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Search Results for " acetaminophen "

21

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20215	Acetaminophen mercapturate
	Paracetamol Mercapturate is a metabolite of Acetaminophen. It can also be used in the biological study of urinary antihypertensive drugs.
T19175	Acetaminophen metabolite 3-hydroxy-acetaminophen 对乙酰氨基酚代谢物,3-Hydroxyacetaminophen	Others	Others
	3-hydroxy-acetaminophen is a metabolite of Acetaminophen. Acetaminophen is a pain medicine.
T36826	Acetaminophen Glucuronide (sodium salt)
	Acetaminophen glucuronide is an inactive metabolite of the analgesic and antipyretic agent acetaminophen . It is formed via glucuronidation of acetaminophen by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A9, UGT1A1, and UGT2B15.
T38206	3-Cysteinylacetaminophen (trifluoroacetate salt) APAP-Cys,3-(cysteine-S-yl)acetaminophen,3-Cysteinylacetaminophen (trifluoroacetate salt)
	3-Cysteinylacetaminophen is an acetaminophen-protein adduct formed during the metabolism of acetaminophen.[1],[2] 3-Cysteinylacetaminophen has been found in isolated human serum following therapeutic and supratherapeutic doses of acetaminophen and in the presence and absence of hepatotoxicity.[3],[4] In mice, 3-cysteinylacetaminophen decreases renal glutathione (GSH) levels, an effect that can be blocked by the γ-glutamyl inhibitor acivicin.
T29415	3-Methylacetaminophen
	3-Methylacetaminophen is a bioactive chemical.
T4545	Propacetamol Hydrochloride 盐酸丙帕他莫,Propacetamol HCL	Others	Others
	Propacetamol Hydrochloride (Propacetamol HCL) 是 paracetamol(acetaminophen) 的前药，具有改善的水溶性。当口服非甾体抗炎药不合适或矛盾时，丙帕西莫是一种静脉给药的镇痛药。
T0914	Metacetamol 酰胺苯酚,3-Acetamidophenol	Others	Others
	Metacetamol (3-Acetamidophenol) 是对乙酰氨基酚的衍生物，为其无毒区域异构体，是一种非处方镇痛剂和解热剂，也可用作有机合成中间体。
T7280	CAY10594	Phospholipase	Metabolism
	CAY10594 是磷脂酶 D2 抑制剂 (体外IC50=140 nM，细胞IC50=110 nM)。它在体外显著阻碍乳腺癌细胞的侵袭性迁移，并调节磷酸化 GSK-3β/JNK 轴改善扑热息痛诱导的急性肝损伤。
TF0106	Cholesteryl Hemisuccinate Tris Salt	Apoptosis	Apoptosis
	Cholesteryl Hemisuccinate Tris Salt 是一种具有保肝和抗癌活性的酸性胆固醇酯，是一种含有柴胡皂苷-d的二棕榈酰磷脂酰胆碱脂质体中的膜稳定剂，可增强顺铂的抗癌功效。Cholesteryl hemisuccinate 具有抗肿瘤活性，抑制肿瘤生长，抑制对乙酰氨基酚 (AAP) 的肝毒性，预防 AAP 诱导的肝细胞凋亡。Cholesteryl hemisuccinate 可保护啮齿动物免受对乙酰氨基酚、阿霉素、四氯化碳、氯仿和半乳糖胺的毒性作用。
T67509	Cholesteryl Hemisuccinate Cholesterol hydrogen succinate	Apoptosis; DNA/RNA Synthesis; Topoisomerase	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) 是一种经常使用在极性溶液中具有高溶解度的胆固醇类似物，具有保肝、抗癌和抑制肿瘤生长的作用。Cholesteryl Hemisuccinate 抑制对乙酰氨基酚的肝毒性，并防止 AAP 诱导的肝细胞凋亡和坏死。Cholesteryl Hemisuccinate 抑制 DNA 聚合酶和 DNA 拓扑异构酶，从而抑制 DNA 复制和修复以及细胞分裂。
T9948	NecroX-7 LC-280126,LC28-0126,LC28 0126	NADPH-oxidase	Immunology/Inflammation
	NecroX-7 (LC-280126) 是一种有效的自由基清除剂和 HMGB1(高迁移率族蛋白 1) 抑制剂。NecroX-7 可以作为对乙酰氨基酚毒性的解毒剂。NecroX-7 通过抑制缺血/再灌注损伤中 HMGB1 的释放发挥保护作用。NecroX-7 抑制 HMGB1 诱导的 TNF 和 IL-6的释放，以及TLR-4和晚期糖基化终产物受体的表达，用于移植物抗宿主病 (GVHD) 研究。
T33881	Paracetamol mercapturate
	Paracetamol mercapturate is a deuterated metabolite of acetaminophen.
T10135	4-Acetamidophenyl acetate	Others	Others
	4-Acetamidophenyl acetate is an impurity of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor (IC50: 25.8 μM) and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
T10143	4-Hydroxyacetophenone oxime	Others	Others
	4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent COX-2 and hepatic NAT2 inhibitor and used antipyretic and analgesic drug.
T69218	PUMAi HCl
	PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury.
T83050	Anti-inflammatory agent 62
	Anti-inflammatory agent 62 减轻乙酰氨基酚诱导的HepG2肝毒性，其机制是通过调节炎症和氧化应激途径。
T38312	L-Cysteine-glutathione disulfide
	L-Cysteine-glutathione disulfide, a glutathione derivative endogenous to mammalian cells, is comprised of the oxidized form of free glutathione tripeptide linked via a disulfide bond to L-cysteine. It has been shown to protect mice against acetaminophen-induced hepatotoxicity.
T11752	Keap1-Nrf2-IN-1 Keap1–Nrf2-IN-1	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	Keap1–Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1–Nrf2 IN-1 is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (
T76364	Ac-Leu-Leu-Norleucinol
	Ac-Leu-Leu-Norleucinol 是钙蛋白酶抑制剂，可用于研究对 Acetaminophen 引起的急性肝损伤，并能够降低诱导引发的谷草转氨酶 (ALT) 和谷丙转氨酶 (AST) 水平。
T64218	Keap1-Nrf2-IN-1 TFA
	Keap1-Nrf2-IN-1 TFA (compound35) 是一种 Keap1-Nrf2 蛋白-蛋白相互作用抑制剂 (IC50: 43 nM)，可以激活 Nrf2 调节的细胞保护反应。在细胞和体内模型中。Keap1-Nrf2-IN-1 TFA 能够拮抗对乙酰氨基酚诱导的肝损伤。
T63930	DI-1859
	DI-1859 是选择性的、有效的、共价的 DCN1 抑制剂。低纳摩尔浓度下，DI-1859 能够抑制细胞中 cullin 3 的 neddylation。DI-1859 能够促使小鼠肝脏中 NRF2 蛋白（一种 CRL3 底物）显著提高，并有效保护小鼠，防止乙酰氨基酚诱导的肝损伤。

化合物

Acetaminophen mercapturate

Cat.No: T20215

Acetaminophen metabolite 3-hydroxy-acetaminophen

Cat.No: T19175

Synonym: 对乙酰氨基酚代谢物,3-Hydroxyacetaminophen

Target: Others

Acetaminophen Glucuronide (sodium salt)

Cat.No: T36826

3-Cysteinylacetaminophen (trifluoroacetate salt)

Cat.No: T38206

Synonym: APAP-Cys,3-(cysteine-S-yl)acetaminophen,3-Cysteinylacetaminophen (trifluoroacetate salt)

3-Methylacetaminophen

Cat.No: T29415

Propacetamol Hydrochloride

Cat.No: T4545

Synonym: 盐酸丙帕他莫,Propacetamol HCL

Target: Others

Cat.No: T0914

Synonym: 酰胺苯酚,3-Acetamidophenol

Target: Others

Cat.No: T7280

Target: Phospholipase

Cholesteryl Hemisuccinate Tris Salt

Cat.No: TF0106

Target: Apoptosis

Cholesteryl Hemisuccinate

Cat.No: T67509

Synonym: Cholesterol hydrogen succinate

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase

Cat.No: T9948

Synonym: LC-280126,LC28-0126,LC28 0126

Target: NADPH-oxidase

Paracetamol mercapturate

Cat.No: T33881

4-Acetamidophenyl acetate

Cat.No: T10135

Target: Others

4-Hydroxyacetophenone oxime

Cat.No: T10143

Target: Others

Cat.No: T69218

Anti-inflammatory agent 62

Cat.No: T83050

L-Cysteine-glutathione disulfide

Cat.No: T38312

Keap1-Nrf2-IN-1

Cat.No: T11752

Synonym: Keap1–Nrf2-IN-1

Target: Src

Ac-Leu-Leu-Norleucinol

Cat.No: T76364

Keap1-Nrf2-IN-1 TFA

Cat.No: T64218

Cat.No: T63930

Cat. No.	Product Name	Target	Signaling Pathways
T0065	Acetaminophen 对乙酰氨基酚,醋氨酚,4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol	COX; Endogenous Metabolite; Histone Acetyltransferase	Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Neuroscience
	Acetaminophen (APAP) 是一种 COX 抑制剂，抑制 COX-1 和 COX-2 (IC50=113.7/25.8 μM)。Acetaminophen 具有解热镇痛活性，以及较弱的抗炎活性。
TN7063	N-Acetaminophen NSC 403155,N-Acetyldemecolcine,N-Methylcolchicine,N-甲基-秋水仙碱,N-Acetylcolchamine	Others	Others
	N-Acetaminophen (N-Methylcolchicine) 是秋水仙碱的甲基化形式。
T3913	Saikosaponin D	Estrogen Receptor/ERR; NF-κB; Antibacterial; STAT	Endocrinology/Hormones; JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells
	Saikosaponin D 是一种从柴胡中分离到的三萜皂苷类天然产物，具有抗炎，抗菌，抗肿瘤，抗过敏作用。它抑制 selectin，STAT3和 NF-kB 的活性，活化estrogen receptor-β。
T4322	2-Hydroxybutyric acid α-Hydroxybutyric acid	Endogenous Metabolite	Metabolism
	2-Hydroxybutyric acid (α-Hydroxybutyric acid) 是蛋白质代谢的产物，是 2 型糖尿病和先兆子痫的生物标志物，是合成生物降解材料和各种化合物的重要中间体。2-Hydroxybutyric acid 可预防 acetaminophen (AP) 引起的肝损伤，可参与抗肿瘤抗生素和可生物降解的聚（2-羟基丁酸）阿齐诺菊酯家族的合成。
T82219	Heilaohuguosu F
	Heilaohuguosu F (compound 6)为一类四氢呋喃木脂素，表现出轻度肝脏保护效果。该化合物对于APAP诱导的HepG2细胞所呈现的肝毒性具有微弱的防护作用。
T82365	Fulvotomentoside B
	Fulvotomentoside B, 一种可从黄毛乳杆菌中分离的皂苷，对于CCl4、d-gal 和对乙酰氨基酚所致中毒小鼠具有显著的保护作用。在减低血清SGPT和GT水平以及减轻肝脏病理损伤方面表现出突出的效果。
TN4223	Homopterocarpin	Antifection	Microbiology/Virology
	Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property

天然产物

Acetaminophen

Cat.No: T0065

Synonym: 对乙酰氨基酚,醋氨酚,4-Acetamidophenol,4'-Hydroxyacetanilide,APAP,Paracetamol

Target: COX, Endogenous Metabolite, Histone Acetyltransferase

N-Acetaminophen

Cat.No: TN7063

Synonym: NSC 403155,N-Acetyldemecolcine,N-Methylcolchicine,N-甲基-秋水仙碱,N-Acetylcolchamine

Target: Others

Cat.No: T3913

Target: Estrogen Receptor/ERR, NF-κB, Antibacterial, STAT

2-Hydroxybutyric acid

Cat.No: T4322

Synonym: α-Hydroxybutyric acid

Target: Endogenous Metabolite

Heilaohuguosu F

Cat.No: T82219

Fulvotomentoside B

Cat.No: T82365

Homopterocarpin

Cat.No: TN4223

Target: Antifection

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