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44

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T40997	GLP-1R modulator C16 GLP-1R modulator C16	Glucagon Receptor	GPCR/G Protein
	GLP-1R modulator C16 是一种变构调节剂，显著增加了 GLP-4 的结合亲和力。
T37562	C16 Ceramide N-acylsphingosine,C16 Ceramide (d18:1/16:0),Palmitoyl Ceramide,N-Palmitoylsphingosine	p53	Apoptosis
	C16 Ceramide (Palmitoyl Ceramide) 是一种天然小分子，通过直接选择性结合激活 p53。
T16550	PKR-IN-C16	Others	Others
	PKR-IN-C16 是一种特异性蛋白激酶抑制剂。它能够抑制 PKR 的自磷酸化，解除 PKR 在原代神经元细胞培养中诱导的翻译阻断。
T9783	Boc-C16-COOH	PROTAC Linker	PROTAC
	Boc-C16-COOH 可以作为 ADC linker 或 PROTAC linker，用于合成抗体偶联药物或合成 PROTAC。
T35805	C16 Sphingomyelin (d18:1/16:0) Sphingomyelin 16:0,N-Palmitoyl-D-sphingomyelin	Endogenous Metabolite	Metabolism
	C16 Sphingomyelin (d18:1/16:0) (N-Palmitoyl-D-sphingomyelin) 是磷脂双层膜的磷脂类化合物，可用于研究生物膜的活性。
T21547	PAF (C16) C16-PAF	ERK; MEK; MAPK; Endogenous Metabolite	MAPK; Metabolism
	PAF (C16) 是有效的 MAPK 和 MEK/ERK 激活剂，可诱导血管通透性增加。PAF (C16) (PAF (C16)) 是血小板活化因子，是一种磷脂衍生介质，也是 PAF G 蛋白偶联受体 (PAFR) 的配体。PAF (C16) 在体外实验中显示出抗凋亡和抗炎活性，通过与其受体（PAF-R）相互作用以执行细胞信号传导来抑制 caspase 依赖性凋亡。
T36859	C16 Globotriaosylceramide (d18:1/16:0) C16 Globotriaosylceramide (d18:1/16:0)
	C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien...
T37872	C16 Galactosylceramide (d18:1/16:0) C16 Galactosylceramide (d18:1/16:0)
	C16 Galactosylceramide is a glycosphingolipid that contains a galactose moiety attached to a ceramide acylated with palmitic acid .
T17472	Azide-PEG9-amido-C16-Boc 17-(Azide-PEG9-ethylcarbamoyl)heptadecanoic t-butyl ester	Others	Others
	Azide-PEG9-amido-C16-Boc is an alkyl/ether-based PROTAC linker with utility in PROTAC synthesis [1].
T17438	Amino-PEG6-amido-C16-COOH 17-(Amino-PEG6-ethylcarbamoyl)heptadecanoic acid	Others	Others
	Amino-PEG6-amido-C16-COOH, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].
T38180	C16 Phytoceramide (t18:0/16:0)
	C16 Phytoceramide (t18:0/16:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C16 Phytoceramide (t18:0/16:0) is composed of a phytosphingosine backbone amine-linked to a C16 fatty acid chain. The levels of C16 phytoceramide (t18:0/16:0) increase following heat stress in S. cerevisiae. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous ...
T35804	C16 Lactosylceramide (d18:1/16:0)
	C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle. C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder.
T17648	Boc-C16-NHS ester	Others	Others
	Boc-C16-NHS ester, an alkyl/ether-based PROTAC linker, enables the synthesis of PROTACs[1].
T69361	C16-Urea-Ceramide
	C16-Urea-Ceramide s a neutral ceramidase (nCDase) inhibitor. It is a bioactive ceramide.
T17437	Amino-PEG6-amido-C16-Boc 17-(Amino-PEG6-ethylcarbamoyl)heptadecanoic t-butyl ester	Others	Others
	Amino-PEG6-amido-C16-Boc is a PEG-based PROTAC linker employed for the synthesis of PROTACs[1].
T17442	Amino-PEG9-amido-C16-Boc 17-(Amino-PEG9-ethylcarbamoyl)heptadecanoic t-butyl ester	Others	Others
	Amino-PEG9-amido-C16-Boc is a polyethylene glycol (PEG)-based linker utilized for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
T36149	13C C16 Sphingomyelin (d18:1/16:0)
	13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in or...
T17470	Azide-PEG6-amido-C16-Boc 17-(Azide-PEG6-ethylcarbamoyl)heptadecanoic t-butyl ester	Others	Others
	Azide-PEG6-amido-C16-Boc is an alkyl/ether-based PROTAC linker utilized in PROTAC synthesis[1].
TF0041	PMAL-C16
	PMAL-C16 在生命科学相关研究中具有广泛的应用。
T74304	C16 PEG-Ceramide
	C16 PEG-Ceramide为一种聚乙二醇化神经酰胺，具备脂质载体传递功能，并能诱导自噬(autophagy)，在癌症研究中有应用。
T37454	C16 dihydro Ceramide (d18:0/16:0) Ceramide (d18:0/16:0),Cer(d18:0/16:0),N-hexadecanoyl-D-erythro-Dihydrosphingosine,N-Palmitoyl Sphinganine
	C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) that lacks the 4,5-trans double bond.[1] C16 dihydro Ceramide (0-46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome C oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability ...
T14185	Alkynyl Palmitic Acid	Others; PROTAC Linker	Others; PROTAC
	Alkynyl Palmitic Acid 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T73127	C16-K-cBB1
	C16-K-cBB1 是一种对 MRSA(甲氧西林耐药金黄色葡萄球菌)有效且选择性的抗菌剂，其 MIC 为 1 μg/mL。C16-K-cBB1 具有很好的选择性，由于其溶血活性较弱。在 12.5 μg/mL 浓度下，C16-K-cBB1 能够在 120 分钟内杀死 MRSA 细胞。
T37741	N-hexadecanoyl-L-Homoserine lactone C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which...
T29350	2-Hexyldecanoic acid Pentadecane-7-carboxylic Acid,Isopalmitic Acid,7-Pentadecanecarboxylic acid,C16 Guerbet fatty acid,2-Hexyldecansaeure
	2-Hexyldecanoic acid is a biochemical.
T37268	PAF C-16 Carboxylic Acid
	PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling" and 'de novo' pathways. It is a potent mediator of neutrophil migration and the production of reactive oxygen species and IL-6. Pathological processes involving PAF include necrotizing enterocolitis
T36205	Methylcarbamyl PAF C-16
	Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH. It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma. In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase. Methy...
T8929	BC1618 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-	Mitophagy; Others; E1/E2/E3 Enzyme; AMPK	Autophagy; Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling; Ubiquitination
	BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) 是一种具有口服活性的 Fbxo48 抑制剂，可刺激 Ampk 依赖性信号传导。它促进线粒体分裂，促进自噬并提高肝脏胰岛素敏感性。
T16351	NSC16168	Estrogen/progestogen Receptor	Endocrinology/Hormones
	NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM).
T24150	HR22C16 HR-22-C-16,HR 22 C 16
	HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor.
T38693	TRC160334 TRC160334
	TRC160334 is a hydroxylase inhibitor of hypoxia-inducible factor (HIF). It is employed in research about ischemia/reperfusion injury.
T71044	TRC160334 sodium
	TRC160334 is a HIF hydroxylases inhibitor.
T83842	LHC165 hydrate
	LHC165是一种对Toll样受体7（TLR7）具有激动作用的化合物。
T40141	Palmitic acid-13C16 sodium Palmitic acid-13C16 sodium
	Palmitic acid-13C16 sodium, a 13C-labeled form of the naturally occurring saturated fatty acid Palmitic acid sodium, is prevalent in animals and plants. This compound can trigger the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells.
T70687	UNC1666
	UNC1666 is a dual ATP-competitive small molecule tyrosine kinase inhibitor, which potently diminishes Mer and Flt3 phosphorylation in AML.
T37563	C22 Ceramide (d18:1/22:0) Cer(d18:1/22:0),C22 Ceramide,Ceramide (d18:1/22:0)
	C22 Ceramide (d18:1/22:0) (C22 Ceramide) 是一种从海绵Haliclona koremella 中分离出含有山嵛酸的长链神经酰胺，是一种内源性生物活性鞘脂。C22 Ceramide (d18:1/22:0) 可特异性抑制MCSR，降低离体大鼠肝线粒体和脂质体中 C16-神经酰胺通道的形成。
T37955	Sphingosine-1-phosphate (d16:1) Sphingosine-1-phosphate (d16:1)
	C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells. C16 S1P was increased in postmortem primary open angle glaucoma trabecular meshwork samples.
T36468	ARN14988
	ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively).
T36860	C22 Sphingomyelin (d18:1/22:0) C22 Sphingomyelin (d18:1/22:0)
	C22 Sphingomyelin is a naturally occurring form of sphingomyelin . Plasma levels of C22 sphingomyelin positively correlate with hepatic steatosis severity in patients with chronic hepatitis C virus (HCV). C22 Sphingomyelin levels are decreased in T-47D mammary epithelial cells and increased in MDA-MB-231 breast cancer cells relative to C16 sphingomyelin .
T37337	N-3-oxo-hexadecanoyl-L-Homoserine lactone
	N-3-oxo-hexadecanoyl-L-Homoserine lactone is an unusual, substituted, long-chain N-acyl-homoserine lactone (AHL) produced by some bacteria, including strains of Agrobacterium vitis and Pseudomonas. Like other AHLs, this C16-containing form is thought to be involved in quorum sensing. Substituted, long-chain AHLs, including N-3-oxo-tetradecanoyl-L-homoserine lactone , prime for systemic acquired resistance to pathogen attack in plants.
T36321	C6 Urea Ceramide
	C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 μM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the ...
T37336	N-3-oxo-hexadec-11(Z)-enoyl-L-Homoserine lactone
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which gener...
T37736	N-cis-hexadec-9Z-enoyl-L-Homoserine lactone N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone
	Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density.[1] This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production.[2] Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of whic...
T36929	Pal-KTTKS (acetate)
	Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS...

化合物

GLP-1R modulator C16

Cat.No: T40997

Synonym: GLP-1R modulator C16

Target: Glucagon Receptor

Cat.No: T37562

Synonym: N-acylsphingosine,C16 Ceramide (d18:1/16:0),Palmitoyl Ceramide,N-Palmitoylsphingosine

Target: p53

Cat.No: T16550

Target: Others

Cat.No: T9783

Target: PROTAC Linker

C16 Sphingomyelin (d18:1/16:0)

Cat.No: T35805

Synonym: Sphingomyelin 16:0,N-Palmitoyl-D-sphingomyelin

Target: Endogenous Metabolite

Cat.No: T21547

Synonym: C16-PAF

Target: ERK, MEK, MAPK, Endogenous Metabolite

C16 Globotriaosylceramide (d18:1/16:0)

Cat.No: T36859

Synonym: C16 Globotriaosylceramide (d18:1/16:0)

C16 Galactosylceramide (d18:1/16:0)

Cat.No: T37872

Synonym: C16 Galactosylceramide (d18:1/16:0)

Azide-PEG9-amido-C16-Boc

Cat.No: T17472

Synonym: 17-(Azide-PEG9-ethylcarbamoyl)heptadecanoic t-butyl ester

Target: Others

Amino-PEG6-amido-C16-COOH

Cat.No: T17438

Synonym: 17-(Amino-PEG6-ethylcarbamoyl)heptadecanoic acid

Target: Others

C16 Phytoceramide (t18:0/16:0)

Cat.No: T38180

C16 Lactosylceramide (d18:1/16:0)

Cat.No: T35804

Boc-C16-NHS ester

Cat.No: T17648

Target: Others

C16-Urea-Ceramide

Cat.No: T69361

Amino-PEG6-amido-C16-Boc

Cat.No: T17437

Synonym: 17-(Amino-PEG6-ethylcarbamoyl)heptadecanoic t-butyl ester

Target: Others

Amino-PEG9-amido-C16-Boc

Cat.No: T17442

Synonym: 17-(Amino-PEG9-ethylcarbamoyl)heptadecanoic t-butyl ester

Target: Others

13C C16 Sphingomyelin (d18:1/16:0)

Cat.No: T36149

Azide-PEG6-amido-C16-Boc

Cat.No: T17470

Synonym: 17-(Azide-PEG6-ethylcarbamoyl)heptadecanoic t-butyl ester

Target: Others

Cat.No: TF0041

C16 PEG-Ceramide

Cat.No: T74304

C16 dihydro Ceramide (d18:0/16:0)

Cat.No: T37454

Synonym: Ceramide (d18:0/16:0),Cer(d18:0/16:0),N-hexadecanoyl-D-erythro-Dihydrosphingosine,N-Palmitoyl Sphinganine

Alkynyl Palmitic Acid

Cat.No: T14185

Target: Others, PROTAC Linker

Cat.No: T73127

N-hexadecanoyl-L-Homoserine lactone

Cat.No: T37741

Synonym: C16-HSL,N-palmitoyl-L-Homoserine,N-hexadecanoyl-L-Homoserine lactone

2-Hexyldecanoic acid

Cat.No: T29350

Synonym: Pentadecane-7-carboxylic Acid,Isopalmitic Acid,7-Pentadecanecarboxylic acid,C16 Guerbet fatty acid,2-Hexyldecansaeure

PAF C-16 Carboxylic Acid

Cat.No: T37268

Methylcarbamyl PAF C-16

Cat.No: T36205

Cat.No: T8929

Synonym: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

Target: Mitophagy, Others, E1/E2/E3 Enzyme, AMPK

Cat.No: T16351

Target: Estrogen/progestogen Receptor

Cat.No: T24150

Synonym: HR-22-C-16,HR 22 C 16

Cat.No: T38693

Synonym: TRC160334

TRC160334 sodium

Cat.No: T71044

Cat.No: T83842

Palmitic acid-13C16 sodium

Cat.No: T40141

Synonym: Palmitic acid-13C16 sodium

Cat.No: T70687

C22 Ceramide (d18:1/22:0)

Cat.No: T37563

Synonym: Cer(d18:1/22:0),C22 Ceramide,Ceramide (d18:1/22:0)

Sphingosine-1-phosphate (d16:1)

Cat.No: T37955

Synonym: Sphingosine-1-phosphate (d16:1)

Cat.No: T36468

C22 Sphingomyelin (d18:1/22:0)

Cat.No: T36860

Synonym: C22 Sphingomyelin (d18:1/22:0)

N-3-oxo-hexadecanoyl-L-Homoserine lactone

Cat.No: T37337

C6 Urea Ceramide

Cat.No: T36321

N-3-oxo-hexadec-11(Z)-enoyl-L-Homoserine lactone

Cat.No: T37336

N-cis-hexadec-9Z-enoyl-L-Homoserine lactone

Cat.No: T37736

Synonym: N-(2-oxotetrahydrofuran-3S-yl) Palmitoleyl Amide,N-cis-hexadec-9Z-enoyl-L-Homoserine lactone

Pal-KTTKS (acetate)

Cat.No: T36929

Cat. No.	Product Name	Target	Signaling Pathways
T38179	C16 3'-sulfo Galactosylceramide (d18:1/16:0) C16 3'-sulfo Galactosylceramide (d18:1/16:0)	Others	Others
	C16 3'-sulfo Galactosylceramide (d18:1/16:0)是硫酸盐类糖脂的一种。C16 3'-sulfo Galactosylceramide (d18:1/16:0)是在猪脑和血浆中发现的一种比较丰富的硫化物，在小鼠的整个发育过程中会有所减少。C16 3'-sulfo Galactosylceramide (d18:1/16:0)在体外可抑制视网膜神经节细胞生长。C16 3'-sulfo Galactosylceramide (d18:1/16:0)已被用作量化大鼠小脑和多发性硬化症患者分离的白质中的硫化物的参照物。
T82572	D-Glucosyl-β-1,1′-N-palmitoylsphingosine C16 Glucosyl(β) Ceramide (d18:1/16:0)
	D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) 是内源性Mincle配体，具免疫刺激活性。

天然产物

C16 3'-sulfo Galactosylceramide (d18:1/16:0)

Cat.No: T38179

Synonym: C16 3'-sulfo Galactosylceramide (d18:1/16:0)

Target: Others

D-Glucosyl-β-1,1′-N-palmitoylsphingosine

Cat.No: T82572

Synonym: C16 Glucosyl(β) Ceramide (d18:1/16:0)

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