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26

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0005	Aspirin 阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA	Mitophagy; Virus Protease; COX; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Aspirin (Acetylsalicylic Acid) 是一种选择性 COX 抑制剂，具有多种药理活性。它是组蛋白去乙酰化酶抑制剂，可上调细胞周期阻滞蛋白 p21，抑制携带 COX-1 的卵巢 Y 细胞。它还抑制 HUVEC 和新生大鼠心室心肌细胞中 COX-2 的表达，分别减少 PG 的产生和 ERK 和 NF-KB 的下调。
T10391	Aspirin Aluminum Aluminum diacetylsalicylate,阿司匹林铝	Others	Others
	Aspirin Aluminum is an intermolecular compound that can inhibit gastrointestinal mucosal disorders induced by NSAIDs.
T68847	Aspirin calcium
	Aspirin calcium is the prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
T20458	Aspirin DL-lysine DL-Lysine acetylsalicylic acid salt,Aspegic,ASL,Aspisol
	Aspirin DL-lysine is a non-steroidal anti-inflammatory drug. It also may inhibit cancer growth. Aspirin DL-lysine is a water-soluble, injectable aspirin derivative.
T35946	17(R)-Resolvin D1 Aspirin-triggered Resolvin D1,17(R)-Resolvin D1
	Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the ear...
T16328	Nitroaspirin 2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016	Apoptosis; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	Nitroaspirin (NCX 4016) 是一氧化氮供体和阿司匹林的硝基衍生物，与 Aspirin 结合可抑制环氧合酶=，可作为 COX-1 的直接和不可逆抑制剂。它通过下调 EGFR/PI3K/STAT3 信号传导和调节 Bcl-2 家族蛋白，显着诱导顺铂耐药人卵巢癌细胞的细胞周期停滞和凋亡，具有抗血栓和抗血小板特性。
T22447	Tri-Salicylic Acid 三水杨酸	Others	Others
	Tri-Salicylic acid 是一种和水杨酸具有相似性质的化合物。它对肥胖、炎症及心血管疾病具有潜在的研究价值。
T0705	Triflusal 三氟柳,三氟醋柳酸,UR1501	COX; PDE; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience
	Triflusal (UR1501) 能够利用乙酰化COX-1途径，不可逆地减少血小板中血栓素B2的生成。
T19967	Fendosal 芬度柳,HP 129,P 71-0129,P71-0129,P-71-0129,HP129,HP-129	Immunology/Inflammation related	Immunology/Inflammation
	Fendosal (HP-129) 是一种非甾体抗炎药。在预防性和治疗性辅助诱导的慢性炎症多关节炎模型中，它的活性是阿司匹林的 6.9 至 9.5 倍。
T39988	6'-GNTI dihydrochloride	Opioid Receptor; Akt	Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Neuroscience; PI3K/Akt/mTOR signaling
	6'-GNTI dihydrochloride 是一种κ-阿片受体（KOR）激动剂，它偏向于激活 G 蛋白介导的信号传导，而不是β-阿司匹林2的募集。6'-GNTI dihydrochloride 只能激活纹状体神经元中的 Akt 通路。
T67924	ABzOH
	ABzOH 是一种苯甲酸衍生物，结构类似于阿司匹林等非甾体抗炎药，具有抗炎、抗肿瘤和抗增殖作用。ABzOH 不仅可以抑制肿瘤坏死因子- α (TNF-a)、白细胞介素-1β (IL-1β)和白细胞介素-6 (IL-6)等促炎细胞因子的表达还对乳腺癌、肺癌和胰腺癌具有抑制作用。
T69926	APHS
	APHS is a cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory action. It also more potent than aspirin in the inhibition of COX-1.
T36042	17(R)-HDHA
	Resolvins are a group of polyhydroxylated metabolites of docosahexaenoic acid (DHA) found in the inflammatory exudates of aspirin-treated experimental animals. 17(R)-HDHA is the primary oxygenation product of DHA when exposed to aspirin-inhibited cyclooxygenase-2. 17(R)-HDHA serves as a precursor to resolvins and has intrinsic biological activity, such as the inhibition of TNFα-induced IL-1β expression in human glioma cells.
T80635	Gentisuric acid	Drug Metabolite	Metabolism
	Gentisuric Acid，作为Aspirin的代谢产物同时也是α-酰胺化单加氧酶（PAM）的底物，可抵御Mitomycin C导致的DNA损伤。
T36043	17(R)-Protectin D1 17(R)-Protectin D1
	17(R)-Protectin D1 is an aspirin-triggered epimer of the specialized pro-resolving mediator protectin D1 .1It decreases leukotriene B4-induced transendothelial migration of human polymorphonuclear (PMN) neutrophils when used at concentrations ranging from 0.1 to 10 nM. 17(R)-Protectin D1 (0.01-10 ng) reduces the recruitment of neutrophils in a mouse model of TNF-α-induced peritonitis. 1.Serhan, C.N., Fredman, G., Yang, R., et al.Novel proresolving aspirin-triggered DHA pathwayChem. Biol.18(18)97...
T37484	1-Salicylate Glucuronide
	1-Salicylate glucuronide is a metabolite of salicylic acid and aspirin .1It is formed from salicylic acid primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A9 but also by a variety of other UGT isoforms and from aspirinviasalicylic acid as an intermediate. 1.Kuehl, G.E., Bigler, J., Potter, J.D., et al.Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomesDrug Metab. Dispos.34(2)199-202(2006)
T25576	KF 392 KF392,KF-392
	KF 392 is antiulcer. It was found that KF-392 given orally to rats at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions.
T37633	17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
	17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).
T37265	15(R)-Lipoxin A4 15(R)-Lipoxin A4,AT-Lipoxin A4
	Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspirin-triggered formation of 15(R)-HETE from arachidonic acid. [1] [2] 15(R)-LXA4 inhibits LTB4-induced chemotaxis, adherence, and transmigration of neutrophils with twice the potency of LXA4 demonstrating activity in the nM range.[2] [3] The anti-inflammatory effects of aspirin may...
T37634	17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid
	Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).
T37490	11(R)-HETE
	11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. purpuratus, and the fresh water hydra, H. vulgaris. The biological activity of 11(R)-HETE relates to oocyte maturation and tentacle regeneration, respectively, in these two species. 11(R)-HETE is also produced when aspirin-treated recombinant COX-2 is incubated with arachidonic acid. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
T83599	(+)-Leucocyanidin 2,3-trans-3,4-trans-Leucocyanidin,(2R,3S,4R)-Leucocyanidin,3,4-trans-Leucocyanidin
	(+)-Leucocyanidin为Leucocyanidin的同分异构体，自荔枝(Litchi Chinensis)中提取，具备显著的抗溃疡活性。在大鼠模型上，该化合物能有效保护大鼠免受阿司匹林诱导的胃侵蚀。
T35431	(±)-Clopidogrel (hydrochloride)
	Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite via CYP2C19 in the liver enables its anti-aggregating activity. Marketed under the name Plavix , clopidogrel in combination with aspirin has been shown to be beneficial in the prevention of vascu...
T17231	Vicagrel	Others	Others
	Vicagrel 是一种有效的、具有口服活性抗血小板化合物，通过不可逆地抑制 P2Y12 受体，降低代谢失活，增强了阿司匹林对啮齿类动物血小板聚集和血栓形成起抑制作用。Viagrel 可用于治疗冠状动脉疾病、外周血管疾病和脑血管疾病中血栓。
T35881	Resolvin E2
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m...
T37176	Edoxaban impurity 6
	Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention[1][2]. [1]. Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6(9):1542-9.[2]. Mendell J, Lee F, Chen S, The Effe...

化合物

Cat.No: T0005

Synonym: 阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA

Target: Mitophagy, Virus Protease, COX, Autophagy

Aspirin Aluminum

Cat.No: T10391

Synonym: Aluminum diacetylsalicylate,阿司匹林铝

Target: Others

Aspirin calcium

Cat.No: T68847

Aspirin DL-lysine

Cat.No: T20458

Synonym: DL-Lysine acetylsalicylic acid salt,Aspegic,ASL,Aspisol

17(R)-Resolvin D1

Cat.No: T35946

Synonym: Aspirin-triggered Resolvin D1,17(R)-Resolvin D1

Cat.No: T16328

Synonym: 2-乙酰氧基苯甲酸-3-硝酸甲基苯酯,NCX 4016

Target: Apoptosis, COX

Tri-Salicylic Acid

Cat.No: T22447

Synonym: 三水杨酸

Target: Others

Cat.No: T0705

Synonym: 三氟柳,三氟醋柳酸,UR1501

Target: COX, PDE, PPAR

Cat.No: T19967

Synonym: 芬度柳,HP 129,P 71-0129,P71-0129,P-71-0129,HP129,HP-129

Target: Immunology/Inflammation related

6'-GNTI dihydrochloride

Cat.No: T39988

Target: Opioid Receptor, Akt

Cat.No: T67924

Cat.No: T69926

Cat.No: T36042

Gentisuric acid

Cat.No: T80635

Target: Drug Metabolite

17(R)-Protectin D1

Cat.No: T36043

Synonym: 17(R)-Protectin D1

1-Salicylate Glucuronide

Cat.No: T37484

Cat.No: T25576

Synonym: KF392,KF-392

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid

Cat.No: T37633

15(R)-Lipoxin A4

Cat.No: T37265

Synonym: 15(R)-Lipoxin A4,AT-Lipoxin A4

17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic Acid

Cat.No: T37634

Cat.No: T37490

(+)-Leucocyanidin

Cat.No: T83599

Synonym: 2,3-trans-3,4-trans-Leucocyanidin,(2R,3S,4R)-Leucocyanidin,3,4-trans-Leucocyanidin

(±)-Clopidogrel (hydrochloride)

Cat.No: T35431

Cat.No: T17231

Target: Others

Cat.No: T35881

Edoxaban impurity 6

Cat.No: T37176

Cat. No.	Product Name	Target	Signaling Pathways
T0004	Salicylamide 水杨酰胺,Salamide,2-Hydroxybenzamide	COX	Immunology/Inflammation; Neuroscience
	Salicylamide(2-Hydroxybenzamide) 是一种止痛剂和抗热解药剂，是一种微粒体 UDP-葡糖醛酸基转移酶抑制剂。
T4810	Pyrocatechuic acid 3-Hydroxysalicylic acid,2,3-二羟基苯甲酸,O-Pyrocatechuic acid,Catecholcarboxylic acid,NSC 27435,2,3-Dihydroxybenzoic acid	Others; Endogenous Metabolite	Metabolism; Others
	Pyrocatechuic acid (Catecholcarboxylic acid) 是一种存在于血浆中的苯甲酸代谢物，当摄入阿司匹林后，它的含量会提高。
T5917	2-Hydroxy-6-methoxybenzoic acid 6-甲氧基水杨酸,2-羟基-6-甲氧基苯甲酸,6-Methoxysalicylic acid	Others	Others
	2-Hydroxy-6-methoxybenzoic acid (6-Methoxysalicylic acid) 可用于动物血浆中乙酸水杨酸及其主要代谢物水杨酸含量的测定，表现出较好的抗缓解疼痛活性。
T4S21320	ISOGINKGETIN 异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮	MMP; Others	Others; Proteases/Proteasome
	ISOGINKGETIN (4',4'''-Dimethylamentoflavone) 是一种MMP9抑制剂，也是一种Pre-mRNA Splicing 抑制剂。
T3S0509	Gaultherin	COX	Immunology/Inflammation; Neuroscience
	Gaultherin 是一种分离自 Gaultheria yunnanensis 中的天然水杨酸酯衍生物。它是一种非甾体类抗炎药，具有止痛和抗炎作用，与 Aspirin 相比没有胃溃疡作用。
TN4465	Luvangetin	COX; Prostaglandin Receptor; Antifection	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rats and cold restraint stress-induced

天然产物

Cat.No: T0004

Synonym: 水杨酰胺,Salamide,2-Hydroxybenzamide

Target: COX

Pyrocatechuic acid

Cat.No: T4810

Synonym: 3-Hydroxysalicylic acid,2,3-二羟基苯甲酸,O-Pyrocatechuic acid,Catecholcarboxylic acid,NSC 27435,2,3-Dihydroxybenzoic acid

Target: Others, Endogenous Metabolite

2-Hydroxy-6-methoxybenzoic acid

Cat.No: T5917

Synonym: 6-甲氧基水杨酸,2-羟基-6-甲氧基苯甲酸,6-Methoxysalicylic acid

Target: Others

Cat.No: T4S21320

Synonym: 异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮

Target: MMP, Others

Cat.No: T3S0509

Target: COX

Cat.No: TN4465

Target: COX, Prostaglandin Receptor, Antifection

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