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Search Results for " crt "

Targets Recommended: PDE

20

抑制剂 & 化合物

23

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T31101	CRT0273750 CRT 0273750,CRT-0273750	PDE	Metabolism
	CRT0273750 是一种 ATX 抑制剂的先导化合物，可调节血浆中 LPA 水平，用于 ATX/LPA 依赖性癌症模型。
T23917	CRT-0105950 CRT 0105950
	CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.
TQ0104	CRT0066101 dihydrochloride CRT0066101二盐酸盐	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	CRT0066101 dihydrochloride 是一种选择性PKD 有效抑制剂，对PKD1、2和3的IC50值分别为1、2.5和2 nM。
T10888	CRT0066854 hydrochloride	ROCK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells
	CRT0066854 hydrochloride 是一种强效选择性非典型 PKCs 抑制剂。CRT0066854 hydrochloride 抑制 PKCι，PKCζ 和 ROCK-II 的 IC50 的值分别为 132nM，639 nM 和 620 nM。
T23916	CRT-0105446 CRT0105446
	CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.
T8957L	CRT0066101 dihydrochloride(956121-30-5 free base)	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	CRT0066101 dihydrochloride(956121-30-5 free base) 是 PKD 的抑制剂。
T27089	CRT0066854 CRT0066854 HCl,CRT-0066854 HCl,CRT 0066854,CRT-0066854
	CRT-0066854 is a PKCι and PKCζ inhibitor. CRT0066854 was able to restore polarized morphogenesis in the dysplastic H-Ras spheroids.
T23914	CRT0083914 CRT-0083914,CRT 0083914
	CRT0083914 is a potent and selective AKR1C3 inhibitor.
T23915	CRT0093964 CRT-0093964,CRT 0093964
	CRT0093964 is a selective AKR1C3 inhibitor.
T8957	CRT0066101	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	CRT0066101 是 PKD 的抑制剂。
T6456	CRT0044876 NSC 69877,7-NO2-ICA,7-硝基吲哚-2-甲酸,NSC 69877,7-Nitroindole-2-Carboxylic Acid	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	CRT0044876 (7-NO2-ICA) 是一种高选择性的嘌呤/嘧啶核苷核酸内切酶 1 抑制剂，IC50约为 3 μM。它也是 APE1 所属的核酸外切酶 III 家族的特异性抑制剂，可抑制 APE1 的 AP 内切酶、3′-磷酸二酯酶和 3′-磷酸酶活性，可增强几种 DNA 碱基靶向化合物的细胞毒性。
T21795	CRT5
	CRT5 是一种吡嗪苯甲酰胺，对经 VEGF 处理的内皮细胞中的所有三种 PKD 亚型 (对 PKD1、PKD2 和 PKD3 的 IC50s 分别为 1、2 和 1.5 nM) 都是一种有效的选择性抑制剂，并且 CRT5 减少 VEGF 诱导的内皮细胞迁移、增殖和微管生成。
T82667	CRT0063465
	CRT0063465是一种同时针对人类PGK1和Stress Sensor DJ1的配体，其对PGK1的Kd值为24 μM。该化合物能够调节端粒蛋白复合体的形成及端粒长度。
T4486	iCRT 14	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	iCRT 14 是 β-连环蛋白应答转录抑制剂，能够抑制 Wnt 信号通路(IC50:40.3 nM)。
T10889	CRTh2 antagonist 2	GPR	Endocrinology/Hormones; GPCR/G Protein
	CRTh2 antagonist 2 是一种有效的选择性 CRTH2 抑制剂，对 CRTH2 的 IC50 值为 ≤10 nM。CRTh2 antagonist 2 可用于雄激素性脱发的研究。
T27582	iCRT-5 iCRT 5,iCRT5	Apoptosis; Wnt/beta-catenin	Apoptosis; Cytoskeletal Signaling; Stem Cells
	iCRT-5 是一种有效的 Wnt 通路抑制剂。iCRT-5 具有抗增殖活性，可以阻断 Wnt/β-catenin 表达，诱导细胞凋亡。iCRT-5 可用于研究多发性骨髓瘤。
T4302	iCRT3	Apoptosis; Wnt/beta-catenin	Apoptosis; Cytoskeletal Signaling; Stem Cells
	iCRT3 是一种Wnt 和 β-连环蛋白应答转录抑制剂。
T10084	CRTh2 antagonist 1	GPR	Endocrinology/Hormones; GPCR/G Protein
	CRTh2 antagonist 1 是 CRTh2 拮抗剂，IC50 值为 89 nM。
T10890	CRTh2 antagonist 3	Others	Others
	CRTh2 antagonist 3 is a powerful chemokine receptor homologous molecule expressed on Th2 cell (CRTh2) antagonists. CRTh2 antagonist 3 enhanced the activity of PDK1 on short peptide substrates with EC50 of 2 μM and Kd of 8.4 μM. CRTh2 antagonist 3 has the
T10891	CRTH2-IN-1 Ramatroban analog	P450	Metabolism
	CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.

化合物

Cat.No: T31101

Synonym: CRT 0273750,CRT-0273750

Target: PDE

Cat.No: T23917

Synonym: CRT 0105950

CRT0066101 dihydrochloride

Cat.No: TQ0104

Synonym: CRT0066101二盐酸盐

Target: Serine/threonin kinase

CRT0066854 hydrochloride

Cat.No: T10888

Target: ROCK, PKC

Cat.No: T23916

Synonym: CRT0105446

CRT0066101 dihydrochloride(956121-30-5 free base)

Cat.No: T8957L

Target: Serine/threonin kinase

Cat.No: T27089

Synonym: CRT0066854 HCl,CRT-0066854 HCl,CRT 0066854,CRT-0066854

Cat.No: T23914

Synonym: CRT-0083914,CRT 0083914

Cat.No: T23915

Synonym: CRT-0093964,CRT 0093964

Cat.No: T8957

Target: Serine/threonin kinase

Cat.No: T6456

Synonym: NSC 69877,7-NO2-ICA,7-硝基吲哚-2-甲酸,NSC 69877,7-Nitroindole-2-Carboxylic Acid

Target: DNA/RNA Synthesis

Cat.No: T21795

Cat.No: T82667

Cat.No: T4486

Target: Wnt/beta-catenin

CRTh2 antagonist 2

Cat.No: T10889

Target: GPR

Cat.No: T27582

Synonym: iCRT 5,iCRT5

Target: Apoptosis, Wnt/beta-catenin

Cat.No: T4302

Target: Apoptosis, Wnt/beta-catenin

CRTh2 antagonist 1

Cat.No: T10084

Target: GPR

CRTh2 antagonist 3

Cat.No: T10890

Target: Others

Cat.No: T10891

Synonym: Ramatroban analog

Target: P450

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00085	Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc) CTR,CTR1,CT-R,calcitonin receptor,CRT	Human	HEK293
	Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 42.1 kDa. Accession number: P30988-2
TMPY-03259	Calreticulin Protein, Human, Recombinant (His) HEL-S-99n,cC1qR,SSA,CRT,RO,calreticulin	Human	HEK293
	Calreticulin is a multifunctional protein. It acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin binds Ca2+ ions (a second messenger in signal transduction), rendering it inactive. The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal. Located in storage compartments associated with the endoplasmic reticulum, calreticulin also binds to misfolded proteins and prevents them from being exported from the endoplasm...
TMPY-03258	Calreticulin Protein, Human, Recombinant (hFc) RO,cC1qR,HEL-S-99n,CRT,calreticulin,SSA	Human	HEK293
	Calreticulin is a multifunctional protein. It acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin binds Ca2+ ions (a second messenger in signal transduction), rendering it inactive. The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal. Located in storage compartments associated with the endoplasmic reticulum, calreticulin also binds to misfolded proteins and prevents them from being exported from the endoplasm...
TMPY-00317	Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc) CTR,calcitonin receptor,CRT,CTR1,CT-R	Human	HEK293
	Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 43.9 kDa. Accession number: P30988-1
TMPJ-01277	CRT2 Protein, Human, Recombinant CALR3,Calreticulin-3,calreticulin-2,calsperin,CRT2	Human	E. coli
	Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy t...
TMPY-06327	Calreticulin Protein, Human, Recombinant HEL-S-99n,calreticulin,cC1qR,CRT,RO,SSA	Human	HEK293
	Calreticulin is a multifunctional protein. It acts as a main Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. Calreticulin binds Ca2+ ions (a second messenger in signal transduction), rendering it inactive. The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal. Located in storage compartments associated with the endoplasmic reticulum, calreticulin also binds to misfolded proteins and prevents them from being exported from the endoplasm...
TMPH-00436	Calreticulin Protein, Cricetulus griseus, Recombinant (His) ERp60,Calreticulin,Calregulin,CRT,CRP55,HACBP,CALR,...	Chinese hamster	Yeast
	Calreticulin Protein, Cricetulus griseus, Recombinant (His) is expressed in Yeast.
TMPH-02559	Calreticulin Protein, Mouse, Recombinant (GST) ERp60,Calreticulin,Endoplasmic reticulum resident protein 60...	Mouse	E. coli
	Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Present in ...
TMPH-02558	Calreticulin Protein, Mouse, Recombinant (His) ERp60,CRP55,CRT,CALR,Calregulin,Calreticulin,Endopl...	Mouse	Yeast
	Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Present in ...
TMPH-03105	Calreticulin Protein, Pig, Recombinant (His) Endoplasmic reticulum resident protein 60,CRP55,CRT...	Sus scrofa (Pig)	Yeast
	Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Present in ...
TMPJ-01422	CRTAM Protein, Cynomolgus, Recombinant (His) Cytotoxic and Regulatory T-Cell Molecule,CD355,CRTA...	Cynomolgus	Human Cells
	Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and it is highly expressed by Purkinje cells of the cerebellum. CRTAM is a type I transmembrane glycoprotein containing one Ig-like C2-type domain and one Ig-like V-type domain in its extracellular domain, while its cytoplasmic region shows a potential class I PDZ...
TMPJ-00233	CD200R1/CRTR2 Protein, Human, Recombinant (His) Cell Surface Glycoprotein CD200 Receptor 1,OX2R,MOX2R,CD200 ...	Human	Human Cells
	Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. CD200R1 and CD200 associate via their respective N-terminal Ig-like domains. CD200R1 is restricted primarily to mast cells, basophils, macrophages, and dendritic cells. It propagates inhibitory signals despite its lacking a cytopla...
TMPK-00624	CD200R1/CRTR2 Protein, Human, Recombinant (hFc) MOX2R,CRTR2,CD200R,HCRTR2,CD200 R1,MOX2 re...	Human	HEK293
	CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand.
TMPH-03084	CrtX Protein, Pantoea ananas, Recombinant (E. coli, His & Myc) Zeaxanthin glucosyltransferase,crtX,ugt101	Pantoea ananas	E. coli
	Catalyzes the glycosylation reaction which converts zeaxanthin to zeaxanthin bis(beta-D-glucoside). The reaction proceeds in two steps with the monoglucoside as an intermediate.
TMPK-00971	CRTAM Protein, Mouse, Recombinant (His) CRTAM,CD355,CD355 antigen	Mouse	HEK293
	Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis.
TMPK-01262	CD200R1/CRTR2 Protein, Cynomolgus, Recombinant (His) CD200 receptor 1,OX2R,MOX2R,CD200 R1,MOX2 receptor,CD200R,H<...	Cynomolgus	HEK293
	CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand.
TMPK-00623	CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi), Biotinylated CRTR2,MOX2R,OX2R,CD200 R1,HCRTR2,CD200 rec...	Human	HEK293
	CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand.
TMPK-00622	CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi) OX2R,CD200R,MOX2R,CD200 R1,CRTR2,HCRTR2,CD...	Human	HEK293
	CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand.
TMPY-01674	CRTAM Protein, Human, Recombinant (His) cytotoxic and regulatory T cell molecule,CD355	Human	HEK293
	Cytotoxic and regulatory T-cell molecule, also known as Class-I MHC-restricted T-cell-associated molecule and CRTAM, is a single-pass type I membrane protein which belongs to thenectin family.CRTAM contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. In the immune system, the expression of CRTAM is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. It is strongly expressed in spleen, thymus, small inte...
TMPJ-00429	CRTAM Protein, Cynomolgus, Recombinant (hFc) CRTAM,CD355,Cytotoxic and Regulatory T-Cell Molecul...	Cynomolgus	Human Cells
	Cytotoxic and Regulatory T-Cell Molecule (CRTAM) is a member of Nectin family under the immunoglobulin superfamily that is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and it is highly expressed by Purkinje cells of the cerebellum. CRTAM is a type I transmembrane glycoprotein containing one Ig-like C2-type domain and one Ig-like V-type domain in its extracellular domain, while its cytoplasmic region shows a potential class I PDZ...
TMPK-01385	CRTAM Protein, Canine, Recombinant (His) CRTAM,CD355 antigen,CD355	Canine	HEK293
	Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis.
TMPH-03083	CrtX Protein, Pantoea ananas, Recombinant (His & Myc) Zeaxanthin glucosyltransferase,ugt101,crtX	Pantoea ananas	Baculovirus
	Catalyzes the glycosylation reaction which converts zeaxanthin to zeaxanthin bis(beta-D-glucoside). The reaction proceeds in two steps with the monoglucoside as an intermediate.
TMPY-05059	LACRT Protein, Human, Recombinant (His) lacritin	Human	HEK293
	LACRT Protein, Human, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 13.7 kDa. Accession number: Q9GZZ8

重组蛋白

Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc)

Cat.No: TMPY-00085

Species: Human

Expression System: HEK293

Calreticulin Protein, Human, Recombinant (His)

Cat.No: TMPY-03259

Species: Human

Expression System: HEK293

Calreticulin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03258

Species: Human

Expression System: HEK293

Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc)

Cat.No: TMPY-00317

Species: Human

Expression System: HEK293

CRT2 Protein, Human, Recombinant

Cat.No: TMPJ-01277

Species: Human

Expression System: E. coli

Calreticulin Protein, Human, Recombinant

Cat.No: TMPY-06327

Species: Human

Expression System: HEK293

Calreticulin Protein, Cricetulus griseus, Recombinant (His)

Cat.No: TMPH-00436

Species: Chinese hamster

Expression System: Yeast

Calreticulin Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02559

Species: Mouse

Expression System: E. coli

Calreticulin Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02558

Species: Mouse

Expression System: Yeast

Calreticulin Protein, Pig, Recombinant (His)

Cat.No: TMPH-03105

Species: Sus scrofa (Pig)

Expression System: Yeast

CRTAM Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-01422

Species: Cynomolgus

Expression System: Human Cells

CD200R1/CRTR2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00233

Species: Human

Expression System: Human Cells

CD200R1/CRTR2 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00624

Species: Human

Expression System: HEK293

CrtX Protein, Pantoea ananas, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-03084

Species: Pantoea ananas

Expression System: E. coli

CRTAM Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00971

Species: Mouse

Expression System: HEK293

CD200R1/CRTR2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01262

Species: Cynomolgus

Expression System: HEK293

CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00623

Species: Human

Expression System: HEK293

CD200R1/CRTR2 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00622

Species: Human

Expression System: HEK293

CRTAM Protein, Human, Recombinant (His)

Cat.No: TMPY-01674

Species: Human

Expression System: HEK293

CRTAM Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPJ-00429

Species: Cynomolgus

Expression System: Human Cells

CRTAM Protein, Canine, Recombinant (His)

Cat.No: TMPK-01385

Species: Canine

Expression System: HEK293

CrtX Protein, Pantoea ananas, Recombinant (His & Myc)

Cat.No: TMPH-03083

Species: Pantoea ananas

Expression System: Baculovirus

LACRT Protein, Human, Recombinant (His)

Cat.No: TMPY-05059

Species: Human

Expression System: HEK293

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