole ketone erastin
IKE |
Ferroptosis | Apoptosis |
Imidazole ketone erastin (IKE) 是一种铁死亡诱导剂,对 system Xc-胱氨酸/谷氨酸转运蛋白具有抑制作用。Imidazole ketone erastin 具有抗肿瘤活性,可以诱导谷胱甘肽耗竭和脂质过氧化。 | |||
T35994 |
Erastin2
Erastin2 |
||
Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.[1] [2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM).[2] It induces cell death in HAP1 cells when used at a concentration of 5 µM, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 or deferoxamine . [1] Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM), an effect that can be blocked by the reducing agent β-merc... | |||
T1787 |
Levobupivacaine
|
Sodium Channel | Membrane transporter/Ion channel |
Levobupivacaine 是一种氨基酰胺类局麻药,属于n-alkylsubstituted pipecoloxylidide 家族。它是bupivacaine 的 S-对映异构体。 | |||
T6566 |
Levobupivacaine hydrochloride
Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,盐酸左布比卡因,(S)-(-)-Bupivacaine monohydrochloride |
Sodium Channel | Membrane transporter/Ion channel |
Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) 是有效的钠通道阻滞剂。 | |||
T13619 |
Cloperastine fendizoate
Hustazol |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Cloperastine fendizoate (Hustazol) 是 hERG K+ 电流的抑制剂,IC50 为 27 nM。 | |||
T25875 |
Noberastine
R64947,T25875,R-64947,R 64947 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Noberastine (R 64947) 是一种新型组胺 H1拮抗剂,具有强效和特异性的外周抗组胺活性。 | |||
T0723 |
Cloperastine hydrochloride
HT-11 hydrochloride,盐酸氯哌斯丁 |
Potassium Channel; 5-HT Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Cloperastine hydrochloride (HT-11 hydrochloride) 是 hERG K+电流的抑制剂,IC50为 27 nM,具有浓度依赖性。 | |||
T70773 | Noberastine citrate | ||
Noberastine citrate, a histamine H1 antagonist, has potent and specific peripheral antihistaminic activity. Noberastine, a furan derivative of nor-astemizole (an astemizole metabolite), has been shown to have a more rapid onset, and shorter duration of action than astemizole with peak antihistaminic activity at 4h following ingestion. Noberastine is rapidly absorbed and the peak plasma levels are obtained within 2 h of oral dosing. In preclinical studies Noberastine has been shown to lack centra... | |||
T33927 |
Perastine
|
||
Perastine is a biochemical. | |||
T71425 | Noberastine maleate | ||
Noberastine maleate, a histamine H1 antagonist, has potent and specific peripheral antihistaminic activity. Noberastine, a furan derivative of nor-astemizole (an astemizole metabolite), has been shown to have a more rapid onset, and shorter duration of action than astemizole with peak antihistaminic activity at 4h following ingestion. Noberastine is rapidly absorbed and the peak plasma levels are obtained within 2 h of oral dosing. In preclinical studies Noberastine has been shown to lack centra... | |||
T68889 |
Esterastin
|
||
Esterastin is an Inhibitor of esterases. | |||
T36404L |
PRLX-93936 HCL
PRLX-93936 hcl(903499-49-0 Free base) |
Ferroptosis; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB |
PRLX-93936 HCL 是 erastin 的类似物,并显示出与顺铂对非小细胞肺癌 (NSCLC) 细胞的协同作用。 | |||
T2376 |
Liproxstatin-1
|
Ferroptosis | Apoptosis |
Liproxstatin-1 是一种铁死亡抑制剂 (IC50=22 nM),具有强效性和选择性。Liproxstatin-1 可以保护细胞免受铁死亡诱导剂 (如 Erastin、RSL3) 诱导的铁死亡。 | |||
T6500 |
Ferrostatin-1
Ferrostatin 1,Ferrostatin-1 (Fer-1) |
Ferroptosis; Antifungal | Apoptosis; Microbiology/Virology |
Ferrostatin-1 (Fer-1) 是一种铁死亡抑制剂,具有强效性和选择性。Ferrostatin-1 有效抑制 Erastin 诱导的 HT-1080 细胞铁死亡 (EC50=60 nM)。Ferrostatin-1 还具抗氧化和抗真菌活性。 | |||
T8922 |
SRS11-92
AA9 |
Ferroptosis | Apoptosis |
SRS11-92 (AA9) 是一种铁死亡抑制剂和 Ferrostatin-1 的衍生物。它抑制 Erastin 诱导的 HT-1080 人纤维肉瘤细胞铁致细胞死亡,EC50为6 nM。 | |||
T36003 | 1(R)-(Trifluoromethyl)oleyl alcohol | ||
1(R)-(Trifluoromethyl)oleyl alcohol is an analog of oleic acid .1It inhibits ferroptosis induced by erastin in primary fibroblasts isolated from patients with Friedreich ataxia, a neuro- and cardiodegenerative disorder characterized by loss or impaired activity of frataxin (FXN), when used at concentrations of 5, 10, or 20 μM. 1(R)-(Trifluoromethyl)oleyl alcohol (5 μM) reduces lipid peroxidation induced byFXNsiRNA knockdown in NBT human myoblasts. 1.Cotticelli, M.G., Forestieri, R., Xia, S., et ... | |||
T74461 | Chalcones A-N-5 | ||
ChalconesA-N-5, 一种三羟基查耳酮衍生物化合物,浓度低于100 µM (IC50> 1 mM) 时无细胞毒性,能显着促进细胞增殖。此外,ChalconesA-N-5 能促进受损脑组织中神经元的生长,抑制RSL或erastin诱导的铁死亡,并降低Aβ1-42蛋白聚集引发的脂质过氧化水平。因此,ChalconesA-N-5 作为分子骨架的候选物,对于开发用以研究AD的体内试验先导化合物具有重要潜力。 | |||
T36404 |
PRLX-93936
|
||
PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1 μM) also inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells. It inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells with IC50 values of less than 100 nM... | |||
T37248 |
Pantothenate Kinase Inhibitor
|
||
Pantothenate Kinase Inhibitor (PANKi) is a reversible inhibitor of pantothenate kinase (PanK; IC50s = 70, 92, and 25 nM for PanK1β, PanK2, and PanK3, respectively), the rate-limiting enzyme in the synthesis of coenzyme A .1It binds to the ATP-PanK3 complex with an apparent binding constant of 300 nM and exhibits mixed-type inhibition with respect to ATP and pantothenate. PANKi inhibits CoA biosynthesis in C3A cells (IC50= 0.9 μM) with no effect on cell viability when used at concentrations up to... |