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Search Results for " 2,3-dioxygenase "

43

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11615	IDO-IN-12	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-12 是吲哚胺 2,3-双加氧酶抑制剂。
T11901	IDO1-IN-5	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-5 是可透过血脑屏障的、选择性的IDO1抑制剂，能够与缺乏血红素的 apo-IDO1 结合，但无法与成熟血红素的 IDO1 结合。
T11616	IDO-IN-13 GS-4361	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-13 (GS-4361) 是 indoleamine 2,3-dioxygenase 1 抑制剂，EC50=17 nM。
T10199	GNF-PF-3777 8-Nitrotryptanthrin	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	GNF-PF-3777 (8-Nitrotryptanthrin) 是人吲哚胺2，3-双加氧酶 2 (hIDO2) 抑制剂，能够降低IDO2活性，Ki=为 0.97 μM。
T9164	BMS-986242 BMS986242	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂，可用于研究癌症。
T2647	IDO5L INCB024360 analogue,INCB14943	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO5L (INCB024360 analogue) 是一种有效的吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，IC50=67 nM。
T4532	Linrodostat BMS-986205	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Linrodostat (BMS-986205) 是选择性的、不可逆的吲哚胺 2,3-双加氧酶 1(IDO1) 抑制剂，能够有效抑制 IDO1-HEK293 细胞，其IC50=1.1 nM。它在晚期癌症中具有良好的药理特性。
T4307	PF-06840003 EOS200271,PF 06840003	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	PF-06840003 (EOS200271) 是口服具有活力的、选择性的IDO-1抑制剂，抑制 hIDO-1， dIDO-1和 mIDO-1 的IC50分别为 0.41 μM， 0.59 μM，和 1.5 μM。
TQ0071	Navoximod GDC-0919,NLG-919	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Navoximod (GDC-0919) 是 IDO(indoleamine-(2,3)-dioxygenase) 抑制剂，Ki=7 nM/，EC50=75 nM。
T7181	IDO-IN-1 4-氨基-N-(3-溴-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-1 是吲哚胺-2,3-双加氧酶抑制剂，IC50=59 nM。
T3548	Epacadostat INCB 024360,艾卡哚司他,IDO Inhibitor 1	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Epacadostat (INCB 024360) 是选择性的IDO1抑制剂，IC50=71.8 nM。
T1847	Necrostatin-1 Nec-1,Necrostatin 1	Indoleamine 2,3-Dioxygenase (IDO); Ferroptosis; Autophagy; RIP kinase	Apoptosis; Autophagy; Metabolism; NF-κB
	Necrostatin-1 (Nec-1) 是一种坏死性凋亡抑制剂和 RIP1 抑制剂，具有特异性。Necrostatin-1 抑制 TNF-α 诱导的坏死性凋亡。Necrostatin-1 也可以抑制 IDO。
T1806	IDO-IN-7 NLG919,Navoximod,NLG-919 analogue,GDC-0919	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-7 (NLG-919 analogue) 是 IDO1 抑制剂，IC50=38 nM。
T4142	PCC0208009 IDO inhibitor 1,DO-IN-2,IDO-IN-2	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	PCC0208009 (IDO-IN-2) 是一种有效的 IDO 抑制剂，其在 HeLa 细胞中的 IC50=4.52 nM。它调节 ACC 和杏仁核的突触可塑性，减少神经性疼痛和合并症。
T6543	Indoximod NLG-8189,Indoximod (NLG-8189）,1-Methyl-D-tryptophan,吲哚莫德	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Indoximod (Indoximod (NLG-8189)) 是一种具有口服具有活力的吲哚胺2,3-双加氧酶(IDO) 途径抑制剂。它在调节 mTOR 中充当 Trp 模拟物。它是一种可用于癌症研究的免疫代谢佐剂。
T20513	IDO1-IN-1 IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1	IDO	Metabolism
	IDO1-IN-1 (2 HzBTZ) 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。
T39476	NLG802	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	NLG802 是 indoximod 的前药，indoximod 是一种口服活性的吲哚胺2,3-双加氧酶（IDO）抑制剂。
T7660	IDO inhibitor 1 4-[[2-[(氨基磺酰基)氨基]乙基]氨基]-N'-(3-溴-4-氟苯基)-N-羟基-1,2,5-恶二唑-3-甲脒	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO inhibitor 1 是一种有效的吲哚胺-2,3 双加氧酶 (IDO) 抑制剂 (IC50 <100 nM)。具有潜在的免疫调节和抗肿瘤活性。
T61202	TDO-IN-1	Others	Others
	TDO-IN-1 是一种具有口服活性、有效性和选择性的色氨酸 2,3-双加氧酶 (TDO)抑制剂，对吲哚胺-2,3-双加氧酶具有抑制作用。TDO-IN-1 具有抗肿瘤活性，能够通过逆转肿瘤组织的局部免疫耐受来发挥作用。
T4410	LM10	Others	Others
	LM10 是有效的色氨酸 2,3-双加氧酶的抑制剂。色氨酸 2,3-双加氧酶是一种无关的肝酶，它可通过犬尿氨酸途径降解色氨酸。它对研究癌症疾病具有潜在的研究价值。
T11617	IDO-IN-3	IDO	Metabolism
	IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
T11621	IDO-IN-8 NLG-1487	IDO	Metabolism
	IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11618	IDO-IN-4	Others	Others
	IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor.
T11619	IDO-IN-5 NLG-1489	IDO	Metabolism
	IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11623	IDO/TDO-IN-1	Others	Others
	IDO/TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM).
T11620	IDO-IN-6 NLG-1486	IDO	Metabolism
	IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T70189	Navoximod phosphate
	Navoximod phosphate is an indoleamine 2,3-dioxygenase (IDO) inhibitor, immunomodulator and antineoplastic.
T11622	IDO-IN-9	IDO	Metabolism
	IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
T74992	NU223612
	NU223612 是一种有效的PROTAC(PROTACs)，可降解吲哚胺 2,3-双加氧酶 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO))，Kd 为 640 nM。NU223612 通过CRBN 介导的蛋白酶体降解有效降解IDO1蛋白。NU223612 以 290 nM 的亲和力与 CRBN 结合。NU223612 可以穿过血脑屏障 (BBB)。
T11614	IDO-IN-11	IDO	Metabolism
	IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
T73437	DP00477
	DP00477，一种高效IDO1(indoleamine 2,3-dioxygenase 1)抑制剂，IC50为7.0 µM，展现在癌症研究中的潜力。
T60698	Roxyl-9
	Roxyl-9 是一种 IDO1 (吲哚胺2,3-双加氧酶1) 抑制剂。
T12668	(Rac)-IDO1-IN-5	Others	Others
	(Rac)-IDO1-IN-5 is a racemate of IDO1-IN-5, a potent, selective, and brain-penetrating inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity. It specifically binds to apo-IDO1, which lacks heme, instead of mature heme-bound IDO1.
T82082	IDO1-IN-23	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-23（化合物41）是一种有效的人类IDO1抑制剂，具备13 μM的IC50值。
T76560	Imsamotide
	Imsamotide (IDO194-214) 为一种具有序列 DTLLKALLEIASCLEKALQVF 的吲哚胺 2,3-双加氧酶 (IDO) 肽。它同时作为主动免疫的免疫剂和抗肿瘤剂。
T39888	IDO1-IN-7 IDO1-IN-7
	IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.
T60266	(Rac)-Indoximod
	(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardiac myofibroblasts (hCMs) and promotes apoptosis by up-regulating the genes IRF-1, Fas, and FasL. Moreover, this co-treatment effectively improves cardiac fibrosis[1].
T37329	PROTAC IDO1 Degrader-1 PROTAC IDO1 Degrader-1
	PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. PROTAC IDO1 Degrader-1 (compound 2c) (10 μM; 24 hours) notably decreases IDO1 level induced by IFN-γ[1].PROTAC IDO1 Degrader-1 and IFN-γ (5 ng/mL) are incubated with HeLa cells for 24...
T63814	IDO2-IN-1
	IDO2-IN-1 是一种口服活性的强效IDO2抑制剂，其IC50为112 nM。该化合物适用于炎症性自身免疫研究。
T38276	Benzomalvin C
	Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/ml in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC50 value of 130 μM for recombinant IDO. It was isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.
T36645	CAY10763 CAY10763
	CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM...
T69944	NLG802 HCl
	NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indoximod. Indoximod targets, binds to and inhibits the enzyme indoleamine 2,3-dioxygenase (IDO; IDO1), which converts the essential amino acid tryptophan into the immunosuppressive metabolite kynurenine. By increasing tryptophan levels and decreasing kynurenine levels, indoximod res...
T73581	HI5
	HI5 是一种有效的微管蛋白 (tublin)和IDO 抑制剂，对 HeLa 细胞的IC50为 70 nM。HI5 抑制IDO 的表达，减少犬尿氨酸的产生，从而刺激 T 细胞活化和增殖。HI5 对 HeLa 细胞可抑制微管蛋白聚合和细胞迁移，引起 G2/M 期阻滞，同时通过线粒体依赖性凋亡途径诱导细胞凋亡 (apoptosis) 并引起反应性氧化应激。HI5 可用于抗癌研究。

化合物

Cat.No: T11615

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T11901

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T11616

Synonym: GS-4361

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T10199

Synonym: 8-Nitrotryptanthrin

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T9164

Synonym: BMS986242

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T2647

Synonym: INCB024360 analogue,INCB14943

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4532

Synonym: BMS-986205

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4307

Synonym: EOS200271,PF 06840003

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: TQ0071

Synonym: GDC-0919,NLG-919

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T7181

Synonym: 4-氨基-N-(3-溴-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T3548

Synonym: INCB 024360,艾卡哚司他,IDO Inhibitor 1

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T1847

Synonym: Nec-1,Necrostatin 1

Target: Indoleamine 2,3-Dioxygenase (IDO), Ferroptosis, Autophagy, RIP kinase

Cat.No: T1806

Synonym: NLG919,Navoximod,NLG-919 analogue,GDC-0919

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4142

Synonym: IDO inhibitor 1,DO-IN-2,IDO-IN-2

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T6543

Synonym: NLG-8189,Indoximod (NLG-8189）,1-Methyl-D-tryptophan,吲哚莫德

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T20513

Synonym: IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1

Target: IDO

Cat.No: T39476

Target: Indoleamine 2,3-Dioxygenase (IDO)

IDO inhibitor 1

Cat.No: T7660

Synonym: 4-[[2-[(氨基磺酰基)氨基]乙基]氨基]-N'-(3-溴-4-氟苯基)-N-羟基-1,2,5-恶二唑-3-甲脒

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T61202

Target: Others

Cat.No: T4410

Target: Others

Cat.No: T11617

Target: IDO

Cat.No: T11621

Synonym: NLG-1487

Target: IDO

Cat.No: T11618

Target: Others

Cat.No: T11619

Synonym: NLG-1489

Target: IDO

Cat.No: T11623

Target: Others

Cat.No: T11620

Synonym: NLG-1486

Target: IDO

Navoximod phosphate

Cat.No: T70189

Cat.No: T11622

Target: IDO

Cat.No: T74992

Cat.No: T11614

Target: IDO

Cat.No: T73437

Cat.No: T60698

(Rac)-IDO1-IN-5

Cat.No: T12668

Target: Others

Cat.No: T82082

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T76560

Cat.No: T39888

Synonym: IDO1-IN-7

(Rac)-Indoximod

Cat.No: T60266

PROTAC IDO1 Degrader-1

Cat.No: T37329

Synonym: PROTAC IDO1 Degrader-1

Cat.No: T63814

Cat.No: T38276

Cat.No: T36645

Synonym: CAY10763

Cat.No: T69944

Cat.No: T73581

Cat. No.	Product Name	Target	Signaling Pathways
T4S0051	Coptisine sulfate	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine Sulfate 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T3S1967	(S)-Indoximod N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine	Others; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism; Others
	(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，可用于研究癌症。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T2718	Palmatine chloride	Others; Indoleamine 2,3-Dioxygenase (IDO); Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Others
	Palmatine chloride 是口服具有活力的不可逆 IDO-1抑制剂。它能够减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，并改善 DSS 诱发的结肠炎。
T5S0056	Coptisine chloride 盐酸黄连碱,氯化黄连碱,Q-100696,NSC-119754	Indoleamine 2,3-Dioxygenase (IDO); Influenza Virus; Antibacterial	Metabolism; Microbiology/Virology
	Coptisine chloride (NSC-119754) 是从黄连中分离到的一种生物碱，是一种非竞争性 IDO 抑制剂，Ki 值为 5.8 μM，IC50值为 6.3 μM。它是一种 H1N1 神经氨酸酶抑制剂，可用于甲型流感病毒感染，IC50为 104.6 μg/mL。
T5S0802	Palmatine 巴马汀,Berbericinine,Burasaine	Indoleamine 2,3-Dioxygenase (IDO); AChR; AChE; Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Neuroscience
	Palmatine (Burasaine) 是口服具有活力的、不可逆IDO-1抑制剂。它可以减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，从而改善DSS (Dextran Sulphate Sodium Salt) 诱发的结肠炎。它有用于结肠炎的研究潜力。
T8214	Kushenol E 苦参醇E,Flemiphilippinin D	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Kushenol E (Flemiphilippinin D) 是一种分离自Sophora flavescens 中的类黄酮，是一种IDO1的非竞争性抑制剂，其IC50=7.7 µM，Ki=为 9.5 µM，具有抗肿瘤特性。
T4779	4-Methylcatechol p-Methylcatechol,3,4-二羟基甲苯,Homocatechol,4-methylbenzene-1,2-diol,3,4-Dihydroxytoluene	Others; Endogenous Metabolite	Metabolism; Others
	4-Methylcatechol (3,4-Dihydroxytoluene) 是 p-toluate 的代谢物，它是 Catechol 2,3-Dioxygenase 的自杀性底物抑制剂。
T72508	Palmatine hydroxide
	Palmatine hydroxide 是不可逆的口服活性IDO-1抑制剂，其对HEK 293-hIDO-1 和 rhIDO-1的IC50值分别为3 μM和157 μM。该化合物还能非竞争性抑制(WNV)NS2B-NS3蛋白酶，IC50值为96 μM。Palmatine hydroxide展现了抗癌、抗炎、神经保护、抗细菌和抗病毒的活性。

天然产物

Coptisine sulfate

Cat.No: T4S0051

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T3S1967

Synonym: N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine

Target: Others, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Palmatine chloride

Cat.No: T2718

Target: Others, Indoleamine 2,3-Dioxygenase (IDO), Aurora Kinase

Coptisine chloride

Cat.No: T5S0056

Synonym: 盐酸黄连碱,氯化黄连碱,Q-100696,NSC-119754

Target: Indoleamine 2,3-Dioxygenase (IDO), Influenza Virus, Antibacterial

Cat.No: T5S0802

Synonym: 巴马汀,Berbericinine,Burasaine

Target: Indoleamine 2,3-Dioxygenase (IDO), AChR, AChE, Aurora Kinase

Cat.No: T8214

Synonym: 苦参醇E,Flemiphilippinin D

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

4-Methylcatechol

Cat.No: T4779

Synonym: p-Methylcatechol,3,4-二羟基甲苯,Homocatechol,4-methylbenzene-1,2-diol,3,4-Dihydroxytoluene

Target: Others, Endogenous Metabolite

Palmatine hydroxide

Cat.No: T72508

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