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24
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T80131 |
C5a Anaphylatoxin (human)
|
Complement System | Immunology/Inflammation |
C5a Anaphylatoxin (human)为促炎多肽及白细胞化学引诱剂,主要应用于炎症与免疫领域研究,例如过敏性哮喘。 | |||
T80265 |
C5a Receptor agonist, mouse, human
|
Complement System | Immunology/Inflammation |
C5a Receptor agonist, mouse, human 是一种源自血浆蛋白C5a C末端的生物活性肽,充当C5a受体激动剂。此化合物在调控细胞炎症反应中起关键作用,包括促进趋化性、白细胞脱颗粒、增加血管通透性以及刺激细胞因子的产生。化合物的结构中,第5位环己基丙氨酸对激动剂功能至关重要,同时末端的Arg采用d-异构体形式。 | |||
T17250 |
W-54011
|
ROS; Complement System | Immunology/Inflammation |
W-54011 是口服有效的非肽 C5a 受体拮抗剂,抑制125I 标记的 C5a 与人嗜中性白细胞的结合,Ki 为 2.2 nM。它还抑制C5a 诱导的人嗜中性粒细胞的细胞内 Ca2+动员,趋化性和ROS 的生成,IC50分别为 3.1 nM、2.7 nM 和1.6 nM。 | |||
T9915 | Eculizumab | Complement System | Immunology/Inflammation |
Eculizumab 是针对补体 C5 的长效人源化单克隆抗体。它对 C5 裂解为 C5a 和 C5b 具有抑制作用,并抑制了末端补体系统的部署,其中包括膜攻击复合物的形成。它可用于溶血的研究。 | |||
T82797 |
C5aR1 antagonist peptide
|
||
C5aR1 antagonist peptide 是一种源自C5a (趋化因子补体片段5过敏毒素) C末端的生物活性线性肽。它能在人和大鼠的C5a受体上阻断C5a的结合,对于细胞免疫反应的触发起着关键作用。C5a的过度表达与多种免疫炎性疾病如关节炎、阿尔茨海默病、囊性纤维化和系统性红斑狼疮等有着密切关联。 | |||
T73262 | C5aR-IN-3 | ||
C5aR-IN-3 是一种有效的 C5aR 抑制剂。C5a 水平升高与自身免疫性疾病和炎症性疾病等疾病有关。C5aR-IN-3 具有研究炎症性疾病的潜力。 | |||
T73261 |
C5aR-IN-1
|
||
C5aR-IN-1 是一种有效的C5aR 抑制剂。C5a 水平升高与自身免疫性疾病和炎症性疾病等疾病有关。C5aR-IN-1 具有研究炎症性疾病的潜力。 | |||
T64200 |
C5aR-IN-2
|
||
C5aR-IN-2 是一种 C5aR 的有效抑制剂。其中 C5a 水平升高与自身免疫性疾病和炎症性疾病等疾病有关。C5aR-IN-2 对炎症性疾病表现出研究潜力。 | |||
TP1834 |
MUC5AC motif peptide
|
||
MUC5AC motif peptide is a 16-amino acid fragment of mucin 5. | |||
T60161 |
CP-289
|
Complement System | Immunology/Inflammation |
CP-289是一种有效的C5a 受体拮抗剂,IC50为1μM。 | |||
T12506L1 |
PMX 205 acetate(514814-49-4 free base)
|
Complement System | Immunology/Inflammation |
PMX 205 acetate(514814-49-4 free base) 是补体 C5a 受体 (C5aR; CD88) 的拮抗剂。 | |||
T60151 | CP-447697 | Complement System | Immunology/Inflammation |
CP-447697 是亲脂性的 C5a 受体拮抗剂,IC50 值为 31 nM。CP-447697 可用于炎症的研究。 | |||
TP2334 |
PMX 53 acetate(219639-75-5 free base)
|
Complement System | Immunology/Inflammation |
PMX 53 acetate(219639-75-5 free base) 是一种有效的口服活性 CD88 (C5aR) 拮抗剂 (IC50: 20 nM),抑制 C5a 诱导的中性粒细胞髓过氧化物酶释放和趋化性,IC50 值分别为 22 nM 和 75 nM。 PMX-53 也是 Mas 相关基因 2 (MrgX2) 的激动剂。 | |||
T9316 |
JR14a
5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride |
Complement System | Immunology/Inflammation |
JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) 是补体C3a 受体噻吩拮抗剂,可抑制 C3aR 介导的炎症,对人 C3a 受体的选择性高于 C5a 受体。 | |||
T73710 | PMX 205 Trifluoroacetate | ||
PMX 205 Trifluoroacetate 是一种有效的补体C5a 受体 (C5aR;CD88) 拮抗剂。 | |||
T12506L |
PMX 205
|
Others | Others |
PMX 205 is an effective complement antagonist of the C5a receptor. | |||
T76913 | Avdoralimab | ||
Avdoralimab (IPH 5401),一种全人IgGκ单克隆抗体,针对补体C5a受体1 (C5aR1),阻碍其与C5a结合。该药物适用于研究补体驱动的炎症性疾病及实体瘤。 | |||
T12506 |
PMX 205 Trifluoroacetate (514814-49-4 free base)
PMX 205 Trifluoroacetate |
Others | Others |
PMX 205 Trifluoroacetate is a potent complement antagonist of C5a receptor. | |||
T83669 |
PMX-53 TFA
AcPhe-[Orn-Pro-D-Cyclohexylalanine-Trp-Arg],AcF-[OPdChaWR],3D53 |
||
PMX-53是一种大环型补体5a (C5a) 类肽模拟物及C5a受体的拮抗剂(IC50 = 0.3 µM)。它能抑制C5a诱导的人类分离性多形核白细胞(PMNs)中的髓过氧化物酶(MPO)分泌。在大鼠腹膜亚瑟斯反应模型中,PMX-53(10 mg/kg, p.o.)能够抑制血管渗漏、多形核白细胞浸润以及腹膜TNF-α和IL-6的产生。在3-硝基丙酸(3-NP)诱导的亨廷顿病大鼠模型中,它能减少体重损失和厌食,抑制纹状体退化。PMX-53(3 mg/kg)还能在ApoE-/-小鼠中减小动脉粥样硬化斑块大小和脂质含量。 | |||
T76958 | Vilobelimab | ||
Vilobelimab (CaCP-29, IFX-1) 是一种单克隆抗 C5a 抗体,过敏毒素 C5a 是一种促炎补体分裂产物,在介导器官功能障碍中起核心作用。Vilobelimab 可作为一种 C5a 抑制剂,抑制中性粒细胞活化、趋化性,减少炎症信号等,可用于败血症,COVID-19 等相关研究。 | |||
T74551 |
Avacincaptad pegol sodium
|
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Avacincaptad pegol (ARC1905) 是一种靶向补体因子5 (C5)的核酸适配体,抑制C5剪切为C5a 和C5b。Avacincaptad pegol 被用于研究与年龄相关的黄斑变性(AMD)。 | |||
T28429 |
PMX-53
PMX53,PMX 53 |
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PMX-53 is a Mas-related gene 2 (MrgX2) agonist and C5aR(CD88) antagonist. PMX-53 reduces atherosclerotic lesions in a mouse model of atherosclerosis, inhibits lung metastasis in a mouse breast cancer model, inhibits C5a-induced hypernociception in rats. | |||
T35836 |
PMX-205 (trifluoroacetate salt)
|
||
PMX-205 is a cyclic hexapeptide that acts as a potent antagonist of C5a receptor (C5aR; IC50= 31 nM).1It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma.2,3PMX-205 is also brain penetrant and reduces neuroinflammation and neurodegeneration in an animal model of Alzheimer's disease.4 1.March, D.R., Proctor, L.M., Stoermer, M.J., et al.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Rela... | |||
T8223 |
Avacopan
CCX168 |
Complement System | Immunology/Inflammation |
Avacopan (CCX168) 是一种口服小分子 C5aR (IC50: 0.1 nM.) 拮抗剂,可阻断 C5a 的作用并防止 AAV 小鼠模型中抗髓过氧化物酶抗体诱导的 GN 发展。 | |||
T74650 | JPE-1375 | ||
JPE-1375 是一种补体C5a 受体 1 (C5aR1) 拮抗剂。JPE-1375 能有效抑制小鼠体内多形核白细胞动员 (EC50=6.9 µM) 和降低TNF 水平 (EC50=4.5 µM)。JPE-1375 可用于自身免疫性和炎性疾病的研究。 | |||
T74552 | Non-PEGylated/naked ARC1905 | ||
Non-PEGylated/naked ARC1905 是一种没有偶联PEG 的靶向补体因子5 (C5)的核酸适配体,抑制C5剪切为C5a 和C5b。Non-PEGylated/naked ARC1905 被用于研究与年龄相关的黄斑变性(AMD)。 | |||
T77107 | Olendalizumab | ||
Olendalizumab (ALXN1007)为源自小鼠的人源化IgG2-G4-κ抗体,专一靶向补体蛋白C5a(Ki=60 pM),用于探究冠状病毒引发的补体介导疾病,并针对补体炎症通路。 | |||
T79376 |
SARS-CoV-2 3CLpro-IN-19
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SARS-CoV | Microbiology/Virology |
SARS-CoV-2 3CLpro-IN-19 (Compound C5a)为非共价、非肽类SARS-CoV-2 3CLpro抑制剂,具IC50s值为0.7μM。该化合物对Omicron亚变体(包括BA.5、BQ.1.1及XBB.1.5)在人细胞内的感染显示出具有广谱抗病毒活性,其EC50值介于30-69 nM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00653 |
Complement C5 Protein, Human, Recombinant (Complement C5a)
C5D,C5b,CPAMD4,complement component 5,Complement C5,ECLZB, |
Human | E. coli |
Complement C5 Protein, Human, Recombinant (Complement C5a) is expressed in E. coli expression system. The predicted molecular weight is 8.3 kDa and the accession number is P01031. | |||
TMPH-03107 |
Complement C5a Protein, Pig, Recombinant (His)
Complement C5a anaphylatoxin,C5 |
Sus scrofa (Pig) | P. pastoris (Yeast) |
Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.... | |||
TMPY-05057 |
Complement C5 Protein, Human, Recombinant (His & FLAG)
C5b,ECLZB,C5a,CPAMD4,C5D,complement component 5,Com... |
Human | HEK293 Cells |
Complement C5 Protein, Human, Recombinant (His & FLAG) is expressed in HEK293 mammalian cells with His and Flag tag. The predicted molecular weight is 188.8 kDa and the accession number is P01031. | |||
TMPY-04902 |
Complement C5a Protein, Mouse, Recombinant
complement component 5 |
Mouse | E. coli |
Complement C5a Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 9 kDa and the accession number is P06684. | |||
TMPH-01022 |
C5AR1 Protein-VLP, Human, Recombinant (His)
C5a anaphylatoxin chemotactic receptor 1,CD88,C... |
Human | HEK293 Cells |
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. C5AR1 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-... | |||
TMPH-01023 |
C5AR1 Protein, Human, Recombinant (Cell-Free, His)
C5a anaphylatoxin chemotactic receptor 1,C5R1,C... |
Human | E. coli |
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. C5AR1 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression syst... | |||
TMPY-06814 |
Complement C5 Protein, Human, Recombinant (Flag)
C5a,CPAMD4,ECLZB,C5b,C5D,Complement C5,complement c... |
Human | HEK293 Cells |
Complement C5 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with Flag tag. The predicted molecular weight is 187.36 kDa and the accession number is NP_001726.2. | |||
TMPY-05459 |
Complement C5a Protein, Mouse, Recombinant, Biotinylated
complement component 5 |
Mouse | E. coli |
Complement C5a Protein, Mouse, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 9 kDa and the accession number is P06684. | |||
TMPH-02120 |
SLC5A5 Protein, Human, Recombinant (His)
|
Human | E. coli |
Mediates iodide uptake in the thyroid gland. SLC5A5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 17.4 kDa and the accession number is Q92911. | |||
TMPK-01218 |
MDL-1/CLEC5A Protein, Mouse, Recombinant (hFc)
MDL1,DAP12-associating lectin 1,MDL-1,CLEC5A,CLECSF... |
Mouse | HEK293 Cells |
MDL-1/CLEC5A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is Q9R007-1. | |||
TMPH-02121 |
SLC5A5 Protein, Human, Recombinant (B2M & His)
|
Human | E. coli |
May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. SLC5A5 Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 27.1 kDa and the accession number is O95436. | |||
TMPY-03872 |
CLEC5A Protein, Rat, Recombinant (His)
C-type lectin domain family 5, member A |
Rat | HEK293 Cells |
CLEC5A Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.6 kDa and the accession number is F7GAV1. | |||
TMPH-02119 |
SLC5A2 Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. | |||
TMPY-00999 |
UNC5A Protein, Human, Recombinant (His)
unc-5 homolog A (C. elegans),UNC5H1 |
Human | HEK293 Cells |
The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cumulatively downregulated by the unfolding protein response (UPR) at the transcriptional level in vitro and at the translational level both in vitro and in vivo. Also, UNC5A is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis. UNC5A Protein, Human,... | |||
TMPY-00648 |
UNC5A Protein, Human, Recombinant (hFc)
UNC5H1,unc-5 homolog A (C. elegans) |
Human | HEK293 Cells |
The netrin-1 receptor Uncoordinated Phenotype-5A, or UNC5A, plays an important role in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer. Moreover, UNC5A is cumulatively downregulated by the unfolding protein response (UPR) at the transcriptional level in vitro and at the translational level both in vitro and in vivo. Also, UNC5A is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis. UNC5A Protein, Human,... | |||
TMPH-02032 |
GPRC5A Protein, Human, Recombinant (GST)
|
Human | E. coli |
Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. May act as a lung tumor suppressor. GPRC5A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 37.0 kDa and the accession number i... | |||
TMPY-03760 |
CLEC5A Protein, Rhesus, Recombinant (His)
C-type lectin domain family 5, member A |
Rhesus | HEK293 Cells |
CLEC5A Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21 kDa and the accession number is A0A1D5QX52. | |||
TMPY-03928 |
CLEC5A Protein, Rhesus, Recombinant (mFc)
C-type lectin domain family 5, member A |
Rhesus | HEK293 Cells |
CLEC5A Protein, Rhesus, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45.3 kDa and the accession number is A0A1D5QX52. | |||
TMPH-03074 |
UBC5A Protein, Japonica rice, Recombinant (His & Myc)
|
Rice | E. coli |
E2 conjugating enzyme that associates with the E3 ubiquitin-protein ligase EL5 to mediates ubiquitination of target proteins. UBC5A Protein, Japonica rice, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.6 kDa and the accession number is Q8S920. | |||
TMPK-01205 |
MDL-1/CLEC5A Protein, Human, Recombinant (hFc)
DAP12-associating lectin 1,MDL-1,MDL1,CLEC5A,CLECSF... |
Human | HEK293 Cells |
MDL-1/CLEC5A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 46 kDa and the accession number is Q9NY25-1. | |||
TMPH-03529 |
Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Recombinant (His)
CHIPS,Chemotaxis inhibitory protein,chp |
Staphylococcus aureus | P. pastoris (Yeast) |
Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain MRSA252), Re... | |||
TMPH-03528 |
Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc)
chp,Chemotaxis inhibitory protein,CHIPS |
Staphylococcus aureus | E. coli |
Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS... | |||
TMPH-01773 |
ELANE Protein, Human, Recombinant (GST)
Neutrophil elastase,ELA2,Medullasin,Elastase-2,ELANE,Bone ma... |
Human | E. coli |
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae. ELANE Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 52.6 kDa and the accession number is P08246. | |||
TMPH-03578 |
SCIN Protein, S. aureus, Recombinant (His & Myc)
|
Staphylococcus aureus | E. coli |
Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses. SCIN Protein, S. aureus, ... |