Cat. No. | Product Name | Target | Signaling Pathways |
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T0010 |
6-Mercaptopurine
6-巯基嘌呤,乐疾宁,6-MP,Mercaptopurine,6-巯基嘌呤 |
Nucleoside Antimetabolite/Analog; Others; Dehydrogenase; Endogenous Metabolite; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others |
6-Mercaptopurine (6-MP) 是一种具有免疫抑制特性的抗代谢物抗肿瘤剂。它通过抑制嘌呤代谢来干扰核酸合成,通常与其他药物联合用于白血病的治疗或缓解维持计划。 | |||
T2201 |
6-Mercaptopurine hydrate
6-Mercaptopurine monohydrate,6-巯基嘌呤(一水合物),6-Mercaptopurine (6-MP) Monohydrate,6-巯基嘌呤 一水合物 |
Nucleoside Antimetabolite/Analog; Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
6-Mercaptopurine hydrate (6-Mercaptopurine monohydrate) 是一种核苷代谢抑制剂。它通过抑制嘌呤代谢来干扰核酸合成,通常与其他药物联合用于白血病的治疗或缓解维持计划。 | |||
T26399 |
7-Methyl-6-mercaptopurine
7-Methyl-6-thiopurine,6-Mercapto-7-methylpurine |
Others | Others |
7-Methyl-6-mercaptopurine (7-Methyl-6-thiopurine) 是 PRPP 氨基转移酶的抑制剂,抑制 IMP 代谢并阻止嘌呤、DNA 和 RNA 合成。 | |||
T7621 |
6-Thioinosine
6-Mercaptopurine riboside,6-疏基嘌呤核苷,6TI |
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
6-Thioinosine (6TI) 是一种嘌呤抗代谢物,是抗脂肪形成剂,能降低PPAR γ和C/EBPα及其目标基因 aP2、CD36、LPL 和 LXRα 的 mRNA 水平。 | |||
T3089 |
6-Thioguanine
6-TG,2-Amino-6-purinethiol,2-Amino-6-mercaptopurine,Thioguanine,6-硫代鸟嘌呤 |
Apoptosis; DNA Methyltransferase; SARS-CoV; Endogenous Metabolite; DUB; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Ubiquitination |
6-Thioguanine (2-Amino-6-purinethiol) 是一种抗白血病和免疫抑制剂,是 SARS 和 MERS 冠状病毒木瓜样蛋白酶抑制剂,也抑制 USP2的活性,IC50值分别为 25 μM 和 40 μM。 | |||
T1237 |
Azathioprine
硫唑嘌呤,BW 57-322 |
Apoptosis; GPR; Rho | Apoptosis; Cell Cycle/Checkpoint; Endocrinology/Hormones; GPCR/G Protein |
Azathioprine (BW 57-322) 是一种免疫抑制剂。 | |||
T40359 |
Thio-ITP
6-Thio-ITP,Thio-ITP,6-Mercaptopurine-riboside-5'-triphosphate,6-Thioinosine 5′-triphosphate |
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Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I and 38.0 μM for RNA polymerase II. | |||
T69099 | Azathioprine Sodium | ||
Azathioprine Sodium is the sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. | |||
T36385 |
Ansatrienin A
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Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fl... | |||
T36650 |
Ansatrienin B
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Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellul... |