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Cat. No. | Product Name | Target | Signaling Pathways |
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T79059 | CXCR4-IN-1 | CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
CXCR4-IN-1 (Example C5) 为CXCR4抑制剂,IC50值为20 nM。该化合物主要适用于癌症、HIV、糖尿病视网膜病变、炎症等领域的研究。 | |||
TQ0174 |
Mavorixafor
AMD-070 |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
Mavorixafor (AMD-070) 是一种有效的特异性 CXCR4 拮抗剂,对 CXCR4 125I-SDF 结合的 IC50 值为 13 nM。 Mavorixafor 在 MT-4 细胞 (IC50 = 1 nM) 和 PBMC (IC50 = 9 nM) 中抑制 T-tropic HIV-1 (NL4.3 株) 的复制。 | |||
T11693L |
IT1t dihydrochloride
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CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
IT1t dihydrochloride 抑制 CXCL12/CXCR4 相互作用,IC50 为 2.1 nM。 IT1t dihydrochloride 是 CXCR4 的拮抗剂。 | |||
T10296 |
Mavorixafor trihydrochloride
AMD-070 trihydrochloride |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM). | |||
T7208 |
AMD 3465 hexahydrobromide
GENZ-644494 (hexahydrobromide) |
HIV Protease; CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) 是一种 CXCR4受体拮抗剂,具有潜在的抗癌和抗 HIV 活性。 | |||
T14208 |
AMD 3465
GENZ-644494 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC | |||
T62007 |
CXCR4 modulator-1
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CXCR4 modulator-1 (compound ZINC72372983) 是有效的CXCR4调节剂(EC50= 100 nM)。CXCR4 modulator-1 在抗炎、抗癌及抗 HIV 感染方面有研究价值。 | |||
T61363 |
CXCR4 antagonist 8
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CXCR4 antagonist 8 (Compound 3) is a potent inhibitor of CXCR4. It demonstrates an IC50 value of 57 nM in CXCR4 antagonism. In addition, it effectively inhibits the increase in cytosolic calcium induced by CXCL12 with an IC50 value of 0.24 nM. Furthermore, Compound 3 shows efficacy in the inhibition of CXCL12/CXCR4-mediated cell migration [1]. | |||
T75802 |
CTCE-9908 TFA
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CTCE-9908 TFA 是一种有效的,选择性的 CXCR4抑制剂。CTCE-9908 TFA 在表达 CXCR4的卵巢癌细胞中诱导有丝分裂突变,诱导细胞毒性,抑制迁移。 | |||
T61420 |
CXCR4 antagonist 6
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CXCR4 antagonist 6 (compound 46) is a highly potent inhibitor of CXCR4 with an IC50 value of 79 nM. It effectively inhibits the cytosolic calcium flux induced by CXCL12, achieving an IC50 of 0.25 nM. Moreover, CXCR4 antagonist 6 demonstrates significant mitigation of cell migration mediated by the CXCL12/CXCR4 interaction. Notably, this compound exhibits remarkable efficacy in a mouse model of cancer metastasis [1]. | |||
T78879 |
CXCR4-IN-2
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CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
CXCR4-IN-2(compound A1)是一款具有抗癌活性的双功能氟化小分子,是CXCR4的强效抑制剂。它对小鼠结直肠癌(CRC)细胞展现出显著的细胞毒性(IC50:60 μg/mL;72小时)和抗增殖能力,能够引导细胞在G2/M期发生阻滞并诱导细胞凋亡(apoptosis)。 | |||
T63004 |
NUCC-390 dihydrochloride
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NUCC-390 dihydrochloride 是新型的选择性小分子CXCR4receptor 受体激动剂。NUCC-390 dihydrochloride 可以诱导CXCR4受体的内化,作用方式与 AMD3100 相反。NUCC-390 dihydrochloride 在动物模型中,有助于神经退行性变后神经功能恢复。 | |||
T80216 |
DOTA-CXCR4-L
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CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
DOTA-CXCR4-L为针对CXCR4的靶向肽,适用于癌症研究,如胶质母细胞瘤和三阴性乳腺癌。 | |||
T69582 |
AMD-3451 free base
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AMD-3451 free base is a dual CCR5/CXCR4 antagonist which may be useful in the treatment of a wide variety of R5, R5/X4, and X4 strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2. AMD3451 is the first low-molecular-weight anti-HIV agent with selective HIV coreceptor, CCR5 and CXCR4, interaction. | |||
T61419 | CXCR4 antagonist 5 | ||
CXCR4 antagonist 5 (compound 23), a potent CXCR4 antagonist, exhibits high inhibition efficacy against CXCR4 with an IC50 value of 8.8 nM. It effectively suppresses CXCL12-induced cytosolic calcium increase (IC50 = 0.02 nM) and hinders CXCR4/CXCL12-mediated chemotaxis. Moreover, Compound 23 demonstrates favorable physicochemical properties and in vitro safety profiles, exhibiting only marginal to moderate inhibition of CYP isozymes and hERG [1]. | |||
T60811 |
CXCR4 antagonist 7
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CXCR4 antagonist 7 (Compound PARA-B) 是可用于研究HIV 感染、炎症性疾病、癌症和 WHIM 综合症的CXCR4拮抗剂 (IC50 = 9.3 nM)。 | |||
T69081 | KRH-1636 | ||
KRH-1636 is an orally active, selective and extremely potent CXC chemokine receptor 4 antagonist. KRH-1636 exhibits a potent and selective anti-HIV-1 activity. KRH-1636 efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXC chemokine receptor (CXCR)4 coreceptor but not via CC chemokine receptor 5. KRH-1636 also inhibits binding of the CXC chem... | |||
T68457 | GSK812397 | ||
GSK812397 is a potent entry inhibitor of X4-tropic strains of HIV-1, as demonstrated in multiple in vitro cellular assays. GSK812397 is a noncompetitive antagonist of the CXCR4 receptor, with GSK812397 producing a concentration-dependent decrease in both an SDF-1-mediated chemotaxis and intracellular calcium release (IC50s were 0.34+/-0.01 nM and 2.41+/-0.50 nM, respectively). GSK812397 is effective against a broad range of X4- and X4R5-utilizing clinical isolates. The potency and efficacy of GS... | |||
T80130 |
SDF-1α (human)
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CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
SDF-1α (human) 是一种能够与CXCR4受体相结合的单核细胞趋化剂,它在心肌梗死模型中的干细胞归巢、维持、生存、增殖、心肌细胞修复、血管形成以及心室重构过程扮演关键角色。SDF-1α (human) 常用于心血管病研究。 | |||
T76543 |
NoxaBH3
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NoxaBH3,一种基于半胱氨酸的交联肽,具备提高的细胞渗透性及较高对Mcl-1的抑制效能。该化合物通过与CXCR4的内源性配体结合,形成泛素-NoxaBH3偶联物,进而被导向癌细胞。 | |||
T76327 |
CTCE-0214
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CTCE-0214 是一种 CXCR4(chemokine CXC receptor 4) 激动剂,是 SDF-1α 肽类似物。CTCE-0214 具有抗炎活性,可用于炎症败血症和系统性炎症综合征的研究。 | |||
T70259 | AMD-3329 free base | ||
AMD-3329 free base is a biochemical in the class of potent and selective anti-HIV-1 and HIV-2 agents that inhibit virus replication by binding to the chemokine receptor CXCR4, the co-receptor for entry of X4 viruses. | |||
T76548 |
Peptide R
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Peptide R 是一种环状肽,是一种特异性 CXCR4拮抗剂。Peptide R 显示出有效的重塑肿瘤间质的出色能力。Peptide R 具有用于肿瘤研究的潜力。 | |||
T70260 |
AMD-3329 hydrobromide
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AMD-3329 hydrobromide is a biochemical in the class of potent and selective anti-HIV-1 and HIV-2 agents that inhibit virus replication by binding to the chemokine receptor CXCR4, the co-receptor for entry of X4 viruses. | |||
TP1354 |
ATI-2341 TFA (1337878-62-2 free base)
ATI-2341 TFA |
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ATI-2341 is an effective functionally selective allosteric agonist for the c-x-c chemokine receptor type 4 (CXCR4), which ACTS as a biased ligand in favor of G G G G G 1 activation instead of G G G G G 13.ATI-2341 activates the inhibitory heterotrimer G p | |||
T37604 | ITK inhibitor | ||
Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways. ITK inhibitors can be used for the treatment of inflammation and immune-mediated disorders. ITK inhibitor (N-[5-[[3-[(4-Acetylpiperazin-1-yl)carbonyl]-4-methyl-6-methoxy-phenyl]thio]thiazol-2-yl]-4-(N-1,2-dimethylpropylaminome... | |||
T11693 |
IT1t
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Others | Others |
IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist. |
Cat. No. | Product Name | Target | Signaling Pathways |
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T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 |