首页工具

登录

搜索结果

Search Results for " cereblon inhibitor 1 "

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T82745	Cereblon inhibitor 1	Others	Others
	Cereblon inhibitor1，一种异吲哚啉衍生的分子，作为cereblon E3 泛素连接酶的调节剂，展现了在癌症研究中的应用潜力。
T13721	Homo-PROTAC cereblon degrader 1	Others; PROTACs	Others; PROTAC
	Homo-PROTAC cereblon degrader 1 (compound 15a) 是一种高效 cereblon 降解剂，对 IKZF1 和 IKZF3 的影响很小。
T10765	Eragidomide CC-90009,Cereblon modulator 1	Apoptosis; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Cereblon modulator 1 是一种 GSPT1 选择性cereblon (CRBN)E3 连接酶调节剂，以分子胶的方式作用。它通过 CRL4CRBN选择性靶向 GSPT1 进行泛素化和蛋白酶体降解。
T17325	Pomalidomide-PEG4-C-COOH Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1	Others; E3 Ligase Ligand-Linker Conjugate	Others; PROTAC
	Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) 包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。
T36243	PROTAC RIPK degrader-6	PROTACs	PROTAC
	PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linker to a cereblon binder[1].
T11975	PROTAC Mcl1 degrader-1	BCL; PROTACs	Apoptosis; PROTAC
	PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.
T84904	Thalidomide-Piperazine 5-fluoride hydrochloride UUN-14238,Pomalidomide 5'-fluoro-6'-piperazine,UUN14238,UUN 14238	Others	Others
	Thalidomide-Piperazine 5-fluoride hydrochloride，作为Thalidomide衍生物，是一种cereblon(CRBN)抑制剂，用作E3 泛素连接酶的配体(Ligands for E3 Ligase)，适用于PROTACs合成。
T18641	SirReal1-O-propargyl PROTAC Sirt2-binding moiety 1	Others	Others
	SirReal1-O-propargyl is a selective and highly potent Sirtuin 2 (Sirt2) inhibitor, with an IC50 of 2.4 μM. SirReal1-O-propargyl, the SirReal1-based moiety, binds to the cereblon ligand via a linker to form PROTAC to degrade Sirt2[1].
T16667	PROTAC Sirt2 Degrader-1	Sirtuin; PROTACs	Chromatin/Epigenetic; DNA Damage/DNA Repair; PROTAC
	PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
T18601	Desmethyl-QCA276 PROTAC BRD4-binding moiety 4	Others	Others
	Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1].
T84709	PRO-6E	Others	Others
	PRO-6E是一种基于Cereblon配体的口服活性PROTAC，能在1 μM浓度下使MKN-45细胞中MET的降解率达到81.9%。该化合物有效地在体内外抑制肿瘤生长，并能诱导细胞凋亡(apoptosis)及细胞周期阻滞(结构备注:(Blue:Cereblon配体, Black: linker；Pink: ALK/c-Met抑制剂Crizotinib)。
T18598	PROTAC BRD2/BRD4 degrader-1	Others	Others
	PROTAC BRD2/BRD4 degrader-1 (compound 15) serves as a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly selective elimination of BRD4 and BRD2 compared to BRD3. Its efficacy in suppressing solid tumors manifest with minimal cytotoxic effects. This compound comprises a BET inhibitor, a connecting linker, and thalidomide as the ligand for cereblon (CRBN)/cullin 4A[1].
T73909	Abemaciclib metabolite M18 LSN3106729	Ligands for Target Protein for PROTAC	PROTAC
	Abemaciclibmetabolite M18 (LSN3106729) 是一种CDK抑制剂，具有抗肿瘤活性。作为Abemaciclib的代谢物，Abemaciclibmetabolite M18 能与CRBN配体结合，用于设计PROTAC CDK4/6降解剂。
T79230	JET-209	PROTACs	PROTAC
	JET-209为高效PROTAC CBP/p300降解剂，DC50分别为CBP和p300的0.05 nM与0.2 nM。该化合物融合了Lenalidomide (cereblon配体)、连接子以及GNE-207 (溴结构域抑制剂)。JET-209主要应用于癌症研究领域。
T83857	Soluble Epoxide Hydrolase PROTAC 1a sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a	Others	Others
	Soluble epoxide hydrolase (sEH) PROTAC 1a是一种利用蛋白质降解靶向嵌合体(PROTAC)技术，通过连接区域将cereblon配体1与sEH抑制剂t-TUCB结合。该化合物通过促进sEH的降解，特异性抑制sEH的水解酶活性(IC50 = 0.8 nM)，相较于其磷酸酶活性(IC50 = >10,000 nM)具有较高选择性。sEH PROTAC 1a还特定促进细胞质中而非过氧体中的sEH降解，并通过溶酶体而非蛋白酶体实现其降解。它能够降低thapsigargin诱导的HepG2与293T细胞中磷酸化的inositol-requiring enzyme 1α (IRE1α)水平和X-box结合蛋白1 (XBP1)剪接，表明能减少ER应激。
T83889	C-02	Others	Others
	C-02是一种由巨噬细胞抑制剂Lonidamine和Cereblon配体Thalidomide组成的蛋白酶体靶向嵌合体（PROTAC）。在20 µM浓度下使用时，可诱导786-O和PANC-1细胞中的Hexokinase 2降解。C-02对786-O、4T1、PANC-1、HGC-27和MCF-7癌细胞具有细胞毒性（IC50分别为34.07、5.08、31.53、6.11和21.65 µM）。同时，20 µM浓度下减少4T1细胞的细胞外酸化率（ECAR）和氧气消耗率（OCR），表明其抑制糖酵解和引起线粒体损伤。在体内，C-02（50 mg/kg）能减少4T1小鼠乳腺癌模型的肿瘤体积，并诱导肿瘤内细胞因子积累和细胞焦亡。

化合物

Cereblon inhibitor 1

Cat.No: T82745

Target: Others

Homo-PROTAC cereblon degrader 1

Cat.No: T13721

Target: Others, PROTACs

Cat.No: T10765

Synonym: CC-90009,Cereblon modulator 1

Target: Apoptosis, Ligand for E3 Ligase, Molecular Glues

Pomalidomide-PEG4-C-COOH

Cat.No: T17325

Synonym: Cereblon Ligand -Linker Conjugates 1,E3 Ligase Ligand-Linker Conjugates 1

Target: Others, E3 Ligase Ligand-Linker Conjugate

PROTAC RIPK degrader-6

Cat.No: T36243

Target: PROTACs

PROTAC Mcl1 degrader-1

Cat.No: T11975

Target: BCL, PROTACs

Thalidomide-Piperazine 5-fluoride hydrochloride

Cat.No: T84904

Synonym: UUN-14238,Pomalidomide 5'-fluoro-6'-piperazine,UUN14238,UUN 14238

Target: Others

SirReal1-O-propargyl

Cat.No: T18641

Synonym: PROTAC Sirt2-binding moiety 1

Target: Others

PROTAC Sirt2 Degrader-1

Cat.No: T16667

Target: Sirtuin, PROTACs

Desmethyl-QCA276

Cat.No: T18601

Synonym: PROTAC BRD4-binding moiety 4

Target: Others

Cat.No: T84709

Target: Others

PROTAC BRD2/BRD4 degrader-1

Cat.No: T18598

Target: Others

Abemaciclib metabolite M18

Cat.No: T73909

Synonym: LSN3106729

Target: Ligands for Target Protein for PROTAC

Cat.No: T79230

Target: PROTACs

Soluble Epoxide Hydrolase PROTAC 1a

Cat.No: T83857

Synonym: sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a

Target: Others

Cat.No: T83889

Target: Others

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼