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Search Results for " cystic fibrosis transmembrane conductance regulator "

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Cat. No.	Product Name	Target	Signaling Pathways
T14935	Elexacaftor VX-445	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Elexacaftor (VX-445) 是一种囊性纤维化跨膜电导调节因子 (CFTR) 校正剂。它促进CFTR 的加工和转运，增加细胞表面CFTR 的数量。
T3135	KM11060	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	KM11060 是 F508del-CFTR 运输缺陷的新型校正剂，可纠正 F508del-CFTR 运输，增加质膜上功能性 CFTR 的数量。它可用于 F508del-CFTR 加工缺陷的研究和囊性纤维化治疗剂的开发。
T16681	Nesolicaftor PTI-428	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Nesolicaftor (PTI-428) 特异性增强囊性纤维化跨膜电导调节蛋白合成。
T9499	Icenticaftor QBW251	CFTR	Membrane transporter/Ion channel
	Icenticaftor (QBW251) 是一种具有口服活性CFTR 通道增强剂，可用于慢性阻塞性肺疾病 (COPD) 和囊性纤维化研究，对F508del 和G551D CFTR 的EC50分别为 79 和 497 nM。
T1634	Glibenclamide 格列本脲,Glyburide	Potassium Channel; Mitochondrial Metabolism; CFTR; P-gp; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Glibenclamide (Glyburide) 是一种具有口服活性的 ATP 敏感的 K+通道抑制剂，可研究糖尿病和肥胖。它抑制 P-糖蛋白，可直接结合并阻断 KATP 的 SUR1亚基并抑制囊性纤维化跨膜传导调节蛋白。它通过诱导膜离子通透性干扰线粒体生物能，可诱导自噬。
T1805	Ataluren PTC124	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Ataluren (PTC124) 是一种可口服的 CFTR-G542X 无义等位基因抑制剂。
T5312	CFTR corrector 2 FDL169	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	CFTR corrector 2 (FDL169) 是一种新型有效的囊性纤维化跨膜电导调节因子(CFTR)调节剂，用于治疗携带 F508del 突变的囊性纤维化患者。
T7083	GLPG1837 ABBV-974	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	GLPG1837 (ABBV-974) 是一种有效的 CFTR 增强剂，对其 F508del 和 G551D 的 EC50 分别为 3 nM 和 339 nM。
T2451	GlyH-101 GlyH 101	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	GlyH-101 是一种可渗透入细胞的 CFTR 阻断剂，Ki 为1.4 uM。
T2588	Ivacaftor Ivacaftor (VX-770),VX-770,依伐卡托	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Ivacaftor (VX-770) 是一种 CFTR 增强剂，靶向G551D-CFTR 和F508del-CFTR 的EC50分别为100 和 25 nM。
T1874	PPQ-102 PPQ102,CFTR Inhibitor,PPQ 102	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	PPQ-102 (CFTR Inhibitor) 是一种CFTR 抑制剂，可以完全抑制CFTR 氯化物电流，IC50为90 nM。
T10591	BPO-27 racemate BPO-27 (racemate)	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	BPO-27 racemate (BPO-27(racemate)) 是一种CFTR 抑制剂，IC50为8 nM。
T2486	IOWH-032 IOWH032,IOWH 032	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	IOWH-032 (IOWH032) 是一种合成 CFTR 抑制剂，可用于研究治疗霍乱、腹泻和分泌性腹泻，在T84和CHO-CFTR 细胞实验中IC50为1.01 uM。
T2595	Lumacaftor 鲁玛卡托,VX-809,VRT 826809	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Lumacaftor (VRT 826809) 是一种 CFTR 调节剂，可纠正 CFTR 蛋白的折叠和运输。它增强了 FRT 细胞中 F508del-CFTR 蛋白的成熟，EC50为100 nM。
T2355	CFTR(inh)-172 CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	CFTR(inh)-172 (CFTR Inhibitor-172) 是一种不依赖电压的选择性 CFTR 抑制剂，在2分钟内可逆地抑制CFTR 短路电流的Ki 值为300 nM。
T2263	Tezacaftor VX661,1-(2,2-二氟-1,3-苯并二氧戊环-5-基)-N-[1-[(2R)-2,3-二羟基丙基]-6-氟-2-(2-羟基-1,1-二甲基乙基)-1H-吲哚-5-基]-环丙烷甲酰胺	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Tezacaftor (VX661) 是一种小分子，可用作囊性纤维化跨膜电导调节器基因功能的校正剂。
T20341	DNDS	CFTR	Membrane transporter/Ion channel
	DNDS 是电压依赖性囊性纤维化跨膜电导调节剂 (CFTR) 的通道阻滞剂。
T63806	CFTR corrector 8	CFTR	Membrane transporter/Ion channel
	CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic disorder primarily affecting the lungs and digestive system [1].
T26955	Cavosonstat N91115,N 91115,N-91115	GSNOR; CFTR	Membrane transporter/Ion channel; Metabolism
	Cavosonstat (N91115) 是一种口服活性 S-亚硝基谷胱甘肽还原酶(GSNOR)抑制剂，可促进囊性纤维化跨膜传导调节器(CFTR)成熟和质膜稳定。
T60653	CFTR corrector 9	CFTR	Membrane transporter/Ion channel
	CFTR corrector 9是一种囊性纤维化跨膜传导调节蛋白 (CFTR)调节剂。CFTR corrector 9 可用于研究囊性纤维化 (CF) 和其他 CFTR 相关疾病。
T10776	CFTR corrector 4	CFTR	Membrane transporter/Ion channel
	CFTR corrector 4是一种高效且可口服的囊性纤维化跨膜电导调节剂 (CFTR)，是一种有效的 (R，R) 型活性对映体。CFTR corrector 4 可以增加细胞表面的 CFTR 水平，是用来研究囊性纤维化的潜在化合物。
T23648	AF-2785
	In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels.
T29040	UCCF-029 UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029
	UCCF-029 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR).
T27098	Ivacaftor-D9 deutivacaftor,CTP-656
	CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.
T13705	GLPG2451	Cysteine Protease	Proteases/Proteasome
	GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1 nM).
T13704	GLPG-3221	Others	Others
	GLPG-3221 can be uesd for the treatment of cystic fibrosis.GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM.
T74417	Vanzacaftor
	Vanzacaftor 是一种囊性纤维化跨膜电导调节体（CFTR）的调节剂，用于研究囊性纤维化。
T37686	CFTR corrector 6
	CFTR corrector 6 is a highly effective CFTR potentiator utilized in research on cystic fibrosis (CF) and related CFTR-associated disorders[1]. This potent compound exhibits potentiation activity on the Cystic Fibrosis Transmembrane conductance Regulator (CFTR), rendering it beneficial for investigations in CF and other associated conditions.
T72860	(R)-Olacaftor (R)-VX-440
	(R)-Olacaftor ((R)-VX-440)，一种对囊性纤维化 (CF) 具有研究潜力的囊性纤维化跨膜调节因子 (CFTR) 调节剂。
T61306	SRI-41315
	SRI-41315, a chemical compound, effectively addresses premature termination codons (PTCs) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells. It induces a prolonged pause at stop codons, resulting in the restoration of cystic fibrosis transmembrane conductance regulator (CFTR) expression and function. This compound achieves PTC suppression by reducing the abundance of the termination factor eRF1. Additionally, SRI-41315 synergistically enhances CFTR acti...
T78240	(R)-Elexacaftor (R)-VX-445	CFTR	Membrane transporter/Ion channel
	(R)-Elexacaftor，Elexacaftor (Compound 1) 的对映异构体，为囊性纤维化跨膜电导调节因子（CFTR）校正剂，其针对CFTR dF508突变体的EC50值为0.29 uM。
T37564	C4 Ceramide (d18:1/4:0) C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)
	C4 Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. [1] [2] [3] It inhibits IL-4 production by 16% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. [1] C4 Ceramide is cytotoxic to SK-BR-3 and MCF-7/Adr breast cancer cells (IC50s = 15.9 and 19.9 μM, respectively). [2] C4 Ceramide also increases maturation and stability of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing...
T37756	Phloxine B
	Phloxine B is a red dye, the USP grade of which is used as a color additive for food, drugs, and cosmetics. It has also been used as an alternative to Gram staining, to differentiate between Gram-negative and Gram-positive bacteria. At 100 μg/ml, it can inhibit methicillin-resistant S. aureus growth in vitro. Phloxine B has also been shown to modulate channel activity of wild-type cystic fibrosis transmembrane conductance regulator chloride channels (CFTR; Ki = 38 μM) and mutant delta F508 CFTR ...
T71303	Flufenamic Acid-d4
	Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...

化合物

Cat.No: T14935

Synonym: VX-445

Target: CFTR, Autophagy

Cat.No: T3135

Target: CFTR, Autophagy

Cat.No: T16681

Synonym: PTI-428

Target: CFTR, Autophagy

Cat.No: T9499

Synonym: QBW251

Target: CFTR

Cat.No: T1634

Synonym: 格列本脲,Glyburide

Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy

Cat.No: T1805

Synonym: PTC124

Target: CFTR, Autophagy

CFTR corrector 2

Cat.No: T5312

Synonym: FDL169

Target: CFTR, Autophagy

Cat.No: T7083

Synonym: ABBV-974

Target: CFTR, Autophagy

Cat.No: T2451

Synonym: GlyH 101

Target: CFTR, Autophagy

Cat.No: T2588

Synonym: Ivacaftor (VX-770),VX-770,依伐卡托

Target: CFTR, Autophagy

Cat.No: T1874

Synonym: PPQ102,CFTR Inhibitor,PPQ 102

Target: CFTR, Autophagy

BPO-27 racemate

Cat.No: T10591

Synonym: BPO-27 (racemate)

Target: CFTR, Autophagy

Cat.No: T2486

Synonym: IOWH032,IOWH 032

Target: CFTR, Autophagy

Cat.No: T2595

Synonym: 鲁玛卡托,VX-809,VRT 826809

Target: CFTR, Autophagy

Cat.No: T2355

Synonym: CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172

Target: CFTR, Autophagy

Cat.No: T2263

Synonym: VX661,1-(2,2-二氟-1,3-苯并二氧戊环-5-基)-N-[1-[(2R)-2,3-二羟基丙基]-6-氟-2-(2-羟基-1,1-二甲基乙基)-1H-吲哚-5-基]-环丙烷甲酰胺

Target: CFTR, Autophagy

Cat.No: T20341

Target: CFTR

CFTR corrector 8

Cat.No: T63806

Target: CFTR

Cat.No: T26955

Synonym: N91115,N 91115,N-91115

Target: GSNOR, CFTR

CFTR corrector 9

Cat.No: T60653

Target: CFTR

CFTR corrector 4

Cat.No: T10776

Target: CFTR

Cat.No: T23648

Cat.No: T29040

Synonym: UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029

Cat.No: T27098

Synonym: deutivacaftor,CTP-656

Cat.No: T13705

Target: Cysteine Protease

Cat.No: T13704

Target: Others

Cat.No: T74417

CFTR corrector 6

Cat.No: T37686

Cat.No: T72860

Synonym: (R)-VX-440

Cat.No: T61306

(R)-Elexacaftor

Cat.No: T78240

Synonym: (R)-VX-445

Target: CFTR

C4 Ceramide (d18:1/4:0)

Cat.No: T37564

Synonym: C4 Ceramide (d18:1/4:0),Cer(d18:1/4:0)

Cat.No: T37756

Flufenamic Acid-d4

Cat.No: T71303

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