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PMX 205

产品编号 T12506L CAS 514814-49-4

PMX 205 is an effective complement antagonist of the C5a receptor. 在相同实验条件下，摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性，但盐形式 PMX 205 acetate(514814-49-4 free base) 的水溶性和稳定性通常比游离态更好。

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PMX 205, CAS 514814-49-4

规格	价格/CNY		货期	数量
1 mg	￥ 6,490		35日内发货

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PMX 205 的其他形式现货产品:

PMX 205 acetate(514814-49-4 free base)

其他形式的 PMX 205:

PMX 205 acetate(514814-49-4 free base)
现货
PMX 205 Trifluoroacetate
询价
PMX 205 Trifluoroacetate (514814-49-4 free base)
询价
PMX-205 (trifluoroacetate salt)
询价

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	PMX 205 is an effective complement antagonist of the C5a receptor.
体外活性	In the MTT assay, in 24 h plate, it shows that all groups are significant when compared with negative control group. For the PMX 205 group, the value recorded is between 0.09893 to 0.2465, EP54 group, 0.02724 to 0.1748, and Tamoxifen group, the value recorded in between 0.09880 to 0.2464. Only one group shows a significant result for the 72 h plate, PMX 205 (antagonist group) with the value recorded in between 0.02136 to 0.5322. Only two groups show a significant result for the 48 h plate of incubation time, which are PMX 205 and Tamoxifen. The values recorded are between 0.04987 to 0.3273 and 0.5777 to 0.8551 respectively [1].
体内活性	PMX 205 (1 mg/kg/day; SOD1G93A rats; p.o.) from two-time points (days 28 and 70) before the onset of major clinical symptoms. Both treatment groups have a significant extension in survival time compared with untreated rats (p=0.022, day 28; p=0.015, day 70), with no clear differences in outcomes between the two treatment regimens. PMX 205-treated animals also display reduced levels of astroglial proliferation in the lumbar spinal cord. Animals treated with PMX 205 (1 mg/kg/day, oral) show a significant extension of survival time and a reduction in end-stage motor scores, as compared with vehicle-treated rats. Tg2576 mice are treated with PMX 205 (PMX205) at 20 μg/mL in the drinking water (n=17) from 12 to 15 mo of age, the time frame at which there is a rapid accumulation of amyloid deposits in these animals. Untreated Tg2576 animals (n=11) are used as controls. After 3 mo, animals treated with PMX 205 show significantly less fibrillar plaque load (thioflavine reactivity) than do untreated animals. PMX 205 also significantly reduces hyperphosphorylated tau (69%) in 3×Tg mice [2][3].

分子量	839.04
分子式	C45H62N10O6
CAS No.	514814-49-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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参考文献

1. Kosni NN, et al. Expression of complement C5a receptor and the viability of 4T1 tumor cells following agonist-antagonist treatment. J Cancer Res Ther. 2016 Apr-Jun;12(2):590-6. 2. Woodruff TM, et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008 Dec 15;181(12):8727-34. 3. Fonseca MI, et al. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15;183(2):1375-83.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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