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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T36933	Cdk2 Inhibitor II Cdk2 Inhibitor II,CDK2-IN-3	CDK	Cell Cycle/Checkpoint
	Cdk2 Inhibitor II 是一种具有选择性和有效性的 CDK2 抑制剂，50 为 60 nM。
T35555	GSK-3/CDK5/CDK2-IN-1 GSK-3/CDK5/CDK2-IN-1
	GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].
T79728	EGFR/CDK2-IN-3	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/CDK2-IN-3（compound 4b）是一种针对EGFR与CDK-2的双重抑制剂，分别具有71.7 nM和113.7 nM的IC50s。该化合物在MCF-7细胞中能诱导凋亡，导致细胞周期在S期停滞，并显示出对癌细胞的明显毒性，其对MCF-7细胞的IC50值为3.16 μM。
T77341	GSK-3 inhibitor 4	GSK-3; CDK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	GSK-3 inhibitor 4 是一种具有口服活性和脑渗透性的 GSK-3，CDK2 和 CDK5 三重抑制剂，对 GSK-3β，GSK-3α，CDK2 和 CDK5 具有抑制作用，IC50 值分别为 0.56 nM ，0.45 nM ，0.47 μM，0.68 μM。GSK-3 inhibitor 4 可有效降低 Tau protein 水平。GSK-3 inhibitor 4 可用于研究阿尔茨海默症。
T14136	AG-024322	CDK	Cell Cycle/Checkpoint
	AG-024322 is a potent ATP-competitive inhibitor of pan-CDK against cell cycle kinases CDK1, CDK2, and CDK4(Ki values in the 1-3 nM range)
T61362	CDK5-IN-3
	CDK5-IN-3 (compound 11) is a highly potent and selective inhibitor of CDK5, demonstrating significant inhibition with IC50 values of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. This compound holds promise for further investigation in the context of autosomal dominant polycystic kidney disease (ADPKD) research [1].
T63933	CDK1-IN-3
	CDK1-IN-3 (8g) 是一种选择性的 CDK1 抑制剂，能够作用于 CDK1 (IC50: 36.8 nM)，CDK2 (IC50: 305.17 nM) 和 CDK5 (IC50: 369.37 nM)。CDK1-IN-3 能够影响细胞周期，进而抑制癌细胞的生长，能够用于研究癌症。
T40546	3-Methylthienyl-carbonyl-JNJ-7706621
	3-Methylthienyl-carbonyl-JNJ-7706621 is a highly potent and selective inhibitor of cyclin-dependent kinase (CDK). It exhibits impressive IC50 values of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. Additionally, 3-Methylthienyl-carbonyl-JNJ-7706621 demonstrates potent inhibition against GSK-3 (IC50 = 0.041 μM) and moderate potency towards CDK4, VEGF-R2, and FGF-R2 (IC50 = 0.11 μM, 0.13 μM, and 0.22 μM, respectively). Its applications in cancer research are noteworthy.
T60583	CDK1/2/4-IN-1
	CDK1/2/4-IN-1 (compound 3a) 是 CDK 的有效抑制剂，其对于 CDK1、CDK2 和 CDK4 的 IC50值分别为 1.47、0.78 和 0.87 μM。CDK1/2/4-IN-1 可用于癌症研究。CDK1/2/4-IN-1 可将细胞周期阻滞在 G2/M 期并诱导细胞凋亡。CDK1/2/4-IN-1 提高 Bax、caspase-3和 P53 的水平并降低 Bcl-2 水平。

化合物

Cdk2 Inhibitor II

Cat.No: T36933

Synonym: Cdk2 Inhibitor II,CDK2-IN-3

Target: CDK

GSK-3/CDK5/CDK2-IN-1

Cat.No: T35555

Synonym: GSK-3/CDK5/CDK2-IN-1

Target: GSK-3, CDK

3-Methylthienyl-carbonyl-JNJ-7706621

Cat. No.	Product Name	Target	Signaling Pathways
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。

天然产物

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

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