9
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10520 |
BET-IN-2
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
BET-IN-2 is a BET inhibitor (IC50: 52 nM for BRD4-BD1). | |||
T3504 |
AZD5153 6-Hydroxy-2-naphthoic acid
AZD5153,AZD5153结晶体(API形式),AZD-5153 HNT salt |
Epigenetic Reader Domain | Chromatin/Epigenetic |
AZD5153 6-Hydroxy-2-naphthoic acid (AZD5153) 是 AZD5153的6-羟基-2-萘甲酸盐形式。AZD5153是一种有口服活性的选择性 BET/BRD4溴结构域抑制剂,对BRD4的IC50值为1.7nM。 | |||
T13671 |
(S,R,S)-AHPC-Me hydrochloride
VHL ligand 2 hydrochloride,E3 ligase Ligand 1 |
Others; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cells resistant to castration, exhibiting a remarkable DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, (S,R,S)-AHPC-Me hydrochloride serves as the VHL ligand derived from (S,R,S)-AHPC for the recruitment of von Hippel-Lindau (VHL) protein. | |||
T19618 |
(R)-(-)-JQ1 Enantiomer
(R)-(-)2-(4-(4-氯苯基)-2,3,9-三甲基-6H-噻吩并[3,2-F][1,2,4]三唑并[4,3-A][1,4]二氮杂环庚烷-6-基)乙酸叔丁酯 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
(R)-(-)-JQ1 Enantiomer 是 (+)-JQ1 的立体异构体。 (+)-JQ1 是一种 BET 溴结构域抑制剂,对BRD4(1/2)的IC50 为 77 和 33 nM。 | |||
T10773 |
CF53
|
Epigenetic Reader Domain; CDK | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
CF53 是一种高效、选择性、可口服的 BET 抑制剂,对 BRD4 BD1 的 Ki 值为 <1 nM,Kd 值为 2.2 nM,IC50 值为 2 nM;CF53 对 BRD2,BRD3,BRD4 和 BRDT BET 蛋白的 BD1 和 BD2 两个结构域都有高亲和性,对其选择性远高于非含溴结构域 BET 蛋白。CF53 在体外和体内都具有显著的抗肿瘤活性。 | |||
T7752 |
(S,R,S)-AHPC-Me
VHL ligand 2,E3 ligase Ligand 1A |
Ligand for E3 Ligase | PROTAC |
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) 是基于 (S,R,S)-AHPC 的的 VHL 配体,可用于募集 von Hippel-Lindau (VHL) 蛋白。它可有效降解去势抵抗性前列腺癌细胞中的 BET 蛋白,DC50<1 nM。它可用于合成 ARV-771。 | |||
T74753 | JQ1-TCO | ||
JQ1-TCO (JQ1-trans-cycloctene) 是一种 BET 抑制剂 JQ1 的衍生物。JQ1-TCO 适用于点击化学,可作为体外和体内的分子探针。 | |||
T13671L |
(S,R,S)-AHPC-Me dihydrochloride
VHL ligand 2 dihydrochloride,E3 ligase Ligand 1 dihydrochloride,(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base) |
Others | Others |
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound utilized in the synthesis of ARV-771. ARV-771, a BET PROTAC degrader relying on von Hippel-Landau (VHL) E3 ligase, demonstrates potent degradation of BET protein in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound serves as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, that facilitates the recruitment of von Hippel-Lindau (VHL) prote... | |||
T36103 |
TW9
TW9 |
||
TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 μM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 μM) and for HDAC1 over HDAC2 (IC50= 2.5 μM). TW9 (50 nM) induces apoptosis in, and inhibits proliferation of, MIA PaCa-2 pancreatic cancer cells. It induces cell cycle arrest at the G1phase in HPAC pancreatic cancer cells when used at a concentration of 2 μM. TW9 acts synergistica... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5681 |
ETHYL CAFFEATE
咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE |
NF-κB; COX; PGE Synthase; NO Synthase | Immunology/Inflammation; Neuroscience; NF-κB |
Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) 是从鬼针草分离的一种酚类天然产物,在体外或在小鼠皮肤中抑制NF-κB 活化及其下游炎症介质的诱导型一氧化氮合酶、环氧合酶 2 和前列腺素 E2。 | |||
T3824 |
Jaceosidin
|
Apoptosis; BCL; COX; UGT | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。 |